Laurence de Leval

Summary

Country: Belgium

Publications

  1. pmc CD28-B7 costimulatory blockade by CTLA4Ig delays the development of retrovirus-induced murine AIDS
    L de Leval
    Laboratory of Pathology, University of Liege, Liege, Belgium
    J Virol 72:5285-90. 1998
  2. ncbi T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities
    Laurence de Leval
    Department of Pathology, CHU Sart Tilman, Liege, Belgium
    APMIS 114:474-8. 2006
  3. ncbi Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus
    Laurence de Leval
    Department of Pathology, Center for Experimental Cancer Research, University of Liege, Liege, Belgium
    Am J Surg Pathol 30:319-27. 2006
  4. ncbi Hodgkin's lymphoma presenting as a bladder tumour
    Laurence de Leval
    Department of Pathology CHU Sart Tilman Tour de Pathologie, B23 B 4000 Liège, Belgium
    Haematologica 91:ECR03. 2006
  5. doi Molecular classification of T-cell lymphomas
    Laurence de Leval
    The Pathology Department, CHU Sart Tilman, University of Liege, 4000 Liege, Belgium
    Crit Rev Oncol Hematol 72:125-43. 2009
  6. doi Diffuse large B-cell lymphomas and burkitt lymphoma
    Laurence de Leval
    Department of Pathology, CHU Sart Tilman, Institute of Pathology, Liege, Belgium
    Hematol Oncol Clin North Am 23:791-827. 2009
  7. doi Scary but benign. Follicular lymphoid hyperplasia
    Laurence de Leval
    Department of Pathology, C H U Sart Tilman, Liege, Belgium
    Int J Surg Pathol 16:65. 2008
  8. ncbi Distinct clonal origin in two cases of Hodgkin's lymphoma variant of Richter's syndrome associated With EBV infection
    Laurence de Leval
    Department of Pathology, CHU Sart Tilman, Liege, Belgium
    Am J Surg Pathol 28:679-86. 2004
  9. ncbi Variability in immunophenotype in diffuse large B-cell lymphoma and its clinical relevance
    L de Leval
    Department of Pathology, C H U of Liège, Belgium
    Histopathology 43:509-28. 2003
  10. ncbi Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome
    Laurence de Leval
    Department of Pathology, CHU of Liege, Sart Tilman, 4000 Liege, Belgium
    Virchows Arch 441:462-5. 2002

Detail Information

Publications53

  1. pmc CD28-B7 costimulatory blockade by CTLA4Ig delays the development of retrovirus-induced murine AIDS
    L de Leval
    Laboratory of Pathology, University of Liege, Liege, Belgium
    J Virol 72:5285-90. 1998
    ..Relative expression of Du5H did not differ between treated and untreated animals. These results suggest that the CD28/B7 costimulatory pathway contributes to MAIDS development...
  2. ncbi T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities
    Laurence de Leval
    Department of Pathology, CHU Sart Tilman, Liege, Belgium
    APMIS 114:474-8. 2006
    ....
  3. ncbi Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus
    Laurence de Leval
    Department of Pathology, Center for Experimental Cancer Research, University of Liege, Liege, Belgium
    Am J Surg Pathol 30:319-27. 2006
    ..Thus, HDAC8 detection may be useful in helping the differential diagnosis of uterine mesenchymal tumors...
  4. ncbi Hodgkin's lymphoma presenting as a bladder tumour
    Laurence de Leval
    Department of Pathology CHU Sart Tilman Tour de Pathologie, B23 B 4000 Liège, Belgium
    Haematologica 91:ECR03. 2006
  5. doi Molecular classification of T-cell lymphomas
    Laurence de Leval
    The Pathology Department, CHU Sart Tilman, University of Liege, 4000 Liege, Belgium
    Crit Rev Oncol Hematol 72:125-43. 2009
    ..In PTCL, not otherwise specified (PTCL, NOS), novel molecular biomarkers of potential therapeutic interest have been recently identified...
  6. doi Diffuse large B-cell lymphomas and burkitt lymphoma
    Laurence de Leval
    Department of Pathology, CHU Sart Tilman, Institute of Pathology, Liege, Belgium
    Hematol Oncol Clin North Am 23:791-827. 2009
    ..In particular, the diagnostic and therapeutic problems related to neoplasms with features intermediate between DLBCL and BL will be discussed...
  7. doi Scary but benign. Follicular lymphoid hyperplasia
    Laurence de Leval
    Department of Pathology, C H U Sart Tilman, Liege, Belgium
    Int J Surg Pathol 16:65. 2008
  8. ncbi Distinct clonal origin in two cases of Hodgkin's lymphoma variant of Richter's syndrome associated With EBV infection
    Laurence de Leval
    Department of Pathology, CHU Sart Tilman, Liege, Belgium
    Am J Surg Pathol 28:679-86. 2004
    ....
  9. ncbi Variability in immunophenotype in diffuse large B-cell lymphoma and its clinical relevance
    L de Leval
    Department of Pathology, C H U of Liège, Belgium
    Histopathology 43:509-28. 2003
    ..This review summarizes these studies in regard to their clinical significance and in the light of recent advances in our understanding of the molecular pathology and histogenesis of DLBCL...
  10. ncbi Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome
    Laurence de Leval
    Department of Pathology, CHU of Liege, Sart Tilman, 4000 Liege, Belgium
    Virchows Arch 441:462-5. 2002
    ..The unusual macroscopical, histological, and immunohistochemical features of this case and its specific clinical setting are discussed...
  11. ncbi The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells
    Laurence de Leval
    Department of Pathology, Centre Hospitalo Universitaire Sart Tilman, Tour de Pathologie 1, University of Liege, 4000 Liege, Belgium
    Blood 109:4952-63. 2007
    ..Our findings strongly support that T(FH) cells represent the normal counterpart of AITL, and suggest that the AITL spectrum may be wider than suspected, as a subset of CD30(-) PTCLs-u may derive from or be related to AITL...
  12. ncbi Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis
    Laurence de Leval
    Department of Pathology, C H U Sart Tilman, Tour de Pathologie, B23, 1, 4000, Liege, Belgium
    Virchows Arch 442:388-92. 2003
    ..Demonstration of a recurrent abnormal karyotype largely supports its relevance to the malignant clone and suggests a role of supernumerary chromosome(s) 8 in the determinism of malignant behavior in SFT...
  13. ncbi Establishment and characterisation of two novel human KSHV- and EBV-negative Burkitt cell lines, GAL-01 and GAL-02, from a primary lymphomatous effusion
    Caroline Thielen
    Department of Pathology, C H U of Liège, Liege, Belgium
    Eur J Haematol 77:318-26. 2006
    ..The in vivo effusion occurred in a very peculiar clinical setting; the patient having a previous history of intestinal diffuse large B-cell lymphoma...
  14. doi The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP
    Jean Jacques Goval
    Department of Pathology, CHU Sart Tilman, Liege, Belgium
    Haematologica 93:1169-77. 2008
    ..The aim of our study was to characterize the spontaneous apoptosis of follicular lymphoma cells in vitro, and the modulation of this apoptosis by follicular dendritic cells...
  15. ncbi Report of two cases of gastric cancer after bariatric surgery: lymphoma of the bypassed stomach after Roux-en-Y gastric bypass and gastrointestinal stromal tumor (GIST) after vertical banded gastroplasty
    Arnaud De Roover
    Department of Abdominal Surgery and Transplantation, CHU, ULg, Domaine du Sart Tilman, Liege, Belgium
    Obes Surg 16:928-31. 2006
    ..Based on the few reports of cancer in the literature, analysis of these cases suggests that the main risk of gastric cancer after bariatric surgery comes from the delayed diagnosis of malignancy...
  16. doi Characterization of an antibody panel for immunohistochemical analysis of canine muscle cells
    Stephanie Gofflot
    Department of Pathology, University of Liege, Liege, Belgium
    Vet Immunol Immunopathol 125:225-33. 2008
    ..5). This antibody panel may be useful not only for the evaluation of cell-based therapies in muscle disorders, but also for the evaluation of canine soft tissue neoplasms in veterinary pathology...
  17. doi Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion
    Bettina Bisig
    Department of Pathology, Centre Hospitalier Universitaire du Sart Tilman, Liege, Belgium
    Hum Pathol 40:1504-9. 2009
    ....
  18. doi Hyperacute graft rejection during heart transplantation for giant cell myocarditis: a case report
    Eugene Mutijima
    Department of Pathology, CHU Sart Tilman, University of Liege, Belgium
    Pathol Res Pract 206:411-4. 2010
    ..This case raises the questions of the need for intensive immunosuppressive therapy before transplantation in giant cell myocarditis and of the management of patients with positive cross-match in the context of a giant cell myocarditis...
  19. doi Diverse phenotypic profile of uterine tumors resembling ovarian sex cord tumors: an immunohistochemical study of 12 cases
    Laurence de Leval
    Department of Pathology, C H U Sart Tilman, Liege, Belgium
    Am J Surg Pathol 34:1749-61. 2010
    ..Our study aimed to delineate the immunophenotype of these tumors and to verify whether their morphology reflects true sex cord-like differentiation...
  20. ncbi Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage
    Thibaut Dassesse
    Metastasis Research Laboratory, Center of Experimental Cancer Research, University of Liege, B 4000 Liege, Belgium
    Eur Urol 50:1021-31; discussion 1031. 2006
    ..We investigated the potential involvement of the thromboxane A(2) (TXA(2)) pathway in human prostate cancer (PCa)...
  21. pmc Identification of stromal proteins overexpressed in nodular sclerosis Hodgkin lymphoma
    Philippe Kischel
    Metastasis Research Laboratory, GIGA Cancer, University of Liege, Bat, B23, CHU Sart Tilman Liege, B 4000 Liege, Belgium
    Proteome Sci 9:63. 2011
    ..These proteins were validated by immunohistochemistry on a larger series of biopsy samples, and bear the potential to become targets for antibody-based anti-cancer therapies...
  22. ncbi Transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a non-heart beating donor
    Olivier Detry
    Department of Abdominal Surgery, University of Liege, CHU Sart Tilman, Liege, Belgium
    Liver Transpl 11:696-9. 2005
    ..The management of liver graft recipients is very difficult in this setting, and long-term survival was very rarely reported...
  23. ncbi Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature
    Sabine Olivier
    Department of Rheumatology, Center for Biomedical Integrative Genoproteomics, University of Liege, Centre Hospitalier Universitaire Sart Tilman, Belgium
    Mol Pharmacol 69:1615-23. 2006
    ..These findings also provide a transcriptional profile of raloxifene treatment on multiple myeloma cells, offering the framework for future studies of selective estrogen receptor modulators therapy in multiple myeloma...
  24. pmc Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
    Denis Bedoret
    Laboratory of Cellular and Molecular Physiology, GIGA Research, University of Liege, Liege, Belgium
    J Clin Invest 119:3723-38. 2009
    ....
  25. doi Advances in the understanding and management of angioimmunoblastic T-cell lymphoma
    Laurence de Leval
    Department of Pathology, CHU Sart Tilman, University of Liege, Institute of Pathology, Belgium
    Br J Haematol 148:673-89. 2010
    ..In this respect, efforts will be needed to evaluate promising innovative therapies in prospective clinical trials...
  26. pmc Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues
    David Waltregny
    Metastasis Research Laboratory, Pathology Building, Bat B23, Level 1, CHU Sart Tilman Liege, B 4000 Liege 1, Belgium
    Am J Pathol 165:553-64. 2004
    ....
  27. ncbi Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on blee
    Jean Michel Dogne
    Natural and Synthetic Drug Research Center, University of Liege, Belgium
    J Pharmacol Exp Ther 309:498-505. 2004
    ..Moreover, BM-573 lost the diuretic property of torasemide and has no impact on glycemia...
  28. doi BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase
    Céline Cherdon
    Department of Cardiovascular Research, University of Liege, Belgium
    Prostaglandins Other Lipid Mediat 94:124-32. 2011
    ..Our results show that a molecule combining receptor antagonism and thromboxane synthase inhibition is more efficient in delaying atherosclerosis in Apo E(-/-) mice than sole inhibition of TXA(2) formation...
  29. pmc An improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2Rγnull mice allows HIV replication and development of anti-HIV immune responses
    Maneesh Singh
    Immunology and infectious diseases unit GIGA I3, University of Liege, Liege, Belgium
    PLoS ONE 7:e38491. 2012
    ..We believe that NSG mice reconstituted according to our easy to use protocol will provide a better in vivo model for HIV-1 replication and anti-HIV-1 therapy trials...
  30. ncbi Identification of specific reachable molecular targets in human breast cancer using a versatile ex vivo proteomic method
    Vincent Castronovo
    Metastasis Research Laboratory, Center for Experimental Cancer Research, University of Liege, Liege, Belgium
    Proteomics 7:1188-96. 2007
    ..Overall, this powerful technology may lay the ground not only for custom-made therapies in cancer, but also for the development of therapies that need to be selectively delivered in a specific tissue...
  31. ncbi Germinal center dendritic cells express more ICAM-1 than extrafollicular dendritic cells and ICAM-1/LFA-1 interactions are involved in the capacity of dendritic cells to induce PBMCs proliferation
    Jean Jacques Goval
    Department of Pathology, CHU Sart Tilman, B23 Tour de Pathologie, Liege, Belgium
    J Histochem Cytochem 54:75-84. 2006
    ....
  32. ncbi Early inflammation in the airways of a cystic fibrosis foetus
    Catherine Verhaeghe
    Department of Human Genetics, Center for Biomedical Integrative Genoproteomics CBIG, University of Liege, CHU Sart Tilman B35, B 4000 Liege, Belgium
    J Cyst Fibros 6:304-8. 2007
    ..Our findings suggest therefore the existence of an early intrinsic pro-inflammatory state in cystic fibrosis airways...
  33. doi TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas
    Caroline Thielen
    Department of Pathology, CHU of Liege, University of Liege, Liege, Belgium
    Leuk Res 32:1431-8. 2008
    ..Our data indicate that IL-5 and TARC expression highly correlate with eosinophilia in T-cell lymphomas, suggesting that these chemokines are involved in the recruitment of eosinophils into the tumors...
  34. doi New biomarkers in T-cell lymphomas
    Bettina Bisig
    Department of Pathology, Centre Hospitalier Universitaire Sart Tilman, Liege, Belgium
    Best Pract Res Clin Haematol 25:13-28. 2012
    ..Deregulated molecules within oncogenic pathways (NF-κB, Syk, PDGFRα) and immunoreactive cell-surface antigens (CD30, CD52) have been brought to the fore as potential targets for guiding the development of novel therapies...
  35. ncbi Deletion (6)(p22p25) is a recurrent anomaly of thymoma: report of a second case and review of the literature
    Christian Herens
    Department of Human Genetics, University of Liege, Tour de Pathologie, B23 Sart Tilman, 4000 Liege, Belgium
    Cancer Genet Cytogenet 146:66-9. 2003
    ..Both patients presented with benign tumors. These data suggest that partial deletion of the short arm of chromosome 6 is a nonrandom change associated with benign thymomas...
  36. ncbi Adrenal ganglioneuroma
    Sylvie Maweja
    Department of Endocrine Surgery, University Hospital, Domaine Universitaire du Sart Tilman B35, 4000 Liege, Belgium
    Am J Surg 194:683-4. 2007
    ..Pathological examination after adrenalectomy concluded it was an adrenal ganglioneuroma. We studied the characteristics of adrenal ganglioneuroma...
  37. doi Identification and validation of the methylated TWIST1 and NID2 genes through real-time methylation-specific polymerase chain reaction assays for the noninvasive detection of primary bladder cancer in urine samples
    Isabelle Renard
    OncoMethylome Sciences SA, Liege, Belgium
    Eur Urol 58:96-104. 2010
    ..Accumulating evidence suggests that DNA methylation markers could serve as sensitive and specific cancer biomarkers...
  38. doi Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic graft-versus-host disease
    France Bruck
    Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA I 3, University of Liege, Liege, Belgium
    Cytotherapy 15:267-79. 2013
    ..Previous studies have suggested that mesenchymal stromal cells (MSCs) could exert potent immunosuppressive effects...
  39. doi Quantitative immunohistochemical fingerprinting of adhesion/growth-regulatory galectins in salivary gland tumours: divergent profiles with diagnostic potential
    Myriam Remmelink
    Department of Pathology, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Histopathology 58:543-56. 2011
    ..This study tests the hypothesis that histopathological fingerprinting of galectins, which are emerging multifunctional effectors in cell sociology, could refine the differential diagnosis of salivary tumours...
  40. doi An unusual uterine tumor with signet ring cell features
    Rossella Sarro
    Institute of Pathology, Multidisciplinary Oncology Centre, Lausanne, Switzerland
    Int J Gynecol Pathol 31:236-41. 2012
    ..This exceptional case exemplifies a diagnostically challenging situation and expands the differential diagnosis of uterine neoplasms displaying signet ring cell morphology...
  41. ncbi Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo
    Laurent Gillet
    Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of Liege, Liege, Belgium
    Cancer Res 65:9463-72. 2005
    ..Moreover, further identification of BoHV-4 proapoptotic gene(s) and the cellular pathways targeted by this or these gene(s) could lead to the design of new cancer therapeutic strategies...
  42. ncbi Association between Epstein-Barr virus and Hodgkin's lymphoma in Belgium: a pathological and virological study
    Mounir Trimeche
    Department of Pathology, CHU Farhat Hached of Sousse, Sousse, Tunisia
    Leuk Lymphoma 48:1323-31. 2007
    ..6%) EBV-positive cHL cases, and in 41.7% of reactive tonsil samples. This variant did not correlate with any clinical or pathological feature. The EBV strain was type A in all cHL and reactive samples...
  43. ncbi Diffuse large B-cell lymphoma of bone: an analysis of differentiation-associated antigens with clinical correlation
    Laurence de Leval
    Department of Pathology, Massachusetts General Hospital, Boston, 02114, USA
    Am J Surg Pathol 27:1269-77. 2003
    ..0046). In conclusion, a GC-like immunophenotype characterizes roughly half of large B-cell lymphomas of bone and is associated with an improved survival...
  44. ncbi BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma
    Kristina M Braaten
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Cancer Res 9:1063-9. 2003
    ..v. high-dose methotrexate therapy...
  45. ncbi The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma
    Kerry J Savage
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 102:3871-9. 2003
    ..In almost all cases, c-REL was localized to the nucleus, consistent with activation of the NF-kappa B pathway. These studies identify a molecular link between MLBCL and cHL and a shared survival pathway...
  46. ncbi NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes
    Friedrich Feuerhake
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 106:1392-9. 2005
    ..In this large series of primary MLBCLs and DLBCLs, NFkappaB activation was not associated with amplification of the cREL locus, suggesting alternative pathogenetic mechanisms...
  47. ncbi High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection
    Esther Oliva
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 31:1277-84. 2007
    ..Our results indicate that the detection of this chromosomal abnormality can be used to diagnose ESTs with smooth muscle differentiation when the smooth muscle component is predominant...
  48. doi Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics
    Karin Bink
    Institutes of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Oberschleissheim, Germany
    Haematologica 93:623-6. 2008
    ..However, the distribution of IGH translocation partners, with the notable absence of t(11;14), is different. Key words: extramedullary plasmacytoma, multiple myeloma, cytogenetics, IGH translocation, fluorescence in situ hybridization...
  49. doi Report of a case of Streptococcus agalactiae mycotic aneurysm and review of the literature
    Kavitha Chandrikakumari
    Department of Infectious Diseases, Center Hospitalier Universitaire de Ligeg, Ligeg, Belgium
    Int J Surg Pathol 16:314-9. 2008
    ..Sixteen months after stopping the antibiotics, the patient is doing well, and the control imaging studies are satisfactory...
  50. ncbi Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm
    Henry Y Dong
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 29:1633-41. 2005
    ..We conclude that most plasmacytic tumors in HIV-positive individuals are extramedullary, clinically aggressive EBV(+) tumors identical to plasmablastic lymphoma that does not have the clinical features of plasma cell myeloma...
  51. pmc Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells
    Richard J Bende
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Pathol 162:105-13. 2003
    ..The combined data suggests that primary FL of the small intestine is a distinct entity that originates from local antigen-responsive B cells...
  52. doi Cyclin D1-negative mantle cell lymphoma with cryptic t(12;14)(p13;q32) and cyclin D2 overexpression
    Christian Herens
    Blood 111:1745-6. 2008
  53. ncbi [Prevalence of Epstein-Barr virus in non-Hodgkin's lymphomas in central region of Tunisia]
    Mounir Trimeche
    Laboratoire d anatomie et de cytologie pathologiques, CHU Farhat Hached, 4000 Sousse, Tunisia
    Ann Pathol 25:95-102. 2005
    ..03). In conclusion, the prevalence of EBV in Tunisian non-Hodgkin's lymphomas is low but variable depending on the histological type and anatomical location with a predilection for small intestine and nasal lymphomas...