Yves Lamberty

Summary

Affiliation: Chemin du Foriest
Country: Belgium

Publications

  1. ncbi First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants
    Thomas Ryckmans
    Chemical Research, R and D, UCB Pharma SA, Chemin du Foriest, B 1420 Braine l Alleud, Belgium
    Bioorg Med Chem Lett 12:261-4. 2002
  2. doi Behavioural phenotyping reveals anxiety-like features of SV2A deficient mice
    Yves Lamberty
    Preclinical CNS Research, UCB Pharma S A, Braine l Alleud, Belgium
    Behav Brain Res 198:329-33. 2009
  3. ncbi The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice
    Yves Lamberty
    UCB Pharma, Chemin du Foriest, B 1420, Braine l Alleud, Belgium
    Eur J Pharmacol 439:101-6. 2002
  4. ncbi Hydroxyzine prevents isolation-induced vocalization in guinea pig pups: comparison with chlorpheniramine and immepip
    Yves Lamberty
    Psychopharmacology Unit, Preclinical CNS Research, Chemin du Foriest, UCB Pharma S A, B 1420, Braine l Alleud, Belgium
    Pharmacol Biochem Behav 79:119-24. 2004
  5. ncbi Anxiolytic profile of the antiepileptic drug levetiracetam in the Vogel conflict test in the rat
    Yves Lamberty
    UCB S A Pharma Sector, Preclinical CNS Research, Chemin du Foriest, B 1420 Braine l Alleud, Belgium
    Eur J Pharmacol 469:97-102. 2003
  6. ncbi H3 agonist immepip markedly reduces cortical histamine release, but only weakly promotes sleep in the rat
    Yves Lamberty
    UCB Pharma, Preclinical CNS Research, Chemin du Foriest, B 1420, Braine l Alleud, Belgium
    Pharmacol Res 48:193-8. 2003
  7. ncbi Anxiolytic effects of the novel anti-epileptic drug levetiracetam in the elevated plus-maze test in the rat
    Alma J Gower
    UCB S A, Pharma Sector, Chemin du Foriest, B 1420 Braine l Alleud, Belgium
    Eur J Pharmacol 481:67-74. 2003
  8. doi Lead optimization of thiazolo[5,4-c]piperidines: 3-cyclobutoxy linker as a key spacer for H(3)R inverse agonists
    Laurent Provins
    UCB NewMedicines, UCB Pharma, Chemin du Foriest, 1420 Braine L Alleud, Belgium
    ChemMedChem 7:2087-92. 2012
  9. ncbi Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives
    Thomas Ryckmans
    Chemical Research, R and D, UCB Pharma SA, Chemin du Foriest, B 1420, Braine l Alleud, Belgium
    Bioorg Med Chem Lett 12:3195-8. 2002
  10. doi Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists
    Sylvain Celanire
    UCB New Medicines, Chemin du Foriest, 1420 Braine L Alleud, Belgium
    ChemMedChem 4:1063-8. 2009

Collaborators

Detail Information

Publications15

  1. ncbi First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants
    Thomas Ryckmans
    Chemical Research, R and D, UCB Pharma SA, Chemin du Foriest, B 1420 Braine l Alleud, Belgium
    Bioorg Med Chem Lett 12:261-4. 2002
    ..Compound 24 displays good affinities for both the NK(1) receptor and the serotonin reuptake site (32 and 25 nM, respectively)...
  2. doi Behavioural phenotyping reveals anxiety-like features of SV2A deficient mice
    Yves Lamberty
    Preclinical CNS Research, UCB Pharma S A, Braine l Alleud, Belgium
    Behav Brain Res 198:329-33. 2009
    ..These results suggest an anxiety-like phenotype for SV2A (+/-) mice indicated by increased open-arm avoidance in the elevated plus-maze test as well as a shorter latency to escape from a lit area in the inhibitory avoidance procedure...
  3. ncbi The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice
    Yves Lamberty
    UCB Pharma, Chemin du Foriest, B 1420, Braine l Alleud, Belgium
    Eur J Pharmacol 439:101-6. 2002
    ..This suggests that the observed effects are dependent upon the level of stress or anxiety of the animals. These results support potential efficacy of levetiracetam in the benzodiazepine withdrawal syndrome...
  4. ncbi Hydroxyzine prevents isolation-induced vocalization in guinea pig pups: comparison with chlorpheniramine and immepip
    Yves Lamberty
    Psychopharmacology Unit, Preclinical CNS Research, Chemin du Foriest, UCB Pharma S A, B 1420, Braine l Alleud, Belgium
    Pharmacol Biochem Behav 79:119-24. 2004
    ..However, in view of the lack of effect of either chlorpheniramine or immepip, it is proposed that additional nonhistaminergic effects are involved in the tranquilizing action of hydroxyzine...
  5. ncbi Anxiolytic profile of the antiepileptic drug levetiracetam in the Vogel conflict test in the rat
    Yves Lamberty
    UCB S A Pharma Sector, Preclinical CNS Research, Chemin du Foriest, B 1420 Braine l Alleud, Belgium
    Eur J Pharmacol 469:97-102. 2003
    ..This suggests that levetiracetam may have potential anxiolytic effects and may provide therapeutic benefits to individual with anxiety spectrum disorders...
  6. ncbi H3 agonist immepip markedly reduces cortical histamine release, but only weakly promotes sleep in the rat
    Yves Lamberty
    UCB Pharma, Preclinical CNS Research, Chemin du Foriest, B 1420, Braine l Alleud, Belgium
    Pharmacol Res 48:193-8. 2003
    ..These results reveal that a marked H3 receptor agonist-mediated reduction in cortical histamine release is not corroborated by a significant sleep promoting effect and therefore question the hypnotic potential of H3 agonists...
  7. ncbi Anxiolytic effects of the novel anti-epileptic drug levetiracetam in the elevated plus-maze test in the rat
    Alma J Gower
    UCB S A, Pharma Sector, Chemin du Foriest, B 1420 Braine l Alleud, Belgium
    Eur J Pharmacol 481:67-74. 2003
    ....
  8. doi Lead optimization of thiazolo[5,4-c]piperidines: 3-cyclobutoxy linker as a key spacer for H(3)R inverse agonists
    Laurent Provins
    UCB NewMedicines, UCB Pharma, Chemin du Foriest, 1420 Braine L Alleud, Belgium
    ChemMedChem 7:2087-92. 2012
    ....
  9. ncbi Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives
    Thomas Ryckmans
    Chemical Research, R and D, UCB Pharma SA, Chemin du Foriest, B 1420, Braine l Alleud, Belgium
    Bioorg Med Chem Lett 12:3195-8. 2002
    ..This class of compounds potentially represents a new generation of antidepressants...
  10. doi Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists
    Sylvain Celanire
    UCB New Medicines, Chemin du Foriest, 1420 Braine L Alleud, Belgium
    ChemMedChem 4:1063-8. 2009
    ..H(3)R inverse agonists based on an aminopropoxy-phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse model of recognition memory...
  11. doi The inhibitory avoidance test optimized for discovery of cognitive enhancers
    Eric R A Y Detrait
    CNS Pharmacology Department Cognitive Psychopharmacology, UCB Pharma, Braine l Alleud, Belgium
    Behav Res Methods 41:805-11. 2009
    ..The double-trial acquisition protocol is suitable for testing cognitive enhancers, while also providing a clearly enhanced throughput...
  12. ncbi Use of epileptic animals for adverse effect testing
    Henrik Klitgaard
    Preclinical CNS Research, UCB S A Pharma Sector, Chemin du Foriest, Braine l Alleud, Belgium
    Epilepsy Res 50:55-65. 2002
    ..In that respect, limbic kindling appears to represent a sensitive and relevant approach...
  13. ncbi Antihyperalgesic effect of levetiracetam in neuropathic pain models in rats
    Denis Ardid
    EMI 9904 INSERM UdA, IUT de génie biologique, Ensemble Universitaire des Cézeaux, 63172 Aubiere, France
    Eur J Pharmacol 473:27-33. 2003
    ..These results indicate that levetiracetam induces an antihyperalgesic effect in two models of human neuropathic pain, suggesting a therapeutic potential in neuropathic pain patients...
  14. ncbi Levetiracetam reduces anesthetic-induced hyperalgesia in rats
    David P Archer
    Department of Anesthesiology, Faculty of Medicine, University of Calgary, Calgary, Canada
    Anesth Analg 104:180-5. 2007
    ..The pharmacological profile of the novel antiepileptic drug, levetiracetam, suggests that it may reduce the intensity of the excitatory stages of anesthesia...
  15. ncbi Histamine H3 antagonist thioperamide dose-dependently enhances memory consolidation and reverses amnesia induced by dizocilpine or scopolamine in a one-trial inhibitory avoidance task in mice
    Pascale Bernaerts
    Laboratoire de Neurosciences Comportementales and Psychopharmacologie Expérimentale, Universite de Liege, Boulevard du Rectorat 5 Building 32, B 4000 Liege, Belgium
    Behav Brain Res 154:211-9. 2004
    ..The results strongly support the view that the brain mechanisms of memory consolidation involve a functional interaction between the NMDA and the H3 sites...