Daniel De Backer

Summary

Country: Belgium

Publications

  1. ncbi request reprint Sublingual capnometry tracks microcirculatory changes in septic patients
    Jacques Creteur
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 32:516-23. 2006
  2. doi request reprint Does ultrasound guidance improve the efficacy of dorsal penile nerve block in children?
    David Faraoni
    Department of Anesthesia, CUB Erasme Hospital, Brussels, Belgium
    Paediatr Anaesth 20:931-6. 2010
  3. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
  4. doi request reprint The role of invasive techniques in cardiopulmonary evaluation
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Crit Care 19:228-33. 2013
  5. doi request reprint Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 41:791-9. 2013
  6. ncbi request reprint Clinical management of the cardiovascular failure in sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, Belgium
    Curr Vasc Pharmacol 11:222-42. 2013
  7. doi request reprint Characteristics of fluids used for intravascular volume replacement
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 26:441-51. 2012
  8. doi request reprint Monitoring the microcirculation
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Clin Monit Comput 26:361-6. 2012
  9. pmc Vasopressors in shock: too early to move away from catecholamines?
    D De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Br J Pharmacol 165:2012-4. 2012
  10. pmc Year in review 2010: Critical Care--Cardiology
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care 15:241. 2011

Detail Information

Publications140 found, 100 shown here

  1. ncbi request reprint Sublingual capnometry tracks microcirculatory changes in septic patients
    Jacques Creteur
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 32:516-23. 2006
    ..To test the hypothesis that microcirculatory blood flow is the main determinant of sublingual carbon dioxide pressure in patients with septic shock...
  2. doi request reprint Does ultrasound guidance improve the efficacy of dorsal penile nerve block in children?
    David Faraoni
    Department of Anesthesia, CUB Erasme Hospital, Brussels, Belgium
    Paediatr Anaesth 20:931-6. 2010
    ..The goal of this study was to compare the efficacy of ultrasound-guided PNB versus the classical landmark-based technique (LBT) in children undergoing circumcision...
  3. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
    ....
  4. doi request reprint The role of invasive techniques in cardiopulmonary evaluation
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Crit Care 19:228-33. 2013
    ..To discuss the role of the invasive monitoring techniques pulmonary artery catheter (PAC) and transpulmonary thermodilution (TPD) for cardiopulmonary monitoring in the critically ill patient...
  5. doi request reprint Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 41:791-9. 2013
    ..We investigated which factors may influence microcirculatory alterations in patients with severe sepsis and whether these are independently associated with mortality...
  6. ncbi request reprint Clinical management of the cardiovascular failure in sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, Belgium
    Curr Vasc Pharmacol 11:222-42. 2013
    ..Finally, various inotropic agents can counteract septic myocardial depression. So far, no study supports their routine use, but these may be justified on an individual basis...
  7. doi request reprint Characteristics of fluids used for intravascular volume replacement
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 26:441-51. 2012
    ..Hypertonic solutions may represent an interesting option in some groups of patients but more research is needed in this field...
  8. doi request reprint Monitoring the microcirculation
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Clin Monit Comput 26:361-6. 2012
    ..These different devices have provided important data helping us to better understand the pathophysiology of sepsis and multiple organ failure...
  9. pmc Vasopressors in shock: too early to move away from catecholamines?
    D De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Br J Pharmacol 165:2012-4. 2012
    ..Here, we present an alternative interpretation...
  10. pmc Year in review 2010: Critical Care--Cardiology
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care 15:241. 2011
    ..Papers were grouped into the following categories: cardiovascular therapies, biomarkers, hemodynamic monitoring, cardiovascular diseases, and microcirculation...
  11. doi request reprint Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis*
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 40:725-30. 2012
    ..The objective was to evaluate the effects of norepinephrine and dopamine on outcome and adverse events in patients with septic shock...
  12. ncbi request reprint Treatment of shock
    D De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Belgium
    Acta Clin Belg 66:438-42. 2011
    ..The place of epinephrine is not well defined, this agent is associated with tachycardia, increased incidence of arrhythmic events, and undesired metabolic effects...
  13. pmc European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)
    Peter J D Andrews
    Department of Anaesthesia, Critical Care and Pain Management, University of Edinburgh, UK
    Trials 12:8. 2011
    ..Previous experience with cooling also appears to be important if complications, which may outweigh the benefits of hypothermia, are to be avoided...
  14. doi request reprint Monitoring the microcirculation in the critically ill patient: current methods and future approaches
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 36:1813-25. 2010
    ..To discuss the techniques currently available to evaluate the microcirculation in critically ill patients. In addition, the most clinically relevant microcirculatory alterations will be discussed...
  15. pmc Can passive leg raising be used to guide fluid administration?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care 10:170. 2006
    ..This commentary discusses some of the technical issues related to this test...
  16. pmc Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 37:233-40. 2011
    ..The aim of the present multicenter study was to investigate the accuracy of the third-generation software in patients with sepsis, particularly when total systemic vascular resistance (TSVR) is low...
  17. doi request reprint Coupling microcirculation to systemic hemodynamics
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Crit Care 16:250-4. 2010
    ..To discuss the role of microcirculatory abnormalities in critically ill patients and the link between systemic hemodynamics and microvascular perfusion...
  18. ncbi request reprint Microvascular alterations in patients with acute severe heart failure and cardiogenic shock
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Am Heart J 147:91-9. 2004
    ..We hypothesized that microvascular blood flow alterations are present in patients with severe heart failure and cardiogenic shock...
  19. doi request reprint Comparison of dopamine and norepinephrine in the treatment of shock
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    N Engl J Med 362:779-89. 2010
    ..Both dopamine and norepinephrine are recommended as first-line vasopressor agents in the treatment of shock. There is a continuing controversy about whether one agent is superior to the other...
  20. ncbi request reprint Assessment of splanchnic circulation: which relevance?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Acta Gastroenterol Belg 66:288-9. 2003
  21. pmc Why do pulse pressure variations fail to predict the response to fluids in acute respiratory distress syndrome patients ventilated with low tidal volume?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Crit Care 15:150. 2011
    ..In this issue, a trial investigates the value of pulse pressure variation to predict fluid responsiveness in a large series of patients with ARDS ventilated according to current guidelines...
  22. ncbi request reprint Pulse pressure variations to predict fluid responsiveness: influence of tidal volume
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital of the Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 31:517-23. 2005
    ..To evaluate the influence of tidal volume on the capacity of pulse pressure variation (DeltaPP) to predict fluid responsiveness...
  23. pmc Microcirculatory alterations: potential mechanisms and implications for therapy
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Ann Intensive Care 1:27. 2011
    ..In conclusion, microcirculatory alterations may play an important role in the development of sepsis-related organ dysfunction. At this stage, therapies to target microcirculation specifically are still being investigated...
  24. pmc The cuff-leak test: what are we measuring?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care 9:31-3. 2005
    ..In this editorial, the author discuss the factors influencing the leak and hence its predictive value...
  25. pmc How to evaluate the microcirculation: report of a round table conference
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Crit Care 11:R101. 2007
    ..This paper reports the results of a round table conference that was organized in Amsterdam in November 2006 in order to achieve consensus on image acquisition and analysis...
  26. ncbi request reprint OPS techniques
    D De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Minerva Anestesiol 69:388-91. 2003
    ..Microvascular blood flow alterations are frequently observed in patients with sepsis and can have major pathophysiological implications...
  27. pmc Optimal management of the high risk surgical patient: beta stimulation or beta blockade?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care 9:645-6. 2005
    ..Monitoring central venous oxygen saturation may be useful to individualize therapy, but further studies are required to validate this option...
  28. doi request reprint Influence of respiratory rate on stroke volume variation in mechanically ventilated patients
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Anesthesiology 110:1092-7. 2009
    ....
  29. ncbi request reprint Microvascular blood flow is altered in patients with sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Am J Respir Crit Care Med 166:98-104. 2002
    ..The topical application of acetylcholine totally reversed these alterations. In conclusion, microvascular blood flow alterations are frequent in patients with sepsis and are more severe in patients with a worse outcome...
  30. ncbi request reprint Lactic acidosis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 29:699-702. 2003
  31. doi request reprint Link between coagulation abnormalities and microcirculatory dysfunction in critically ill patients
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Anaesthesiol 22:150-4. 2009
    ..The current review discusses the role of coagulation in microcirculatory abnormalities and whether anticoagulants may improve microvascular perfusion...
  32. ncbi request reprint Assessment of the microcirculatory flow in patients in the intensive care unit
    D De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik, 808 B 1070 Brussels, Belgium
    Curr Opin Crit Care 7:200-3. 2001
    ....
  33. ncbi request reprint Guidelines for the use of fresh frozen plasma
    D De Backer
    Service soins intensifs, Hôpital universitaire Erasme ULB, Bruxelles, Belgique
    Acta Clin Belg 63:381-90. 2008
    ..The recommendations formulated by the experts were validated by the working group with the purpose of harmonising FFP transfusion in Belgian hospitals...
  34. doi request reprint Microcirculatory alterations in cardiac surgery: effects of cardiopulmonary bypass and anesthesia
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Ann Thorac Surg 88:1396-403. 2009
    ..Heterogeneity in microvascular perfusion is associated with impaired tissue oxygenation. We hypothesized that cardiac surgery with or without cardiopulmonary bypass (CPB) could induce microvascular alterations...
  35. ncbi request reprint Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care Med 31:1659-67. 2003
    ..To assess the effects of different doses of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in patients with septic shock...
  36. ncbi request reprint Lactic acidosis
    D De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Minerva Anestesiol 69:281-4. 2003
    ..The interpretation of blood lactate levels is difficult. Nevertheless, monitoring blood lactate levels can be useful to detect tissue hypoxia and to monitor the effects of therapy...
  37. ncbi request reprint Stroke volume variations
    D De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Minerva Anestesiol 69:285-8. 2003
    ..Stroke volume variations can be useful to detect fluid responsiveness in mechanically ventilated patients...
  38. pmc Perioperative optimization and right heart catheterization: what technique in which patient?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, University of Brussels, Belgium
    Crit Care 7:201-2. 2003
  39. ncbi request reprint Low-dose vasopressin in the treatment of septic shock in sheep
    Qinghua Sun
    Ph D Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Am J Respir Crit Care Med 168:481-6. 2003
    ..In this clinically relevant model of septic shock due to peritonitis, vasopressin administration (alone or with norepinephrine) can prolong survival...
  40. ncbi request reprint Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 32:1825-31. 2004
    ..To characterize the time course of microcirculatory alterations and their relation to outcome in patients with septic shock...
  41. ncbi request reprint The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:403-8. 2006
    ..To evaluate the effects of dobutamine on microcirculatory blood flow alterations in patients with septic shock...
  42. doi request reprint Effects of a selective iNOS inhibitor versus norepinephrine in the treatment of septic shock
    Fuhong Su
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Belgium
    Shock 34:243-9. 2010
    ..Combination of this selective iNOS inhibitor with NE allowed a higher arterial pressure and renal blood flow to be maintained...
  43. doi request reprint Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis
    Colin L Verdant
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 37:2875-81. 2009
    ..To determine the relationship between sublingual and intestinal mucosal microcirculatory perfusion...
  44. ncbi request reprint Microvascular response to red blood cell transfusion in patients with severe sepsis
    Yasser Sakr
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 35:1639-44. 2007
    ..The effects of red blood cell transfusions on microvascular perfusion are not well defined. We investigated the effects of red blood cell transfusion on sublingual microvascular perfusion in patients with sepsis...
  45. doi request reprint Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis
    Fabio Silvio Taccone
    1Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium 2Department of Anesthesia and Intensive Care, ZOL St Jan, Genk, Belgium 3Department of Neurosurgery, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Crit Care Med 42:e114-22. 2014
    ..We studied the evolution of microvascular blood flow, brain oxygen tension (PbO2), and metabolism in a clinically relevant animal model of septic shock...
  46. ncbi request reprint Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock
    Xinrong He
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 40:2833-40. 2012
    ..We studied whether tetrahydrobiopterin administration exerts beneficial effects in an ovine septic shock model...
  47. doi request reprint Can changes in arterial pressure be used to detect changes in cardiac index during fluid challenge in patients with septic shock?
    Charalampos Pierrakos
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 38:422-8. 2012
    ..However, in clinical practice CI values are often not available. We evaluated whether changes in mean arterial pressure (MAP) correlate with changes in CI after fluid challenge in patients with septic shock...
  48. pmc Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy
    Lucie Seyler
    Department of Infectious Diseases, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Crit Care 15:R137. 2011
    ..We studied whether these recommendations met optimal pharmacokinetic criteria for broad-spectrum antibiotic levels in septic shock patients undergoing CRRT...
  49. ncbi request reprint Can changes in renal function predict variations in β-lactam concentrations in septic patients?
    Giuseppe Stefano Casu
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Int J Antimicrob Agents 42:422-8. 2013
    ..Routine TDM should be considered to adapt β-lactam doses in this setting. ..
  50. ncbi request reprint Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:589-97. 2006
    ..The optimal adrenergic support in shock is controversial. We investigated whether dopamine administration influences the outcome from shock...
  51. doi request reprint Effects of fluids on microvascular perfusion in patients with severe sepsis
    Gustavo Ospina-Tascon
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 36:949-55. 2010
    ..To evaluate the effects of fluid administration on microcirculatory alterations in sepsis...
  52. pmc Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Bruxelles, Belgium
    Crit Care 14:R53. 2010
    ..The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients...
  53. doi request reprint Drotrecogin alfa (activated) for severe sepsis: could we consider a shorter treatment period in patients with a favorable course?
    David Ahishakiye
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Crit Care 24:590-4. 2009
    ..The objective of this study was to develop a model to identify patients in whom drotrecogin alfa (activated) (DAA) might be administered for periods shorter than the recommended 96 hours...
  54. ncbi request reprint Effect of vasopressin on sublingual microcirculation in a patient with distributive shock
    Marc J Dubois
    Department of Intensive Care Medicine, Erasme Hospital, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 29:1020-3. 2003
    ..To assess the sublingual microcirculation in a patient during vasopressin administration for a distributive shock after cardiopulmonary bypass...
  55. pmc Case-control study of drug monitoring of β-lactams in obese critically ill patients
    Maya Hites
    Department of Infectious Diseases, Universite Libre de Bruxelles, Brussels, Belgium
    Antimicrob Agents Chemother 57:708-15. 2013
    ..No differences were observed in pharmacokinetic variables between the two groups. Routine therapeutic drug monitoring of β-lactams should be continued in obese critically ill patients...
  56. doi request reprint Continuous infusion of vancomycin in septic patients receiving continuous renal replacement therapy
    Cecilia Covajes
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles ULB, Route de Lennik 808, 1070 Brussels, Belgium
    Int J Antimicrob Agents 41:261-6. 2013
    ..Most patients with adequate drug concentrations received a daily dose of 16-35 mg/kg. The intensity of CRRT directly influenced vancomycin concentrations on Day 1 of therapy...
  57. ncbi request reprint The hepatosplanchnic contribution to hyperlactatemia in endotoxic shock: effects of tissue ischemia
    Jacques Creteur
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Shock 21:438-43. 2004
    ..In endotoxic shock, GLP is increased, but the liver can metabolize this additional load of lactate, so that the hepatosplanchnic area is not a major source of lactate unless the liver becomes profoundly hypoxic...
  58. ncbi request reprint Microcirculatory effects of angiotensin II inhibitors in patients with severe heart failure
    Diamantino Ribeiro Salgado
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, Brussels, Belgium
    Clin Hemorheol Microcirc 54:87-98. 2013
    ..The renin-angiotensin system is activated in patients with acute severe heart failure, and increased levels of angiotensin II could contribute to microcirculatory defects in these patients...
  59. ncbi request reprint The prognostic value of muscle StO2 in septic patients
    Jacques Creteur
    Erasme University Hospital, Free University of Brussels, Department of Intensive Care, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 33:1549-56. 2007
    ..To quantify sepsis-induced alterations in changes in muscle tissue oxygenation (StO(2)) after an ischemic challenge using near-infrared spectroscopy (NIRS), and to test the hypothesis that these alterations are related to outcome...
  60. pmc Effects of changes in arterial pressure on organ perfusion during septic shock
    Aurélie Thooft
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 15:R222. 2011
    ..The aim of this study was to assess the effects of increasing MAP using norepinephrine (NE) on hemodynamic and metabolic variables and on microvascular reactivity in patients with septic shock...
  61. doi request reprint Determinants of early inadequate vancomycin concentrations during continuous infusion in septic patients
    Eva Ocampos-Martinez
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Int J Antimicrob Agents 39:332-7. 2012
    ..A high CL(Cr) was the variable most strongly associated with insufficient drug concentrations...
  62. doi request reprint Sublingual and muscular microcirculatory alterations after cardiac arrest: a pilot study
    Katia Donadello
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Resuscitation 82:690-5. 2011
    ..We investigated microvascular density and reactivity in the early phase following cardiac arrest...
  63. doi request reprint Pharmacokinetics of a loading dose of amikacin in septic patients undergoing continuous renal replacement therapy
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Int J Antimicrob Agents 37:531-5. 2011
    ..The therapeutic benefit of high-dose aminoglycoside therapy should be balanced with its potential renal effects in septic patients receiving CRRT...
  64. ncbi request reprint Optimal adrenergic support in septic shock due to peritonitis
    Qinghua Sun
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Anesthesiology 98:888-96. 2003
    ..The authors evaluated optimal adrenergic support using norepinephrine, dopamine, and dobutamine in a clinically relevant model of septic shock...
  65. ncbi request reprint Do all nonsurvivors of cardiogenic shock die with a low cardiac index?
    Noelle Lim
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Chest 124:1885-91. 2003
    ..To characterize the hemodynamic course of cardiogenic shock and to relate the cause of death to ongoing cardiac failure or multiple organ dysfunction...
  66. doi request reprint ICU nephrology: the implications of cardiovascular alterations in the acutely ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Kidney Int 81:1060-6. 2012
    ..In this text, we will return to the basic physiology of cardiac output and its components so that we can better understand the effects of cardiovascular alterations in critically ill patients, and how best to treat them...
  67. pmc Cerebral microcirculation is impaired during sepsis: an experimental study
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R140. 2010
    ..Cerebral microcirculatory alterations may play a role; however, experimental data are scarce. This study sought to investigate whether the cerebral microcirculation is altered in a clinically relevant animal model of septic shock...
  68. ncbi request reprint Oxygen transport-the oxygen delivery controversy
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 30:1990-6. 2004
  69. ncbi request reprint Efficacy of allogeneic red blood cell transfusions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 21:209-19. 2007
    ..In this article, several key factors influencing the systemic and regional efficacy of blood transfusion will be reviewed...
  70. ncbi request reprint Effects of fluid challenge on gastric mucosal PCO2 in septic patients
    Eliezer Silva
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 30:423-9. 2004
    ..To determine the effects of fluid challenge on systemic hemodynamic variables and gastric intramucosal partial pressure of carbon dioxide (PCO(2)) in septic patients...
  71. ncbi request reprint Effects of hydrocortisone on microcirculatory alterations in patients with septic shock
    Gustavo Luiz Büchele
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 37:1341-7. 2009
    ..To evaluate the effects of hydrocortisone on microcirculatory blood flow alterations in patients with septic shock...
  72. pmc How can the response to volume expansion in patients with spontaneous respiratory movements be predicted?
    Sarah Heenen
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik, 808, B 1070 Brussels, Belgium
    Crit Care 10:R102. 2006
    ..The aim of the study was to evaluate the ability of different static and dynamic measurements of preload to predict fluid responsiveness in patients with spontaneous respiratory movements...
  73. pmc The International Sepsis Forum's controversies in sepsis: my initial vasopressor agent in septic shock is dopamine rather than norepinephrine
    Jean Louis Vincent
    Head, Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Crit Care 7:6-8. 2003
  74. ncbi request reprint Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study
    Marc Jacques Dubois
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 34:2536-40. 2006
    ..To test the hypothesis that administration of albumin to correct hypoalbuminemia might have beneficial effects on organ function in a mixed population of critically ill patients...
  75. pmc Prediction of postoperative complications after urgent laparotomy by intraperitoneal microdialysis: A pilot study
    Colin L Verdant
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Ann Surg 244:994-1002. 2006
    ..The aim of the present study was to investigate the role of intraperitoneal microdialysis (IPM) techniques in monitoring the evolution of postoperative critically ill patients requiring urgent laparotomy...
  76. doi request reprint Microcirculatory alterations in the critically ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Hosp Pract (1995) 37:107-12. 2009
    ..Whether monitoring the microcirculation can be used to guide therapy remains unclear and requires further study, and this is an exciting field of ongoing research...
  77. doi request reprint Microcirculatory abnormalities in patients with severe influenza A (H1N1) infection
    Diamantino R Salgado
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles ULB, 808 Route de Lennik, B 1070 Brussels, Belgium
    Can J Anaesth 57:940-6. 2010
    ..This study was designed to evaluate the degree of microcirculatory abnormalities in patients with severe influenza A (H1N1) infection...
  78. ncbi request reprint Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 34:1918-24. 2006
    ..We investigated whether DAA can influence microcirculatory alterations in patients with severe sepsis...
  79. doi request reprint Sublingual microcirculatory effects of enalaprilat in an ovine model of septic shock
    Diamantino Ribeiro Salgado
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Shock 35:542-9. 2011
    ....
  80. doi request reprint Cardiogenic shock with stunned myocardium during triple-H therapy treated with intra-aortic balloon pump counterpulsation
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, 808, 1070, Brussels, Belgium
    Neurocrit Care 10:76-82. 2009
    ..Excessive use of adrenergic agents may result in stunned myocardium...
  81. ncbi request reprint Management of septic shock
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 80, B 1070 Brussels, Belgium
    Ann Med 34:606-13. 2002
    ..While intensive early resuscitation remains the cornerstone of management, new approaches are beginning to form part of sepsis management protocols and will lead to improved outcomes for patients with this disease process...
  82. pmc Microvascular dysfunction as a cause of organ dysfunction in severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 9:S9-12. 2005
    ....
  83. ncbi request reprint How monitoring of the microcirculation may help us at the bedside
    Colin Verdant
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Curr Opin Crit Care 11:240-4. 2005
    ..Recent technologic developments have allowed the direct visualization of the microcirculation at the bedside. The present review explores how the monitoring of microcirculation can help in clinical practice...
  84. ncbi request reprint Septic shock of early or late onset: does it matter?
    Oscar Roman-Marchant
    Department of Intensive Care Medicine, Erasme University Hospital, Free University of Brussels, Belgium
    Chest 126:173-8. 2004
    ..To determine possible differences in morbidity and mortality between early and late onset of septic shock in ICU patients...
  85. pmc The 32nd Annual Congress of the Society of Critical Care Medicine, 28 January - 2 February 2003, San Antonio, USA
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 7:193-5. 2003
  86. doi request reprint Gamma-globulin levels in patients with community-acquired septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik, Brussels, Belgium
    Shock 32:379-85. 2009
    ..Patients with low IgG concentrations may represent a logical target group to study the effects of Ig supplementation in septic shock...
  87. doi request reprint No evidence of memory processing during propofol-remifentanil target-controlled infusion anesthesia with bispectral index monitoring in cardiac surgery
    Gilbert Bejjani
    Department of Anesthesiology, Erasme University Hospital, Brussels, Belgium
    J Cardiothorac Vasc Anesth 23:175-81. 2009
    ..Surgical stimulation may enhance memory formation. The authors' hypothesis is that implicit memory processing is not preserved during unconsciousness, even in the presence of a surgical stimulus...
  88. ncbi request reprint The cuff leak test to predict failure of tracheal extubation for laryngeal edema
    Yann De Bast
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, 808 route de Lennick, 1070 Brussels, Belgium
    Intensive Care Med 28:1267-72. 2002
    ..We evaluated the usefulness of a quantitative assessment of such a leak to identify the patients who will require early re-intubation for laryngeal edema...
  89. doi request reprint A large-bolus injection, but not continuous infusion of sodium selenite improves outcome in peritonitis
    Zhen Wang
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Shock 32:140-6. 2009
    ..05). Hence, in this model of septic shock, the administration of a large bolus of sodium selenite (rather than a continuous administration) resulted in beneficial effects, probably by a transient oxidative effect...
  90. ncbi request reprint Benefit-risk assessment of drotrecogin alfa (activated) in the treatment of sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Drug Saf 30:995-1010. 2007
    ....
  91. ncbi request reprint Remifentanil for cardiac anaesthesia
    Luc Barvais
    Erasmus Hospital, 808 Lennikstreet, Brussels, Belgium
    Adv Exp Med Biol 523:171-87. 2003
  92. ncbi request reprint Does aprotinin influence the inflammatory response to cardiopulmonary bypass in patients?
    Denis Schmartz
    Department of Anesthesiology, Erasme University Hospital, Brussels, Belgium
    J Thorac Cardiovasc Surg 125:184-90. 2003
    ..This prospective, randomized, double-blind study evaluated the influence of aprotinin on various blood markers of inflammation during and after cardiopulmonary bypass...
  93. ncbi request reprint Assessment of thoracic epidural analgesia during general anesthesia using pupillary reflex dilation: a preliminary study
    Isabelle Huybrechts
    Department of Anesthesiology, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Cardiothorac Vasc Anesth 20:664-7. 2006
    ..Therefore, the adequacy of PRD-guided thoracic epidural infusion during general anesthesia for thoracotomy was studied...
  94. doi request reprint Clinical application of the cardioprotective effects of volatile anaesthetics: CON--total intravenous anaesthesia or not total intravenous anaesthesia to anaesthetise a cardiac patient?
    Nicolas Van Rompaey
    Department of Anaesthesiology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Eur J Anaesthesiol 28:623-7. 2011
    ..Further large multi-centre clinical investigations are still required...
  95. doi request reprint How much does pharmacologic prophylaxis reduce postoperative vomiting in children? Calculation of prophylaxis effectiveness and expected incidence of vomiting under treatment using Bayesian meta-analysis
    Edgard Engelman
    Department of Anesthesiology, Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium
    Anesthesiology 109:1023-35. 2008
    ....
  96. doi request reprint Combined ultrasound and nerve stimulation-guided thoracic epidural catheter placement for analgesia following anterior spine fusion in scoliosis
    Pierre Pandin
    Department of Anesthesiology, Erasmus Hospital, Free University of Brussels, Brussels, Belgium
    Pain Pract 9:230-4. 2009
    ..The combination of US and nerve stimulation in this setting may be associated with easier, potentially safer, and more accurate insertion...
  97. ncbi request reprint Intranasal sufentanil is effective for postoperative analgesia in adults
    Nathalie Mathieu
    Department of Anesthesiology, Erasme Hospital, Free University of Brussels, University of Route de Lennik 808, B 1070 Brussels, Belgium
    Can J Anaesth 53:60-6. 2006
    ....
  98. ncbi request reprint Lactic acidosis during propofol-remifentanil anesthesia in an adult
    Jean Corentin Salengros
    Department of Anaesthesiology, CUB Hopital Erasme, Belgium
    Anesthesiology 101:241-3. 2004
  99. ncbi request reprint Dopamine versus norepinephrine: is one better?
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Minerva Anestesiol 75:333-7. 2009
    ..Observational studies have provided conflicting results regarding the effects of these two drugs on outcomes, and results from a recently completed randomized controlled trial are eagerly waited...