Nathalie M Delzenne

Summary

Country: Belgium

Publications

  1. ncbi request reprint Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain
    Claude Knauf
    Unit Mixte de Recherche, 5018, Centre National de la Recherche Scientifique University Paul Sabatier, IFR 31, Bt L1 Rue J Poulhès, 31403 Toulouse, France
    Endocrinology 147:4067-78. 2006
  2. ncbi request reprint Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
  3. ncbi request reprint Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    J Nutr 137:2547S-2551S. 2007
  4. ncbi request reprint Gut microflora as a target for energy and metabolic homeostasis
    Patrice D Cani
    Universite Catholique de Louvain, Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 10:729-34. 2007
  5. doi request reprint [Gut microflora is a key player in host energy homeostasis]
    Nathalie M Delzenne
    Universite Catholique de Louvain, Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Bruxelles, Belgique UCL, Unit PMNT 7369, avenue E Mounier, 73 69, B 1200 Bruxelles, Belgique
    Med Sci (Paris) 24:505-10. 2008
  6. pmc Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets
    Barbara D Pachikian
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 6:e23365. 2011
  7. pmc Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice
    Audrey M Neyrinck
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 6:e20944. 2011
  8. pmc Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model
    Laure B Bindels
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 7:e37971. 2012
  9. pmc Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women
    Evelyne M Dewulf
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier 73, PO Box B1 73 11, 1200 Brussels, Belgium
    Gut 62:1112-21. 2013
  10. pmc Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice
    A M Neyrinck
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Nutr Diabetes 2:e28. 2012

Detail Information

Publications79

  1. ncbi request reprint Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain
    Claude Knauf
    Unit Mixte de Recherche, 5018, Centre National de la Recherche Scientifique University Paul Sabatier, IFR 31, Bt L1 Rue J Poulhès, 31403 Toulouse, France
    Endocrinology 147:4067-78. 2006
    ..By contrast, activation of PPARalpha in the brain stimulates peripheral glucose use. This suggests that the alteration in adipocyte glucose metabolism in the knockout mice may result from the absence of PPARalpha in the brain...
  2. ncbi request reprint Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
    ..We conclude that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity. Lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases...
  3. ncbi request reprint Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    J Nutr 137:2547S-2551S. 2007
    ..Several studies in humans already support interest in OFS in the control of satiety, triglyceridemia, or steatohepatitis. The link with gut peptides production in humans remains to be proven...
  4. ncbi request reprint Gut microflora as a target for energy and metabolic homeostasis
    Patrice D Cani
    Universite Catholique de Louvain, Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 10:729-34. 2007
    ..This review discusses new findings that may explain how gut microbiota can be involved in the control of energy and metabolic homeostasis...
  5. doi request reprint [Gut microflora is a key player in host energy homeostasis]
    Nathalie M Delzenne
    Universite Catholique de Louvain, Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Bruxelles, Belgique UCL, Unit PMNT 7369, avenue E Mounier, 73 69, B 1200 Bruxelles, Belgique
    Med Sci (Paris) 24:505-10. 2008
    ..Changing gut microflora composition could be a useful tool to prevent or to treat high-fat/low fibres diet-induced metabolic syndrome. double dagger...
  6. pmc Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets
    Barbara D Pachikian
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 6:e23365. 2011
    ..In conclusion, n-3 PUFA depletion in liver phospholipids leads to activation of SREBP-1c and lipogenesis, which contributes to hepatic steatosis...
  7. pmc Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice
    Audrey M Neyrinck
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 6:e20944. 2011
    ..We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both the gut microbiota and lipid metabolism in high-fat (HF) diet-induced obese mice...
  8. pmc Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model
    Laure B Bindels
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 7:e37971. 2012
    ..Altogether, these results suggest that the gut microbiota could constitute a novel therapeutic target in the management of leukemia-associated inflammation and related disorders in the muscle...
  9. pmc Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women
    Evelyne M Dewulf
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier 73, PO Box B1 73 11, 1200 Brussels, Belgium
    Gut 62:1112-21. 2013
    ..To highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women...
  10. pmc Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice
    A M Neyrinck
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Nutr Diabetes 2:e28. 2012
    ..Conclusion:Together, these findings suggest that specific non-digestible carbohydrates produced from cereals such as AXOS constitute a promising prebiotic nutrient in the control of obesity and related metabolic disorders...
  11. pmc Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
    L B Bindels
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Br J Cancer 107:1337-44. 2012
    ..We have tested the hypothesis that inulin-type fructans (ITF), by promoting microbial production of short-chain fatty acids (SCFA), influence cancer cell proliferation outside the gut...
  12. pmc Role of the lower and upper intestine in the production and absorption of gut microbiota-derived PUFA metabolites
    Céline Druart
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 9:e87560. 2014
    ....
  13. doi request reprint Gut microbiota and metabolic disorders: How prebiotic can work?
    Nathalie M Delzenne
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Avenue Mounier 73, Box B1 73 11, B 1200 Brussels, Belgium
    Br J Nutr 109:S81-5. 2013
    ..We will evaluate their potential relevance in the management of obesity and related metabolic disturbances, in view of the experimental data and intervention studies published up to date...
  14. pmc Evaluation of the relationship between GPR43 and adiposity in human
    Evelyne M Dewulf
    Metabolism and Nutrition Research Group, LDRI, Universite Catholique de Louvain, Avenue E, Mounier 73, PO box B1, 73, 11, 1200, Brussels, Belgium
    Nutr Metab (Lond) 10:11. 2013
    ..abstract:..
  15. pmc Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition
    B D Pachikian
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    BMC Physiol 8:21. 2008
    ..This experiment carried out in mice aims at studying the impact of dietary n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic metabolism...
  16. doi request reprint Gut microbiota and the pathogenesis of insulin resistance
    Nathalie M Delzenne
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Curr Diab Rep 11:154-9. 2011
    ..Adequate intervention studies in diabetic patients are required to assess the relevance of those experimental data for human health...
  17. pmc Involvement of gut microbial fermentation in the metabolic alterations occurring in n-3 polyunsaturated fatty acids-depleted mice
    Barbara D Pachikian
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Nutr Metab (Lond) 8:44. 2011
    ..abstract:..
  18. pmc Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome
    Nathalie M Delzenne
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Microb Cell Fact 10:S10. 2011
    ....
  19. doi request reprint Interaction between obesity and the gut microbiota: relevance in nutrition
    Nathalie M Delzenne
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Annu Rev Nutr 31:15-31. 2011
    ..The prebiotic and probiotic approaches are presented as interesting research tools to counteract the drop in target bacteria and thereby to estimate their relevance in the improvement of host metabolism...
  20. doi request reprint Lipid peroxidation is not a prerequisite for the development of obesity and diabetes in high-fat-fed mice
    Florence M Sohet
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier 73 69, Brussels, Belgium
    Br J Nutr 102:462-9. 2009
    ..Thus, lipid peroxidation in key organs is not necessarily related to the development of metabolic disorders associated with diabetes and obesity...
  21. doi request reprint Prebiotic approach alleviates hepatic steatosis: implication of fatty acid oxidative and cholesterol synthesis pathways
    Barbara D Pachikian
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Mol Nutr Food Res 57:347-59. 2013
    ..We report how fermentable dietary fructo-oligosaccharides (FOS) control hepatic steatosis induced by n-3 PUFA depletion, which leads to hepatic alterations similar to those observed in non-alcoholic fatty liver disease patients...
  22. ncbi request reprint Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1
    Patrice D Cani
    Université Catholique de Louvain Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie 7369, 73 Avenue Mounier, B 1200 Brussels, Belgium
    Obes Res 13:1000-7. 2005
    ..To analyze the putative interest of oligofructose (OFS) in the modulation of food intake after high-fat diet in rats and to question the relevance of the expression and secretion of intestinal peptides in that context...
  23. ncbi request reprint Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice
    Florence M Sohet
    Louvain Drug Research Institute, Nutrition and Metabolism Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Biochem Pharmacol 78:1391-400. 2009
    ..Diabetes and obesity are metabolic disorders induced by an excessive dietary intake of fat, usually related to inflammation and oxidative stress...
  24. pmc Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    Amandine Everard
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 60:2775-86. 2011
    ..To investigate deep and comprehensive analysis of gut microbial communities and biological parameters after prebiotic administration in obese and diabetic mice...
  25. doi request reprint Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
    ..e., metabolic endotoxemia. Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases...
  26. ncbi request reprint Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota
    Audrey M Neyrinck
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue Mounier 73, Box B1 73 11, B 1200 Brussels, Belgium
    Br J Nutr 109:802-9. 2013
    ....
  27. doi request reprint Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice
    Audrey M Neyrinck
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Nutr Biochem 23:51-9. 2012
    ....
  28. doi request reprint Critical role of Kupffer cells in the management of diet-induced diabetes and obesity
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Biochem Biophys Res Commun 385:351-6. 2009
    ..Therefore, strategies targeting Kupffer cell functions could be a promising approach to counteract obesity and related metabolic disorders...
  29. pmc Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    Amandine Everard
    Metabolism and Nutrition Research Group, Walloon Excellence in Life sciences and BIOtechnology WELBIO, Louvain Drug Research Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 110:9066-71. 2013
    ..These results also provide a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders...
  30. doi request reprint Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice
    Evelyne M Dewulf
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, LDRI, Universite Catholique de Louvain, 1200 Brussels, Belgium
    J Nutr Biochem 22:712-22. 2011
    ....
  31. ncbi request reprint Dietary supplementation with laminarin, a fermentable marine beta (1-3) glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, School of Pharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Int Immunopharmacol 7:1497-506. 2007
    ..These effects could be due to a direct effect of beta-glucan on immune cells, or to an indirect effect through their dietary fibre properties (fermentation in the gut)...
  32. doi request reprint Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice, a phenomenon linked to its lipid-lowering action
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, PMNT7369 73 av Mounier, B 1200 Brussels, Belgium
    Int Immunopharmacol 9:767-73. 2009
    ....
  33. pmc Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue
    Audrey M Neyrinck
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    PLoS ONE 8:e81252. 2013
    ..We questioned the potential relevance of changes in adiposity and gut microbiota in the effect of Curcuma-P® in obesity...
  34. doi request reprint Implication of fermentable carbohydrates targeting the gut microbiota on conjugated linoleic acid production in high-fat-fed mice
    Céline Druart
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Br J Nutr 110:998-1011. 2013
    ..We postulate that the CLA-producing bacteria could be a mediator to consider in the metabolic effects of both HF diet feeding and prebiotic supplementation...
  35. pmc The endocannabinoid system links gut microbiota to adipogenesis
    Giulio G Muccioli
    Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Mol Syst Biol 6:392. 2010
    ..These data indicate that gut microbiota determine adipose tissue physiology through LPS-eCB system regulatory loops and may have critical functions in adipose tissue plasticity during obesity...
  36. doi request reprint Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice
    Barbara D Pachikian
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels 1200, Belgium
    J Nutr 140:509-14. 2010
    ....
  37. ncbi request reprint Impact of inulin and oligofructose on gastrointestinal peptides
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD FARM PMNT 7369, Universite Catholique de Louvain, Avenue E Mounier 73, B 1200 Brussels, Belgium
    Br J Nutr 93:S157-61. 2005
    ....
  38. ncbi request reprint Kupffer cell activity is involved in the hepatoprotective effect of dietary oligofructose in rats with endotoxic shock
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, School of Pharmacy, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Nutr 134:1124-9. 2004
    ..This study supports the hypothesis that oligofructose might decrease liver tissue injury after endotoxic shock and sepsis...
  39. pmc The loss of metabolic control on alcohol drinking in heavy drinking alcohol-dependent subjects
    Philippe de Timary
    Department of Adult Psychiatry, Saint Luc Academic Hospital and Psychological Development Research Unit, Institute of Neuroscience and Institute of Psychology, Catholic University of Louvain, Brussels, Belgium
    PLoS ONE 7:e38682. 2012
    ..We also examined the potential role of a disruption in energy balance in alcohol-dependence...
  40. doi request reprint Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation
    Mireille Alhouayek
    Universite Catholique de Louvain, Louvain Drug Research Institute, Bioanalysis and Pharmacology of Bioactive Lipids Research Group, CHAM7230, Av E Mounier 72, 1200 Bruxelles, Belgium
    FASEB J 25:2711-21. 2011
    ..This could offer a novel pharmacological approach for the treatment of IBD based on the new protective role of 2-arachidonoylglycerol described here...
  41. ncbi request reprint Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
    Patrice D Cani
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Am J Clin Nutr 90:1236-43. 2009
    ..In rodents, these effects are associated with an increase in plasma gut peptide concentrations, which are involved in appetite regulation and glucose homeostasis...
  42. ncbi request reprint Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    J Endocrinol 185:457-65. 2005
    ....
  43. ncbi request reprint Kupffer cell-derived prostaglandin E2 is involved in regulation of lipid synthesis in rat liver tissue
    Audrey M Neyrinck
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, département des sciences pharmaceutiques, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Cell Biochem Funct 22:327-32. 2004
    ....
  44. pmc Tetrahydro iso-alpha acids from hops improve glucose homeostasis and reduce body weight gain and metabolic endotoxemia in high-fat diet-fed mice
    Amandine Everard
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    PLoS ONE 7:e33858. 2012
    ..In conclusion, this research allows us to decipher a novel mechanism contributing to the positive effects of META060 treatment, and supports the need to investigate such compounds in obese and type 2 diabetic patients...
  45. ncbi request reprint Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide
    Patrice D Cani
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Ecole de Pharmacie, Universite Catholique de Louvain, Brussels, Belgium
    Br J Nutr 92:757-61. 2004
    ....
  46. doi request reprint The gut microbiome as therapeutic target
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Pharmacol Ther 130:202-12. 2011
    ....
  47. ncbi request reprint Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT 73 69, Universite Catholique de Louvain, Av E Mounier, Brussels, Belgium
    Br J Nutr 98:32-7. 2007
    ..These results suggest a new mechanism by which dietary fibres may lower food intake and fat mass development...
  48. doi request reprint Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Int Immunopharmacol 8:1423-32. 2008
    ..We propose that specific and early immunomodulatory properties of cereal products with prebiotic properties, may occur in obese mice independently of extensive gut fermentation...
  49. doi request reprint Ripened dairy products differentially affect hepatic lipid content and adipose tissue oxidative stress markers in obese and type 2 diabetic mice
    Lucie Geurts
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Av E Mounier, 73 Box B1 73 11, B 1200 Brussels, Belgium
    J Agric Food Chem 60:2063-8. 2012
    ..Further investigations are warranted to decipher the interactions between milk products fermentation, lipids, and host metabolism...
  50. doi request reprint Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages
    Cláudia A Fernandes
    Universite Catholique de Louvain, Louvain Drug Research Institute LDRI, Pharmaceutics and Drug Delivery Research Group, Brussels B 1200, Belgium
    Biochem Biophys Res Commun 420:857-61. 2012
    ..This work shows that sirtuin pharmacologic inhibitors are a promising tool for the treatment of inflammatory conditions...
  51. doi request reprint Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, PMNT Unit, Brussels, Belgium
    Curr Opin Pharmacol 9:737-43. 2009
    ....
  52. ncbi request reprint Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice
    Evelyne Delmée
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Life Sci 79:1007-13. 2006
    ..This remains to be proven in human studies...
  53. doi request reprint Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects
    Sophie Leclercq
    Department of Adult Psychiatry and Institute of Neurosciences, Universite Catholique de Louvain, Brussels, Belgium
    Brain Behav Immun 26:911-8. 2012
    ..Our second goal was to test correlations between these biochemical and the behavioral variables to explore the possibility of a role for a gut-brain interaction in the development of alcohol-dependence...
  54. pmc Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia
    Lucie Geurts
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    PLoS ONE 8:e55963. 2013
    ..The aim of this study was to decipher the specific role of eCB-system stimulation or metabolic endotoxaemia in the onset of glucose intolerance, metabolic inflammation and altered lipid metabolism...
  55. ncbi request reprint The role of the gut microbiota in energy metabolism and metabolic disease
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Brussels, Belgium
    Curr Pharm Des 15:1546-58. 2009
    ..Thus, it would be useful to find specific strategies for modifying gut microbiota to impact on the occurrence of metabolic diseases...
  56. ncbi request reprint Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Br J Nutr 92:521-6. 2004
    ....
  57. doi request reprint Potential interest of gut microbial changes induced by non-digestible carbohydrates of wheat in the management of obesity and related disorders
    Audrey M Neyrinck
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 13:722-8. 2010
    ..This review discusses how nondigestible carbohydrates (NDC) derived from wheat may constitute functional cereal food products in the management of obesity and diabetes, notably through modulation of gut microbiota...
  58. doi request reprint Prebiotic effects: metabolic and health benefits
    Marcel Roberfroid
    Universite Catholique de Louvain, Brussels, Belgium
    Br J Nutr 104:S1-63. 2010
    ....
  59. doi request reprint Targeting gut microbiota in obesity: effects of prebiotics and probiotics
    Nathalie M Delzenne
    Universite Catholique de Louvain, Brussels, Belgium nathalie delzenne uclouvain be
    Nat Rev Endocrinol 7:639-46. 2011
    ..The gut microbiota is, therefore, a potential nutritional and pharmacological target in the management of obesity and obesity-related disorders...
  60. ncbi request reprint A place for dietary fibre in the management of the metabolic syndrome
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Catholic University of Louvain, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 8:636-40. 2005
    ..This review discusses factors that may explain how dietary fibre would be helpful in the management of food intake, body weight and metabolic syndrome...
  61. ncbi request reprint Gut microbial metabolites of polyunsaturated fatty acids correlate with specific fecal bacteria and serum markers of metabolic syndrome in obese women
    Céline Druart
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier 73, PO Box B1 73 11, 1200, Brussels, Belgium
    Lipids 49:397-402. 2014
    ..and inversely correlated with serum cholesterol (total, LDL, HDL). These correlations suggest a potential beneficial effect of some of these metabolites but this remains to be confirmed by further investigation. ..
  62. ncbi request reprint Role of apoptotic signaling pathway in metabolic disturbances occurring in liver tissue after cryopreservation: Study on rat precision-cut liver slices
    Valérie P Vanhulle
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, 7369, Avenue E Mounier 73, B 1200 Brussels, Belgium
    Life Sci 78:1570-7. 2006
    ....
  63. ncbi request reprint Muscle wasting: the gut microbiota as a new therapeutic target?
    Laure B Bindels
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Int J Biochem Cell Biol 45:2186-90. 2013
    ..This review also proposes possible molecular mechanisms underlying the gut microbiota-muscle axis. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..
  64. ncbi request reprint Prebiotics and lipid metabolism
    Nathalie M Delzenne
    UCL Université Catholique de Louvain, School of Pharmacy, Brussels, Belgium
    Curr Opin Lipidol 13:61-7. 2002
    ....
  65. ncbi request reprint Positive interaction between prebiotics and thiazolidinedione treatment on adiposity in diet-induced obese mice
    Maud Alligier
    Nutrition and Metabolism Research Group, LDRI, Universite Catholique de Louvain, Brussels, Belgium
    Obesity (Silver Spring) 22:1653-61. 2014
    ....
  66. doi request reprint Is there a place for coenzyme Q in the management of metabolic disorders associated with obesity?
    Florence M Sohet
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Nutr Rev 70:631-41. 2012
    ..The molecular mechanism to explain this effect has only recently been discovered...
  67. doi request reprint Assessment of liver phagocytic activity using EPR spectrometry and imaging
    Nicolas Charlier
    Biomedical Magnetic Resonance Unit, Louvain Drug Research Institute, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Magn Reson Imaging 27:565-9. 2009
    ..EPR imaging carried out on precision-cut liver slices indicated a good correlation between the depletion of Kupffer cells and the EPR signal intensity...
  68. doi request reprint GPR43/FFA2: physiopathological relevance and therapeutic prospects
    Laure B Bindels
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Trends Pharmacol Sci 34:226-32. 2013
    ..Finally, GPR43 could be a key player in gut microbes-host crosstalk, although further research is needed to clearly evaluate its role in the management of host health by nutrients or treatments targeting the gut microbiota...
  69. pmc Precision-cut liver slices in culture as a tool to assess the physiological involvement of Kupffer cells in hepatic metabolism
    Audrey M Neyrinck
    Unit de Pharmacocin tique, M tabolisme, Nutrition et Toxicologie, D partement des Sciences Pharmaceutiques, Universit catholique de Louvain, PMNT UCL 73 avenue Mounier, B 1200 Brussels, Belgium
    Comp Hepatol 3:S45. 2004
  70. ncbi request reprint Inhibition of Kupffer cell activity induces hepatic triglyceride synthesis in fasted rats, independent of lipopolysaccharide challenge
    Audrey M Neyrinck
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, département des sciences pharmaceutiques, Universite Catholique de Louvain, 73 Avenue Mounier, B 1200 Brussels, Belgium
    J Hepatol 36:466-73. 2002
    ..Lipopolysaccharides (LPS), cleared from the blood by Kupffer cells, induce hypertriglyceridemia...
  71. pmc Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue
    Lucie Geurts
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain Brussels, Belgium
    Front Microbiol 2:149. 2011
    ..This indicates specific relationships between the gut microbiota and the regulation of the apelinergic system. However, the exact roles of specific bacteria in shaping the phenotype of db/db mice remain to be determined...
  72. ncbi request reprint SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma
    Anders Kallin
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Experimental Medicine Unit, Brussels, Belgium
    J Lipid Res 48:1628-36. 2007
    ..In conclusion, our data suggest that SREBP-1 regulates the expression of stress response and signaling genes, which could contribute to the metabolic response to insulin and growth factors in various tissues...
  73. doi request reprint Nicotinamide enhances apoptosis of G(M)-CSF-treated neutrophils and attenuates endotoxin-induced airway inflammation in mice
    Cláudia A Fernandes
    Unite de Pharmacie Galenique, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Lung Cell Mol Physiol 300:L354-61. 2011
    ..Our findings suggest that nicotinamide is an apoptotic stimulus for neutrophils, thereby contributing to the resolution of neutrophilic inflammation in the lungs...
  74. ncbi request reprint Spelt (Triticum aestivum ssp. spelta) as a source of breadmaking flours and bran naturally enriched in oleic acid and minerals but not phytic acid
    Nike L Ruibal-Mendieta
    Unite de Biochimie de la Nutrition, Universite Catholique de Louvain, Croix du Sud 2 8, 1348 Louvain la Neuve, Belgium
    J Agric Food Chem 53:2751-9. 2005
    ..Finally, they suggest that aleurone differences, the nature of which still needs to be investigated, may account for the differential nutrient composition of spelt and wheat...
  75. pmc Effect on components of the intestinal microflora and plasma neuropeptide levels of feeding Lactobacillus delbrueckii, Bifidobacterium lactis, and inulin to adult and elderly rats
    Violetta Lesniewska
    Northern Ireland Centre of Food and Health, University of Ulster, Coleraine, United Kingdom
    Appl Environ Microbiol 72:6533-8. 2006
    ....
  76. ncbi request reprint GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion
    Patrice D Cani
    Institut de Medecine Moleculaire de Rangueil, I 2 MR, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Cell Endocrinol 276:18-23. 2007
    ..In conclusion, both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2...
  77. pmc Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    Claude Knauf
    UMR 5018, Universite Paul Sabatier, IFR31, Toulouse, France USA
    J Clin Invest 115:3554-63. 2005
    ..Our data show that during hyperglycemia, brain GLP-1 inhibited muscle glucose utilization and increased insulin secretion to favor hepatic glycogen stores, preparing efficiently for the next fasting state...
  78. ncbi request reprint Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor
    Patrice D Cani
    CNRS UMR 5018, University Paul Sabatier, Hopital Rangueil, 1 BP 84225, 31432 Toulouse Cedex 4, France
    Diabetes 55:1484-90. 2006
    ..In summary, our data show that the antidiabetic actions of OFS require a functional GLP-1 receptor. These findings highlight the therapeutic potential of enhancing endogenous GLP-1 secretion for the treatment of type 2 diabetes...
  79. ncbi request reprint Physiological effects of dietary fructans extracted from Agave tequilana Gto. and Dasylirion spp
    Judith E Urías-Silvas
    Unidad de Biotecnología e Ingeniería Genética de Plantas, CINVESTAV IPN Unidad Irapuato, A P 629, Irapuato, Gto, 36500, Mexico
    Br J Nutr 99:254-61. 2008
    ....