Jozef Bartunek

Summary

Affiliation: Cardiovascular Center
Country: Belgium

Publications

  1. doi request reprint Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics
    Jozef Bartunek
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    J Am Coll Cardiol 61:2329-38. 2013
  2. pmc Ventricular-arterial uncoupling in heart failure with preserved ejection fraction after myocardial infarction in dogs - invasive versus echocardiographic evaluation
    Myrielle Mathieu
    Department of Physiology and Pathophysiology, ULB, Brussels, Belgium
    BMC Cardiovasc Disord 10:32. 2010
  3. ncbi request reprint Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Circulation 112:I178-83. 2005
  4. ncbi request reprint Bone-marrow-derived cells for cardiac stem cell therapy: safe or still under scrutiny?
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Moorselbaan 164, 9 300 Aalst, Belgium
    Nat Clin Pract Cardiovasc Med 4:S100-5. 2007
  5. ncbi request reprint Timing of intracoronary bone-marrow-derived stem cell transplantation after ST-elevation myocardial infarction
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Nat Clin Pract Cardiovasc Med 3:S52-6. 2006
  6. doi request reprint Mesenchymal stem cells and cardiac repair: principles and practice
    Jozef Bartunek
    Cardiovascular Center and Cardiovascular Research Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
    J Cardiovasc Transl Res 1:115-9. 2008
  7. ncbi request reprint Deoxyribonucleic acid damage/repair proteins are elevated in the failing human myocardium due to idiopathic dilated cardiomyopathy
    Jozef Bartunek
    Cardiovascular Center, Aalst, Belgium
    J Am Coll Cardiol 40:1097-103; discussion 1104-5. 2002
  8. ncbi request reprint Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium
    Jozef Bartunek
    Cardiovascular Center and Cardiovascular Research Center, Aalst, Moorselbaan 164, 9300 Aalst, Belgium
    Am J Physiol Heart Circ Physiol 292:H1095-104. 2007
  9. doi request reprint Myocardial gene expression in heart failure patients treated with cardiac resynchronization therapy responders versus nonresponders
    Marc Vanderheyden
    Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Am Coll Cardiol 51:129-36. 2008
  10. doi request reprint Long-term follow-up after fractional flow reserve-guided treatment strategy in patients with an isolated proximal left anterior descending coronary artery stenosis
    Olivier Muller
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 4:1175-82. 2011

Detail Information

Publications93

  1. doi request reprint Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics
    Jozef Bartunek
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    J Am Coll Cardiol 61:2329-38. 2013
    ..This study sought to evaluate the feasibility and safety of autologous bone marrow-derived and cardiogenically oriented mesenchymal stem cell therapy and to probe for signs of efficacy in patients with chronic heart failure...
  2. pmc Ventricular-arterial uncoupling in heart failure with preserved ejection fraction after myocardial infarction in dogs - invasive versus echocardiographic evaluation
    Myrielle Mathieu
    Department of Physiology and Pathophysiology, ULB, Brussels, Belgium
    BMC Cardiovasc Disord 10:32. 2010
    ..The aim of this study was to investigate the physiopathology of heart failure with preserved ejection fraction in a model of healed myocardial infarction in dogs...
  3. ncbi request reprint Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Circulation 112:I178-83. 2005
    ..We tested the feasibility, safety, and functional effects of the use of enriched CD133+ progenitor cells after intracoronary administration in patients with recent myocardial infarction...
  4. ncbi request reprint Bone-marrow-derived cells for cardiac stem cell therapy: safe or still under scrutiny?
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Moorselbaan 164, 9 300 Aalst, Belgium
    Nat Clin Pract Cardiovasc Med 4:S100-5. 2007
    ..The proactive scrutiny of these phenomena could eventually facilitate the translation of the promise of cardiac regeneration into a safe and effective therapy...
  5. ncbi request reprint Timing of intracoronary bone-marrow-derived stem cell transplantation after ST-elevation myocardial infarction
    Jozef Bartunek
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Nat Clin Pract Cardiovasc Med 3:S52-6. 2006
    ..Here we highlight several aspects of the timing of intracoronary stem cell therapy and focus on time-related questions that are relevant to the design of future experimental and basic studies...
  6. doi request reprint Mesenchymal stem cells and cardiac repair: principles and practice
    Jozef Bartunek
    Cardiovascular Center and Cardiovascular Research Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
    J Cardiovasc Transl Res 1:115-9. 2008
    ....
  7. ncbi request reprint Deoxyribonucleic acid damage/repair proteins are elevated in the failing human myocardium due to idiopathic dilated cardiomyopathy
    Jozef Bartunek
    Cardiovascular Center, Aalst, Belgium
    J Am Coll Cardiol 40:1097-103; discussion 1104-5. 2002
    ..The study investigated the expression and relationship of deoxyribonucleic acid (DNA) repair enzymes with hemodynamic and nitric oxide (NO)-mediated stress in the failing myocardium...
  8. ncbi request reprint Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium
    Jozef Bartunek
    Cardiovascular Center and Cardiovascular Research Center, Aalst, Moorselbaan 164, 9300 Aalst, Belgium
    Am J Physiol Heart Circ Physiol 292:H1095-104. 2007
    ....
  9. doi request reprint Myocardial gene expression in heart failure patients treated with cardiac resynchronization therapy responders versus nonresponders
    Marc Vanderheyden
    Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Am Coll Cardiol 51:129-36. 2008
    ..We studied whether functional improvement after cardiac resynchronization therapy (CRT) is associated with reversal of the heart failure (HF) gene program...
  10. doi request reprint Long-term follow-up after fractional flow reserve-guided treatment strategy in patients with an isolated proximal left anterior descending coronary artery stenosis
    Olivier Muller
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 4:1175-82. 2011
    ....
  11. ncbi request reprint Synergistic effect of thrombus aspiration and abciximab in primary percutaneous coronary intervention
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium Cardiovascular Department, University Hospital of Trieste, Trieste, Italy
    Catheter Cardiovasc Interv 82:604-11. 2013
    ..Previous studies failed to assess the individual prognostic role of thrombus aspiration (TA) or abciximab in primary percutaneous coronary intervention (pPCI), due their prevalent combined use...
  12. ncbi request reprint Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis
    Narbeh Melikian
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    EuroIntervention 5:939-45. 2010
    ..We examined the influence of epicardial vessel atherosclerosis on coronary microvascular function using the index of myocardial resistance (IMR)...
  13. doi request reprint Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease
    Olivier Muller
    Cardiovascular Center and Translational Cardiology Unit, Aalst, Belgium
    J Cardiovasc Transl Res 6:536-44. 2013
    ..01 and 0.67 to 0.77 (95 % CI: 0.69-0.84) p < 0.01, respectively). Serum sPLA2 activity as well as sPLA2-IIA level is related to functional characteristics of coronary stenoses in patients with stable coronary artery disease...
  14. ncbi request reprint Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease
    Alexandre Berger
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:438-42. 2005
    ....
  15. doi request reprint Thrombus aspiration in primary percutaneous coronary intervention in high-risk patients with ST-elevation myocardial infarction: a real-world registry
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Moorselbaan 164, Aalst, Belgium
    Catheter Cardiovasc Interv 76:70-6. 2010
    ..To evaluate the effect of thrombus aspiration in a real-world all-comer patient population with STEMI undergoing primary PCI...
  16. doi request reprint Comparison of 600 versus 300-mg Clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary coronary angioplasty
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Am J Cardiol 106:1208-11. 2010
    ....
  17. ncbi request reprint Early and late effects of cardiac resynchronization therapy on exercise-induced mitral regurgitation: relationship with left ventricular dyssynchrony, remodelling and cardiopulmonary performance
    Juraj Madaric
    Cardiovascular Center, OLV Ziekenhuis, Moorselbaan 164, BE 9300 Aalst, Belgium
    Eur Heart J 28:2134-41. 2007
    ..We investigated serial changes in functional MR in relation to left ventricular (LV) remodelling and cardiopulmonary performance after CRT...
  18. doi request reprint High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention
    Fabio Mangiacapra
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    JACC Cardiovasc Interv 3:35-40. 2010
    ..We tested the hypothesis that residual platelet reactivity after clopidogrel correlates with the extent and severity of coronary atherosclerosis in patients undergoing elective percutaneous coronary intervention (PCI)...
  19. doi request reprint Endomyocardial upregulation of beta1 adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy
    Marc Vanderheyden
    Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Card Fail 14:172-8. 2008
    ..We investigated whether acute and chronic cardiac resynchronization therapy (CRT) was capable of reversing the blunted FFR and MCR and if this was associated with upregulation of beta1-AR...
  20. doi request reprint Effective radiation dose, time, and contrast medium to measure fractional flow reserve
    Argyrios Ntalianis
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Aalst, Belgium
    JACC Cardiovasc Interv 3:821-7. 2010
    ..This study sought to define the additional effective radiation dose, procedural time, and contrast medium needed to obtain fractional flow reserve (FFR) measurements after a diagnostic coronary angiogram...
  21. ncbi request reprint Effect of mitral valve repair on exercise tolerance in asymptomatic patients with organic mitral regurgitation
    Juraj Madaric
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Am Heart J 154:180-5. 2007
    ..The aim of the study was to quantify the changes in cardiopulmonary function after minimally invasive video-assisted mitral valve repair for organic mitral regurgitation (MR) in asymptomatic or minimally symptomatic patients...
  22. doi request reprint Fractional flow reserve and myocardial perfusion imaging in patients with angiographic multivessel coronary artery disease
    Narbeh Melikian
    Cardiovascular Center Aalst, OLV Clinic, Moorselbaan 164, Aalst, Belgium
    JACC Cardiovasc Interv 3:307-14. 2010
    ....
  23. doi request reprint Dopamine-induced changes in renal blood flow in normals and in patients with renal dysfunction
    Benny Drieghe
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Catheter Cardiovasc Interv 72:725-30. 2008
    ..Despite their controversial effect, "renal" doses of dopamine (3-5 microg kg(-1) min(-1)) are often used in intensive care units to preserve renal function and to improve final outcome...
  24. ncbi request reprint Time-dependent effects on coronary remodeling and epicardial conductance after intracoronary injection of enriched hematopoietic bone marrow stem cells in patients with previous myocardial infarction
    Marc Vanderheyden
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Cell Transplant 16:919-25. 2007
    ..12 (-0.39-0.05) mm, respectively, NS]. Early intracoronary administration of hematopoietic BM stem cells in patients with previous MI is associated with accelerated luminal loss and reduced conductance of the infarct-related artery...
  25. doi request reprint Influence of transradial versus transfemoral diagnostic heart catheterisation on peripheral vascular endothelial function
    Luigi Di Serafino
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    EuroIntervention 8:1252-8. 2013
    ..We aimed at investigating possible alteration of hand endothelial microcirculation secondary to transradial heart catheterisation...
  26. ncbi request reprint Assessment of renal flow and flow reserve in humans
    Ganesh Manoharan
    Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 47:620-5. 2006
    ..The purpose of this work was to establish the normal range of maximal renal hyperemic response in humans and to identify the ideal renal vasodilatory stimuli...
  27. doi request reprint Relation of endothelial function to residual platelet reactivity after clopidogrel in patients with stable angina pectoris undergoing percutaneous coronary intervention
    Olivier Muller
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    Am J Cardiol 105:333-8. 2010
    ..This link might explain the unfavorable PCI outcomes in patients with more severe endothelial impairment...
  28. doi request reprint Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation
    Thomas Cuisset
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    J Am Coll Cardiol 51:1060-5. 2008
    ..We conducted a randomized study to compare the effect of direct stenting (DS) and conventional stenting (CS) on post-procedural index of microcirculatory resistance (IMR) values...
  29. ncbi request reprint Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris
    Thomas Cuisset
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Am J Cardiol 101:1700-3. 2008
    ..6, 95% confidence interval 1.9 to 11.5, p=0.001). In conclusion, point-of-care assessment of clopidogrel response reliably predicted PMI after low- to medium-risk elective PCI for stable angina...
  30. pmc Nonmyocardial production of ST2 protein in human hypertrophy and failure is related to diastolic load
    Jozef Bartunek
    Translational Cardiology Unit, Cardiovascular Center and Cardiovascular Research Center, OLV Hospital, Aalst, Belgium
    J Am Coll Cardiol 52:2166-74. 2008
    ....
  31. ncbi request reprint Tailored echocardiographic interventricular delay programming further optimizes left ventricular performance after cardiac resynchronization therapy
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Heart Rhythm 2:1066-72. 2005
    ..The aim of cardiac resynchronization therapy is correction of left ventricular (LV) dyssynchrony. However, little is known about the optimal timing of LV and right ventricular (RV) stimulation...
  32. ncbi request reprint Non-invasive assessment of coronary flow reserve in idiopathic dilated cardiomyopathy: hemodynamic correlations
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Moorselbaan 164, 9300 Aalst, Belgium
    Eur J Echocardiogr 6:47-53. 2005
    ..In the present study, we investigated whether the blunted vasodilator flow response is related to indices of left ventricular performance in patients with idiopathic dilated cardiomyopathy...
  33. doi request reprint Interference of drug-eluting stents with endothelium-dependent coronary vasomotion: evidence for device-specific responses
    Michalis Hamilos
    Cardiovascular Centre Aalst, OLV Hospital, Moorselbaan 164, Aalst, Belgium
    Circ Cardiovasc Interv 1:193-200. 2008
    ..We studied the effects of different drug-polymer-device iterations on endothelium-dependent coronary vasomotion. Systemic markers of endothelial inflammation were correlated with coronary vasomotor changes...
  34. doi request reprint Long-term clinical outcome in patients with small vessel disease treated with drug-eluting versus bare-metal stenting
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Hospital, Belgium
    Am Heart J 162:907-13. 2011
    ..Available data are less convincing in small vessel disease. Aim of our study is to assess long-term clinical outcome of drug-eluting stents (DES) vs. bare-metal stents (BMS) in small coronary vessel disease...
  35. doi request reprint Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction
    Olivier Muller
    Cardiovascular Center and Translational Cardiology Unit, Aalst, Belgium
    EuroIntervention 7:458-66. 2011
    ..The aim of this study was to decipher the angiogenic, atherosclerotic, and inflammatory mRNA profiles in whole blood samples collected at the site of coronary occlusion in patients with ST-elevation myocardial infarction (STEMI)...
  36. ncbi request reprint Pressure-derived measurement of coronary flow reserve
    Philip MacCarthy
    Cardiovascular Center, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 45:216-20. 2005
    ..We aimed to validate the technique of measuring the coronary flow reserve (CFR) with coronary pressure measurements against an established thermodilution technique...
  37. doi request reprint Chronic kidney disease is associated with decreased exercise capacity and impaired ventilatory efficiency in heart transplantation patients
    Christophe Van Laethem
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Heart Lung Transplant 28:446-52. 2009
    ..Chronic kidney disease (CKD) is common after heart transplantation (HTx). This study assessed the influence of CKD on exercise capacity and ventilatory efficiency after HTx...
  38. pmc Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy
    Emanuele Barbato
    Molecular Biology and Cardiology Unit, Cardiovascular Center and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Heart 93:856-61. 2007
    ..However, heart failure is associated with several abnormalities of beta receptor signalling, and underlying mechanisms are not clear...
  39. doi request reprint On the inappropriateness of noninvasive multidetector computed tomography coronary angiography to trigger coronary revascularization: a comparison with invasive angiography
    Giovanna Sarno
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    JACC Cardiovasc Interv 2:550-7. 2009
    ..Our purpose was to evaluate the appropriateness of multidetector computed tomography angiography (MDCTA) as an anatomical standard for decision making in patients with known or suspected coronary artery disease...
  40. doi request reprint Intracoronary EnalaPrilat to Reduce MICROvascular Damage During Percutaneous Coronary Intervention (ProMicro) study
    Fabio Mangiacapra
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 61:615-21. 2013
    ..This study investigated the influence of intracoronary enalaprilat on coronary microvascular function and peri-procedural outcome measures in patients with stable angina undergoing percutaneous coronary intervention (PCI)...
  41. doi request reprint Relationship between peripheral arterial reactive hyperemia and residual platelet reactivity after 600 mg clopidogrel
    Michalis Hamilos
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium
    J Thromb Thrombolysis 32:64-71. 2011
    ..This improvement is associated with optimal platelet inhibition and it is not observed in patients with post-clopidogrel high platelet reactivity...
  42. doi request reprint Human coronary atherosclerosis modulates cardiac natriuretic peptide release
    Emanuele Barbato
    Cardiovascular Center OLV Aalst, Moorselbaan n 164, Aalst, Belgium
    Atherosclerosis 206:258-64. 2009
    ..Natriuretic peptides (NPs) modulate vasodilatation and vascular remodelling. In human coronary explants, expression of NPs mRNA and their respective receptors is significantly more pronounced with advanced atherosclerotic lesions...
  43. ncbi request reprint Wall stress modulates brain natriuretic peptide production in pressure overload cardiomyopathy
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Moorselbaan 164, 9400 Aalst, Belgium
    J Am Coll Cardiol 44:2349-54. 2004
    ..We postulated that both diastolic and systolic load modulate B-type natriuretic peptide (BNP) production in human pressure overload hypertrophy/failure...
  44. doi request reprint Long-term clinical outcome after fractional flow reserve- versus angio-guided percutaneous coronary intervention in patients with intermediate stenosis of coronary artery bypass grafts
    Luigi Di Serafino
    Cardiovascular Center Aalst OLV Clinic, Aalst, Belgium
    Am Heart J 166:110-8. 2013
    ..It is unknown whether this applies to coronary artery bypass grafts (CABGs)...
  45. doi request reprint von Willebrand factor inhibition improves endothelial function in patients with stable angina
    Olivier Muller
    Cardiovascular Center Aalst OLV Clinic, Moorselbaan 164, B 9300 Aalst, Belgium
    J Cardiovasc Transl Res 6:364-70. 2013
    ..014). A decrease in EMPs was observed after ALX-0081 (p < 0.01), while no changes occurred in placebo pts. An inhibition of vWF with ALX-0081 significantly improves peripheral endothelial function...
  46. doi request reprint Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary revascularization in patients with small-vessel disease
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    Circ Cardiovasc Interv 5:62-8. 2012
    ..The aim of this study was to assess the clinical outcome of fractional flow reserve (FFR)-guided PCI in the treatment of small coronary vessel lesions as compared with an angio-guided PCI...
  47. ncbi request reprint Early and late effects of cardiac resynchronization therapy on force-frequency relation and contractility regulating gene expression in heart failure patients
    Wilfried Mullens
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Heart Rhythm 5:52-9. 2008
    ..Heart failure is associated with a reduction in left ventricular (LV) contractility as evidenced by a blunted force-frequency response (FFR) and downregulation of contractility regulating genes...
  48. ncbi request reprint Long-term clinical outcome after fractional flow reserve-guided treatment in patients with angiographically equivocal left main coronary artery stenosis
    Michalis Hamilos
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan, 164, B 9300 Aalst, Belgium
    Circulation 120:1505-12. 2009
    ....
  49. ncbi request reprint Hyperdynamic myocardial response to beta-adrenergic stimulation in patients with chest pain and normal coronary arteries
    Juraj Madaric
    Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:1270-5. 2005
    ..The goal of this study was to test the hypothesis that an abnormal response to beta-adrenergic stimulation may play a role in the pathophysiology of chest pain in patients with normal coronary arteries...
  50. doi request reprint Novel antiplatelet agents: ALX-0081, a Nanobody directed towards von Willebrand factor
    Jozef Bartunek
    Cardiovascular Center Aalst, OLV Clinic, Moorselbaan 164, 9300 Aalst, Belgium
    J Cardiovasc Transl Res 6:355-63. 2013
    ..Following these results, a phase II study was initiated in high-risk acute coronary syndrome patients undergoing PCI. Based on its mechanism of action, ALX-0081 is also being developed for acquired thrombotic thrombocytopenic purpura...
  51. doi request reprint Safety and effectiveness of drug-eluting stents versus bare-metal stents in elderly patients with small coronary vessel disease
    Etienne Puymirat
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium Department of Cardiology, European Hospital Georges Pompidou, Assistance publique des Hôpitaux de Paris AP HP and Inserm U 970, Paris Descartes University, Paris, France Electronic address
    Arch Cardiovasc Dis 106:554-61. 2013
    ..Whether this is true in elderly patients, it is unclear, as frailty and a high rate of comorbidities could increase the rate of DES-related complications...
  52. ncbi request reprint Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses
    Emanuele Barbato
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Moorselbaan 164, B 9300 Aalst, Belgium
    Eur Heart J 25:2034-9. 2004
    ..Maximal hyperaemia is paramount in the diagnosis of patients with coronary artery disease. However in these patients, enhanced alpha-adrenergic microvascular vasoconstriction may preclude adenosine to induce maximal hyperaemia...
  53. doi request reprint Heart failure with preserved ejection fraction in outpatients with unexplained dyspnea: a pressure-volume loop analysis
    Martin Penicka
    Cardiovascular Center Aalst, Aalst, Belgium
    J Am Coll Cardiol 55:1701-10. 2010
    ....
  54. ncbi request reprint Response of the oxygen uptake efficiency slope to orthotopic heart transplantation: lack of correlation with changes in central hemodynamic parameters and resting lung function
    Christophe Van Laethem
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Heart Lung Transplant 26:921-6. 2007
    ..No data are available on the response of the OUES after orthotopic heart transplantation (HTx)...
  55. ncbi request reprint Tissue doppler imaging predicts recovery of left ventricular function after recanalization of an occluded coronary artery
    Martin Penicka
    Cardiovascular Center, Aalst, Belgium
    J Am Coll Cardiol 43:85-91. 2004
    ..We tested the hypothesis that the tissue Doppler imaging (TDI)-derived positive preejection velocity (+VIC) can predict the recovery of contractile function after revascularization in patients with a recent myocardial infarction...
  56. doi request reprint Assessment of renal artery stenosis: side-by-side comparison of angiography and duplex ultrasound with pressure gradient measurements
    Benny Drieghe
    Cardiovascular Center, OLV Clinic, Moorselbaan 164, 9300 Aalst, Belgium
    Eur Heart J 29:517-24. 2008
    ..90 can be considered a threshold for defining a significant renal artery stenosis (RAS). The aim of this study was to compare renal angiography (QRA) and colour duplex ultrasound (CDUS) to pressure measurements in assessing RAS...
  57. ncbi request reprint Assessment of renal artery stenosis severity by pressure gradient measurements
    Bernard De Bruyne
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 48:1851-5. 2006
    ..The purpose of this study was to define "significant" renal artery stenosis (i.e., a stenosis able to induce arterial hypertension)...
  58. doi request reprint Monocyte-platelets aggregates as cellular biomarker of endothelium-dependent coronary vasomotor dysfunction in patients with coronary artery disease
    Luigi Di Serafino
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan164, 9300, Aalst, Belgium
    J Cardiovasc Transl Res 7:1-8. 2014
    ..26, p < 0.01). MPA levels are significantly higher in patients with abnormal coronary vasomotor function regardless of the presence of functionally significant coronary stenosis...
  59. ncbi request reprint Improvement of left ventricular function after cardiac resynchronization therapy is predicted by tissue Doppler imaging echocardiography
    Martin Penicka
    Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium
    Circulation 109:978-83. 2004
    ..However, the prediction of benefit is controversial. We aimed to investigate predictive factors of LV functional recovery and reversed remodeling after biventricular pacing...
  60. ncbi request reprint Contrast-induced nephropathy in patients undergoing primary percutaneous coronary intervention without acute left ventricular ejection fraction impairment
    Stylianos A Pyxaras
    Cardiovascular Center Aalst, Onze Lieve Vrouwziekenhuis Clinic, Aalst, Belgium
    Am J Cardiol 111:684-8. 2013
    ..When only patients without acute LVEF impairment were considered, CIN confirmed its negative prognostic effect on the 1-year clinical outcomes...
  61. ncbi request reprint Cardiac resynchronization therapy delays heart transplantation in patients with end-stage heart failure and mechanical dyssynchrony
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    J Heart Lung Transplant 25:447-53. 2006
    ..We aimed to investigate the impact of CRT on freedom from Tx and death in transplant candidates with end-stage heart failure...
  62. ncbi request reprint Effects of intravenous dobutamine on coronary vasomotion in humans
    Emanuele Barbato
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    J Am Coll Cardiol 42:1596-601. 2003
    ..We sought to investigate the vascular mechanisms of dobutamine-induced myocardial ischemia...
  63. ncbi request reprint Biomarkers of vulnerable plaque: the missing link with ischemia
    Olivier Muller
    Cardiovascular Center and Cardiovascular Research Center, Molecular Cardiology Unit, OLV Ziekenhuis, Moorselbaan 164, 9300 Aalst, Belgium
    Biomark Med 4:375-83. 2010
    ..Future prospective studies should be performed in larger and more diverse sets of patients presenting with ischemia, and in a complementary fashion in order to provide valuable tools for clinical decision making...
  64. ncbi request reprint Hemodynamic effects of inducible nitric oxide synthase and nitrotyrosine generation in heart failure
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwe Ziekenhuis, Aalst, Belgium
    J Heart Lung Transplant 23:723-8. 2004
    ..The present study investigates the incidence and functional significance of iNOS expression and nitrotyrosine formation in patients with heart failure...
  65. ncbi request reprint Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans
    Bernard De Bruyne
    Cardiovascular Center Aalst, Moorselbaan, 164 B 9300 Aalst, Belgium
    Circulation 107:1877-83. 2003
    ..The present study compares different dosages and routes of administration of adenosine 5'-triphosphate (ATP), adenosine, contrast medium, and papaverine regarding their potential to achieve both maximal and steady-state hyperemia...
  66. doi request reprint Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease
    Emanuele Barbato
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 59:1763-70. 2012
    ..The aim of this study was to investigate the impact of rs5065 atrial natriuretic peptide (ANP) gene variant on coronary artery disease (CAD) and its outcomes and to gain potential mechanistic insights on the association with CAD...
  67. ncbi request reprint The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart
    Jozef Bartunek
    Cardiovascular Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium, and Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Eur Heart J 27:1338-40. 2006
    ..This article is the consensus of this group, of what clinical studies are needed in this field, and the challenges to be addressed in the translation of progenitor/stem cell biology to repair of the heart...
  68. ncbi request reprint GLU-27 variant of beta2-adrenergic receptor polymorphisms is an independent risk factor for coronary atherosclerotic disease
    Emanuele Barbato
    Cardiovascular Center and Molecular Biology and Cardiology Unit, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
    Atherosclerosis 194:e80-6. 2007
    ..Nevertheless, conflicting data have been reported concerning their influence on CAD and cardiovascular clinical events...
  69. ncbi request reprint Oxygen uptake efficiency slope, a new submaximal parameter in evaluating exercise capacity in chronic heart failure patients
    Christophe Van Laethem
    Cardiovascular Center, Onze Lieve Vrouw Hospital, Aalst, Belgium
    Am Heart J 149:175-80. 2005
    ..The present study investigates the stability and the usefulness of OUES in adult cardiac patients with and without heart failure...
  70. doi request reprint Adult stem cells in the treatment of acute myocardial infarction
    Faisal Sharif
    Cardiovascular Center, OLV Zeikenhuis, Aalst, Belgium
    Catheter Cardiovasc Interv 77:72-83. 2011
    ....
  71. ncbi request reprint Hybrid revascularization strategy: a pilot study on the association of robotically enhanced minimally invasive direct coronary artery bypass surgery and fractional-flow-reserve-guided percutaneous coronary intervention
    Giedrius Davidavicius
    Department of Cardiovascular and Thoracic Surgery, OLV Clinic, Aalst, Belgium
    Circulation 112:I317-22. 2005
    ....
  72. doi request reprint B-type natriuretic peptide as a marker of heart failure: new insights from biochemistry and clinical implications
    Marc Vanderheyden
    Department of Cardiology, Onze Lieve Vrouwe Ziekenhuis, Moorselbaan 164, B 9300, Aalst, Belgium
    Biomark Med 4:315-20. 2010
    ....
  73. ncbi request reprint Long-term patency of internal mammary artery bypass grafts: relationship with preoperative severity of the native coronary artery stenosis
    Alexandre Berger
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Circulation 110:II36-40. 2004
    ..Particularly, the preoperative degree of stenosis of the relevant bypassed coronary vessel was assessed to analyze the importance of chronic competitive flow on the arterial graft closure rate...
  74. doi request reprint Multicenter assessment of coronary allograft vasculopathy by intravascular ultrasound-derived analysis of plaque composition
    Giovanna Sarno
    Cardiovascular Center, OLV Hospital, Aalst, Belgium
    Nat Clin Pract Cardiovasc Med 6:61-9. 2009
    ..Coronary allograft vasculopathy is a severe complication of heart transplantation. We used virtual histology intravascular ultrasound to characterize plaque burden and tissue composition over time in heart transplant recipients...
  75. doi request reprint Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwziekenhuis, Aalst, Belgium
    Clin Chem Lab Med 47:248-52. 2009
    ....
  76. doi request reprint The molecular fingerprint of cardiac dyssynchrony and cardiac resynchronization therapy
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwziekenhuis, Aalst, Belgium
    Heart Fail Rev 16:227-33. 2011
    ..We focus upon the molecular portrait of dyssynchronous heart failure and how cardiac resynchronization therapy influences electrophysiologic, metabolic and adrenergic pathways...
  77. ncbi request reprint Brain and other natriuretic peptides: molecular aspects
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwziekenhuis, Moorselbaan 164, 9400 Aalst, Belgium
    Eur J Heart Fail 6:261-8. 2004
    ..This review focuses on the physiology of natriuretic peptides as a group and brain natriuretic peptide in more detail, its structure and regulation as well as its effects at the cellular level...
  78. ncbi request reprint Cardiovascular disease in patients with chronic renal impairment: role of natriuretic peptides
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwe Ziekenhuis, Aalst, Belgium
    Congest Heart Fail 14:38-42. 2008
    ....
  79. ncbi request reprint Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries
    Emanuele Barbato
    Division of Cardiology, Federico II University of Naples, Italy
    Circulation 111:288-94. 2005
    ..This study aimed at assessing the role of beta2-ARs in normal, mildly atherosclerotic, and stenotic human coronary arteries...
  80. ncbi request reprint Coronary thermodilution to assess flow reserve: validation in humans
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Circulation 105:2482-6. 2002
    ....
  81. ncbi request reprint Neutral endopeptidase is activated in cardiomyocytes in human aortic valve stenosis and heart failure
    Jens Fielitz
    Klinik fur Herz, Gefäss und Thoraxchirurgie, DHZB R P, H R Z, R H, V R Z, Berlin, Germany
    Circulation 105:286-9. 2002
    ..It increased 3.6-fold in AS (P<0.02) and 4-fold in DCM (P<0.002). NEP was localized in the myocardium by immunofluorescence microscopy and in situ PCR to myocytes and nonmyocyte areas and cells...
  82. ncbi request reprint Intracoronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction
    Samer Mansour
    J Am Coll Cardiol 47:1727-30. 2006
  83. ncbi request reprint The end of granulocyte colony-stimulating factor in acute myocardial infarction? Reaping the benefits beyond cytokine mobilization
    Jonathan M Hill
    Circulation 113:1926-8. 2006
  84. pmc Late adaptive coronary artery remodelling after implantation of a biodegradable stent
    Benny Drieghe
    Heart 93:1536. 2007
  85. ncbi request reprint Myocardial positive pre-ejection velocity accurately detects presence of viable myocardium, predicts recovery of left ventricular function and bears a prognostic value after surgical revascularization
    Martin Penicka
    Cardiocenter, Department of Cardiology, 3rd Medical School Charles University and University Hospital Kralovske Vinohrady Srobarova 50, 100 34 Prague, Czech Republic
    Eur Heart J 28:1366-73. 2007
    ....
  86. ncbi request reprint Role of imaging in cardiac stem cell therapy
    Saskia L M A Beeres
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 49:1137-48. 2007
    ..In addition, a comprehensive summary is provided of the currently available studies investigating a cell therapy-related effect on left ventricular function, myocardial perfusion, scar tissue, and myocardial viability...
  87. ncbi request reprint Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials
    Michael J Lipinski
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    J Am Coll Cardiol 50:1761-7. 2007
    ..We aimed to perform a meta-analysis of clinical trials on intracoronary cell therapy after acute myocardial infarction (AMI)...
  88. ncbi request reprint Severe left ventricular dyssynchrony is associated with poor prognosis in patients with moderate systolic heart failure undergoing coronary artery bypass grafting
    Martin Penicka
    Cardiocenter, Department of Cardiology, Third Faculty of Medicine, Charles University, and University Hospital Kralovske Vinohrady, Prague, Czech Republic
    J Am Coll Cardiol 50:1315-23. 2007
    ....
  89. ncbi request reprint Left internal mammary artery bypass dysfunction after revascularization of moderately narrowed coronary lesions. Colour-duplex ultrasound versus angiography study
    Juraj Madaric
    Department of Cardiology, National Cardiovascular Institute, Bratislava, Slovak Republic
    Eur J Echocardiogr 9:273-7. 2008
    ....
  90. ncbi request reprint Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial
    Raimund Erbel
    West German Heart Center Essen, Department of Cardiology, Essen, Germany
    Lancet 369:1869-75. 2007
    ..We report a prospective multicentre clinical trial of coronary implantations of absorbable magnesium stents...
  91. ncbi request reprint Tissue Doppler predicts long-term clinical outcome after cardiac resynchronization therapy
    Martin Penicka
    Cardiocenter, Department of Cardiology, 3rd Medical School Charles University and University Hospital Kralovske, Vinohrady Prague, Czech Republic
    Int J Cardiol 124:40-6. 2008
    ..However, few data are available regarding the baseline cardiac asynchrony and clinical outcome after CRT. Therefore, we aimed to investigate the prognostic value of pre-CRT cardiac asynchrony on clinical outcome after CRT...
  92. ncbi request reprint Prospective evaluation of the oxygen uptake efficiency slope as a submaximal predictor of peak oxygen uptake in aged patients with ischemic heart disease
    Christophe Van Laethem
    Department of Cardiology, University Hospital Gent, Belgium
    Am Heart J 152:297.e9-15. 2006
    ....
  93. doi request reprint Cardiac dyssynchrony in congestive heart failure and atrial fibrillation: integrating regularization and resynchronization
    Jozef Bartunek
    J Am Coll Cardiol 52:1247-9. 2008