Robert R Crichton

Summary

Country: Belgium

Publications

  1. doi Brain iron metabolism and its perturbation in neurological diseases
    Robert R Crichton
    Institute of Condensed Material and Nanosciences, Universite Catholique de Louvain, Place Louis Pasteur 1, 1348, Louvain la Neuve, Belgium
    J Neural Transm (Vienna) 118:301-14. 2011
  2. doi X-ray structures of ferritins and related proteins
    Robert R Crichton
    Department of Chemistry, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Biochim Biophys Acta 1800:706-18. 2010
  3. doi Effects of marginal iron overload on iron homeostasis and immune function in alveolar macrophages isolated from pregnant and normal rats
    Roberta J Ward
    Unite de Biochimie, Departement de Chimie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Biometals 22:211-23. 2009
  4. doi Iron and the immune system
    Roberta J Ward
    Biologie du Comportement, Universite Catholique de Louvain, 1348, Louvain la Neuve, Belgium
    J Neural Transm (Vienna) 118:315-28. 2011
  5. ncbi High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites
    Louise Toussaint
    Biochemistry Unit, Universite Catholique de Louvain, 1 Place Louis Pasteur, 1348 Louvain la Neuve, Belgium
    J Mol Biol 365:440-52. 2007
  6. ncbi Mass spectrometry studies of demetallation of haemin by recombinant horse L chain apoferritin and its mutant (E 53,56,57,60 Q)
    Natalia de Val
    Department of Biochemistry, Universite Catholique de Louvain, Batiment Lavoisier, 1 Place Louis Pasteur, 1348 Louvain la Neuve, Belgium
    FEBS Lett 580:6275-80. 2006
  7. ncbi EPR studies of recombinant horse L-chain apoferritin and its mutant (E 53,56,57,60 Q) with haemin
    Natalia de Val
    Unit of Biochemistry, Department of Chemistry, Universite Catholique de Louvain, Batiment Lavoisier, 1 Place Louis Pasteur, 1348, Louvain la Neuve, Belgium
    Biometals 20:21-6. 2007
  8. ncbi An overview of iron metabolism: molecular and cellular criteria for the selection of iron chelators
    Robert R Crichton
    Unite de Biochimie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Curr Med Chem 10:997-1004. 2003
  9. ncbi Iron chelators and their therapeutic potential
    Robert R Crichton
    Unite de Biochimie, Universite Catholique de Louvain, Place Louis Pasteur 1, B 1348 Louvain la Neuve, Belgium
    Met Ions Biol Syst 41:185-219. 2004
  10. ncbi Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells
    Robert R Crichton
    Unite de Biochimie, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    J Inorg Biochem 91:9-18. 2002

Collaborators

Detail Information

Publications14

  1. doi Brain iron metabolism and its perturbation in neurological diseases
    Robert R Crichton
    Institute of Condensed Material and Nanosciences, Universite Catholique de Louvain, Place Louis Pasteur 1, 1348, Louvain la Neuve, Belgium
    J Neural Transm (Vienna) 118:301-14. 2011
    ..We conclude that there is overwhelming evidence for a direct involvement of iron in NDs...
  2. doi X-ray structures of ferritins and related proteins
    Robert R Crichton
    Department of Chemistry, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Biochim Biophys Acta 1800:706-18. 2010
    ..Finally we discuss the three-dimensional structures of the 12-subunit bacterial Dps (DNA-binding protein from starved cells) proteins as well as their intersubunit di-iron ferroxidase site...
  3. doi Effects of marginal iron overload on iron homeostasis and immune function in alveolar macrophages isolated from pregnant and normal rats
    Roberta J Ward
    Unite de Biochimie, Departement de Chimie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Biometals 22:211-23. 2009
    ..Increasing iron status, if only marginally, will reduce the ability of macrophages to mount a sustained response to inflammation as well as altering iron homeostatic mechanisms...
  4. doi Iron and the immune system
    Roberta J Ward
    Biologie du Comportement, Universite Catholique de Louvain, 1348, Louvain la Neuve, Belgium
    J Neural Transm (Vienna) 118:315-28. 2011
    ..Pathologies, where iron loading and depletion occur, may adversely affect the ability of the cell to respond to the bacterial insult...
  5. ncbi High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites
    Louise Toussaint
    Biochemistry Unit, Universite Catholique de Louvain, 1 Place Louis Pasteur, 1348 Louvain la Neuve, Belgium
    J Mol Biol 365:440-52. 2007
    ..The consequences for metal binding and the correlation with Fe(II) oxidation rates are discussed...
  6. ncbi Mass spectrometry studies of demetallation of haemin by recombinant horse L chain apoferritin and its mutant (E 53,56,57,60 Q)
    Natalia de Val
    Department of Biochemistry, Universite Catholique de Louvain, Batiment Lavoisier, 1 Place Louis Pasteur, 1348 Louvain la Neuve, Belgium
    FEBS Lett 580:6275-80. 2006
    ..Martins, B. M. and Huber, R. (2003) Oxygen-dependent coproporphyrinogen IX oxidase from Escherichia coli: one-step purification and biochemical characterization. FEMS. Microbiology Letters 226, 31-37]...
  7. ncbi EPR studies of recombinant horse L-chain apoferritin and its mutant (E 53,56,57,60 Q) with haemin
    Natalia de Val
    Unit of Biochemistry, Department of Chemistry, Universite Catholique de Louvain, Batiment Lavoisier, 1 Place Louis Pasteur, 1348, Louvain la Neuve, Belgium
    Biometals 20:21-6. 2007
    ..These studies confirm the ability of recombinant L-chain apoferritin and its mutant to incorporate and demetallate the haemin in acidic and basic conditions...
  8. ncbi An overview of iron metabolism: molecular and cellular criteria for the selection of iron chelators
    Robert R Crichton
    Unite de Biochimie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Curr Med Chem 10:997-1004. 2003
    ..The potential sites of iron chelation at the molecular level and cellular models which may be useful in the selection of potentially useful therapeutic iron chelators are briefly reviewed...
  9. ncbi Iron chelators and their therapeutic potential
    Robert R Crichton
    Unite de Biochimie, Universite Catholique de Louvain, Place Louis Pasteur 1, B 1348 Louvain la Neuve, Belgium
    Met Ions Biol Syst 41:185-219. 2004
  10. ncbi Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells
    Robert R Crichton
    Unite de Biochimie, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    J Inorg Biochem 91:9-18. 2002
    ..The prospects for chelation therapy in the treatment and possible prevention of neurodegenerative diseases is reviewed...
  11. ncbi Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine
    Rachida Legssyer
    Unite de Biochimie, Catholique University of Louvain, Batiment Lavioisier, Place Louis Pasteur 1, 1348, Louvain la Neuve, Belgium
    J Inorg Biochem 94:36-42. 2003
    ..Such results may have important relevance for the reduced immune function of iron loaded macrophages isolated from thalassaemia patients receiving chelation therapy and their propensity to increased infection...
  12. ncbi Optical and EPR spectroscopic studies of demetallation of hemin by L-chain apoferritins
    Noëlle Carette
    Universite Catholique de Louvain, Unit of Biochemistry, Place Louis Pasteur 1, B 1348 Louvain la Neuve, Belgium
    J Inorg Biochem 100:1426-35. 2006
    ..Interestingly, a signal at g=1.94 is also observed. This signal most likely corresponds to a mixed-valence Fe(II)-Fe(III) cluster suggesting that a redox reaction may also be involved in the mechanism of demetallation...
  13. doi Anti-inflammatory actions of a taurine analogue, ethane β-sultam, in phagocytic cells, in vivo and in vitro
    Roberta J Ward
    Biologie du Comportement, Universite Catholique de Louvain, Belgium
    Biochem Pharmacol 81:743-51. 2011
    ....
  14. doi The role of iron in brain ageing and neurodegenerative disorders
    Roberta J Ward
    Centre for Neuroinflammation and Neurodegeneration, Department of Medicine, Hammersmith Hospital Campus, Imperial College London, London, UK Faculte de Science, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Lancet Neurol 13:1045-60. 2014
    ..An important avenue to reduce iron accumulation is the use of iron chelators that are able to cross the blood-brain barrier, penetrate cells, and reduce excessive iron accumulation, thereby affording neuroprotection...