Bernard De Bruyne

Summary

Affiliation: Cardiovascular Center
Country: Belgium

Publications

  1. doi request reprint Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
    Bernard De Bruyne
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Aalst, Belgium
    N Engl J Med 367:991-1001. 2012
  2. ncbi request reprint Pressure-derived fractional flow reserve to assess serial epicardial stenoses: theoretical basis and animal validation
    B De Bruyne
    Cardiovascular Center, Aalst, Belgium
    Circulation 101:1840-7. 2000
  3. ncbi request reprint Long-term clinical outcome after fractional flow reserve-guided treatment in patients with angiographically equivocal left main coronary artery stenosis
    Michalis Hamilos
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan, 164, B 9300 Aalst, Belgium
    Circulation 120:1505-12. 2009
  4. doi request reprint Fractional flow reserve: a review: invasive imaging
    B De Bruyne
    Cardiovascular Centre Aalst, OLV Clinic, Moorselbaan, Aalst, Belgium
    Heart 94:949-59. 2008
  5. ncbi request reprint Assessment of renal artery stenosis severity by pressure gradient measurements
    Bernard De Bruyne
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 48:1851-5. 2006
  6. ncbi request reprint Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans
    Bernard De Bruyne
    Cardiovascular Center Aalst, Moorselbaan, 164 B 9300 Aalst, Belgium
    Circulation 107:1877-83. 2003
  7. ncbi request reprint Abnormal epicardial coronary resistance in patients with diffuse atherosclerosis but "Normal" coronary angiography
    B De Bruyne
    Cardiovascular Center Aalst, Aalst, Belgium
    Circulation 104:2401-6. 2001
  8. ncbi request reprint Coronary thermodilution to assess flow reserve: experimental validation
    B De Bruyne
    Cardiovascular Center Aalst, Aalst, Belgium
    Circulation 104:2003-6. 2001
  9. ncbi request reprint Fractional flow reserve in patients with prior myocardial infarction
    B De Bruyne
    Cardiovascular Center, Aalst, Belgium, and the Catharina Hospital, Eindhoven, Netherlands
    Circulation 104:157-62. 2001
  10. doi request reprint Long-term follow-up after fractional flow reserve-guided treatment strategy in patients with an isolated proximal left anterior descending coronary artery stenosis
    Olivier Muller
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 4:1175-82. 2011

Detail Information

Publications80

  1. doi request reprint Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
    Bernard De Bruyne
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Aalst, Belgium
    N Engl J Med 367:991-1001. 2012
    ....
  2. ncbi request reprint Pressure-derived fractional flow reserve to assess serial epicardial stenoses: theoretical basis and animal validation
    B De Bruyne
    Cardiovascular Center, Aalst, Belgium
    Circulation 101:1840-7. 2000
    ....
  3. ncbi request reprint Long-term clinical outcome after fractional flow reserve-guided treatment in patients with angiographically equivocal left main coronary artery stenosis
    Michalis Hamilos
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan, 164, B 9300 Aalst, Belgium
    Circulation 120:1505-12. 2009
    ....
  4. doi request reprint Fractional flow reserve: a review: invasive imaging
    B De Bruyne
    Cardiovascular Centre Aalst, OLV Clinic, Moorselbaan, Aalst, Belgium
    Heart 94:949-59. 2008
  5. ncbi request reprint Assessment of renal artery stenosis severity by pressure gradient measurements
    Bernard De Bruyne
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 48:1851-5. 2006
    ..The purpose of this study was to define "significant" renal artery stenosis (i.e., a stenosis able to induce arterial hypertension)...
  6. ncbi request reprint Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans
    Bernard De Bruyne
    Cardiovascular Center Aalst, Moorselbaan, 164 B 9300 Aalst, Belgium
    Circulation 107:1877-83. 2003
    ..The present study compares different dosages and routes of administration of adenosine 5'-triphosphate (ATP), adenosine, contrast medium, and papaverine regarding their potential to achieve both maximal and steady-state hyperemia...
  7. ncbi request reprint Abnormal epicardial coronary resistance in patients with diffuse atherosclerosis but "Normal" coronary angiography
    B De Bruyne
    Cardiovascular Center Aalst, Aalst, Belgium
    Circulation 104:2401-6. 2001
    ..Accordingly, we hypothesized that in patients with coronary artery disease, nonstenotic coronary arteries induce a decrease in pressure along their length due to diffuse coronary atherosclerosis...
  8. ncbi request reprint Coronary thermodilution to assess flow reserve: experimental validation
    B De Bruyne
    Cardiovascular Center Aalst, Aalst, Belgium
    Circulation 104:2003-6. 2001
    ..At present, FFR and CFR can only be obtained by 2 separate guidewires. The present study tested the validity of the thermodilution principle in assessing CFR with one pressure-temperature sensor-tipped guidewire...
  9. ncbi request reprint Fractional flow reserve in patients with prior myocardial infarction
    B De Bruyne
    Cardiovascular Center, Aalst, Belgium, and the Catharina Hospital, Eindhoven, Netherlands
    Circulation 104:157-62. 2001
    ..0009) despite a similar degree of diameter stenosis (67+/-13% versus 68+/-16%, P=NS). A significant inverse correlation was found between LVEF and FFR (R=0.29, P=0.049)...
  10. doi request reprint Long-term follow-up after fractional flow reserve-guided treatment strategy in patients with an isolated proximal left anterior descending coronary artery stenosis
    Olivier Muller
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 4:1175-82. 2011
    ....
  11. doi request reprint Myocardial gene expression in heart failure patients treated with cardiac resynchronization therapy responders versus nonresponders
    Marc Vanderheyden
    Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Am Coll Cardiol 51:129-36. 2008
    ..We studied whether functional improvement after cardiac resynchronization therapy (CRT) is associated with reversal of the heart failure (HF) gene program...
  12. doi request reprint Severity of coronary arterial stenoses responsible for acute coronary syndromes
    Ganesh Manoharan
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Am J Cardiol 103:1183-8. 2009
    ..In conclusion, most STEMIs occurred at the site of severe coronary stenosis. Diameter stenosis severity was <50% in a minority of cases...
  13. ncbi request reprint Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis
    Narbeh Melikian
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    EuroIntervention 5:939-45. 2010
    ..We examined the influence of epicardial vessel atherosclerosis on coronary microvascular function using the index of myocardial resistance (IMR)...
  14. ncbi request reprint Synergistic effect of thrombus aspiration and abciximab in primary percutaneous coronary intervention
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium Cardiovascular Department, University Hospital of Trieste, Trieste, Italy
    Catheter Cardiovasc Interv 82:604-11. 2013
    ..Previous studies failed to assess the individual prognostic role of thrombus aspiration (TA) or abciximab in primary percutaneous coronary intervention (pPCI), due their prevalent combined use...
  15. doi request reprint Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease
    Olivier Muller
    Cardiovascular Center and Translational Cardiology Unit, Aalst, Belgium
    J Cardiovasc Transl Res 6:536-44. 2013
    ..01 and 0.67 to 0.77 (95 % CI: 0.69-0.84) p < 0.01, respectively). Serum sPLA2 activity as well as sPLA2-IIA level is related to functional characteristics of coronary stenoses in patients with stable coronary artery disease...
  16. doi request reprint Comparison of 600 versus 300-mg Clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary coronary angioplasty
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Am J Cardiol 106:1208-11. 2010
    ....
  17. doi request reprint High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    JACC Cardiovasc Interv 3:35-40. 2010
    ..We tested the hypothesis that residual platelet reactivity after clopidogrel correlates with the extent and severity of coronary atherosclerosis in patients undergoing elective percutaneous coronary intervention (PCI)...
  18. doi request reprint Thrombus aspiration in primary percutaneous coronary intervention in high-risk patients with ST-elevation myocardial infarction: a real-world registry
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Moorselbaan 164, Aalst, Belgium
    Catheter Cardiovasc Interv 76:70-6. 2010
    ..To evaluate the effect of thrombus aspiration in a real-world all-comer patient population with STEMI undergoing primary PCI...
  19. ncbi request reprint Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease
    Alexandre Berger
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:438-42. 2005
    ....
  20. ncbi request reprint Time-dependent effects on coronary remodeling and epicardial conductance after intracoronary injection of enriched hematopoietic bone marrow stem cells in patients with previous myocardial infarction
    Marc Vanderheyden
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Cell Transplant 16:919-25. 2007
    ..12 (-0.39-0.05) mm, respectively, NS]. Early intracoronary administration of hematopoietic BM stem cells in patients with previous MI is associated with accelerated luminal loss and reduced conductance of the infarct-related artery...
  21. doi request reprint Endomyocardial upregulation of beta1 adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy
    Marc Vanderheyden
    Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Card Fail 14:172-8. 2008
    ..We investigated whether acute and chronic cardiac resynchronization therapy (CRT) was capable of reversing the blunted FFR and MCR and if this was associated with upregulation of beta1-AR...
  22. doi request reprint Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation
    Thomas Cuisset
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    J Am Coll Cardiol 51:1060-5. 2008
    ..We conducted a randomized study to compare the effect of direct stenting (DS) and conventional stenting (CS) on post-procedural index of microcirculatory resistance (IMR) values...
  23. doi request reprint Effective radiation dose, time, and contrast medium to measure fractional flow reserve
    Argyrios Ntalianis
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 3:821-7. 2010
    ..This study sought to define the additional effective radiation dose, procedural time, and contrast medium needed to obtain fractional flow reserve (FFR) measurements after a diagnostic coronary angiogram...
  24. ncbi request reprint Pressure-derived measurement of coronary flow reserve
    Philip MacCarthy
    Cardiovascular Center, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 45:216-20. 2005
    ..We aimed to validate the technique of measuring the coronary flow reserve (CFR) with coronary pressure measurements against an established thermodilution technique...
  25. doi request reprint Fractional flow reserve and myocardial perfusion imaging in patients with angiographic multivessel coronary artery disease
    Narbeh Melikian
    Cardiovascular Center Aalst, OLV Clinic, Moorselbaan 164, Aalst, Belgium
    JACC Cardiovasc Interv 3:307-14. 2010
    ....
  26. doi request reprint Influence of transradial versus transfemoral diagnostic heart catheterisation on peripheral vascular endothelial function
    Luigi Di Serafino
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    EuroIntervention 8:1252-8. 2013
    ..We aimed at investigating possible alteration of hand endothelial microcirculation secondary to transradial heart catheterisation...
  27. ncbi request reprint Assessment of renal flow and flow reserve in humans
    Ganesh Manoharan
    Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 47:620-5. 2006
    ..The purpose of this work was to establish the normal range of maximal renal hyperemic response in humans and to identify the ideal renal vasodilatory stimuli...
  28. doi request reprint Pressure-diameter relationship in human coronary arteries
    Olivier Muller
    Cardiovascular Centre Aalst, OLV Clinic, Belgium
    Circ Cardiovasc Interv 5:791-6. 2012
    ..To quantify the changes in arterial dimensions after the acute changes in pressure associated with percutaneous coronary intervention (PCI)...
  29. doi request reprint Long-term clinical outcome in patients with small vessel disease treated with drug-eluting versus bare-metal stenting
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Hospital, Belgium
    Am Heart J 162:907-13. 2011
    ..Available data are less convincing in small vessel disease. Aim of our study is to assess long-term clinical outcome of drug-eluting stents (DES) vs. bare-metal stents (BMS) in small coronary vessel disease...
  30. ncbi request reprint Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris
    Thomas Cuisset
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Am J Cardiol 101:1700-3. 2008
    ..6, 95% confidence interval 1.9 to 11.5, p=0.001). In conclusion, point-of-care assessment of clopidogrel response reliably predicted PMI after low- to medium-risk elective PCI for stable angina...
  31. ncbi request reprint Effect of mitral valve repair on exercise tolerance in asymptomatic patients with organic mitral regurgitation
    Juraj Madaric
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Am Heart J 154:180-5. 2007
    ..The aim of the study was to quantify the changes in cardiopulmonary function after minimally invasive video-assisted mitral valve repair for organic mitral regurgitation (MR) in asymptomatic or minimally symptomatic patients...
  32. doi request reprint Dopamine-induced changes in renal blood flow in normals and in patients with renal dysfunction
    Benny Drieghe
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Catheter Cardiovasc Interv 72:725-30. 2008
    ..Despite their controversial effect, "renal" doses of dopamine (3-5 microg kg(-1) min(-1)) are often used in intensive care units to preserve renal function and to improve final outcome...
  33. doi request reprint Intracoronary EnalaPrilat to Reduce MICROvascular Damage During Percutaneous Coronary Intervention (ProMicro) study
    Fabio Mangiacapra
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 61:615-21. 2013
    ..This study investigated the influence of intracoronary enalaprilat on coronary microvascular function and peri-procedural outcome measures in patients with stable angina undergoing percutaneous coronary intervention (PCI)...
  34. ncbi request reprint Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Circulation 112:I178-83. 2005
    ..We tested the feasibility, safety, and functional effects of the use of enriched CD133+ progenitor cells after intracoronary administration in patients with recent myocardial infarction...
  35. doi request reprint On the inappropriateness of noninvasive multidetector computed tomography coronary angiography to trigger coronary revascularization: a comparison with invasive angiography
    Giovanna Sarno
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    JACC Cardiovasc Interv 2:550-7. 2009
    ..Our purpose was to evaluate the appropriateness of multidetector computed tomography angiography (MDCTA) as an anatomical standard for decision making in patients with known or suspected coronary artery disease...
  36. ncbi request reprint Early and late effects of cardiac resynchronization therapy on exercise-induced mitral regurgitation: relationship with left ventricular dyssynchrony, remodelling and cardiopulmonary performance
    Juraj Madaric
    Cardiovascular Center, OLV Ziekenhuis, Moorselbaan 164, BE 9300 Aalst, Belgium
    Eur Heart J 28:2134-41. 2007
    ..We investigated serial changes in functional MR in relation to left ventricular (LV) remodelling and cardiopulmonary performance after CRT...
  37. doi request reprint Assessment of renal artery stenosis: side-by-side comparison of angiography and duplex ultrasound with pressure gradient measurements
    Benny Drieghe
    Cardiovascular Center, OLV Clinic, Moorselbaan 164, 9300 Aalst, Belgium
    Eur Heart J 29:517-24. 2008
    ..90 can be considered a threshold for defining a significant renal artery stenosis (RAS). The aim of this study was to compare renal angiography (QRA) and colour duplex ultrasound (CDUS) to pressure measurements in assessing RAS...
  38. doi request reprint Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction
    Argyrios Ntalianis
    Cardiovascular Center, Aalst, OLV Clinic, Moorselbaan 164, Aalst, Belgium
    JACC Cardiovasc Interv 3:1274-81. 2010
    ..We investigated the reliability of fractional flow reserve (FFR) of nonculprit coronary stenoses during percutaneous coronary intervention (PCI) in acute myocardial infarction...
  39. doi request reprint In vitro and in vivo studies on thermistor-based intracoronary temperature measurements: effect of pressure and flow
    Thomas Cuisset
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Catheter Cardiovasc Interv 73:224-30. 2009
    ..Intracoronary thermography has been proposed to detect vulnerable plaques. We hypothesized that changes in coronary pressure and flow in the coronary tree may interfere with the temperature measurements obtained with thermistors...
  40. pmc Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy
    Emanuele Barbato
    Molecular Biology and Cardiology Unit, Cardiovascular Center and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Heart 93:856-61. 2007
    ..However, heart failure is associated with several abnormalities of beta receptor signalling, and underlying mechanisms are not clear...
  41. ncbi request reprint Non-invasive assessment of coronary flow reserve in idiopathic dilated cardiomyopathy: hemodynamic correlations
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Moorselbaan 164, 9300 Aalst, Belgium
    Eur J Echocardiogr 6:47-53. 2005
    ..In the present study, we investigated whether the blunted vasodilator flow response is related to indices of left ventricular performance in patients with idiopathic dilated cardiomyopathy...
  42. doi request reprint Relation of endothelial function to residual platelet reactivity after clopidogrel in patients with stable angina pectoris undergoing percutaneous coronary intervention
    Olivier Muller
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    Am J Cardiol 105:333-8. 2010
    ..This link might explain the unfavorable PCI outcomes in patients with more severe endothelial impairment...
  43. ncbi request reprint Impact of chronic kidney disease on platelet reactivity and outcomes of patients receiving clopidogrel and undergoing percutaneous coronary intervention
    Fabio Mangiacapra
    Department of Cardiovascular Sciences, Campus Bio Medico University, Rome, Italy Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium Electronic address
    Am J Cardiol 113:1124-9. 2014
    ..However, the association of moderate-to-severe CKD with either high or low PR was a strong determinant of adverse events after PCI...
  44. doi request reprint Quantitative angiography and optical coherence tomography for the functional assessment of nonobstructive coronary stenoses: comparison with fractional flow reserve
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Am Heart J 166:1010-1018.e1. 2013
    ..The purpose was to compare 3-dimensional quantitative coronary angiography (3D-QCA) with optical coherence tomography (OCT) for the functional assessment of nonobstructive coronary stenoses, as evaluated by fractional flow reserve (FFR)...
  45. doi request reprint Interference of drug-eluting stents with endothelium-dependent coronary vasomotion: evidence for device-specific responses
    Michalis Hamilos
    Cardiovascular Centre Aalst, OLV Hospital, Moorselbaan 164, Aalst, Belgium
    Circ Cardiovasc Interv 1:193-200. 2008
    ..We studied the effects of different drug-polymer-device iterations on endothelium-dependent coronary vasomotion. Systemic markers of endothelial inflammation were correlated with coronary vasomotor changes...
  46. ncbi request reprint Hyperdynamic myocardial response to beta-adrenergic stimulation in patients with chest pain and normal coronary arteries
    Juraj Madaric
    Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:1270-5. 2005
    ..The goal of this study was to test the hypothesis that an abnormal response to beta-adrenergic stimulation may play a role in the pathophysiology of chest pain in patients with normal coronary arteries...
  47. doi request reprint Relationship between peripheral arterial reactive hyperemia and residual platelet reactivity after 600 mg clopidogrel
    Michalis Hamilos
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium
    J Thromb Thrombolysis 32:64-71. 2011
    ..This improvement is associated with optimal platelet inhibition and it is not observed in patients with post-clopidogrel high platelet reactivity...
  48. doi request reprint Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction
    Olivier Muller
    Cardiovascular Center and Translational Cardiology Unit, Aalst, Belgium
    EuroIntervention 7:458-66. 2011
    ..The aim of this study was to decipher the angiogenic, atherosclerotic, and inflammatory mRNA profiles in whole blood samples collected at the site of coronary occlusion in patients with ST-elevation myocardial infarction (STEMI)...
  49. doi request reprint Practical tips and tricks for the measurement of fractional flow reserve
    Faisal Sharif
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Catheter Cardiovasc Interv 76:978-85. 2010
    ..This review outlines the practical set up of FFR in the catheterization laboratory and also discusses the potential pitfalls in the measurement of FFR...
  50. ncbi request reprint Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses
    Emanuele Barbato
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Moorselbaan 164, B 9300 Aalst, Belgium
    Eur Heart J 25:2034-9. 2004
    ..Maximal hyperaemia is paramount in the diagnosis of patients with coronary artery disease. However in these patients, enhanced alpha-adrenergic microvascular vasoconstriction may preclude adenosine to induce maximal hyperaemia...
  51. doi request reprint Long-term clinical outcome after fractional flow reserve- versus angio-guided percutaneous coronary intervention in patients with intermediate stenosis of coronary artery bypass grafts
    Luigi Di Serafino
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    Am Heart J 166:110-8. 2013
    ..It is unknown whether this applies to coronary artery bypass grafts (CABGs)...
  52. doi request reprint von Willebrand factor inhibition improves endothelial function in patients with stable angina
    Olivier Muller
    Cardiovascular Center Aalst OLV Clinic, Moorselbaan 164, B 9300 Aalst, Belgium
    J Cardiovasc Transl Res 6:364-70. 2013
    ..014). A decrease in EMPs was observed after ALX-0081 (p < 0.01), while no changes occurred in placebo pts. An inhibition of vWF with ALX-0081 significantly improves peripheral endothelial function...
  53. doi request reprint Fractional flow reserve-guided versus angiography-guided coronary artery bypass graft surgery
    Gabor Toth
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Circulation 128:1405-11. 2013
    ..Fractional flow reserve (FFR) is well established for patients undergoing percutaneous coronary intervention, yet little is known about candidates for coronary artery bypass graft surgery...
  54. doi request reprint High cholesterol levels are associated with coronary microvascular dysfunction
    Fabio Mangiacapra
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    J Cardiovasc Med (Hagerstown) 13:439-42. 2012
    ..We investigated the potential association between serum cholesterol levels and coronary microvascular function, using the index of microvascular resistance (IMR), in patients with coronary artery disease...
  55. doi request reprint Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary revascularization in patients with small-vessel disease
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Circ Cardiovasc Interv 5:62-8. 2012
    ..The aim of this study was to assess the clinical outcome of fractional flow reserve (FFR)-guided PCI in the treatment of small coronary vessel lesions as compared with an angio-guided PCI...
  56. ncbi request reprint Early and late effects of cardiac resynchronization therapy on force-frequency relation and contractility regulating gene expression in heart failure patients
    Wilfried Mullens
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Heart Rhythm 5:52-9. 2008
    ..Heart failure is associated with a reduction in left ventricular (LV) contractility as evidenced by a blunted force-frequency response (FFR) and downregulation of contractility regulating genes...
  57. doi request reprint Human coronary atherosclerosis modulates cardiac natriuretic peptide release
    Emanuele Barbato
    Cardiovascular Center OLV Aalst, Moorselbaan n 164, Aalst, Belgium
    Atherosclerosis 206:258-64. 2009
    ..Natriuretic peptides (NPs) modulate vasodilatation and vascular remodelling. In human coronary explants, expression of NPs mRNA and their respective receptors is significantly more pronounced with advanced atherosclerotic lesions...
  58. ncbi request reprint Wall stress modulates brain natriuretic peptide production in pressure overload cardiomyopathy
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Moorselbaan 164, 9400 Aalst, Belgium
    J Am Coll Cardiol 44:2349-54. 2004
    ..We postulated that both diastolic and systolic load modulate B-type natriuretic peptide (BNP) production in human pressure overload hypertrophy/failure...
  59. doi request reprint Translesional pressure gradients to predict blood pressure response after renal artery stenting in patients with renovascular hypertension
    Fabio Mangiacapra
    Cardiovascular Center, OLV Clinic, Aalst, Belgium
    Circ Cardiovasc Interv 3:537-42. 2010
    ..The aim of the present study was to evaluate whether translesional pressure gradients could identify the patients with renal artery stenosis who might benefit from stenting...
  60. ncbi request reprint ACEF and clinical SYNTAX score in the risk stratification of patients with heavily calcified coronary stenosis undergoing rotational atherectomy with stent implantation
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Catheter Cardiovasc Interv 83:1067-73. 2014
    ..To assess ACEF (age, creatinine, and ejection fraction) and Clinical SYNTAX (CSS) score in the risk stratification of patients with heavily calcified stenosis undergoing rotational atherectomy with stent implantation (rota-stenting)...
  61. doi request reprint Safety and effectiveness of drug-eluting stents versus bare-metal stents in elderly patients with small coronary vessel disease
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium Department of Cardiology, European Hospital Georges Pompidou, Assistance publique des Hôpitaux de Paris AP HP and Inserm U 970, Paris Descartes University, Paris, France Electronic address
    Arch Cardiovasc Dis 106:554-61. 2013
    ..Whether this is true in elderly patients, it is unclear, as frailty and a high rate of comorbidities could increase the rate of DES-related complications...
  62. ncbi request reprint Angiographic, intravascular ultrasound, and fractional flow reserve evaluation of direct stenting vs. conventional stenting using BeStent2 in a multicentre randomized trial
    William Wijns
    Cardiovascular Centre, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
    Eur Heart J 26:1852-9. 2005
    ..The objective was to demonstrate equivalence of post-procedural mean luminal diameter (MLD) by angiography after BeStent2 placement between DS and pre-dilatation (PD) strategy...
  63. doi request reprint Monocyte-platelets aggregates as cellular biomarker of endothelium-dependent coronary vasomotor dysfunction in patients with coronary artery disease
    Luigi Di Serafino
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan164, 9300, Aalst, Belgium
    J Cardiovasc Transl Res 7:1-8. 2014
    ..26, p < 0.01). MPA levels are significantly higher in patients with abnormal coronary vasomotor function regardless of the presence of functionally significant coronary stenosis...
  64. doi request reprint Fractional flow reserve: concepts, applications and use in France in 2010
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Clinic, Moorselbaan 164, 9300, Aalst, Belgium
    Arch Cardiovasc Dis 103:615-22. 2010
    ..The use of FFR is still limited in France because there is no financial support. The present review will focus on coronary pressure-derived FFR...
  65. ncbi request reprint Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium
    Jozef Bartunek
    Cardiovascular Center and Cardiovascular Research Center, Aalst, Moorselbaan 164, 9300 Aalst, Belgium
    Am J Physiol Heart Circ Physiol 292:H1095-104. 2007
    ....
  66. ncbi request reprint Contrast-induced nephropathy in patients undergoing primary percutaneous coronary intervention without acute left ventricular ejection fraction impairment
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, Onze Lieve Vrouwziekenhuis Clinic, Aalst, Belgium
    Am J Cardiol 111:684-8. 2013
    ..When only patients without acute LVEF impairment were considered, CIN confirmed its negative prognostic effect on the 1-year clinical outcomes...
  67. ncbi request reprint Effects of intravenous dobutamine on coronary vasomotion in humans
    Emanuele Barbato
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    J Am Coll Cardiol 42:1596-601. 2003
    ..We sought to investigate the vascular mechanisms of dobutamine-induced myocardial ischemia...
  68. ncbi request reprint Tissue doppler imaging predicts recovery of left ventricular function after recanalization of an occluded coronary artery
    Martin Penicka
    Cardiovascular Center, Aalst, Belgium
    J Am Coll Cardiol 43:85-91. 2004
    ..We tested the hypothesis that the tissue Doppler imaging (TDI)-derived positive preejection velocity (+VIC) can predict the recovery of contractile function after revascularization in patients with a recent myocardial infarction...
  69. doi request reprint The reconciliation of pressure and light: a clinical case of complementary use of fractional flow reserve and optical coherence tomography
    Aaron Peace
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    J Cardiovasc Med (Hagerstown) 12:571-7. 2011
    ..Different tests and imaging modalities for coronary artery disease have been performed in this patient. The potential for integration of the information available is underscored in order to overcome their inherent limitations...
  70. doi request reprint Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease
    Emanuele Barbato
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 59:1763-70. 2012
    ..The aim of this study was to investigate the impact of rs5065 atrial natriuretic peptide (ANP) gene variant on coronary artery disease (CAD) and its outcomes and to gain potential mechanistic insights on the association with CAD...
  71. ncbi request reprint GLU-27 variant of beta2-adrenergic receptor polymorphisms is an independent risk factor for coronary atherosclerotic disease
    Emanuele Barbato
    Cardiovascular Center and Molecular Biology and Cardiology Unit, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Atherosclerosis 194:e80-6. 2007
    ..Nevertheless, conflicting data have been reported concerning their influence on CAD and cardiovascular clinical events...
  72. ncbi request reprint Hybrid revascularization strategy: a pilot study on the association of robotically enhanced minimally invasive direct coronary artery bypass surgery and fractional-flow-reserve-guided percutaneous coronary intervention
    Giedrius Davidavicius
    Department of Cardiovascular and Thoracic Surgery, OLV Clinic, Aalst, Belgium
    Circulation 112:I317-22. 2005
    ....
  73. ncbi request reprint Hemodynamic effects of inducible nitric oxide synthase and nitrotyrosine generation in heart failure
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwe Ziekenhuis, Aalst, Belgium
    J Heart Lung Transplant 23:723-8. 2004
    ..The present study investigates the incidence and functional significance of iNOS expression and nitrotyrosine formation in patients with heart failure...
  74. ncbi request reprint Long-term patency of internal mammary artery bypass grafts: relationship with preoperative severity of the native coronary artery stenosis
    Alexandre Berger
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Circulation 110:II36-40. 2004
    ..Particularly, the preoperative degree of stenosis of the relevant bypassed coronary vessel was assessed to analyze the importance of chronic competitive flow on the arterial graft closure rate...
  75. ncbi request reprint Improvement of left ventricular function after cardiac resynchronization therapy is predicted by tissue Doppler imaging echocardiography
    Martin Penicka
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    Circulation 109:978-83. 2004
    ..However, the prediction of benefit is controversial. We aimed to investigate predictive factors of LV functional recovery and reversed remodeling after biventricular pacing...
  76. ncbi request reprint Validation of coronary flow reserve measurements by thermodilution in clinical practice
    Emanuele Barbato
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Eur Heart J 25:219-23. 2004
    ..The present multicentric study was performed to compare the feasibility of CFR(thermo)obtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFR(Doppler))...
  77. doi request reprint A therapeutic window for platelet reactivity for patients undergoing elective percutaneous coronary intervention: results of the ARMYDA-PROVE (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity for Outcome Valid
    Fabio Mangiacapra
    Department of Cardiovascular Sciences, Campus Bio Medico University, Rome, Italy
    JACC Cardiovasc Interv 5:281-9. 2012
    ..This study sought to validate the ability of the VerifyNow P2Y12 assay (Accumetrics, San Diego, California) in predicting both ischemic and bleeding events after elective percutaneous coronary intervention (PCI)...
  78. ncbi request reprint Renal V-stenting
    Steven Vercauteren
    Cardiovascular Center Aalst, Aalst, Belgium
    J Invasive Cardiol 19:90. 2007
  79. doi request reprint Fractional flow reserve in unstable angina and non-ST-segment elevation myocardial infarction experience from the FAME (Fractional flow reserve versus Angiography for Multivessel Evaluation) study
    Jan Willem E M Sels
    Catharina Hospital, Eindhoven, The Netherlands
    JACC Cardiovasc Interv 4:1183-9. 2011
    ....
  80. ncbi request reprint What does the clinical cardiologist need from noninvasive cardiac imaging: is it time to adjust practices to meet evolving demands?
    William Wijns
    Cardiovascular Center Aalst, OLV Ziekenhuis, Aalst, Belgium
    J Nucl Cardiol 14:366-70. 2007
    ....