Philippe De Witte

Summary

Country: Belgium

Publications

  1. ncbi Imbalance between neuroexcitatory and neuroinhibitory amino acids causes craving for ethanol
    Philippe De Witte
    UCL Biologie du Comportement, Place Croix du Sud, 1 bte 10 B 1348 Louvain la Neuve, Belgium
    Addict Behav 29:1325-39. 2004
  2. ncbi Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action
    Philippe De Witte
    Biologie du Comportement, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    CNS Drugs 19:517-37. 2005
  3. ncbi Ethanol but not acetaldehyde induced changes in brain taurine: a microdialysis study
    V A Kashkin
    Valdman Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Amino Acids 26:117-24. 2004
  4. ncbi Alcohol and withdrawal: from animal research to clinical issues
    Ph De Witte
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, Place Croix du Sud, 1 Bte 10, B 1348, Louvain la Neuve, Belgium
    Neurosci Biobehav Rev 27:189-97. 2003
  5. ncbi Nicotine-induced changes of glutamate and arginine in naive and chronically alcoholized rats: an in vivo microdialysis study
    Frederic Lallemand
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, 1 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Brain Res 1111:48-60. 2006
  6. doi Binge drinking +/- chronic nicotine administration alters extracellular glutamate and arginine levels in the nucleus accumbens of adult male and female Wistar rats
    Frederic Lallemand
    Universite Catholique de Louvain, Biologie du Comportement, Louvain la Neuve, Belgium
    Alcohol Alcohol 46:373-82. 2011
  7. ncbi Production of reactive oxygen species following acute ethanol or acetaldehyde and its reduction by acamprosate in chronically alcoholized rats
    Abdelkader Dahchour
    Biologie du Comportement, Universite Catholique de Louvain, 1 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Eur J Pharmacol 520:51-8. 2005
  8. ncbi The influence of chronic nicotine administration on behavioural and neurochemical parameters in male and female rats after repeated binge drinking exposure
    Frederic Lallemand
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Alcohol Alcohol 44:535-46. 2009
  9. ncbi Nicotine increases ethanol preference but decreases locomotor activity during the initial stages of chronic ethanol withdrawal
    Frederic Lallemand
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, 1 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Alcohol Alcohol 42:207-18. 2007
  10. ncbi Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods
    Abdelkader Dahchour
    Université catholique de Louvain Biologie du Comportement, 1, Place Croix du Sud, B 1348 Louvain la Neuve, Belgium
    Alcohol Clin Exp Res 27:465-70. 2003

Detail Information

Publications27

  1. ncbi Imbalance between neuroexcitatory and neuroinhibitory amino acids causes craving for ethanol
    Philippe De Witte
    UCL Biologie du Comportement, Place Croix du Sud, 1 bte 10 B 1348 Louvain la Neuve, Belgium
    Addict Behav 29:1325-39. 2004
    ....
  2. ncbi Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action
    Philippe De Witte
    Biologie du Comportement, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    CNS Drugs 19:517-37. 2005
    ....
  3. ncbi Ethanol but not acetaldehyde induced changes in brain taurine: a microdialysis study
    V A Kashkin
    Valdman Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Amino Acids 26:117-24. 2004
    ..Ethanol significantly affected the levels of taurine in rat pre-treated with AT. In the final part, ethanol was administered following the pre-treatment with AT but the dependent variable was the concentration of ethanol in the brain...
  4. ncbi Alcohol and withdrawal: from animal research to clinical issues
    Ph De Witte
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, Place Croix du Sud, 1 Bte 10, B 1348, Louvain la Neuve, Belgium
    Neurosci Biobehav Rev 27:189-97. 2003
    ....
  5. ncbi Nicotine-induced changes of glutamate and arginine in naive and chronically alcoholized rats: an in vivo microdialysis study
    Frederic Lallemand
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, 1 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Brain Res 1111:48-60. 2006
    ....
  6. doi Binge drinking +/- chronic nicotine administration alters extracellular glutamate and arginine levels in the nucleus accumbens of adult male and female Wistar rats
    Frederic Lallemand
    Universite Catholique de Louvain, Biologie du Comportement, Louvain la Neuve, Belgium
    Alcohol Alcohol 46:373-82. 2011
    ..The effect of 'binge drinking' coupled or not with chronic nicotine administration on nucleus accumbens (NAc) glutamate, arginine, taurine and hydroxyl radical levels has been investigated in these present studies...
  7. ncbi Production of reactive oxygen species following acute ethanol or acetaldehyde and its reduction by acamprosate in chronically alcoholized rats
    Abdelkader Dahchour
    Biologie du Comportement, Universite Catholique de Louvain, 1 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Eur J Pharmacol 520:51-8. 2005
    ..Oral administration of Acamprosate, 400 mg/kg/day, during the chronic ethanol intoxication procedure prevented the increased formation of 2,3- and 2,5-DHBA by comparison to rats chronically ethanol intoxicated alone...
  8. ncbi The influence of chronic nicotine administration on behavioural and neurochemical parameters in male and female rats after repeated binge drinking exposure
    Frederic Lallemand
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Alcohol Alcohol 44:535-46. 2009
    ..The possible interaction between nicotine and 'binge drinking' in eliciting changes in behavioural patterns of 'binge drinking' rats as well as nucleus accumbens (NAc) glutamate levels has been investigated in these present studies...
  9. ncbi Nicotine increases ethanol preference but decreases locomotor activity during the initial stages of chronic ethanol withdrawal
    Frederic Lallemand
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, 1 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Alcohol Alcohol 42:207-18. 2007
    ..The ability of nicotine to modify withdrawal symptoms in rats chronically treated with alcohol, with respect to locomotor activity and ethanol or nicotine preference, has been evaluated in these studies...
  10. ncbi Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods
    Abdelkader Dahchour
    Université catholique de Louvain Biologie du Comportement, 1, Place Croix du Sud, B 1348 Louvain la Neuve, Belgium
    Alcohol Clin Exp Res 27:465-70. 2003
    ..Our previous studies on the effects of acamprosate on enhanced locomotion during repeated withdrawals are now extended to the effects of acamprosate on excitatory amino acids in the hippocampus during repeated ethanol withdrawals...
  11. ncbi SR147778, a CB1 cannabinoid receptor antagonist, suppresses ethanol preference in chronically alcoholized Wistar rats
    Frederic Lallemand
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, 1 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Alcohol 39:125-34. 2006
    ....
  12. doi Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking' alcohol abuse
    Roberta J Ward
    Biologie du Comportement, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Alcohol Alcohol 44:128-35. 2009
    ..In contrast, 'binge drinking' induces immediate and toxic effects and there is no evidence of an increased preference for alcohol as seen after withdrawal from chronic alcoholization...
  13. ncbi Excitatory and inhibitory amino acid changes during repeated episodes of ethanol withdrawal: an in vivo microdialysis study
    Abdelkader Dahchour
    Laboratoire de Biologie du Comportement, Place Croix du Sud 1, Universite Catholique de Louvain, B 1348, Louvain la Neuve, Belgium
    Eur J Pharmacol 459:171-8. 2003
    ..The results of this study demonstrate that excitatory amino acid levels increased with subsequent withdrawal periods...
  14. doi Neurochemical pathways involved in the protective effects of nicotine and ethanol in preventing the development of Parkinson's disease: potential targets for the development of new therapeutic agents
    Roberta J Ward
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, 1 Croix du Sud, 1348 Louvain la Neuve, Belgium
    Prog Neurobiol 85:135-47. 2008
    ....
  15. ncbi Systemic osmotic manipulations modulate ethanol-induced taurine release: a brain microdialysis study
    Etienne Quertemont
    Biologie du Comportement, Universite Catholique de Louvain, Place Croix du Sud 1, 1348 Louvain la Neuve, Belgium
    Alcohol 29:11-9. 2003
    ..Ethanol-induced cell swelling probably activates volume-sensitive channels, and taurine passively diffuses outside the cells along its concentration gradient...
  16. ncbi Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic alcohol administration combined with repeated re-exposures and withdrawals
    Frederic Lallemand
    Laboratoire Biologie du Comportement, Universite Catholique de Louvain, 1 Croix du Sud, 1348 Louvain la Neuve, Belgium
    Alcohol Alcohol 39:486-92. 2004
    ..In this study, ethanol preference was investigated in chronically alcoholized rats that underwent regular withdrawal periods during which the brain cannabinoid CB(1) receptor antagonist, SR141716A, was administered...
  17. ncbi Role of catalase in ethanol-induced conditioned taste aversion: a study with 3-amino-1,2,4-triazole
    Etienne Quertemont
    Biologie du Comportement, Universite Catholique de Louvain, Place Croix du Sud 1, 1348, Louvain la Neuve, Belgium
    Drug Alcohol Depend 70:77-83. 2003
    ..The present study argues against a role for brain acetaldehyde in ethanol's aversive effects but in favor of its involvement in ethanol rewarding properties...
  18. doi Anti-inflammatory actions of a taurine analogue, ethane β-sultam, in phagocytic cells, in vivo and in vitro
    Roberta J Ward
    Biologie du Comportement, Universite Catholique de Louvain, Belgium
    Biochem Pharmacol 81:743-51. 2011
    ....
  19. ncbi Acamprosate reduces context-dependent ethanol effects
    Etienne Quertemont
    Biologie de Comportement, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Psychopharmacology (Berl) 164:10-8. 2002
    ..Acamprosate was recently suggested to reduce the effects of environmental stimuli previously associated with ethanol administrations. This action is believed to contribute to the clinical benefits of acamprosate treatment in alcoholics...
  20. ncbi Influence of adolescent heavy session drinking on the systemic and brain innate immune system
    Roberta J Ward
    Corresponding author Biologie du Comportement, Universite Catholique de Louvain, Croix du Sud, 1 box L7 04 03, 1348 Louvain la Neuve, Belgium
    Alcohol Alcohol 49:193-7. 2014
    ....
  21. ncbi Functional characteristics of TauA binding protein from TauABC Escherichia coli system
    Cédric Javaux
    Biologie du Comportement, Universite Catholique de Louvain, Place Croix du Sud 1, 1348 Louvain la Neuve, Belgium
    Protein J 26:231-8. 2007
    ..Comparisons with other periplasmic binding proteins suggests TauA plays a major role in ABC transport system and could be ideal candidate to serve as taurine catcher in biological fluids...
  22. ncbi Differential taurine responsiveness to ethanol in high- and low-alcohol sensitive rats: a brain microdialysis study
    Etienne Quertemont
    Biologie du Comportement, Universite Catholique de Louvain, Place Croix du Sud 1, 1348 Louvain la Neuve, Belgium
    Eur J Pharmacol 444:143-50. 2002
    ..Such an effect remains unexplained but suggests that discrepancies between the results of previous microdialysate studies may be related to differences in the ethanol sensitivities of various rat strains...
  23. ncbi Glutamic acid in withdrawal and weaning in patients classified according to Cloninger's and Lesch's typologies
    Henriette Walter
    Department of Psychiatry, Gastroenterology and Hepatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Alcohol Alcohol 41:505-11. 2006
    ....
  24. ncbi Nicotine increases microdialysate brain amino acid concentrations and induces conditioned place preference
    Vladimir A Kashkin
    Valdman Institute of Pharmacology, Pavlov Medical University, St Petersburg, 197089, Russia
    Eur Neuropsychopharmacol 15:625-32. 2005
    ..The same doses of nicotine were able to elicit a reinforcing effect in a CPP paradigm which was probably associated with the increased brain levels of excitatory acids triggering additional dopamine release in the mesolimbic system...
  25. ncbi Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats
    M Dolores Escarabajal
    Area de Psicobiologia, Universidad de Jaen, 23071, Jaen, Spain
    Psychopharmacology (Berl) 167:130-6. 2003
    ..In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing and/or aversive effects of ethanol...
  26. ncbi Potential neuroprotective effects of acamprosate
    George F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 26:586-92. 2002
    ..Siggins; (3) Acamprosate and glutamate during ethanol withdrawal, by Philippe De Witte; (4) Clinical evidence of protective CNS effects of acamprosate in alcohol-dependent individuals, by Barbara ..
  27. ncbi Challenges to medications development in treating alcohol dependence: an international perspective
    John M Littleton
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Cooper and University Drives, Lexington 40546 0236, USA
    Alcohol Alcohol 39:271-5. 2004
    ..The investment risk to industry should be appraised not only in terms of the rather poor results of previous marketing efforts but with a view to the opportunity to penetrate a potentially enormous and largely untapped market...