P D Cani

Summary

Country: Belgium

Publications

  1. ncbi Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Br J Nutr 92:521-6. 2004
  2. ncbi Gut microflora as a target for energy and metabolic homeostasis
    Patrice D Cani
    Universite Catholique de Louvain, Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 10:729-34. 2007
  3. doi Gut microbiota, enteroendocrine functions and metabolism
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Welbio Walloon Excellence in Life Sciences and Biotechnology, Metabolism and Nutrition Research Group, Av E Mounier, 73 Box B1 73 11, B 1200 Brussels, Belgium Electronic address
    Curr Opin Pharmacol 13:935-40. 2013
  4. pmc Evaluation of the relationship between GPR43 and adiposity in human
    Evelyne M Dewulf
    Metabolism and Nutrition Research Group, LDRI, Universite Catholique de Louvain, Avenue E, Mounier 73, PO box B1, 73, 11, 1200, Brussels, Belgium
    Nutr Metab (Lond) 10:11. 2013
  5. doi Gut microbiota and obesity: lessons from the microbiome
    Patrice D Cani
    Universite Catholique de Louvain, LDRI, Metabolism and Nutrition Research Group, avenue E Mounier, 73, PO Box B1 73 11, B 1200 Brussels, Belgium
    Brief Funct Genomics 12:381-7. 2013
  6. pmc Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Gut Microbes 3:279-88. 2012
  7. doi Crosstalk between the gut microbiota and the endocannabinoid system: impact on the gut barrier function and the adipose tissue
    P D Cani
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Clin Microbiol Infect 18:50-3. 2012
  8. pmc Involvement of gut microbial fermentation in the metabolic alterations occurring in n-3 polyunsaturated fatty acids-depleted mice
    Barbara D Pachikian
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Nutr Metab (Lond) 8:44. 2011
  9. pmc Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome
    Nathalie M Delzenne
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Microb Cell Fact 10:S10. 2011
  10. doi Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
    Patrice D Cani
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Am J Clin Nutr 90:1236-43. 2009

Collaborators

Detail Information

Publications58

  1. ncbi Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Br J Nutr 92:521-6. 2004
    ....
  2. ncbi Gut microflora as a target for energy and metabolic homeostasis
    Patrice D Cani
    Universite Catholique de Louvain, Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 10:729-34. 2007
    ..This review discusses new findings that may explain how gut microbiota can be involved in the control of energy and metabolic homeostasis...
  3. doi Gut microbiota, enteroendocrine functions and metabolism
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Welbio Walloon Excellence in Life Sciences and Biotechnology, Metabolism and Nutrition Research Group, Av E Mounier, 73 Box B1 73 11, B 1200 Brussels, Belgium Electronic address
    Curr Opin Pharmacol 13:935-40. 2013
    ..Here, we explore how crosstalk between the ligands produced by the gut microbiota (short chain fatty acids, or SCFAs), or produced by the host but influenced by gut microbes (endocannabinoids and bile acids), impact host physiology. ..
  4. pmc Evaluation of the relationship between GPR43 and adiposity in human
    Evelyne M Dewulf
    Metabolism and Nutrition Research Group, LDRI, Universite Catholique de Louvain, Avenue E, Mounier 73, PO box B1, 73, 11, 1200, Brussels, Belgium
    Nutr Metab (Lond) 10:11. 2013
    ..abstract:..
  5. doi Gut microbiota and obesity: lessons from the microbiome
    Patrice D Cani
    Universite Catholique de Louvain, LDRI, Metabolism and Nutrition Research Group, avenue E Mounier, 73, PO Box B1 73 11, B 1200 Brussels, Belgium
    Brief Funct Genomics 12:381-7. 2013
    ..Recent results are discussed in the framework of the interactions between gut microbiota and host metabolism. ..
  6. pmc Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Gut Microbes 3:279-88. 2012
    ..Finally, we will introduce the role of the gut microbiota in specific dietary treatments (prebiotics and probiotics) and surgical interventions (gastric bypass)...
  7. doi Crosstalk between the gut microbiota and the endocannabinoid system: impact on the gut barrier function and the adipose tissue
    P D Cani
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Clin Microbiol Infect 18:50-3. 2012
    ..This review briefly discusses the role of prebiotics as a key tool to modulate the gut microbiota, the gut barrier function, inflammation and the insulin resistance associated with obesity...
  8. pmc Involvement of gut microbial fermentation in the metabolic alterations occurring in n-3 polyunsaturated fatty acids-depleted mice
    Barbara D Pachikian
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Nutr Metab (Lond) 8:44. 2011
    ..abstract:..
  9. pmc Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome
    Nathalie M Delzenne
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Microb Cell Fact 10:S10. 2011
    ....
  10. doi Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
    Patrice D Cani
    Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Am J Clin Nutr 90:1236-43. 2009
    ..In rodents, these effects are associated with an increase in plasma gut peptide concentrations, which are involved in appetite regulation and glucose homeostasis...
  11. pmc Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gut 58:1091-103. 2009
    ....
  12. ncbi Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Av E Mounier, 73 69, 1200 Brussels, Belgium
    Diabetologia 50:2374-83. 2007
    ..caecal content in mice. We therefore tested whether restoration of the quantity of caecal Bifidobacterium spp. could modulate metabolic endotoxaemia, the inflammatory tone and the development of diabetes...
  13. ncbi Involvement of the gut microbiota in the development of low grade inflammation associated with obesity: focus on this neglected partner
    P D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Acta Gastroenterol Belg 73:267-9. 2010
    ....
  14. doi The gut microbiome as therapeutic target
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Pharmacol Ther 130:202-12. 2011
    ....
  15. ncbi The role of the gut microbiota in energy metabolism and metabolic disease
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Brussels, Belgium
    Curr Pharm Des 15:1546-58. 2009
    ..Thus, it would be useful to find specific strategies for modifying gut microbiota to impact on the occurrence of metabolic diseases...
  16. doi Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, avenue E Mounier, 73 69, 1200 Brussels, Belgium
    Pathol Biol (Paris) 56:305-9. 2008
    ..Therefore, specific strategies aiming to regulate gut microbiota could be useful means to reduce the impact of high-fat feeding on the occurrence of metabolic diseases...
  17. doi Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, PMNT Unit, Brussels, Belgium
    Curr Opin Pharmacol 9:737-43. 2009
    ....
  18. ncbi Oligofructose promotes satiety in healthy human: a pilot study
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Clin Nutr 60:567-72. 2006
    ..The aim of the study was to assess the relevance of those effects of oligofructose on satiety and energy intake in humans...
  19. doi Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice
    Florence M Sohet
    Louvain Drug Research Institute, Nutrition and Metabolism Research Group, Universite Catholique de Louvain, Brussels, Belgium
    Biochem Pharmacol 78:1391-400. 2009
    ..Diabetes and obesity are metabolic disorders induced by an excessive dietary intake of fat, usually related to inflammation and oxidative stress...
  20. doi Lipid peroxidation is not a prerequisite for the development of obesity and diabetes in high-fat-fed mice
    Florence M Sohet
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier 73 69, Brussels, Belgium
    Br J Nutr 102:462-9. 2009
    ..Thus, lipid peroxidation in key organs is not necessarily related to the development of metabolic disorders associated with diabetes and obesity...
  21. doi Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics
    L Geurts
    WELBIO, Walloon Excellence in Life Sciences and BIOtechnology Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Universite Catholique de Louvain, Av E Mounier, 73 Box B1 73 11, 1200 Brussels, Belgium
    Benef Microbes 5:3-17. 2014
    ..e. inulin-type fructans, arabinoxylans, chitin glucans and polyphenols). Their effects on the composition of the gut microbiota and activity are discussed in the context of obesity and type 2 diabetes. ..
  22. pmc Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition
    B D Pachikian
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    BMC Physiol 8:21. 2008
    ..This experiment carried out in mice aims at studying the impact of dietary n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic metabolism...
  23. ncbi Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    J Nutr 137:2547S-2551S. 2007
    ..Several studies in humans already support interest in OFS in the control of satiety, triglyceridemia, or steatohepatitis. The link with gut peptides production in humans remains to be proven...
  24. doi [Gut microflora is a key player in host energy homeostasis]
    Nathalie M Delzenne
    Universite Catholique de Louvain, Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Bruxelles, Belgique UCL, Unit PMNT 7369, avenue E Mounier, 73 69, B 1200 Bruxelles, Belgique
    Med Sci (Paris) 24:505-10. 2008
    ..Changing gut microflora composition could be a useful tool to prevent or to treat high-fat/low fibres diet-induced metabolic syndrome. double dagger...
  25. pmc The endocannabinoid system links gut microbiota to adipogenesis
    Giulio G Muccioli
    Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Mol Syst Biol 6:392. 2010
    ..These data indicate that gut microbiota determine adipose tissue physiology through LPS-eCB system regulatory loops and may have critical functions in adipose tissue plasticity during obesity...
  26. doi Kupffer cell activation is a causal factor for hepatic insulin resistance
    Nicolas Lanthier
    Laboratoire de gastro entérologie, Universite Catholique de Louvain, GAEN 53 79, Ave Mounier 53, B 1200 Brussels, Belgium
    Am J Physiol Gastrointest Liver Physiol 298:G107-16. 2010
    ....
  27. ncbi Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice
    Evelyne Delmée
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Life Sci 79:1007-13. 2006
    ..This remains to be proven in human studies...
  28. ncbi Impact of inulin and oligofructose on gastrointestinal peptides
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, MD FARM PMNT 7369, Universite Catholique de Louvain, Avenue E Mounier 73, B 1200 Brussels, Belgium
    Br J Nutr 93:S157-61. 2005
    ....
  29. pmc Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
    L B Bindels
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Br J Cancer 107:1337-44. 2012
    ..We have tested the hypothesis that inulin-type fructans (ITF), by promoting microbial production of short-chain fatty acids (SCFA), influence cancer cell proliferation outside the gut...
  30. doi Critical role of Kupffer cells in the management of diet-induced diabetes and obesity
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Biochem Biophys Res Commun 385:351-6. 2009
    ..Therefore, strategies targeting Kupffer cell functions could be a promising approach to counteract obesity and related metabolic disorders...
  31. doi Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice, a phenomenon linked to its lipid-lowering action
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, PMNT7369 73 av Mounier, B 1200 Brussels, Belgium
    Int Immunopharmacol 9:767-73. 2009
    ....
  32. ncbi Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide
    Patrice D Cani
    Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie, Ecole de Pharmacie, Universite Catholique de Louvain, Brussels, Belgium
    Br J Nutr 92:757-61. 2004
    ....
  33. doi Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
    ..e., metabolic endotoxemia. Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases...
  34. pmc Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice
    A M Neyrinck
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    Nutr Diabetes 2:e28. 2012
    ..Conclusion:Together, these findings suggest that specific non-digestible carbohydrates produced from cereals such as AXOS constitute a promising prebiotic nutrient in the control of obesity and related metabolic disorders...
  35. doi Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice
    Barbara D Pachikian
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels 1200, Belgium
    J Nutr 140:509-14. 2010
    ....
  36. ncbi Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, PMNT 73 69, Universite Catholique de Louvain, Av E Mounier, Brussels, Belgium
    Br J Nutr 98:32-7. 2007
    ..These results suggest a new mechanism by which dietary fibres may lower food intake and fat mass development...
  37. doi Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet
    Audrey M Neyrinck
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Int Immunopharmacol 8:1423-32. 2008
    ..We propose that specific and early immunomodulatory properties of cereal products with prebiotic properties, may occur in obese mice independently of extensive gut fermentation...
  38. ncbi Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    J Endocrinol 185:457-65. 2005
    ....
  39. ncbi A place for dietary fibre in the management of the metabolic syndrome
    Nathalie M Delzenne
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Catholic University of Louvain, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 8:636-40. 2005
    ..This review discusses factors that may explain how dietary fibre would be helpful in the management of food intake, body weight and metabolic syndrome...
  40. doi Prebiotic effects: metabolic and health benefits
    Marcel Roberfroid
    Universite Catholique de Louvain, Brussels, Belgium
    Br J Nutr 104:S1-63. 2010
    ....
  41. pmc Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    Amandine Everard
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 60:2775-86. 2011
    ..To investigate deep and comprehensive analysis of gut microbial communities and biological parameters after prebiotic administration in obese and diabetic mice...
  42. pmc Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    Claude Knauf
    UMR 5018, Universite Paul Sabatier, IFR31, Toulouse, France USA
    J Clin Invest 115:3554-63. 2005
    ..Our data show that during hyperglycemia, brain GLP-1 inhibited muscle glucose utilization and increased insulin secretion to favor hepatic glycogen stores, preparing efficiently for the next fasting state...
  43. ncbi Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1
    Patrice D Cani
    Université Catholique de Louvain Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie 7369, 73 Avenue Mounier, B 1200 Brussels, Belgium
    Obes Res 13:1000-7. 2005
    ..To analyze the putative interest of oligofructose (OFS) in the modulation of food intake after high-fat diet in rats and to question the relevance of the expression and secretion of intestinal peptides in that context...
  44. ncbi Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor
    Patrice D Cani
    CNRS UMR 5018, University Paul Sabatier, Hopital Rangueil, 1 BP 84225, 31432 Toulouse Cedex 4, France
    Diabetes 55:1484-90. 2006
    ..In summary, our data show that the antidiabetic actions of OFS require a functional GLP-1 receptor. These findings highlight the therapeutic potential of enhancing endogenous GLP-1 secretion for the treatment of type 2 diabetes...
  45. ncbi Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain
    Claude Knauf
    Unit Mixte de Recherche, 5018, Centre National de la Recherche Scientifique University Paul Sabatier, IFR 31, Bt L1 Rue J Poulhès, 31403 Toulouse, France
    Endocrinology 147:4067-78. 2006
    ..By contrast, activation of PPARalpha in the brain stimulates peripheral glucose use. This suggests that the alteration in adipocyte glucose metabolism in the knockout mice may result from the absence of PPARalpha in the brain...
  46. doi Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice
    Mathieu Membrez
    Nestle Research Center, P O Box 44, CH 1000 Lausanne, Switzerland
    FASEB J 22:2416-26. 2008
    ....
  47. doi Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure
    Claude Knauf
    Institut de Medecine Moleculaire de Rangueil, Toulouse III University, Centre Hospitalier Universitaire Rangueil, BP84225, 31432 Toulouse Cedex 4, France
    Endocrinology 149:4768-77. 2008
    ..Thus, we have demonstrated that in response to a HFD, brain GLP-1 signaling induces hyperinsulinemia and insulin resistance and decreases energy expenditure by reducing metabolic thermogenesis and ambulatory activity...
  48. ncbi Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes
    J Andrew Pospisilik
    Institute of Molecular Biotechnology of the Austrian Academy of Science, Dr Bohrgasse 3, 1030, Vienna, Austria
    Cell 131:476-91. 2007
    ..These findings establish that tissue-specific as well as global OxPhos defects in mice can counteract the development of insulin resistance, diabetes, and obesity...
  49. ncbi Energy intake is associated with endotoxemia in apparently healthy men
    Jacques Amar
    INSERM 558, Toulouse, France
    Am J Clin Nutr 87:1219-23. 2008
    ..The bridge between food intake and weight is not fully understood. Recently, the role of gut microbiota and bacterial lipopolysacharides (LPS) in weight has been noted...
  50. ncbi Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
    ..We conclude that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity. Lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases...
  51. pmc Effect on components of the intestinal microflora and plasma neuropeptide levels of feeding Lactobacillus delbrueckii, Bifidobacterium lactis, and inulin to adult and elderly rats
    Violetta Lesniewska
    Northern Ireland Centre of Food and Health, University of Ulster, Coleraine, United Kingdom
    Appl Environ Microbiol 72:6533-8. 2006
    ....
  52. ncbi GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion
    Patrice D Cani
    Institut de Medecine Moleculaire de Rangueil, I 2 MR, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Cell Endocrinol 276:18-23. 2007
    ..In conclusion, both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2...
  53. ncbi Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
    Fabrizio Andreelli
    Institut National de la Santé et de la Recherche Médicale Unité 567, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Universite Rene Descartes Paris 5, France
    Endocrinology 147:2432-41. 2006
    ..We also demonstrate that regulation of hepatic glucose production by leptin and adiponectin, but not insulin, requires hepatic AMPKalpha2 activity...
  54. ncbi Central insulin regulates heart rate and arterial blood flow: an endothelial nitric oxide synthase-dependent mechanism altered during diabetes
    Cendrine Cabou
    INSERM U858, Institute of Molecular Medicine, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Diabetes 56:2872-7. 2007
    ..Its role in the central nervous system remains to be determined. We studied the effects of central insulin infusion on femoral arterial blood flow and heart rate in normal chow-fed, high-fat diet-fed diabetic, and eNOS-null mice...
  55. ncbi [GLP-1 and cerebral detection of glucose, a key mechanism for the regulation of glucose homeostasis]
    Remy Burcelin
    Med Sci (Paris) 22:237-9. 2006
  56. ncbi Lower insulin secretory response to glucose induced by artificial nutrition in children: prolonged and total parenteral nutrition
    Jacques Beltrand
    INSERM, U690, Paris, 75019, France
    Pediatr Res 62:624-9. 2007
    ..These data emphasize that metabolic conditions induced by TPN can lead to lower insulin secretory response to glucose. Patients who remain dependent on TPN are at risk of developing glucose tolerance disorders...
  57. ncbi Glucagon-like peptide-1 and energy homeostasis
    Remy Burcelin
    Institute of Molecular Medicine Rangueil IMR, INSERM 858, Universite Paul Sabatier, IFR31, CHU Rangueil, Toulouse Cedex 4, France
    J Nutr 137:2534S-2538S. 2007
    ..Furthermore, recent evidence has suggested that the nervous system is a key player accounting for the beneficial role of GLP-1 on the control of energy homeostasis. Hence, the role of GLP-1 on the gut-to-brain axis is reviewed...
  58. ncbi Physiological effects of dietary fructans extracted from Agave tequilana Gto. and Dasylirion spp
    Judith E Urías-Silvas
    Unidad de Biotecnología e Ingeniería Genética de Plantas, CINVESTAV IPN Unidad Irapuato, A P 629, Irapuato, Gto, 36500, Mexico
    Br J Nutr 99:254-61. 2008
    ....