G R Cornelis

Summary

Country: Belgium

Publications

  1. ncbi Assembly and function of type III secretory systems
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Annu Rev Microbiol 54:735-74. 2000
  2. pmc Molecular and cell biology aspects of plague
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, and Faculté de Médecine, Universite Catholique de Louvain, Avenue Hippocrate, 74, UCL 74 49, B 1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 97:8778-83. 2000
  3. pmc Type III secretion: a bacterial device for close combat with cells of their eukaryotic host
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology ICP, Universite Catholique de Louvain, Brussels, Belgium
    Philos Trans R Soc Lond B Biol Sci 355:681-93. 2000
  4. pmc The virulence plasmid of Yersinia, an antihost genome
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Microbiol Mol Biol Rev 62:1315-52. 1998
  5. ncbi The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells
    G R Cornelis
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 23:861-7. 1997
  6. ncbi Yersinia lead SUMO attack
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculty of Medicine, Universite de Louvain, 74 Av Hippocrate, B1200 Brussels, Belgium
    Nat Med 7:21-3. 2001
  7. pmc TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors
    M Iriarte
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Avenue Hippocrate 74, UCL 74 49, B 1200 Brussels, Belgium
    EMBO J 17:1907-18. 1998
  8. pmc The fliA gene encoding sigma 28 in Yersinia enterocolitica
    M Iriarte
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Bacteriol 177:2299-304. 1995
  9. pmc The rpoS gene from Yersinia enterocolitica and its influence on expression of virulence factors
    M Iriarte
    Microbial Pathogenesis Unit, Faculte de Medecine, Universite Catholique de Louvain, Brussels, Belgium
    Infect Immun 63:1840-7. 1995
  10. pmc Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica
    T Michiels
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Bacteriol 173:4994-5009. 1991

Collaborators

Detail Information

Publications26

  1. ncbi Assembly and function of type III secretory systems
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Annu Rev Microbiol 54:735-74. 2000
    ..It is even more mysterious for plant cells where a thick wall has to be crossed. In spite of these haunting questions, type III secretion appears as a fascinating trans-kingdom communication device...
  2. pmc Molecular and cell biology aspects of plague
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, and Faculté de Médecine, Universite Catholique de Louvain, Avenue Hippocrate, 74, UCL 74 49, B 1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 97:8778-83. 2000
    ..YopP/YopJ plays an anti-inflammatory role by preventing the activation of the transcription factor NF-kappaB. It also induces rapid apoptosis of macrophages. Less is known about the role of the phosphoserine kinase YopO/YpkA and YopM...
  3. pmc Type III secretion: a bacterial device for close combat with cells of their eukaryotic host
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology ICP, Universite Catholique de Louvain, Brussels, Belgium
    Philos Trans R Soc Lond B Biol Sci 355:681-93. 2000
    ..One of the proteins injected by the enteropathogenic E. coli serves as a membrane receptor for the docking of the bacterium itself at the surface of the cell...
  4. pmc The virulence plasmid of Yersinia, an antihost genome
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Microbiol Mol Biol Rev 62:1315-52. 1998
    ..enterocolitica and Y. pseudotuberculosis also encodes the adhesin YadA. The virulence plasmid contains some evolutionary remnants including, in Y. enterocolitica, an operon encoding resistance to arsenic compounds...
  5. ncbi The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells
    G R Cornelis
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 23:861-7. 1997
    ..The whole virulon is encoded by a 70 kb plasmid designated pYV. Transcription of the genes is controlled both by temperature and by contact with a eukaryotic cell...
  6. ncbi Yersinia lead SUMO attack
    G R Cornelis
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculty of Medicine, Universite de Louvain, 74 Av Hippocrate, B1200 Brussels, Belgium
    Nat Med 7:21-3. 2001
    ..Now it appears that Yops are the first bacterial member of a new family of ubiquitin-like proteases...
  7. pmc TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors
    M Iriarte
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Avenue Hippocrate 74, UCL 74 49, B 1200 Brussels, Belgium
    EMBO J 17:1907-18. 1998
    ..Our results suggest that TyeA forms part of the translocation-control apparatus together with YopD and YopN, and that the interaction of these proteins is required for selective translocation of Yops inside eukaryotic cells...
  8. pmc The fliA gene encoding sigma 28 in Yersinia enterocolitica
    M Iriarte
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Bacteriol 177:2299-304. 1995
    ..The fliA mutant allowed us to monitor the role of motility in pathogenesis. At least in the mouse model, motility seemed not to be required for Y. enterocolitica pathogenesis...
  9. pmc The rpoS gene from Yersinia enterocolitica and its influence on expression of virulence factors
    M Iriarte
    Microbial Pathogenesis Unit, Faculte de Medecine, Universite Catholique de Louvain, Brussels, Belgium
    Infect Immun 63:1840-7. 1995
    ..An intact rpoS gene was necessary for full expression of yst in the stationary phase but not for the expression of myf and of pYV-encoded virulence determinants...
  10. pmc Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica
    T Michiels
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Bacteriol 173:4994-5009. 1991
    ..Its product does not appear to be necessary for the production of Yops. Transcription of the virC operon was subjected to the same regulation as the yop genes...
  11. ncbi A new class of proteins regulating gene expression in enterobacteria
    A V Mikulskis
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, UCL 54 90, Brussels, Belgium
    Mol Microbiol 11:77-86. 1994
    ..We suggest that both YmoA and Hha belong to a new family of proteins downregulating gene expression in different enterobacteria...
  12. ncbi YscM1 and YscM2, two Yersinia enterocolitica proteins causing downregulation of yop transcription
    I Stainier
    Microbial Pathogenesis Unit, International Institute of Cellular and Molecular Pathology ICP and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 26:833-43. 1997
    ..We have also ruled out that YscM acts by obstructing the secretion channel...
  13. pmc VirG, a Yersinia enterocolitica lipoprotein involved in Ca2+ dependency, is related to exsB of Pseudomonas aeruginosa
    A Allaoui
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Bacteriol 177:4230-7. 1995
    ..Interestingly, the exsA gene, located just downstream of exsB, is also homologous to virF...
  14. pmc Virulence and arsenic resistance in Yersiniae
    C Neyt
    Microbial Pathogenesis Unit, International Institute of Cellular and Molecular Pathology, and Faculté de Médecine, Université Catholique deLouvain, Brussels, Belgium
    J Bacteriol 179:612-9. 1997
    ..enterocolitica strains. The presence of this ars operon also constitutes the first significant difference between the pYV plasmids from different Yersinia species...
  15. ncbi Heparin interferes with translocation of Yop proteins into HeLa cells and binds to LcrG, a regulatory component of the Yersinia Yop apparatus
    A P Boyd
    International Institute of Cellular and Molecular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 27:425-36. 1998
    ..This is the first report of a eukaryotic receptor interacting with the type III secretion and associated translocation machinery of Yersinia or of other bacteria...
  16. pmc Identification of SycN, YscX, and YscY, three new elements of the Yersinia yop virulon
    M Iriarte
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculté de Médecine, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Bacteriol 181:675-80. 1999
    ..We identified three new elements of the Yop virulon: SycN, required for normal secretion of YopN, and YscX and YscY, two new components of the secretion machinery...
  17. pmc YscN, the putative energizer of the Yersinia Yop secretion machinery
    S Woestyn
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Bacteriol 176:1561-9. 1994
    ..We conclude that YscN is a component of the Yop secretion machinery using ATP. We hypothesize that it is either the energizer of this machinery or a part of it...
  18. ncbi YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells
    M Iriarte
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 29:915-29. 1998
    ..This cytotoxic effect was caused by YopT and dependent on YopB. YopT is thus a new effector Yop and a new bacterial toxin affecting the cytoskeleton of eukaryotic cells...
  19. pmc YscU, a Yersinia enterocolitica inner membrane protein involved in Yop secretion
    A Allaoui
    Microbial Pathogenesis Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Bacteriol 176:4534-42. 1994
    ..YscU is related to Spa40 from Shigella flexneri, to SpaS from Salmonella typhimurium, to FlhB from Bacillus subtilis, and to HrpN from Pseudomonas solanacearum...
  20. ncbi The pYV plasmid of Yersinia encodes a lipoprotein, YlpA, related to TraT
    B China
    Unite de Microbiologie, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 4:1585-93. 1990
    ..This co-regulation with the yop genes suggests that ylpA is a virulence determinant. However, mutations in ylpA clearly affect neither the resistance to human serum nor the virulence for intravenously inoculated mice...
  21. ncbi Mutational analysis of the Yersinia enterocolitica virC operon: characterization of yscE, F, G, I, J, K required for Yop secretion and yscH encoding YopR
    A Allaoui
    Microbial Pathogenesis Unit, International Institute of Cellular and Molecular Pathology, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 18:343-55. 1995
    ..These results indicate that YscM plays a role in the feedback inhibition of Yop synthesis when secretion is compromised by acting as a negative regulator of Yop synthesis...
  22. pmc Secretion of hybrid proteins by the Yersinia Yop export system
    T Michiels
    , , Brussels, Belgium
    J Bacteriol 173:1677-85. 1991
    ..This observation opens new prospects in using Yersinia spp. as chimeric-protein producers and as potential live carriers for foreign antigens...
  23. ncbi Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of bid
    G Denecker
    Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, , Avenue Hippocrate 74, B-1200 Brussels, Belgium
    J Biol Chem 276:19706-14. 2001
    ..This finding supports the idea that YopP/J induces apoptosis by directly acting on cell death pathways, rather than being the mere consequence of gene induction inhibition in combination with microbial stimulation of the macrophage...
  24. ncbi Fluorene degradation by Sphingomonas sp. LB126 proceeds through protocatechuic acid: a genetic analysis
    P Wattiau
    Catholic University of Louvain UCL, Microbial Pathogenesis Unit, Brussels, Belgium
    Res Microbiol 152:861-72. 2001
    ....
  25. ncbi The outer membrane component, YscC, of the Yop secretion machinery of Yersinia enterocolitica forms a ring-shaped multimeric complex
    M Koster
    Microbial Pathogenesis Unit, International Institute of Cellular and Molecular Pathology and Faculté de Médecine, Universite Catholique de Louvain, Brussels, Belgium
    Mol Microbiol 26:789-97. 1997
    ..Because of the architecture of the multimer, YscC appears to represent a novel type of channel-forming proteins in the bacterial outer membrane...
  26. ncbi ymoA, a Yersinia enterocolitica chromosomal gene modulating the expression of virulence functions
    G R Cornelis
    Microbiol Pathogenesis Unit, International Institute of Cellular and Molecular Pathology, Brussels, Belgium
    Mol Microbiol 5:1023-34. 1991
    ..This work supports recent reports which propose a role for DNA topology and bacterial chromatin structure in thermoregulation of virulence functions...