Peter Paul De Deyn

Summary

Country: Belgium

Publications

  1. doi request reprint Tolerability of extended-release quetiapine fumarate compared with immediate-release quetiapine fumarate in older patients with Alzheimer's disease with symptoms of psychosis and/or agitation: a randomised, double-blind, parallel-group study
    Peter Paul De Deyn
    Department of Neurology, Middelheim Hospital and Laboratory of Neurochemistry and Behaviour, Department of Biomedical Sciences, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 27:296-304. 2012
  2. ncbi request reprint Risperidone in the management of agitation and aggression associated with psychiatric disorders
    Peter Paul De Deyn
    Department of Neurology, Middelheim Hospital and Laboratory of Neurochemistry and Behavior, Department of Biomedical Sciences, Born Bunge Foundation, University of Antwerp UA, Universiteitsplein 1, 2610 Antwerp Wilrijk, Belgium
    Eur Psychiatry 21:21-8. 2006
  3. ncbi request reprint Management of agitation, aggression, and psychosis associated with dementia: a pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone
    Peter Paul De Deyn
    Department of Neurology, Memory Clinic, Middelheim Hospital, ZNA, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk Antwerp, Belgium
    Clin Neurol Neurosurg 107:497-508. 2005
  4. doi request reprint Prevalence and incidence of dementia among 75-80-year-old community-dwelling elderly in different districts of Antwerp, Belgium: the Antwerp Cognition (ANCOG) Study
    P P De Deyn
    Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium
    Clin Neurol Neurosurg 113:736-45. 2011
  5. doi request reprint Guanidino compounds as uremic (neuro)toxins
    Peter Paul De Deyn
    Department of Neurology, ZNA Middelheim Hospital and Memory Clinic Antwerp, Institute Born Bunge, University of Antwerp, Belgium
    Semin Dial 22:340-5. 2009
  6. pmc Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene
    S Franken
    Department of Physiological Chemistry, University of Bonn, Germany
    Lipids Health Dis 5:21. 2006
  7. pmc More advanced Alzheimer's disease may be associated with a decrease in cerebrospinal fluid pressure
    Peter Wostyn
    Department of Psychiatry, PC Sint Amandus, Reigerlostraat 10, 8730 Beernem, Belgium
    Cerebrospinal Fluid Res 6:14. 2009
  8. doi request reprint Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory
    Annemie Van Dijck
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, Wilrijk, Belgium
    Behav Brain Res 190:147-51. 2008
  9. ncbi request reprint Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease
    Debby Van Dam
    Department of Biomedical Sciences, Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium
    Psychopharmacology (Berl) 197:37-43. 2008
  10. ncbi request reprint Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Eur Neuropsychopharmacol 16:59-69. 2006

Detail Information

Publications53

  1. doi request reprint Tolerability of extended-release quetiapine fumarate compared with immediate-release quetiapine fumarate in older patients with Alzheimer's disease with symptoms of psychosis and/or agitation: a randomised, double-blind, parallel-group study
    Peter Paul De Deyn
    Department of Neurology, Middelheim Hospital and Laboratory of Neurochemistry and Behaviour, Department of Biomedical Sciences, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 27:296-304. 2012
    ....
  2. ncbi request reprint Risperidone in the management of agitation and aggression associated with psychiatric disorders
    Peter Paul De Deyn
    Department of Neurology, Middelheim Hospital and Laboratory of Neurochemistry and Behavior, Department of Biomedical Sciences, Born Bunge Foundation, University of Antwerp UA, Universiteitsplein 1, 2610 Antwerp Wilrijk, Belgium
    Eur Psychiatry 21:21-8. 2006
    ..This review provides an overview of the prevalence and treatment of agitation and aggression, and focuses on the use of risperidone to treat these symptoms in patients from different age groups...
  3. ncbi request reprint Management of agitation, aggression, and psychosis associated with dementia: a pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone
    Peter Paul De Deyn
    Department of Neurology, Memory Clinic, Middelheim Hospital, ZNA, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk Antwerp, Belgium
    Clin Neurol Neurosurg 107:497-508. 2005
    ....
  4. doi request reprint Prevalence and incidence of dementia among 75-80-year-old community-dwelling elderly in different districts of Antwerp, Belgium: the Antwerp Cognition (ANCOG) Study
    P P De Deyn
    Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium
    Clin Neurol Neurosurg 113:736-45. 2011
    ....
  5. doi request reprint Guanidino compounds as uremic (neuro)toxins
    Peter Paul De Deyn
    Department of Neurology, ZNA Middelheim Hospital and Memory Clinic Antwerp, Institute Born Bunge, University of Antwerp, Belgium
    Semin Dial 22:340-5. 2009
    ..In this article, we review the uremic GCs with particular attention to their neurotoxicity. We elaborate in detail on the mechanisms of action of the neurotoxic uremic GCs and summarize the kinetics of these toxins...
  6. pmc Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene
    S Franken
    Department of Physiological Chemistry, University of Bonn, Germany
    Lipids Health Dis 5:21. 2006
    ..This deficiency is known to lead to a decreased synthesis of galactosylceramide and sulfatide, which should reduce sulfatide storage and improve pathology in ASA-deficient mice...
  7. pmc More advanced Alzheimer's disease may be associated with a decrease in cerebrospinal fluid pressure
    Peter Wostyn
    Department of Psychiatry, PC Sint Amandus, Reigerlostraat 10, 8730 Beernem, Belgium
    Cerebrospinal Fluid Res 6:14. 2009
    ..This could result in an abnormally high trans-lamina cribrosa pressure difference and lead to glaucomatous damage...
  8. doi request reprint Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory
    Annemie Van Dijck
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, Wilrijk, Belgium
    Behav Brain Res 190:147-51. 2008
    ..Possible explanations for this discrepancy with earlier published results are the advanced age of the mice or the C57Bl/6J background, in which the model was established...
  9. ncbi request reprint Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease
    Debby Van Dam
    Department of Biomedical Sciences, Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium
    Psychopharmacology (Berl) 197:37-43. 2008
    ....
  10. ncbi request reprint Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Eur Neuropsychopharmacol 16:59-69. 2006
    ..This is the first study reporting disease-modifying efficacy of galantamine and memantine in transgenic mice modeling Alzheimer's disease...
  11. ncbi request reprint APP23 mice display working memory impairment in the plus-shaped water maze
    Ellen Vloeberghs
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Neurosci Lett 407:6-10. 2006
    ..The transgenic mice had slower learning curves; however, consolidation of the learned information appeared intact in this learning paradigm. This report demonstrates impairment of working memory in this transgenic Alzheimer model...
  12. ncbi request reprint Biochemical and behavioural phenotyping of a mouse model for GAMT deficiency
    An Torremans
    Laboratory of Neurochemistry and Behaviour Born Bunge Foundation, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, 2610 Antwerp Wilrijk, Belgium
    J Neurol Sci 231:49-55. 2005
    ..KO mice displayed mild cognitive impairment. In general, it could be concluded that the GAMT mouse model is very useful for biochemical research of GAMT deficiency, but shows only a mild cognitive deficit...
  13. doi request reprint Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model
    Ellen Vloeberghs
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
    Behav Neurosci 122:491-7. 2008
    ..Our results suggest the presence of a hypermetabolic state in this model. This is the first report, evidencing the presence of changes in eating and drinking behavior in a single transgenic Alzheimer mouse model...
  14. ncbi request reprint No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital ZNA, Antwerpen, Belgium
    Brain 130:2320-6. 2007
    ....
  15. doi request reprint Relation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories
    Marcel J H Aries
    Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals ZNA, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 25:1186-95. 2010
    ..To study frontal lobe symptoms in relation to dementia severity within and across diagnostic dementia categories, a cross-sectional analysis of behavioural data was performed...
  16. doi request reprint Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Dementia BIODEM, Antwerp, Belgium
    J Alzheimers Dis 33:807-22. 2013
    ..Only T-tau increased in AD patients in comparison to controls, which does not preclude its use as a diagnostic marker, nor as a potential pharmacodynamic marker...
  17. ncbi request reprint Cognitive decline, neuromotor and behavioural disturbances in a mouse model for fragile-X-associated tremor/ataxia syndrome (FXTAS)
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Behav Brain Res 162:233-9. 2005
    ..The age-dependent cognitive decline and neuromotor disturbances may be related to the progressive cognitive and behavioural difficulties observed in FXTAS patients...
  18. ncbi request reprint Mood and male sexual behaviour in the APP23 model of Alzheimer's disease
    Ellen Vloeberghs
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Behav Brain Res 180:146-51. 2007
    ..The present study nevertheless provides evidence that the APP23 mice are more anxious and fearful in comparison with control littermates, which opens perspectives to future treatment studies...
  19. doi request reprint Validation of the APP23 transgenic mouse model of Alzheimer's disease through evaluation of risperidone treatment on aggressive behaviour
    Ellen Vloeberghs
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
    Arzneimittelforschung 58:265-8. 2008
    ....
  20. ncbi request reprint Aggressive male APP23 mice modeling behavioral alterations in dementia
    Ellen Vloeberghs
    Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
    Behav Neurosci 120:1380-3. 2006
    ..The presence of aggressive disturbances in this valuable mouse model opens perspectives to evaluate aggression-modulating therapies...
  21. doi request reprint Added diagnostic value of CSF biomarkers in differential dementia diagnosis
    Nathalie Le Bastard
    Reference Center for Biological Markers of Memory Disorders, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Neurobiol Aging 31:1867-76. 2010
    ....
  22. ncbi request reprint Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease
    Bianca Van Broeck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Neurobiol Aging 29:241-52. 2008
    ..These data support earlier observations of A beta accumulation in the endosomal-lysosomal pathway and the hypothesis that intraneuronal accumulation of A beta could be an important factor in the AD pathogenesis...
  23. ncbi request reprint Actigraphic measurement of agitated behaviour in dementia
    Guy Nagels
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 21:388-93. 2006
    ..This study examines the correlation between actigraphic measures and a validated assessment scale of agitated behaviour in dementia, the Cohen-Mansfield Agitation Inventory (CMAI)...
  24. ncbi request reprint The efficacy and safety of risperidone in the treatment of psychosis of Alzheimer's disease and mixed dementia: a meta-analysis of 4 placebo-controlled clinical trials
    Ira Katz
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA, and Department of Neurology, Memory Clinic, Middelheim Hospital, ZNA, Wilrijk Antwerp, Belgium
    Int J Geriatr Psychiatry 22:475-84. 2007
    ..Psychosis of Alzheimer's disease (AD) is a specific component of AD, characterized by delusions, misidentifications, and hallucinations...
  25. ncbi request reprint Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Born Bunge Institute, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Neurochem Int 46:409-22. 2005
    ..Transgenic mouse models may be employed as a tool to study early-stage neurochemical changes, which are often not accessible in Alzheimer brain...
  26. doi request reprint Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals ZNA, Antwerpen, Belgium
    J Alzheimers Dis 35:67-73. 2013
    ....
  27. doi request reprint Reversal of head drop after discontinuation of olanzapine in a DLB patient
    Marcel J H Aries
    Department of Neurology and Memory Clinic, ZNA Middelheim and ZNA Hoge Beuken, Antwerp, Belgium
    Mov Disord 23:1760-2. 2008
    ..Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade...
  28. pmc A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats
    Julie van der Zee
    Department of Molecular Genetics, VIB, Antwerp, Belgium
    Hum Mutat 34:363-73. 2013
    ..001) with the most common indel creating one long contiguous imperfect G(4) C(2) repeat, which is likely more prone to replication slippage and pathological expansion...
  29. pmc The genetics and neuropathology of frontotemporal lobar degeneration
    Anne Sieben
    Institute Born Bunge, University of Antwerp, Antwerpen, Belgium
    Acta Neuropathol 124:353-72. 2012
    ..In this review, we summarize the current state of the rapidly progressing field of genetic, neuropathological and clinical research of this intriguing condition...
  30. ncbi request reprint The Middelheim Frontality Score: a behavioural assessment scale that discriminates frontotemporal dementia from Alzheimer's disease
    Peter Paul De Deyn
    Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, 2610 Antwerp, Belgium
    Int J Geriatr Psychiatry 20:70-9. 2005
    ....
  31. ncbi request reprint Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital ZNA, Lindendreef 1, 2020 Antwerp, Belgium
    Neurobiol Aging 29:1143-59. 2008
    ..New models have been developed, achieving sensitivity, specificity and diagnostic accuracy levels, consistently exceeding 80%...
  32. doi request reprint Guanosine triphosphate cyclohydrolase 1 promoter deletion causes dopa-responsive dystonia
    Jessie Theuns
    Neurodegenerative Brain Diseases Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium
    Mov Disord 27:1451-6. 2012
    ..Autosomal dominant dopa-responsive dystonia (AD-DRD) is caused by a biochemical defect primarily resulting from guanosine triphosphate cyclohydrolase 1 gene (GCH1) mutations. Few families have been reported without mutations in GCH1...
  33. doi request reprint Plasma amyloid-beta forms in Alzheimer's disease and non-Alzheimer's disease patients
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 21:291-301. 2010
    ..CSF biomarker analysis remains superior, although the possible application of longitudinal plasma Abeta measurements as screening tools for dementia remains to be elucidated...
  34. ncbi request reprint Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Born Bunge Institute, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Psychopharmacology (Berl) 180:177-90. 2005
    ..A valid animal model should respond to therapeutic interventions in an equivalent manner as human patients...
  35. ncbi request reprint Correlation between actigraphy and nurses' observation of activity in dementia
    Guy Nagels
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 22:84-6. 2007
  36. doi request reprint Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    J Alzheimers Dis 36:759-67. 2013
    ....
  37. ncbi request reprint Effect of Morris water maze diameter on visual-spatial learning in different mouse strains
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Neurobiol Learn Mem 85:164-72. 2006
    ....
  38. ncbi request reprint Neuropeptides in Alzheimer's disease: from pathophysiological mechanisms to therapeutic opportunities
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Department of Biomedical Sciences Universiteitsplein 1, 2610 Wilrijk, Belgium
    Curr Alzheimer Res 10:449-68. 2013
    ..In the past, clinical trials with neuropeptides have often failed due to insufficient delivery to the brain. Therefore, new strategies to target the brain with peptide drugs are also covered...
  39. doi request reprint A behavioural study of neuroglobin-overexpressing mice under normoxic and hypoxic conditions
    Wendy Van Leuven
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    Biochim Biophys Acta 1834:1764-71. 2013
    ..This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. ..
  40. ncbi request reprint Olanzapine versus placebo in the treatment of psychosis with or without associated behavioral disturbances in patients with Alzheimer's disease
    Peter Paul De Deyn
    Department of Neurology, Middelheim Hospital, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 19:115-26. 2004
    ..This study was conducted to compare the efficacy of olanzapine versus placebo in patients with psychotic symptoms associated with AD in long-term or continuing-care settings...
  41. doi request reprint Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment?
    Hans Debruyne
    Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium
    Int J Geriatr Psychiatry 24:556-62. 2009
    ....
  42. ncbi request reprint Drug discovery in dementia: the role of rodent models
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Nat Rev Drug Discov 5:956-70. 2006
    ..Here, we summarize and critically evaluate current rodent models of dementia, and discuss their role in drug discovery and development...
  43. doi request reprint Comparison of extraction methods for peptidomics analysis of mouse brain tissue
    Annemie Van Dijck
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    J Neurosci Methods 197:231-7. 2011
    ..For these reasons, we recommend the use of this protocol in future neuropeptidomics studies...
  44. doi request reprint DLB and PDD: a role for mutations in dementia and Parkinson disease genes?
    Bram Meeus
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Neurobiol Aging 33:629.e5-629.e18. 2012
    ..They do support the hypothesis of a genetic overlap between members of the Lewy body disease spectrum, but additional genes still have to exist...
  45. pmc Animal models in the drug discovery pipeline for Alzheimer's disease
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk Antwerp, Belgium
    Br J Pharmacol 164:1285-300. 2011
    ....
  46. doi request reprint Belgian Fabry study: prevalence of Fabry disease in a cohort of 1000 young patients with cerebrovascular disease
    Raf Brouns
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, and Department of Biomedical Sciences, University of Antwerp CDE, Universiteitsplein 1, 2610 Antwerp, Belgium
    Stroke 41:863-8. 2010
    ..In this study, we assessed the prevalence of Fabry disease in young patients presenting with cerebrovascular disease in Belgium...
  47. doi request reprint Central administration of obestatin fails to show inhibitory effects on food and water intake in mice
    Annemie Van Dijck
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Regul Pept 156:77-82. 2009
    ..Under our experimental conditions, no suppressive effects of obestatin on food or water intake were observed, whereas CRF evoked a significant suppression of food intake, which proves the internal validity of the study design...
  48. doi request reprint Clinical, biochemical and neuroimaging parameters after thrombolytic therapy predict long-term stroke outcome
    Raf Brouns
    Department of Neurology and Memory Clinic, ZNA Middelheim Hospital, Antwerp, Belgium
    Eur Neurol 62:9-15. 2009
    ..We investigated the predictive value of standard neurological evaluation, a commercially available biomarker assay and neuroimaging in the subacute phase for outcome after thrombolytic therapy in ischemic stroke...
  49. ncbi request reprint GSA: behavioral, histological, electrophysiological and neurochemical effects
    An Torremans
    Laboratory of Neurochemistry and Behavior, Born Bunge Foundation, University of Antwerp Campus Drie Eiken, Universiteitsplein 1, B 2610 Antwerp, Wilrijk, Belgium
    Physiol Behav 84:251-64. 2005
    ..Animal models like the 'GSA mouse model' are useful tools for research in this context...
  50. doi request reprint Contribution of VPS35 genetic variability to LBD in the Flanders-Belgian population
    Aline Verstraeten
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium
    Neurobiol Aging 33:1844.e11-3. 2012
    ..Hence, our data do not support a major role for VPS35 variations in the genetic etiology of Lewy body disorders in the Flanders-Belgian population...
  51. ncbi request reprint The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years
    Nathalie Brouwers
    Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology and Institute Born Bunge, University of Antwerp, Universiteitsplein 1, Belgium
    Neurosci Lett 392:72-4. 2006
    ..Our study does not support a major role for this UBQLN1 polymorphism in AD patients with an earlier onset of disease...
  52. ncbi request reprint Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances
    Ellen Vloeberghs
    Laboratory of Neurochemistry and Behaviour, Born Bunge Foundation, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Eur J Neurosci 20:2757-66. 2004
    ..This first report of diurnal rhythm disturbances and sundowning-like phenomena in a transgenic mouse model greatly adds to the validity of the APP23 model...
  53. doi request reprint The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade
    Indra Aerts
    Department of Biomedical Science, Cellular Biochemistry, Campus Drie Eiken, University of Antwerp, Belgium
    Clin Neurol Neurosurg 113:224-9. 2011
    ..In this study, the use of anti-NPP1 antibody in the determination of astrocytic tumor grade is evaluated...