Jean Pierre Cosyns
- Pamidronate-induced tubulointerstitial nephritis with Fanconi syndrome in a patient with primary hyperparathyroidismMartin Buysschaert
Department of Endocrinology and Nutrition, Cliniques Universitaires St Luc, , Bruxelles, Belgium
Nephrol Dial Transplant 18:826-9. 2003
- Lesions in donor kidneys: nature, incidence, and influence on graft functionJ P Cosyns
Department of Pathology, University of Louvain Medical School, Cliniques Universitaires St Luc, Brussels, Belgium
Transpl Int 11:22-7. 1998..There was, however, a correlation with donor age, which was also correlated with the extent of chronic lesions (P < 0.001)...
- Urothelial lesions in Chinese-herb nephropathyJ P Cosyns
Departments of Pathology, Nephrology, Renal and Pancreatic Transplantation, and Urology, Universite Catholique de Louvain, Brussels, Belgium
Am J Kidney Dis 33:1011-7. 1999..Carcinogenesis is associated with the overexpression of p53, which suggests a role for a p53 gene mutation. The relationship of this mutation with the reported presence of AA DNA adducts in the kidney remains to be explored...
- Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy?J P Cosyns
Department of Pathology, Public Health School, Universite Catholique de Louvain, Medical School, Brussels, Belgium
Kidney Int 59:2164-73. 2001..The contribution of other simultaneously prescribed drugs remains disputed. In the present study, the effects of a chronic intake of AA given as a single drug was evaluated through renal histology and function in rabbits...
- Aristolochic acid and 'Chinese herbs nephropathy': a review of the evidence to dateJean Pierre Cosyns
Department of Pathology, Medical School, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
Drug Saf 26:33-48. 2003..Finally, it has led to the withdrawal in several countries of a previously unsuspected carcinogenic and nephrotoxic substance...
- Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: lessons from long-term followup of patients in the Euro-Lupus Nephritis TrialFrédéric A Houssiau
Universite Catholique de Louvain, Brussels, Belgium
Arthritis Rheum 50:3934-40. 2004..After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors...
- Aristolochic acid nephropathy and the peritoneum: Functional, structural, and molecular studiesGaëlle Gillerot
Division of Nephrology and Department of Pathology, Université Catholique de Louvain Medical School, Brussels, Belgium
Kidney Int 64:1883-92. 2003..Although the fibrotic process has been documented in extrarenal tissues, the involvement of the peritoneum, as well as the efficacy of peritoneal dialysis in AAN patients, remain uncertain...
- Repeat kidney biopsies fail to detect differences between azathioprine and mycophenolate mofetil maintenance therapy for lupus nephritis: data from the MAINTAIN Nephritis TrialMaria S Stoenoiu
Department of Rheumatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
Nephrol Dial Transplant 27:1924-30. 2012..Here, we compare the pathological findings on repeat kidney biopsies between the two groups...
- A homozygous mutation in INVS causing juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathwaySalvatore Bellavia
Division of Nephrology, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Bruxelles, Belgium
Nephrol Dial Transplant 25:4097-102. 2010..This case shows that INVS mutation can cause juvenile nephronophthisis with abnormal reactivity of the Wnt/β-catenin pathway...
- A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulinKarin Dahan
Universite Catholique de Louvain, Center for Human Genetics, Brussels, Belgium
J Am Soc Nephrol 14:2883-93. 2003..Mutations in UMOD may critically affect the function of uromodulin, resulting in abnormal accumulation within tubular cells and reduced urinary excretion...
- Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patientsPierre Moulin
Division of Pathology, and Cell Unit, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Brussels, Belgium
Kidney Int 63:1285-95. 2003..Examinations of knockout mice have established the role of ClC-5 in PT endocytosis, but the consequences of ClC-5 mutations on the polarity of H+-ATPase and other plasma membrane proteins remain unknown...
- Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamideFrédéric A Houssiau
Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
Arthritis Rheum 46:2121-31. 2002..Given the side effects of this regimen, we evaluated the efficacy and the toxicity of a course of low-dose IV CYC prescribed as a remission-inducing treatment, followed by azathioprine (AZA) as a remission-maintaining treatment...
- Absence of gadolinium deposits in the peritoneal membrane of patients with encapsulating peritoneal sclerosisEric Goffin
Department of Nephrology, Universite Catholique de Louvain, Cliniques Universitaires St Luc, Brussels, Belgium
Nephrol Dial Transplant 25:1334-9. 2010..CONCLUSIONS: These findings argue against the implication of gadolinium in the development of EPS in long-term PD patients...
- Icodextrin-associated peritonitis: what conclusions thus far?Eric Goffin
Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
Nephrol Dial Transplant 18:2482-5. 2003
- Sterile chemical peritonitis secondary to icodextrin: immunohistopathological descriptionEric Goffin
Department of Nephrology, , Cliniques Universitaires St Luc, Brussels, Belgium
Perit Dial Int 22:723-6. 2002
- Enteric hyperoxaluria: a hidden cause of early renal graft failure in two successive transplants: spontaneous late graft recoveryCharles Cuvelier
Department of Nephrology, Cliniques Universitaires St. Luc, Brussels, Belgium
Am J Kidney Dis 40:E3. 2002..Subclinical evidence of enteric hyperoxaluria should be looked for and appropriate therapy instituted as early as possible. The possibility of a late recovery of renal function warrants attentive patience from attending physicians...
- Telithromycin-induced acute interstitial nephritis: a first case reportMichel Tintillier
Department of Nephrology, Clinique et Maternité Sainte Elisabeth, Namur, Belgium
Am J Kidney Dis 44:e25-27. 2004..The authors report the first case of telithromycin-induced severe acute interstitial nephritis. Practitioners should be aware of the possibility that telithromycin therapy could result in this form of drug-induced acute renal failure...
- Aristolochic acid (AA)-DNA adduct as marker of AA exposure and risk factor for AA nephropathy-associated cancerVolker M Arlt
Int J Cancer 111:977-80. 2004
- When is "aristolochic acid nephropathy" more accurate than "Chinese herbs nephropathy"?Jean Pierre Cosyns
Kidney Int 61:1178. 2002
- The importance of a histology-based diagnosis of interstitial nephropathy in two patients with renal insufficiencyNada Kanaan
Department of Nephrology, Cliniques Universitaires St Luc, , Avenue Hippocrate 10, 1200 Brussels, Belgium
Nephrol Dial Transplant 18:440-2. 2003
- Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?Volker M Arlt
Int J Cancer 101:500-2. 2002