Jean Pierre Devogelaer

Summary

Country: Belgium

Publications

  1. ncbi request reprint Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis
    Daniel Henri Manicourt
    St Luc University Hospital and Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Brussels, Belgium
    Arthritis Rheum 54:3205-11. 2006
  2. doi request reprint Effect on bone turnover markers of once-yearly intravenous infusion of zoledronic acid versus daily oral risedronate in patients treated with glucocorticoids
    Jean Pierre Devogelaer
    Universite Catholique de Louvain, UCL5390, B 1200 Brussels, Belgium
    Rheumatology (Oxford) 52:1058-69. 2013
  3. ncbi request reprint Long-term effects of percutaneous estradiol on bone loss and bone metabolism in postmenopausal hysterectomized women
    J P Devogelaer
    Department of Rheumatology, St Luc University Hospital, Brussels, Belgium
    Maturitas 28:243-9. 1998
  4. ncbi request reprint Modern therapy for Paget's disease of bone: focus on bisphosphonates
    Jean Pierre Devogelaer
    Université Catholique de Louvain in Brussels, Brussels, Belgium
    Treat Endocrinol 1:241-57. 2002
  5. ncbi request reprint Glucocorticoid-induced osteoporosis: mechanisms and therapeutic approach
    Jean Pierre Devogelaer
    Department of Medicine, Arthritis Unit, Saint Luc University Hospital, Universite Catholique de Louvain, 10, Avenue Hippocrate, UCL 5390, B 1200 Brussels, Belgium
    Rheum Dis Clin North Am 32:733-57. 2006
  6. ncbi request reprint Zoledronic acid efficacy and safety over five years in postmenopausal osteoporosis
    J P Devogelaer
    Saint Luc University Hospital, Universite Catholique de Louvain, Bruxelles, Belgium
    Osteoporos Int 18:1211-8. 2007
  7. ncbi request reprint A review of the effects of tibolone on the skeleton
    Jean Pierre Devogelaer
    Rheumatology Unit, Saint Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Expert Opin Pharmacother 5:941-9. 2004
  8. doi request reprint Management of patients with Paget's disease: a consensus document of the Belgian Bone Club
    J P Devogelaer
    Service de Rhumatologie, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium
    Osteoporos Int 19:1109-17. 2008
  9. ncbi request reprint A risk-benefit assessment of alendronate in the treatment of involutional osteoporosis
    J P Devogelaer
    Department of Rheumatology, Saint Luc University Hospital, Louvain University in Brussels, Belgium
    Drug Saf 19:141-54. 1998
  10. ncbi request reprint Treatment of bone diseases with bisphosphonates, excluding osteoporosis
    J P Devogelaer
    Department of Rheumatology, St Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Curr Opin Rheumatol 12:331-5. 2000

Detail Information

Publications50

  1. ncbi request reprint Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis
    Daniel Henri Manicourt
    St Luc University Hospital and Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Brussels, Belgium
    Arthritis Rheum 54:3205-11. 2006
    ..To evaluate the effects of oral salmon calcitonin (sCT) on Lequesne's algofunctional index scores and on biomarkers of joint metabolism in knee osteoarthritis...
  2. doi request reprint Effect on bone turnover markers of once-yearly intravenous infusion of zoledronic acid versus daily oral risedronate in patients treated with glucocorticoids
    Jean Pierre Devogelaer
    Universite Catholique de Louvain, UCL5390, B 1200 Brussels, Belgium
    Rheumatology (Oxford) 52:1058-69. 2013
    ..The aim of this study was to examine the effects of two bisphosphonates, i.v. zoledronic acid (ZOL) versus oral risedronate (RIS), on bone turnover markers (BTMs) in subjects with glucocorticoid-induced osteoporosis (GIO)...
  3. ncbi request reprint Long-term effects of percutaneous estradiol on bone loss and bone metabolism in postmenopausal hysterectomized women
    J P Devogelaer
    Department of Rheumatology, St Luc University Hospital, Brussels, Belgium
    Maturitas 28:243-9. 1998
    ..To determine whether percutaneous estradiol (pE2) (1.5 mg/day) is able to counteract the postmenopausal bone loss in postmenopausal hysterectomized women, in a double-blind study versus oral estriol (E3) (2 mg/day)...
  4. ncbi request reprint Modern therapy for Paget's disease of bone: focus on bisphosphonates
    Jean Pierre Devogelaer
    Université Catholique de Louvain in Brussels, Brussels, Belgium
    Treat Endocrinol 1:241-57. 2002
    ..The increased potency and longer duration of action of newer bisphosphonates more than compensates for their marginally increased cost compared with older bisphosphonates...
  5. ncbi request reprint Glucocorticoid-induced osteoporosis: mechanisms and therapeutic approach
    Jean Pierre Devogelaer
    Department of Medicine, Arthritis Unit, Saint Luc University Hospital, Universite Catholique de Louvain, 10, Avenue Hippocrate, UCL 5390, B 1200 Brussels, Belgium
    Rheum Dis Clin North Am 32:733-57. 2006
    ..Studies of other therapeutic modalities (eg, promoters of bone formation) are in progress...
  6. ncbi request reprint Zoledronic acid efficacy and safety over five years in postmenopausal osteoporosis
    J P Devogelaer
    Saint Luc University Hospital, Universite Catholique de Louvain, Bruxelles, Belgium
    Osteoporos Int 18:1211-8. 2007
    ..BMD increased significantly. Bone turnover markers decreased from baseline and were maintained within premenopausal reference ranges...
  7. ncbi request reprint A review of the effects of tibolone on the skeleton
    Jean Pierre Devogelaer
    Rheumatology Unit, Saint Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Expert Opin Pharmacother 5:941-9. 2004
    ....
  8. doi request reprint Management of patients with Paget's disease: a consensus document of the Belgian Bone Club
    J P Devogelaer
    Service de Rhumatologie, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium
    Osteoporos Int 19:1109-17. 2008
    ..Its therapeutic efficacy, its long-term effect on biologic activity and its good tolerance currently supports its use as a first-line therapeutic option in patients suffering from PDB...
  9. ncbi request reprint A risk-benefit assessment of alendronate in the treatment of involutional osteoporosis
    J P Devogelaer
    Department of Rheumatology, Saint Luc University Hospital, Louvain University in Brussels, Belgium
    Drug Saf 19:141-54. 1998
    ....
  10. ncbi request reprint Treatment of bone diseases with bisphosphonates, excluding osteoporosis
    J P Devogelaer
    Department of Rheumatology, St Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Curr Opin Rheumatol 12:331-5. 2000
    ..Now that the fear of theoretically freezing bone remodeling has been reasonably dismissed, potential uses for bisphosphonates might be considered nearly infinite...
  11. ncbi request reprint New uses of bisphosphonates: osteogenesis imperfecta
    Jean Pierre Devogelaer
    Université Catholique de Louvain in Brussels, The Arthritis Unit, UCL 5390, Saint Luc University Hospital, Avenue Hippocrate 10, B 1200, Brussels, Belgium
    Curr Opin Pharmacol 2:748-53. 2002
    ..Newer, theoretically more potent bisphosphonates are currently being tested in this potentially crippling condition...
  12. doi request reprint Is there a place for bone turnover markers in the assessment of osteoporosis and its treatment?
    Jean Pierre Devogelaer
    Division of Rheumatology and Rheumatology Unit, Department of Medicine, UCL 5390, Université Catholique de Louvain in Brussels, Saint Luc University Hospital, Avenue Hippocrate 10, B 1200 Brussels, Belgium
    Rheum Dis Clin North Am 37:365-86, v-vi. 2011
    ..Whether this behavior is cost-effective remains to be settled...
  13. ncbi request reprint Role of alendronate in therapy for posttraumatic complex regional pain syndrome type I of the lower extremity
    Daniel Henri Manicourt
    St Luc University Hospital, Universite Catholique de Louvain, 5390 Avenue Mounier, 1200 Brussels, Belgium
    Arthritis Rheum 50:3690-7. 2004
    ..To evaluate the effects of the antiresorptive agent alendronate at a daily oral dose of 40 mg in patients with posttraumatic complex regional pain syndrome type I (CRPS I) of the lower extremity...
  14. ncbi request reprint Inulin and fructo-oligosaccharides differ in their ability to enhance the density of cancellous and cortical bone in the axial and peripheral skeleton of growing rats
    Adrien Nzeusseu
    Department of Rheumatology, Saint Luke s University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Bone 38:394-9. 2006
    ..Although cecal wall hyperplasia may be of concern, it remains to establish whether the positive effect of fructans observed on calcium absorption in humans is also associated with a positive effect on bone mass and/or mineral density...
  15. ncbi request reprint Evidence-based guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis: a consensus document of the Belgian Bone Club
    Jean Pierre Devogelaer
    Rheumatology Unit, Saint Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Osteoporos Int 17:8-19. 2006
    ..There is indeed no proof that the increased costs of combined treatments will translate into increased therapeutic efficacy...
  16. ncbi request reprint Celecoxib has a positive effect on the overall metabolism of hyaluronan and proteoglycans in human osteoarthritic cartilage
    Hafida El Hajjaji
    ICP Christian de Duve Institute of Cellular Pathology and the Department of Rheumatology, Saint Luc University Hospital, Catholic University of Louvain, Avenue Mounier, 1200 Brussels, Belgium
    J Rheumatol 30:2444-51. 2003
    ..Results were compared with those of diclofenac, a non-selective COX inhibitor...
  17. pmc Fibroblast growth factor-23 and parathyroid hormone are associated with post-transplant bone mineral density loss
    Nada Kanaan
    Department of Nephrology, Cliniques Universitaires Saint Luc, 10, Av Hippocrate, 1200 Brussels, Belgium
    Clin J Am Soc Nephrol 5:1887-92. 2010
    ..We hypothesized that a high pretransplant level of the recently described phosphaturic hormone fibroblast growth factor 23 (FGF-23) is a risk factor for accelerated BMD loss occurring within the first post-transplant year...
  18. ncbi request reprint Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency
    Catherine Behets
    Department of Anatomy, Universite Catholique de Louvain, Brussels, Belgium
    J Bone Miner Res 19:1821-6. 2004
    ..CT significantly reduced both SBM and cartilage lesions. This study supports the use of CT in the treatment of canine experimental OA...
  19. doi request reprint Baseline glucocorticoid dose and bone mineral density response with teriparatide or alendronate therapy in patients with glucocorticoid-induced osteoporosis
    Jean Pierre Devogelaer
    Universite Catholique de Louvain, B 1200, Brussels, Belgium
    J Rheumatol 37:141-8. 2010
    ....
  20. doi request reprint Biologicals in osteoporosis: teriparatide and parathyroid hormone in women and men
    Jean Pierre Devogelaer
    Department of Rheumatology, Universite Catholique de Louvain, UCL 5390, St Luc University Hospital, Avenue Hippocrate 10, 1200 Brussels, Belgium
    Curr Osteoporos Rep 8:154-61. 2010
    ..New modes of administration (transdermal, intranasal, oral) will probably become available soon. With all the drugs available today and those still in development, it can be hoped that osteoporosis will become a disease of the past...
  21. ncbi request reprint Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis
    Hafida El Hajjaji
    Christian de Duve Institute of Cellular Pathology, Connective Tissue Group, Department of Biochemistry, Catholic University of Louvain in Brussels, 1200 Brussels, Belgium
    Osteoarthritis Cartilage 12:904-11. 2004
    ..To evaluate the effect of calcitonin (CT) on the histology and biochemistry of articular cartilage from unstable operated and nonoperated knee in a canine model of experimental osteoarthritis (OA)...
  22. ncbi request reprint Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis
    Daniel Henri Manicourt
    Department of Rheumatology, Universite Catholique de Louvain, Saint Luc University Hospital Saint Luc, Brussels, Belgium
    Drugs R D 6:261-71. 2005
    ....
  23. ncbi request reprint Tacrolimus and low-dose steroid immunosuppression preserves bone mass after renal transplantation
    Eric Goffin
    Department of Nephrology, Hopital Saint Luc, Universite Catholique de Louvain, 10 Ave Hippocrate, 1200 Brussels, Belgium
    Transpl Int 15:73-80. 2002
    ..Weconclude that tacrolimus associated with low-dose steroids might better preserve bone mass after renal TP than cyclosporine and normal doses of steroids...
  24. ncbi request reprint (18)F-fluoride PET for monitoring therapeutic response in Paget's disease of bone
    Johanne Installé
    Department of Molecular Imaging and Experimental Radiotherapy, Catholic University of Louvain, Brussels, Belgium
    J Nucl Med 46:1650-8. 2005
    ..A prospective study was undertaken to evaluate PET with (18)F-fluoride for monitoring the response to bisphosphonates in Paget's disease of bones...
  25. ncbi request reprint Beneficial effects of creatine supplementation in dystrophic patients
    Magali Louis
    Institut d éducation physique et de réadaptation, Universite Catholique de Louvain, 1 Place Pierre de Coubertin, B 1348 Louvain la Neuve, Belgium
    Muscle Nerve 27:604-10. 2003
    ..05), and urinary excretion of collagen type I cross-linking N-telopeptide declined to about one third (P < 0.001) after Cr. No adverse effect was observed. Thus, Cr may provide some symptomatic benefit in these patients...
  26. doi request reprint Long-term effects on bone mineral density of different therapeutic schemes for acute lymphoblastic leukemia or non-Hodgkin lymphoma during childhood
    Sarra Benmiloud
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Horm Res Paediatr 74:241-50. 2010
    ..Little is known regarding long-term bone deficit in relationship with the modalities of cancer therapy among survivors of childhood malignancy...
  27. ncbi request reprint Zoledronic acid for treatment of Paget's disease of bone
    Jean Pierre Devogelaer
    Professor of Rheumatology, Saint Luc University Hospital, Arthritis Unit, Universite Catholique de Louvain, Avenue Hippocrate 10, B 1200 Brussels, Belgium
    Expert Opin Pharmacother 8:2863-9. 2007
    ..In the long term, prevention of severe complications can be envisaged, with a reasonable pharmacoeconomic cost...
  28. doi request reprint Remission over 3 years in patients with Paget disease of bone treated with a single intravenous infusion of 5 mg zoledronic acid
    Jean Pierre Devogelaer
    Department of Rheumatology, Saint Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Calcif Tissue Int 94:311-8. 2014
    ....
  29. pmc Renal expression of parvalbumin is critical for NaCl handling and response to diuretics
    Hendrica Belge
    Department of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 104:14849-54. 2007
    ..They also provide insights into the Ca(2+)-sparing action of thiazides and the pathophysiology of distal tubulopathies...
  30. doi request reprint Postnatal growth defect in mice upon persistent Hoxa2 expression in the chondrogenic cell lineage
    Pierre Marcel Louis Deprez
    Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Brussels, Belgium
    Differentiation 83:158-67. 2012
    ..The indepth analysis of cartilage and bone histogenesis points towards an initial deficit in cell mobilization to enter chondrogenesis...
  31. ncbi request reprint Spontaneous rupture of the distal iliopsoas tendon: clinical and imaging findings, with anatomic correlations
    Frederic E Lecouvet
    Department of Radiology and Medical Imaging, Saint Luc University Hospital, Universite Catholique de Louvain, Hippocrate Avenue 10 2942, 1200, Brussels, Belgium
    Eur Radiol 15:2341-6. 2005
    ....
  32. doi request reprint Urban tropospheric ozone increases the prevalence of vitamin D deficiency among Belgian postmenopausal women with outdoor activities during summer
    Daniel Henri Manicourt
    Department of Rheumatology, St Luc University Hospital, UCL 5390, 1200 Brussels, Belgium
    J Clin Endocrinol Metab 93:3893-9. 2008
    ..By absorbing sunlight UVB and thereby reducing cutaneous vitamin D photosynthesis, ozone, a common urban pollutant, could cause hypovitaminosis D...
  33. ncbi request reprint Relationship between bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate
    Olivier Bruyere
    World Health Organization Collaborating Center for Public Health Aspect of Osteoarticular Disorders, University of Liege, B 4000 Liege, Belgium
    J Clin Endocrinol Metab 92:3076-81. 2007
    ..Our objective was to analyze the relationship between bone mineral density (BMD) changes and fracture incidence during 3-yr treatment with strontium ranelate...
  34. ncbi request reprint Ten years' experience with alendronate for osteoporosis in postmenopausal women
    Henry G Bone
    Michigan Bone and Mineral Clinic, Detroit 48236, USA
    N Engl J Med 350:1189-99. 2004
    ..Antiresorptive agents are widely used to treat osteoporosis. We report the results of a multinational randomized, double-blind study, in which postmenopausal women with osteoporosis were treated with alendronate for up to 10 years...
  35. ncbi request reprint Evaluation of proposals of Belgian Social Security Institute for reimbursement of bone densitometry tests. Toward a cost-effective strategy for osteoporosis screening?
    Wafa Ben Sedrine
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders, Department of Epidemiology and Public Health, University of Liege, Liege, Belgium
    Aging Clin Exp Res 16:413-9. 2004
    ..The aim of this paper was to evaluate the diagnostic accuracy of the proposed criteria for identifying osteoporosis, and to gauge how useful they are for more rational application of densitometry tests...
  36. ncbi request reprint Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis
    Eric Abadie
    Department of Registration and Clinical Studies, French Agency For the Safety of Health Products AFSSAPS, France
    Osteoarthritis Cartilage 12:263-8. 2004
    ..Recently, new technology has been developed to detect a structural change of the OA joint earlier than conventional X-rays...
  37. ncbi request reprint Alendronate versus calcitriol for prevention of bone loss after cardiac transplantation
    Agnès Dejardin
    N Engl J Med 350:2306-8; author reply 2306-8. 2004
  38. ncbi request reprint Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate
    David Hosking
    City Hospital, Nottingham, UK
    J Bone Miner Res 22:142-8. 2007
    ..This effect is largely independent of pretreatment disease activity and prior bisphosphonate therapy...
  39. ncbi request reprint Intravenous zoledronic acid in postmenopausal women with low bone mineral density
    Ian R Reid
    Department of Medicine, University of Auckland, Auckland, New Zealand
    N Engl J Med 346:653-61. 2002
    ..Gastrointestinal intolerance limits maximal dosing. Although intermittent intravenous treatments have been used, the optimal doses and dosing interval have not been systematically explored...
  40. ncbi request reprint Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Bone Miner Res 19:1531-8. 2004
    ..The results show (1) effective enteral absorption, (2) marked inhibition of bone resorption with minimal alteration of formation, and (3) reproducibility of responses over 3 months...
  41. ncbi request reprint Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic review
    Florent Richy
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders, Liege, Belgium
    Osteoporos Int 14:179-90. 2003
    ..These findings could have practical implication in the long-term management of asthmatic and COPD patients...
  42. ncbi request reprint Deflazacort in giant cell arteritis
    Jean Pierre Devogelaer
    J Rheumatol 29:2244-5. 2002
  43. doi request reprint Founder effect in different European countries for the recurrent P392L SQSTM1 mutation in Paget's Disease of Bone
    Pui Yan Jenny Chung
    Department of Medical Genetics, University and University Hospital of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium
    Calcif Tissue Int 83:34-42. 2008
    ..The chance to obtain this result due to 33 independent mutation events is 3.97 x 10(-14), providing strong evidence for a founder effect of the P392L SQSTM1 mutation in Belgian, Dutch, and Spanish patients with PDB...
  44. ncbi request reprint The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture
    Mark A Bach
    Merck Research Laboratories, Rahway, New Jersey, USA
    J Am Geriatr Soc 52:516-23. 2004
    ..To evaluate the effects of MK-0677, an orally active growth hormone (GH) secretagogue, on functional recovery from hip fracture in previously mobile older individuals...
  45. ncbi request reprint Raloxifene reduces fractures in postmenopausal women with osteoporosis
    Jean Yves Reginster
    Department of Public Health, Epidemiology and Health Economics, University of Liège and the World Health Organization Collaborating Centre for Public Health Aspects of Bone Diseases, Liege, Belgium
    Clin Orthop Relat Res 443:48-54. 2006
    ....
  46. ncbi request reprint Identification of sex-specific associations between polymorphisms of the osteoprotegerin gene, TNFRSF11B, and Paget's disease of bone
    Greet Beyens
    Department of Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium
    J Bone Miner Res 22:1062-71. 2007
    ..We observed no association in men, but a highly significant association was found in women, and this was confirmed in a population from the United Kingdom...
  47. ncbi request reprint Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling
    Wendy Balemans
    Department of Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium
    J Bone Miner Res 22:708-16. 2007
    ..In vitro studies suggest that a reduced antagonistic effect of DKK1 on canonical Wnt signaling contributes to the molecular effect of this mutation and its pathogenic consequence...
  48. ncbi request reprint Dual energy x-ray absorptiometry-based assessment of male patients using standardized bone density values and a national reference database
    Stefan Goemaere
    Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium
    J Clin Densitom 10:25-33. 2007
    ..The current data provide a basis to implement a nation-wide, uniform expression of BMD in male patients and allow harmonization of the BMD-based diagnosis and treatment of osteoporosis in men...
  49. ncbi request reprint Evidence-based guidelines for the treatment of postmenopausal osteoporosis: a consensus document of the Belgian Bone Club
    Steven Boonen
    Center for Metabolic Bone Diseases, Katholieke University Leuven, Leuven, Belgium
    Osteoporos Int 16:239-54. 2005
  50. ncbi request reprint Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia
    Ego Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 23:433-8. 2008
    ..Vertebral fracture risk reduction of 41-59% was shown depending on the site and fracture status at baseline. This is the first report of antivertebral fracture efficacy in women with vertebral osteopenia...