William Wijns

Summary

Affiliation: Cardiovascular Center
Country: Belgium

Publications

  1. ncbi request reprint Angiographic, intravascular ultrasound, and fractional flow reserve evaluation of direct stenting vs. conventional stenting using BeStent2 in a multicentre randomized trial
    William Wijns
    Cardiovascular Centre, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
    Eur Heart J 26:1852-9. 2005
  2. ncbi request reprint The diagnosis of coronary artery disease: in search of a "one-stop shop"?
    William Wijns
    Cardiovascular Center Aalst, OLV Ziekenhuis, Moorselbaan 163, 9400 Aalst, Belgium
    J Nucl Med 46:904-5. 2005
  3. ncbi request reprint What does the clinical cardiologist need from noninvasive cardiac imaging: is it time to adjust practices to meet evolving demands?
    William Wijns
    Cardiovascular Center Aalst, OLV Ziekenhuis, Aalst, Belgium
    J Nucl Cardiol 14:366-70. 2007
  4. doi request reprint Long-term follow-up after fractional flow reserve-guided treatment strategy in patients with an isolated proximal left anterior descending coronary artery stenosis
    Olivier Muller
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 4:1175-82. 2011
  5. doi request reprint Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis
    Narbeh Melikian
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    EuroIntervention 5:939-45. 2010
  6. doi request reprint Severity of coronary arterial stenoses responsible for acute coronary syndromes
    Ganesh Manoharan
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Am J Cardiol 103:1183-8. 2009
  7. doi request reprint Comparison of 600 versus 300-mg Clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary coronary angioplasty
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Am J Cardiol 106:1208-11. 2010
  8. doi request reprint High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    JACC Cardiovasc Interv 3:35-40. 2010
  9. doi request reprint Thrombus aspiration in primary percutaneous coronary intervention in high-risk patients with ST-elevation myocardial infarction: a real-world registry
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Moorselbaan 164, Aalst, Belgium
    Catheter Cardiovasc Interv 76:70-6. 2010
  10. doi request reprint Endomyocardial upregulation of beta1 adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy
    Marc Vanderheyden
    Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Card Fail 14:172-8. 2008

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Angiographic, intravascular ultrasound, and fractional flow reserve evaluation of direct stenting vs. conventional stenting using BeStent2 in a multicentre randomized trial
    William Wijns
    Cardiovascular Centre, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
    Eur Heart J 26:1852-9. 2005
    ..The objective was to demonstrate equivalence of post-procedural mean luminal diameter (MLD) by angiography after BeStent2 placement between DS and pre-dilatation (PD) strategy...
  2. ncbi request reprint The diagnosis of coronary artery disease: in search of a "one-stop shop"?
    William Wijns
    Cardiovascular Center Aalst, OLV Ziekenhuis, Moorselbaan 163, 9400 Aalst, Belgium
    J Nucl Med 46:904-5. 2005
  3. ncbi request reprint What does the clinical cardiologist need from noninvasive cardiac imaging: is it time to adjust practices to meet evolving demands?
    William Wijns
    Cardiovascular Center Aalst, OLV Ziekenhuis, Aalst, Belgium
    J Nucl Cardiol 14:366-70. 2007
    ....
  4. doi request reprint Long-term follow-up after fractional flow reserve-guided treatment strategy in patients with an isolated proximal left anterior descending coronary artery stenosis
    Olivier Muller
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 4:1175-82. 2011
    ....
  5. doi request reprint Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis
    Narbeh Melikian
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    EuroIntervention 5:939-45. 2010
    ..We examined the influence of epicardial vessel atherosclerosis on coronary microvascular function using the index of myocardial resistance (IMR)...
  6. doi request reprint Severity of coronary arterial stenoses responsible for acute coronary syndromes
    Ganesh Manoharan
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Am J Cardiol 103:1183-8. 2009
    ..In conclusion, most STEMIs occurred at the site of severe coronary stenosis. Diameter stenosis severity was <50% in a minority of cases...
  7. doi request reprint Comparison of 600 versus 300-mg Clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary coronary angioplasty
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Am J Cardiol 106:1208-11. 2010
    ....
  8. doi request reprint High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    JACC Cardiovasc Interv 3:35-40. 2010
    ..We tested the hypothesis that residual platelet reactivity after clopidogrel correlates with the extent and severity of coronary atherosclerosis in patients undergoing elective percutaneous coronary intervention (PCI)...
  9. doi request reprint Thrombus aspiration in primary percutaneous coronary intervention in high-risk patients with ST-elevation myocardial infarction: a real-world registry
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Moorselbaan 164, Aalst, Belgium
    Catheter Cardiovasc Interv 76:70-6. 2010
    ..To evaluate the effect of thrombus aspiration in a real-world all-comer patient population with STEMI undergoing primary PCI...
  10. doi request reprint Endomyocardial upregulation of beta1 adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy
    Marc Vanderheyden
    Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Card Fail 14:172-8. 2008
    ..We investigated whether acute and chronic cardiac resynchronization therapy (CRT) was capable of reversing the blunted FFR and MCR and if this was associated with upregulation of beta1-AR...
  11. doi request reprint Effective radiation dose, time, and contrast medium to measure fractional flow reserve
    Argyrios Ntalianis
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 3:821-7. 2010
    ..This study sought to define the additional effective radiation dose, procedural time, and contrast medium needed to obtain fractional flow reserve (FFR) measurements after a diagnostic coronary angiogram...
  12. doi request reprint Interference of drug-eluting stents with endothelium-dependent coronary vasomotion: evidence for device-specific responses
    Michalis Hamilos
    Cardiovascular Centre Aalst, OLV Hospital, Moorselbaan 164, Aalst, Belgium
    Circ Cardiovasc Interv 1:193-200. 2008
    ..We studied the effects of different drug-polymer-device iterations on endothelium-dependent coronary vasomotion. Systemic markers of endothelial inflammation were correlated with coronary vasomotor changes...
  13. doi request reprint Influence of transradial versus transfemoral diagnostic heart catheterisation on peripheral vascular endothelial function
    Luigi Di Serafino
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    EuroIntervention 8:1252-8. 2013
    ..We aimed at investigating possible alteration of hand endothelial microcirculation secondary to transradial heart catheterisation...
  14. ncbi request reprint Time-dependent effects on coronary remodeling and epicardial conductance after intracoronary injection of enriched hematopoietic bone marrow stem cells in patients with previous myocardial infarction
    Marc Vanderheyden
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Cell Transplant 16:919-25. 2007
    ..12 (-0.39-0.05) mm, respectively, NS]. Early intracoronary administration of hematopoietic BM stem cells in patients with previous MI is associated with accelerated luminal loss and reduced conductance of the infarct-related artery...
  15. doi request reprint Fractional flow reserve and myocardial perfusion imaging in patients with angiographic multivessel coronary artery disease
    Narbeh Melikian
    Cardiovascular Center Aalst, OLV Clinic, Moorselbaan 164, Aalst, Belgium
    JACC Cardiovasc Interv 3:307-14. 2010
    ....
  16. doi request reprint On the inappropriateness of noninvasive multidetector computed tomography coronary angiography to trigger coronary revascularization: a comparison with invasive angiography
    Giovanna Sarno
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    JACC Cardiovasc Interv 2:550-7. 2009
    ..Our purpose was to evaluate the appropriateness of multidetector computed tomography angiography (MDCTA) as an anatomical standard for decision making in patients with known or suspected coronary artery disease...
  17. ncbi request reprint Pressure-derived measurement of coronary flow reserve
    Philip MacCarthy
    Cardiovascular Center, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 45:216-20. 2005
    ..We aimed to validate the technique of measuring the coronary flow reserve (CFR) with coronary pressure measurements against an established thermodilution technique...
  18. doi request reprint Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris
    Thomas Cuisset
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Am J Cardiol 101:1700-3. 2008
    ..6, 95% confidence interval 1.9 to 11.5, p=0.001). In conclusion, point-of-care assessment of clopidogrel response reliably predicted PMI after low- to medium-risk elective PCI for stable angina...
  19. ncbi request reprint Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease
    Alexandre Berger
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:438-42. 2005
    ....
  20. doi request reprint Myocardial gene expression in heart failure patients treated with cardiac resynchronization therapy responders versus nonresponders
    Marc Vanderheyden
    Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Am Coll Cardiol 51:129-36. 2008
    ..We studied whether functional improvement after cardiac resynchronization therapy (CRT) is associated with reversal of the heart failure (HF) gene program...
  21. doi request reprint Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation
    Thomas Cuisset
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    J Am Coll Cardiol 51:1060-5. 2008
    ..We conducted a randomized study to compare the effect of direct stenting (DS) and conventional stenting (CS) on post-procedural index of microcirculatory resistance (IMR) values...
  22. ncbi request reprint Assessment of renal flow and flow reserve in humans
    Ganesh Manoharan
    Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 47:620-5. 2006
    ..The purpose of this work was to establish the normal range of maximal renal hyperemic response in humans and to identify the ideal renal vasodilatory stimuli...
  23. doi request reprint Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics
    Jozef Bartunek
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    J Am Coll Cardiol 61:2329-38. 2013
    ..This study sought to evaluate the feasibility and safety of autologous bone marrow-derived and cardiogenically oriented mesenchymal stem cell therapy and to probe for signs of efficacy in patients with chronic heart failure...
  24. doi request reprint Intracoronary EnalaPrilat to Reduce MICROvascular Damage During Percutaneous Coronary Intervention (ProMicro) study
    Fabio Mangiacapra
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 61:615-21. 2013
    ..This study investigated the influence of intracoronary enalaprilat on coronary microvascular function and peri-procedural outcome measures in patients with stable angina undergoing percutaneous coronary intervention (PCI)...
  25. doi request reprint Long-term clinical outcome in patients with small vessel disease treated with drug-eluting versus bare-metal stenting
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Hospital, Belgium
    Am Heart J 162:907-13. 2011
    ..Available data are less convincing in small vessel disease. Aim of our study is to assess long-term clinical outcome of drug-eluting stents (DES) vs. bare-metal stents (BMS) in small coronary vessel disease...
  26. doi request reprint Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction
    Argyrios Ntalianis
    Cardiovascular Center, Aalst, OLV Clinic, Moorselbaan 164, Aalst, Belgium
    JACC Cardiovasc Interv 3:1274-81. 2010
    ..We investigated the reliability of fractional flow reserve (FFR) of nonculprit coronary stenoses during percutaneous coronary intervention (PCI) in acute myocardial infarction...
  27. doi request reprint Relationship between peripheral arterial reactive hyperemia and residual platelet reactivity after 600 mg clopidogrel
    Michalis Hamilos
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium
    J Thromb Thrombolysis 32:64-71. 2011
    ..This improvement is associated with optimal platelet inhibition and it is not observed in patients with post-clopidogrel high platelet reactivity...
  28. doi request reprint Relation of endothelial function to residual platelet reactivity after clopidogrel in patients with stable angina pectoris undergoing percutaneous coronary intervention
    Olivier Muller
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    Am J Cardiol 105:333-8. 2010
    ..This link might explain the unfavorable PCI outcomes in patients with more severe endothelial impairment...
  29. ncbi request reprint Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Circulation 112:I178-83. 2005
    ..We tested the feasibility, safety, and functional effects of the use of enriched CD133+ progenitor cells after intracoronary administration in patients with recent myocardial infarction...
  30. doi request reprint Long-term clinical outcome after fractional flow reserve-guided treatment in patients with angiographically equivocal left main coronary artery stenosis
    Michalis Hamilos
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan, 164, B 9300 Aalst, Belgium
    Circulation 120:1505-12. 2009
    ....
  31. doi request reprint Quantitative angiography and optical coherence tomography for the functional assessment of nonobstructive coronary stenoses: comparison with fractional flow reserve
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Am Heart J 166:1010-1018.e1. 2013
    ..The purpose was to compare 3-dimensional quantitative coronary angiography (3D-QCA) with optical coherence tomography (OCT) for the functional assessment of nonobstructive coronary stenoses, as evaluated by fractional flow reserve (FFR)...
  32. doi request reprint High cholesterol levels are associated with coronary microvascular dysfunction
    Fabio Mangiacapra
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    J Cardiovasc Med (Hagerstown) 13:439-42. 2012
    ..We investigated the potential association between serum cholesterol levels and coronary microvascular function, using the index of microvascular resistance (IMR), in patients with coronary artery disease...
  33. doi request reprint Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction
    Olivier Muller
    Cardiovascular Center and Translational Cardiology Unit, Aalst, Belgium
    EuroIntervention 7:458-66. 2011
    ..The aim of this study was to decipher the angiogenic, atherosclerotic, and inflammatory mRNA profiles in whole blood samples collected at the site of coronary occlusion in patients with ST-elevation myocardial infarction (STEMI)...
  34. doi request reprint von Willebrand factor inhibition improves endothelial function in patients with stable angina
    Olivier Muller
    Cardiovascular Center Aalst OLV Clinic, Moorselbaan 164, B 9300 Aalst, Belgium
    J Cardiovasc Transl Res 6:364-70. 2013
    ..014). A decrease in EMPs was observed after ALX-0081 (p < 0.01), while no changes occurred in placebo pts. An inhibition of vWF with ALX-0081 significantly improves peripheral endothelial function...
  35. doi request reprint St. John's Wort in patients non-responders to clopidogrel undergoing percutaneous coronary intervention: a single-center randomized open-label trial (St. John's Trial)
    Catalina Trana
    Cardiovascular Center Aalst OLV Clinic, Moorselbaan, 164, 9300 Aalst, Belgium
    J Cardiovasc Transl Res 6:411-4. 2013
    ..16 ± 15, p = 0.0033), with no differences at T2 between the groups (Δ%, -30 ± 29 vs. -17 ± 24, p = 0.30). Residual platelet reactivity improved with SJW during the first month post-PCI...
  36. doi request reprint Fractional flow reserve-guided versus angiography-guided coronary artery bypass graft surgery
    Gabor Toth
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Circulation 128:1405-11. 2013
    ..Fractional flow reserve (FFR) is well established for patients undergoing percutaneous coronary intervention, yet little is known about candidates for coronary artery bypass graft surgery...
  37. doi request reprint Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary revascularization in patients with small-vessel disease
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Circ Cardiovasc Interv 5:62-8. 2012
    ..The aim of this study was to assess the clinical outcome of fractional flow reserve (FFR)-guided PCI in the treatment of small coronary vessel lesions as compared with an angio-guided PCI...
  38. pmc Multidetector computed tomography angiography for assessment of in-stent restenosis: meta-analysis of diagnostic performance
    Piet K Vanhoenacker
    Department of Radiology and Imaging, OLV Ziekenhuis, Aalst, Belgium
    BMC Med Imaging 8:14. 2008
    ..The purpose of this study was to perform a structured review and meta-analysis of the diagnostic performance of MDCTA for the detection of in-stent restenosis in the coronary arteries...
  39. ncbi request reprint Effect of mitral valve repair on exercise tolerance in asymptomatic patients with organic mitral regurgitation
    Juraj Madaric
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Am Heart J 154:180-5. 2007
    ..The aim of the study was to quantify the changes in cardiopulmonary function after minimally invasive video-assisted mitral valve repair for organic mitral regurgitation (MR) in asymptomatic or minimally symptomatic patients...
  40. doi request reprint Novel antiplatelet agents: ALX-0081, a Nanobody directed towards von Willebrand factor
    Jozef Bartunek
    Cardiovascular Center Aalst, OLV Clinic, Moorselbaan 164, 9300 Aalst, Belgium
    J Cardiovasc Transl Res 6:355-63. 2013
    ..Following these results, a phase II study was initiated in high-risk acute coronary syndrome patients undergoing PCI. Based on its mechanism of action, ALX-0081 is also being developed for acquired thrombotic thrombocytopenic purpura...
  41. doi request reprint Synergistic effect of thrombus aspiration and abciximab in primary percutaneous coronary intervention
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium Cardiovascular Department, University Hospital of Trieste, Trieste, Italy
    Catheter Cardiovasc Interv 82:604-11. 2013
    ..Previous studies failed to assess the individual prognostic role of thrombus aspiration (TA) or abciximab in primary percutaneous coronary intervention (pPCI), due their prevalent combined use...
  42. doi request reprint Safety and effectiveness of drug-eluting stents versus bare-metal stents in elderly patients with small coronary vessel disease
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium Department of Cardiology, European Hospital Georges Pompidou, Assistance publique des Hôpitaux de Paris AP HP and Inserm U 970, Paris Descartes University, Paris, France Electronic address
    Arch Cardiovasc Dis 106:554-61. 2013
    ..Whether this is true in elderly patients, it is unclear, as frailty and a high rate of comorbidities could increase the rate of DES-related complications...
  43. pmc Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy
    Emanuele Barbato
    Molecular Biology and Cardiology Unit, Cardiovascular Center and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Heart 93:856-61. 2007
    ..However, heart failure is associated with several abnormalities of beta receptor signalling, and underlying mechanisms are not clear...
  44. ncbi request reprint Characterisation of the "vulnerable" coronary plaque by multi-detector computed tomography: a correlative study with intravascular ultrasound-derived radiofrequency analysis of plaque composition
    Giovanna Sarno
    Cardiovascular Center, Aalst, Belgium
    EuroIntervention 4:318-23. 2008
    ....
  45. ncbi request reprint Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses
    Emanuele Barbato
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Moorselbaan 164, B 9300 Aalst, Belgium
    Eur Heart J 25:2034-9. 2004
    ..Maximal hyperaemia is paramount in the diagnosis of patients with coronary artery disease. However in these patients, enhanced alpha-adrenergic microvascular vasoconstriction may preclude adenosine to induce maximal hyperaemia...
  46. doi request reprint Human coronary atherosclerosis modulates cardiac natriuretic peptide release
    Emanuele Barbato
    Cardiovascular Center OLV Aalst, Moorselbaan n 164, Aalst, Belgium
    Atherosclerosis 206:258-64. 2009
    ..Natriuretic peptides (NPs) modulate vasodilatation and vascular remodelling. In human coronary explants, expression of NPs mRNA and their respective receptors is significantly more pronounced with advanced atherosclerotic lesions...
  47. ncbi request reprint Effects of sublingual nitroglycerin on coronary lumen diameter and number of visualized septal branches on 64-MDCT angiography
    Isabel Decramer
    Department of Radiology and Imaging, OLV Ziekenhuis, Moorselbaan 164, Aalst, Oost Vlaanderen 9300, Belgium
    AJR Am J Roentgenol 190:219-25. 2008
    ..This article describes the influence of sublingual nitroglycerin spray on the lumen diameter, number of side branches visualized, contrast-to-noise ratio (CNR), and signal-to-noise ratio (SNR) of the coronary arteries with MDCT angiography...
  48. doi request reprint Mesenchymal stem cells and cardiac repair: principles and practice
    Jozef Bartunek
    Cardiovascular Center and Cardiovascular Research Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
    J Cardiovasc Transl Res 1:115-9. 2008
    ....
  49. ncbi request reprint Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium
    Jozef Bartunek
    Cardiovascular Center and Cardiovascular Research Center, Aalst, Moorselbaan 164, 9300 Aalst, Belgium
    Am J Physiol Heart Circ Physiol 292:H1095-104. 2007
    ....
  50. doi request reprint Long-term clinical outcome after fractional flow reserve- versus angio-guided percutaneous coronary intervention in patients with intermediate stenosis of coronary artery bypass grafts
    Luigi Di Serafino
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    Am Heart J 166:110-8. 2013
    ..It is unknown whether this applies to coronary artery bypass grafts (CABGs)...
  51. doi request reprint Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease
    Olivier Muller
    Cardiovascular Center and Translational Cardiology Unit, Aalst, Belgium
    J Cardiovasc Transl Res 6:536-44. 2013
    ..01 and 0.67 to 0.77 (95 % CI: 0.69-0.84) p < 0.01, respectively). Serum sPLA2 activity as well as sPLA2-IIA level is related to functional characteristics of coronary stenoses in patients with stable coronary artery disease...
  52. pmc Detection of non-ST-elevation myocardial infarction and unstable angina in the acute setting: meta-analysis of diagnostic performance of multi-detector computed tomographic angiography
    Piet K Vanhoenacker
    Department of Radiology and Medical Imaging, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    BMC Cardiovasc Disord 7:39. 2007
    ..The purpose of this study was to review the literature on the diagnostic performance of MDCTA in the acute setting, for the detection of non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris (UAP)...
  53. ncbi request reprint Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans
    Bernard De Bruyne
    Cardiovascular Center Aalst, Moorselbaan, 164 B 9300 Aalst, Belgium
    Circulation 107:1877-83. 2003
    ..The present study compares different dosages and routes of administration of adenosine 5'-triphosphate (ATP), adenosine, contrast medium, and papaverine regarding their potential to achieve both maximal and steady-state hyperemia...
  54. doi request reprint Lack of correlation between platelet reactivity and glycaemic control in type 2 diabetes mellitus patients treated with aspirin and clopidogrel
    Fabio Mangiacapra
    Cardiovascular Center OLV Clinic, Moorselbaan, 164, 9300, Aalst, Belgium
    J Thromb Thrombolysis 32:54-8. 2011
    ..018, P = 0.87). Overall these data suggest that glycaemic control does not appear to influence platelet reactivity in patients with type 2 DM following a loading dose of 600 mg of clopidogrel and aspirin treatment...
  55. ncbi request reprint Hyperdynamic myocardial response to beta-adrenergic stimulation in patients with chest pain and normal coronary arteries
    Juraj Madaric
    Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:1270-5. 2005
    ..The goal of this study was to test the hypothesis that an abnormal response to beta-adrenergic stimulation may play a role in the pathophysiology of chest pain in patients with normal coronary arteries...
  56. doi request reprint Contrast-induced nephropathy in patients undergoing primary percutaneous coronary intervention without acute left ventricular ejection fraction impairment
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, Onze Lieve Vrouwziekenhuis Clinic, Aalst, Belgium
    Am J Cardiol 111:684-8. 2013
    ..When only patients without acute LVEF impairment were considered, CIN confirmed its negative prognostic effect on the 1-year clinical outcomes...
  57. doi request reprint Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease
    Emanuele Barbato
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 59:1763-70. 2012
    ..The aim of this study was to investigate the impact of rs5065 atrial natriuretic peptide (ANP) gene variant on coronary artery disease (CAD) and its outcomes and to gain potential mechanistic insights on the association with CAD...
  58. ncbi request reprint Timing of intracoronary bone-marrow-derived stem cell transplantation after ST-elevation myocardial infarction
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Nat Clin Pract Cardiovasc Med 3:S52-6. 2006
    ..Here we highlight several aspects of the timing of intracoronary stem cell therapy and focus on time-related questions that are relevant to the design of future experimental and basic studies...
  59. ncbi request reprint Diagnostic performance of multidetector CT angiography for assessment of coronary artery disease: meta-analysis
    Piet K Vanhoenacker
    Department of Radiology and Medical Imaging, OLV Ziekenhuis Aalst, Moorselbaan 164, 9300 Aalst, Belgium
    Radiology 244:419-28. 2007
    ..To review the literature on the diagnostic performance of multidetector computed tomographic (CT) angiography for assessment of symptomatic coronary artery disease, with conventional coronary angiography as the reference standard...
  60. ncbi request reprint GLU-27 variant of beta2-adrenergic receptor polymorphisms is an independent risk factor for coronary atherosclerotic disease
    Emanuele Barbato
    Cardiovascular Center and Molecular Biology and Cardiology Unit, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Atherosclerosis 194:e80-6. 2007
    ..Nevertheless, conflicting data have been reported concerning their influence on CAD and cardiovascular clinical events...
  61. ncbi request reprint Effects of intravenous dobutamine on coronary vasomotion in humans
    Emanuele Barbato
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    J Am Coll Cardiol 42:1596-601. 2003
    ..We sought to investigate the vascular mechanisms of dobutamine-induced myocardial ischemia...
  62. doi request reprint Pressure-diameter relationship in human coronary arteries
    Olivier Muller
    Cardiovascular Centre Aalst, OLV Clinic, Belgium
    Circ Cardiovasc Interv 5:791-6. 2012
    ..To quantify the changes in arterial dimensions after the acute changes in pressure associated with percutaneous coronary intervention (PCI)...
  63. doi request reprint Multicenter assessment of coronary allograft vasculopathy by intravascular ultrasound-derived analysis of plaque composition
    Giovanna Sarno
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Nat Clin Pract Cardiovasc Med 6:61-9. 2009
    ..Coronary allograft vasculopathy is a severe complication of heart transplantation. We used virtual histology intravascular ultrasound to characterize plaque burden and tissue composition over time in heart transplant recipients...
  64. doi request reprint Differential effects of drug-eluting stents on local endothelium-dependent coronary vasomotion
    Michalis I Hamilos
    Cardiovascular Centre, Aalst, Belgium
    J Am Coll Cardiol 51:2123-9. 2008
    ..The aim of our study was to compare coronary vasomotion after implantation of a second-generation biolimus A9-eluting stent (BES) and of a sirolimus-eluting stent (SES)...
  65. ncbi request reprint Hybrid revascularization strategy: a pilot study on the association of robotically enhanced minimally invasive direct coronary artery bypass surgery and fractional-flow-reserve-guided percutaneous coronary intervention
    Giedrius Davidavicius
    Department of Cardiovascular and Thoracic Surgery, OLV Clinic, Aalst, Belgium
    Circulation 112:I317-22. 2005
    ....
  66. ncbi request reprint Long-term patency of internal mammary artery bypass grafts: relationship with preoperative severity of the native coronary artery stenosis
    Alexandre Berger
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Circulation 110:II36-40. 2004
    ..Particularly, the preoperative degree of stenosis of the relevant bypassed coronary vessel was assessed to analyze the importance of chronic competitive flow on the arterial graft closure rate...
  67. ncbi request reprint Tissue doppler imaging predicts recovery of left ventricular function after recanalization of an occluded coronary artery
    Martin Penicka
    Cardiovascular Center, Aalst, Belgium
    J Am Coll Cardiol 43:85-91. 2004
    ..We tested the hypothesis that the tissue Doppler imaging (TDI)-derived positive preejection velocity (+VIC) can predict the recovery of contractile function after revascularization in patients with a recent myocardial infarction...
  68. ncbi request reprint Bone-marrow-derived cells for cardiac stem cell therapy: safe or still under scrutiny?
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Moorselbaan 164, 9 300 Aalst, Belgium
    Nat Clin Pract Cardiovasc Med 4:S100-5. 2007
    ..The proactive scrutiny of these phenomena could eventually facilitate the translation of the promise of cardiac regeneration into a safe and effective therapy...
  69. ncbi request reprint The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart
    Jozef Bartunek
    Cardiovascular Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium, and Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Eur Heart J 27:1338-40. 2006
    ..This article is the consensus of this group, of what clinical studies are needed in this field, and the challenges to be addressed in the translation of progenitor/stem cell biology to repair of the heart...
  70. ncbi request reprint Images in cardiovascular medicine. Non-life-threatening leaflet escape
    Filip Casselman
    Department of Cardiovascular and Thoracic Surgery, OLV Clinic, Moorselbaan, Belgium
    Circulation 107:e72. 2003
  71. ncbi request reprint Dose distributions for 90Y intravascular brachytherapy sources used with balloon catheters
    Marleen Piessens
    Department of Radiation Therapy and Oncology, Onze Lieve Vrouw Hospital, Aalst, Belgium
    Med Phys 29:1562-71. 2002
    ..5%) and a time instability of the plastic scintillator, probably due to radiation damage (6%)...
  72. ncbi request reprint Direct stenting
    Emanuele Barbato
    The Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Eur Heart J 24:394-403. 2003
    ..In addition, a significant reduction in terms of costs and duration of procedures was demonstrated, while restenosis rate is not reduced with direct stenting...
  73. ncbi request reprint Advancing the knowledge base on the efficacy-safety ratio with drug-eluting stents contributions from the European Society of Cardiology Congress, Vienna, Austria, September 1-5, 2007
    William Wijns
    Cardiovascular Center Aalst, Aalst, Belgium
    J Am Coll Cardiol 50:2431-3. 2007
  74. ncbi request reprint Maintenance of long-term clinical benefit with sirolimus-eluting coronary stents: three-year results of the RAVEL trial
    Jean Fajadet
    Clinique Pasteur, 45, Avenue du Lombez, 31300 Toulouse, France
    Circulation 111:1040-4. 2005
    ..This analysis examined whether these beneficial effects persist over the longer term...
  75. ncbi request reprint Guidelines for percutaneous coronary interventions. The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology
    Sigmund Silber
    Kardiologische Praxis und Praxisklinik, Munchen, Germany
    Eur Heart J 26:804-47. 2005
    ....
  76. ncbi request reprint Direct stenting of native de novo coronary artery lesions with the sirolimus-eluting stent: a post hoc subanalysis of the pooled E- and C-SIRIUS trials
    Michael Schlüter
    Center for Cardiology and Vascular Intervention, Hamburg, Germany
    J Am Coll Cardiol 45:10-3. 2005
    ..We sought to assess the impact of direct stenting (DS) using the sirolimus-eluting stent (SES) on angiographic and clinical outcomes...
  77. ncbi request reprint Incidence of stent under-deployment as a cause of in-stent restenosis in long stents: take your lesson!
    William Wijns
    Int J Cardiovasc Imaging 20:529-30. 2004
  78. ncbi request reprint Direct stent implantation using the EXPRESS Coronary Stent System: results of a multi-center feasibility study
    Sigmund Silber
    Internistische Klinik Dr Müller, Herzkatheterlabor Cardiology Associates, Munich, Germany
    J Interv Cardiol 16:491-7. 2003
    ..No other MACE were observed during the three-month follow-up period. Based on the findings of this study, direct stenting with the EXPRESS Stent appears feasible and is well tolerated...
  79. ncbi request reprint DECOPI (DEsobstruction COronaire en Post-Infarctus): a randomized multi-centre trial of occluded artery angioplasty after acute myocardial infarction
    Philippe Gabriel Steg
    Department of Cardiology, Hopital Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Eur Heart J 25:2187-94. 2004
    ..To determine whether late recanalization of an occluded infarct artery after acute myocardial infarction is beneficial...
  80. ncbi request reprint Angiographic and three-dimensional intravascular ultrasound analysis of combined intracoronary beta radiation and self-expanding stent implantation in human coronary arteries
    Valeria Ferrero
    Catheterization Laboratory of the Università del Piemonte Orientale, Ospedale Maggiore della Carita, Novara, Italy
    Am J Cardiol 94:1237-42. 2004
    ....
  81. ncbi request reprint Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries
    Emanuele Barbato
    Division of Cardiology, Federico II University of Naples, Italy
    Circulation 111:288-94. 2005
    ..This study aimed at assessing the role of beta2-ARs in normal, mildly atherosclerotic, and stenotic human coronary arteries...
  82. ncbi request reprint Direct stenting versus direct stenting followed by centered beta-radiation with intravascular ultrasound-guided dosimetry and long-term anti-platelet treatment: results of a randomized trial: Beta-Radiation Investigation with Direct Stenting and Galileo i
    Patrick W Serruys
    Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 44:528-37. 2004
    ..We sought to assess the efficacy of vascular brachytherapy (VBT) combined with stenting for the primary prevention of restenosis...
  83. ncbi request reprint Estrogen receptor-alpha polymorphisms and angiographic outcome after coronary artery stenting
    Valeria Ferrero
    Division of Cardiology, Universita del Piemonte Orientale, Ospedale Maggiore della Carita, Novara, Italy
    Arterioscler Thromb Vasc Biol 23:2223-8. 2003
    ....
  84. ncbi request reprint Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomised controlled trial (E-SIRIUS)
    Joachim Schofer
    Centre for Cardiology and Vascular Intervention, Othmarscher Kirchenweg 168, D 22763, Hamburg, Germany
    Lancet 362:1093-9. 2003
    ..We investigated the risk of restenosis with use of sirolimus-eluting stents compared with bare-metal stents to assess possible differences...
  85. ncbi request reprint Geographical miss and restenosis during catheter-based intracoronary beta-radiation for de novo lesions
    Georgios Sianos
    Department of Interventional Cardiology, Erasmus MC Rotterdam, Thoraxcenter Bd 404, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Cardiovasc Radiat Med 3:138-46. 2002
    ..We sought to determine the impact of geographical miss (GM) on restenosis rates after intracoronary beta-radiation therapy for de novo lesions...
  86. ncbi request reprint Geographical miss during centered intracoronary beta-radiation with 90Yttrium: incidence and implications for recurrence rates after vascular brachytherapy for de novo lesions
    Georgios Sianos
    Thorax Center, Erasmus MC, Rotterdam, The Netherlands
    Int J Cardiovasc Intervent 5:181-9. 2003
    ..The authors sought to determine the incidence and causes of geographical miss (GM) and evaluate its impact on edge restenosis after 'primary', centered, intracoronary beta-radiation therapy...
  87. ncbi request reprint Angiographic analysis of the angioplasty versus rotational atherectomy for the treatment of diffuse in-stent restenosis trial (ARTIST)
    Ulrich Dietz
    University Hospital, Mainz, Germany
    Am J Cardiol 90:843-7. 2002
    ..Thus, PTCA and PTCR of diffuse ISRs yield comparable acute angiographic results. The recurrence of a restenosis is higher after PTCR than after PTCA...
  88. ncbi request reprint Intravascular ultrasound findings in the multicenter, randomized, double-blind RAVEL (RAndomized study with the sirolimus-eluting VElocity balloon-expandable stent in the treatment of patients with de novo native coronary artery Lesions) trial
    Patrick W Serruys
    Thoraxcentre, Rotterdam, The Netherlands
    Circulation 106:798-803. 2002
    ..The goal of this intravascular ultrasound investigation was to provide a more detailed morphological analysis of the local biological effects of the implantation of a sirolimus-eluting stent compared with an uncoated stent...
  89. ncbi request reprint Accuracy of PET in predicting functional recovery after revascularisation in patients with chronic ischaemic dysfunction: head-to-head comparison between blood flow, glucose utilisation and water-perfusable tissue fraction
    Jeroen J Bax
    Leiden University Medical Center, The Netherlands
    Eur J Nucl Med Mol Imaging 29:721-7. 2002
    ..It is concluded that metabolic imaging is superior to perfusion-based indexes for assessment of the potential for functional recovery after revascularisation...
  90. ncbi request reprint Haptoglobin phenotype and the risk of restenosis after coronary artery stent implantation
    Ariel Roguin
    The Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Cardiol 89:806-10. 2002
    ....
  91. ncbi request reprint Association of chronic kidney disease with clinical outcomes after coronary revascularization: the Arterial Revascularization Therapies Study (ARTS)
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, Calif, USA
    Am Heart J 149:512-9. 2005
    ..In the Arterial Revascularization Therapies Study (ARTS), we compared long-term clinical outcomes after CABG or PCI with multivessel stenting in patients with CKD...
  92. ncbi request reprint A randomized comparison of the value of additional stenting after optimal balloon angioplasty for long coronary lesions: final results of the additional value of NIR stents for treatment of long coronary lesions (ADVANCE) study
    Patrick W Serruys
    Erasmus University, Rotterdam, The Netherlands
    J Am Coll Cardiol 39:393-9. 2002
    ..We sought to investigate the clinical benefit of additional stent implantation after achieving an optimal result of balloon angioplasty (BA) in long coronary lesions (>20 mm)...
  93. ncbi request reprint Cold cardioplegia for acute infarction a viable adjunct to reperfusion therapy?
    William Wijns
    J Am Coll Cardiol 49:261-2. 2007
  94. ncbi request reprint Intracoronary beta-irradiation for the treatment of de novo lesions: 5-year clinical follow-up of the BetAce randomized trial
    Valeria Ferrero
    Department of Biomedical and Surgical Sciences, Section of Cardiology, University of Verona, Verona, Italy
    Am Heart J 153:398-402. 2007
    ..Despite initial positive results, long-term follow-up has shown a progressive loss of benefit in clinical outcome after beta-irradiation. We report the 5-year follow-up of the BetAce trial...
  95. ncbi request reprint Role of imaging in cardiac stem cell therapy
    Saskia L M A Beeres
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 49:1137-48. 2007
    ..In addition, a comprehensive summary is provided of the currently available studies investigating a cell therapy-related effect on left ventricular function, myocardial perfusion, scar tissue, and myocardial viability...
  96. ncbi request reprint The Cobalt chromium STent with Antiproliferative for Restenosis II (COSTAR II) trial study design: advancing the active-control evaluation of second-generation drug-eluting stents
    Tracy Y Wang
    Duke Clinical Research Institute, Duke University, Durham, NC, USA
    Am Heart J 153:743-8. 2007
    ..The results of COSTAR II will provide information about a novel coronary stent device as well as unique data regarding both control and test DES use in more complex "real-world" patients...
  97. ncbi request reprint Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study
    Nico H J Pijls
    Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 49:2105-11. 2007
    ..The purpose of this study was to investigate the appropriateness of stenting a functionally nonsignificant stenosis...
  98. ncbi request reprint Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes
    Jean Pierre Bassand
    Eur Heart J 28:1598-660. 2007
  99. ncbi request reprint Long-term histological and immunohistochemical findings in human venous aorto-coronary bypass grafts
    Flavio Ribichini
    Division of Cardiology, Department of Biomedical Sciences and Surgery, University of Verona, 37126 Verona, Italy
    Clin Sci (Lond) 114:211-20. 2008
    ....
  100. doi request reprint Quantification of coronary plaque by 64-slice computed tomography: a comparison with quantitative intracoronary ultrasound
    Masato Otsuka
    Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Radiol 43:314-21. 2008
    ..Noninvasive assessment of coronary atherosclerotic plaque may be useful for risk stratification and treatment of atherosclerosis...
  101. ncbi request reprint Myocardial positive pre-ejection velocity accurately detects presence of viable myocardium, predicts recovery of left ventricular function and bears a prognostic value after surgical revascularization
    Martin Penicka
    Cardiocenter, Department of Cardiology, 3rd Medical School Charles University and University Hospital Kralovske Vinohrady Srobarova 50, 100 34 Prague, Czech Republic
    Eur Heart J 28:1366-73. 2007
    ....