N Delzenne

Summary

Country: Belgium

Publications

  1. ncbi request reprint [Interactions of food and drug metabolism]
    N M Delzenne
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Ecole de Pharmacie Université Catholique de Louvain MD FARM PMNT 7369, Avenue Emmanuel Mounier, 73 B 1200 Bruxelles
    J Pharm Belg 56:33-7. 2001
  2. pmc Precision-cut liver slices in culture as a tool to assess the physiological involvement of Kupffer cells in hepatic metabolism
    Audrey M Neyrinck
    Unit de Pharmacocin tique, M tabolisme, Nutrition et Toxicologie, D partement des Sciences Pharmaceutiques, Universit catholique de Louvain, PMNT UCL 73 avenue Mounier, B 1200 Brussels, Belgium
    Comp Hepatol 3:S45. 2004
  3. ncbi request reprint Impact of inulin and oligofructose on gastrointestinal peptides
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD FARM PMNT 7369, Universite Catholique de Louvain, Avenue E Mounier 73, B 1200 Brussels, Belgium
    Br J Nutr 93:S157-61. 2005
  4. ncbi request reprint Prebiotics: actual and potential effects in inflammatory and malignant colonic diseases
    Nathalie Delzenne
    School of Pharmacy, Universite Catholique de Louvain, UCL PMNT 7369, 73 Avenue Mounier, B 1200 Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 6:581-6. 2003
  5. ncbi request reprint Oligosaccharides: state of the art
    N M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, School of Pharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Proc Nutr Soc 62:177-82. 2003
  6. ncbi request reprint Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects
    N M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT 7369 School of Pharmacy Université Catholique de Louvain, Avenue Mounier, 73 B 1200 Brussels, Belgium
    Br J Nutr 87:S255-9. 2002
  7. ncbi request reprint A place for dietary fibre in the management of the metabolic syndrome
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Catholic University of Louvain, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 8:636-40. 2005
  8. ncbi request reprint Study of the regulation by nutrients of the expression of genes involved in lipogenesis and obesity in humans and animals
    N Delzenne
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, School of Pharmacy, Universite Catholique de Louvain, MD FARM PMNT 7369 Avenue Emmanuel Mounier, 73 B 1200 Brussels, Belgium
    Nutr Metab Cardiovasc Dis 11:118-21. 2001
  9. ncbi request reprint Prebiotics and lipid metabolism
    Nathalie M Delzenne
    UCL Université Catholique de Louvain, School of Pharmacy, Brussels, Belgium
    Curr Opin Lipidol 13:61-7. 2002
  10. ncbi request reprint Effects of fructans-type prebiotics on lipid metabolism
    N M Delzenne
    UCL Université Catholique de Louvain, School of Pharmacy, Brussels
    Am J Clin Nutr 73:456S-458S. 2001

Collaborators

Detail Information

Publications37

  1. ncbi request reprint [Interactions of food and drug metabolism]
    N M Delzenne
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Ecole de Pharmacie Université Catholique de Louvain MD FARM PMNT 7369, Avenue Emmanuel Mounier, 73 B 1200 Bruxelles
    J Pharm Belg 56:33-7. 2001
    ..Drug-nutrients interactions may be beneficials, and thus could constitute, i.e. a way to improve drug therapeutic index, or generate adverse effects...
  2. pmc Precision-cut liver slices in culture as a tool to assess the physiological involvement of Kupffer cells in hepatic metabolism
    Audrey M Neyrinck
    Unit de Pharmacocin tique, M tabolisme, Nutrition et Toxicologie, D partement des Sciences Pharmaceutiques, Universit catholique de Louvain, PMNT UCL 73 avenue Mounier, B 1200 Brussels, Belgium
    Comp Hepatol 3:S45. 2004
  3. ncbi request reprint Impact of inulin and oligofructose on gastrointestinal peptides
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD FARM PMNT 7369, Universite Catholique de Louvain, Avenue E Mounier 73, B 1200 Brussels, Belgium
    Br J Nutr 93:S157-61. 2005
    ....
  4. ncbi request reprint Prebiotics: actual and potential effects in inflammatory and malignant colonic diseases
    Nathalie Delzenne
    School of Pharmacy, Universite Catholique de Louvain, UCL PMNT 7369, 73 Avenue Mounier, B 1200 Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 6:581-6. 2003
    ..This paper will summarize the most recent clinical and experimental data on the effects of prebiotics in inflammatory and cancerous diseases of the large intestine...
  5. ncbi request reprint Oligosaccharides: state of the art
    N M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, School of Pharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Proc Nutr Soc 62:177-82. 2003
    ..g. hormone production, lipid and carbohydrates metabolism). The present paper gives an overview of the future development of oligosaccharides, newly recognised as dietary fibre...
  6. ncbi request reprint Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects
    N M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT 7369 School of Pharmacy Université Catholique de Louvain, Avenue Mounier, 73 B 1200 Brussels, Belgium
    Br J Nutr 87:S255-9. 2002
    ....
  7. ncbi request reprint A place for dietary fibre in the management of the metabolic syndrome
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Catholic University of Louvain, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 8:636-40. 2005
    ..This review discusses factors that may explain how dietary fibre would be helpful in the management of food intake, body weight and metabolic syndrome...
  8. ncbi request reprint Study of the regulation by nutrients of the expression of genes involved in lipogenesis and obesity in humans and animals
    N Delzenne
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, School of Pharmacy, Universite Catholique de Louvain, MD FARM PMNT 7369 Avenue Emmanuel Mounier, 73 B 1200 Brussels, Belgium
    Nutr Metab Cardiovasc Dis 11:118-21. 2001
    ..If confirmed in obese humans, this would allow the development of functional food able to counteract the metabolic disturbances linked to obesity...
  9. ncbi request reprint Prebiotics and lipid metabolism
    Nathalie M Delzenne
    UCL Université Catholique de Louvain, School of Pharmacy, Brussels, Belgium
    Curr Opin Lipidol 13:61-7. 2002
    ....
  10. ncbi request reprint Effects of fructans-type prebiotics on lipid metabolism
    N M Delzenne
    UCL Université Catholique de Louvain, School of Pharmacy, Brussels
    Am J Clin Nutr 73:456S-458S. 2001
    ..Recent studies showed that the hypotriglyceridemic effect of fructans also occurs in humans...
  11. ncbi request reprint Accumulation of manganese in the brain of mice after intravenous injection of manganese-based contrast agents
    B Gallez
    Laboratory of Medicinal Chemistry and Radiopharmacy, Catholic University of Louvain, Brussels, Belgium
    Chem Res Toxicol 10:360-3. 1997
    ..In mice whose bile ducts had been ligated 24 h before the administration of the manganese compound, we observed, 1 week after the injection, an amount of manganese accumulated in the brain 2 times higher than in normal mice...
  12. ncbi request reprint Cryopreservation of rat precision-cut liver slices by ultrarapid freezing: influence on phase I and II metabolism and on cell viability upon incubation for 24 hours
    V P Vanhulle
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, , Brussels, Belgium
    Life Sci 68:2391-403. 2001
    ..The results of this study suggest that cryopreserved PCLS are able to maintain some phase I activities for 24 hours after thawing whereas some phase II metabolic capacities are not maintained...
  13. doi request reprint Gastrointestinal targets of appetite regulation in humans
    N Delzenne
    Louvain Drug Research Institute, Unit PMNT 7369, Universite Catholique de Louvain, Brussels, Belgium
    Obes Rev 11:234-50. 2010
    ..The conclusion estimates the relevance of selected biomarkers as representative markers of appetite regulation, in view of the current state of the art...
  14. ncbi request reprint Kupffer cell-derived prostaglandin E2 is involved in regulation of lipid synthesis in rat liver tissue
    Audrey M Neyrinck
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, département des sciences pharmaceutiques, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Cell Biochem Funct 22:327-32. 2004
    ....
  15. doi request reprint Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
    ..e., metabolic endotoxemia. Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases...
  16. ncbi request reprint Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    J Nutr 137:2547S-2551S. 2007
    ..Several studies in humans already support interest in OFS in the control of satiety, triglyceridemia, or steatohepatitis. The link with gut peptides production in humans remains to be proven...
  17. ncbi request reprint Physiological effects of dietary fructans extracted from Agave tequilana Gto. and Dasylirion spp
    Judith E Urías-Silvas
    Unidad de Biotecnología e Ingeniería Genética de Plantas, CINVESTAV IPN Unidad Irapuato, A P 629, Irapuato, Gto, 36500, Mexico
    Br J Nutr 99:254-61. 2008
    ....
  18. ncbi request reprint Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT 73 69, Universite Catholique de Louvain, Av E Mounier, Brussels, Belgium
    Br J Nutr 98:32-7. 2007
    ..These results suggest a new mechanism by which dietary fibres may lower food intake and fat mass development...
  19. pmc Effect on components of the intestinal microflora and plasma neuropeptide levels of feeding Lactobacillus delbrueckii, Bifidobacterium lactis, and inulin to adult and elderly rats
    Violetta Lesniewska
    Northern Ireland Centre of Food and Health, University of Ulster, Coleraine, United Kingdom
    Appl Environ Microbiol 72:6533-8. 2006
    ....
  20. ncbi request reprint Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    J Endocrinol 185:457-65. 2005
    ....
  21. ncbi request reprint Spelt (Triticum aestivum ssp. spelta) as a source of breadmaking flours and bran naturally enriched in oleic acid and minerals but not phytic acid
    Nike L Ruibal-Mendieta
    Unite de Biochimie de la Nutrition, Universite Catholique de Louvain, Croix du Sud 2 8, 1348 Louvain la Neuve, Belgium
    J Agric Food Chem 53:2751-9. 2005
    ..Finally, they suggest that aleurone differences, the nature of which still needs to be investigated, may account for the differential nutrient composition of spelt and wheat...
  22. ncbi request reprint Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide
    Patrice D Cani
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Ecole de Pharmacie, Universite Catholique de Louvain, Brussels, Belgium
    Br J Nutr 92:757-61. 2004
    ....
  23. ncbi request reprint Spelt (Triticum spelta L.) and winter wheat (Triticum aestivum L.) wholemeals have similar sterol profiles, as determined by quantitative liquid chromatography and mass spectrometry analysis
    Nike L Ruibal-Mendieta
    Moulin de Hollange, Rue de Chaumont 5, 6637 Fauvillers, Belgium
    J Agric Food Chem 52:4802-7. 2004
    ..5 and 112.6 microg x g(-1) in winter wheat (values not corrected for recoveries). This is the first report on the application and validation of an LC/MS2 method for the quantification of phytosterols in spelt and winter wheat...
  24. ncbi request reprint Kupffer cell activity is involved in the hepatoprotective effect of dietary oligofructose in rats with endotoxic shock
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, School of Pharmacy, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Nutr 134:1124-9. 2004
    ..This study supports the hypothesis that oligofructose might decrease liver tissue injury after endotoxic shock and sepsis...
  25. ncbi request reprint Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1
    Patrice D Cani
    Université Catholique de Louvain Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie 7369, 73 Avenue Mounier, B 1200 Brussels, Belgium
    Obes Res 13:1000-7. 2005
    ..To analyze the putative interest of oligofructose (OFS) in the modulation of food intake after high-fat diet in rats and to question the relevance of the expression and secretion of intestinal peptides in that context...
  26. ncbi request reprint Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Br J Nutr 92:521-6. 2004
    ....
  27. ncbi request reprint Gut microflora as a target for energy and metabolic homeostasis
    Patrice D Cani
    Universite Catholique de Louvain, Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 10:729-34. 2007
    ..This review discusses new findings that may explain how gut microbiota can be involved in the control of energy and metabolic homeostasis...
  28. doi request reprint [Gut microflora is a key player in host energy homeostasis]
    Nathalie M Delzenne
    Universite Catholique de Louvain, Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Bruxelles, Belgique UCL, Unit PMNT 7369, avenue E Mounier, 73 69, B 1200 Bruxelles, Belgique
    Med Sci (Paris) 24:505-10. 2008
    ..Changing gut microflora composition could be a useful tool to prevent or to treat high-fat/low fibres diet-induced metabolic syndrome. double dagger...
  29. doi request reprint Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Int Immunopharmacol 8:1423-32. 2008
    ..We propose that specific and early immunomodulatory properties of cereal products with prebiotic properties, may occur in obese mice independently of extensive gut fermentation...
  30. ncbi request reprint Inhibition of Kupffer cell activity induces hepatic triglyceride synthesis in fasted rats, independent of lipopolysaccharide challenge
    Audrey M Neyrinck
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, département des sciences pharmaceutiques, Universite Catholique de Louvain, 73 Avenue Mounier, B 1200 Brussels, Belgium
    J Hepatol 36:466-73. 2002
    ..Lipopolysaccharides (LPS), cleared from the blood by Kupffer cells, induce hypertriglyceridemia...
  31. ncbi request reprint Dietary supplementation with laminarin, a fermentable marine beta (1-3) glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, School of Pharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Int Immunopharmacol 7:1497-506. 2007
    ..These effects could be due to a direct effect of beta-glucan on immune cells, or to an indirect effect through their dietary fibre properties (fermentation in the gut)...
  32. ncbi request reprint Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
    ..We conclude that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity. Lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases...
  33. ncbi request reprint Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice
    Evelyne Delmée
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Life Sci 79:1007-13. 2006
    ..This remains to be proven in human studies...
  34. ncbi request reprint Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor
    Patrice D Cani
    CNRS UMR 5018, University Paul Sabatier, Hopital Rangueil, 1 BP 84225, 31432 Toulouse Cedex 4, France
    Diabetes 55:1484-90. 2006
    ..In summary, our data show that the antidiabetic actions of OFS require a functional GLP-1 receptor. These findings highlight the therapeutic potential of enhancing endogenous GLP-1 secretion for the treatment of type 2 diabetes...
  35. pmc Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    Claude Knauf
    UMR 5018, Universite Paul Sabatier, IFR31, Toulouse, France USA
    J Clin Invest 115:3554-63. 2005
    ..Our data show that during hyperglycemia, brain GLP-1 inhibited muscle glucose utilization and increased insulin secretion to favor hepatic glycogen stores, preparing efficiently for the next fasting state...
  36. ncbi request reprint Role of apoptotic signaling pathway in metabolic disturbances occurring in liver tissue after cryopreservation: Study on rat precision-cut liver slices
    Valérie P Vanhulle
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, 7369, Avenue E Mounier 73, B 1200 Brussels, Belgium
    Life Sci 78:1570-7. 2006
    ....
  37. ncbi request reprint Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain
    Claude Knauf
    Unit Mixte de Recherche, 5018, Centre National de la Recherche Scientifique University Paul Sabatier, IFR 31, Bt L1 Rue J Poulhès, 31403 Toulouse, France
    Endocrinology 147:4067-78. 2006
    ..By contrast, activation of PPARalpha in the brain stimulates peripheral glucose use. This suggests that the alteration in adipocyte glucose metabolism in the knockout mice may result from the absence of PPARalpha in the brain...