Melanie Boly

Summary

Country: Belgium

Publications

  1. doi Brain connectivity in disorders of consciousness
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
    Brain Connect 2:1-10. 2012
  2. pmc Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and Sart Tilman Hospital, 4000 Liege, Belgium
    J Neurosci 32:7082-90. 2012
  3. doi Measuring the fading consciousness in the human brain
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
    Curr Opin Neurol 24:394-400. 2011
  4. ncbi Preserved feedforward but impaired top-down processes in the vegetative state
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, 4000 Liege, Belgium
    Science 332:858-62. 2011
  5. pmc Changes in effective connectivity by propofol sedation
    Francisco Gomez
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Liege, Belgium
    PLoS ONE 8:e71370. 2013
  6. doi Thalamus, brainstem and salience network connectivity changes during propofol-induced sedation and unconsciousness
    Pieter Guldenmund
    Coma Science Group, Cyclotron Research Center, University of Liege, Liege, Belgium
    Brain Connect 3:273-85. 2013
  7. pmc Visual fixation in the vegetative state: an observational case series PET study
    Marie Aurelie Bruno
    Coma Science Group and Cyclotron Research Centre, University of Liege, Liege, Belgium
    BMC Neurol 10:35. 2010
  8. ncbi Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state
    Melanie Boly
    Cyclotron Research Center, University of Liege, Liege, Belgium
    Arch Neurol 61:233-8. 2004
  9. doi A French validation study of the Coma Recovery Scale-Revised (CRS-R)
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Brain Inj 22:786-92. 2008
  10. ncbi Perception of pain in the minimally conscious state with PET activation: an observational study
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Lancet Neurol 7:1013-20. 2008

Detail Information

Publications50

  1. doi Brain connectivity in disorders of consciousness
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
    Brain Connect 2:1-10. 2012
    ..We will also discuss the relevance of the study of the level versus the contents of consciousness in this context...
  2. pmc Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and Sart Tilman Hospital, 4000 Liege, Belgium
    J Neurosci 32:7082-90. 2012
    ..These results emphasize the importance of recurrent corticocortical communication in the maintenance of consciousness and suggest a direct effect of propofol on cortical dynamics...
  3. doi Measuring the fading consciousness in the human brain
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
    Curr Opin Neurol 24:394-400. 2011
    ..Recent neuroimaging studies have provided novel insights on residual brain function in patients with disorders of consciousness, but also raised a number of ethical issues concerning the clinical management of these patients...
  4. ncbi Preserved feedforward but impaired top-down processes in the vegetative state
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, 4000 Liege, Belgium
    Science 332:858-62. 2011
    ..This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception...
  5. pmc Changes in effective connectivity by propofol sedation
    Francisco Gomez
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Liege, Belgium
    PLoS ONE 8:e71370. 2013
    ....
  6. doi Thalamus, brainstem and salience network connectivity changes during propofol-induced sedation and unconsciousness
    Pieter Guldenmund
    Coma Science Group, Cyclotron Research Center, University of Liege, Liege, Belgium
    Brain Connect 3:273-85. 2013
    ..It furthermore stresses the necessity of also examining resting state connectivity in networks representing arousal, not only those associated with awareness...
  7. pmc Visual fixation in the vegetative state: an observational case series PET study
    Marie Aurelie Bruno
    Coma Science Group and Cyclotron Research Centre, University of Liege, Liege, Belgium
    BMC Neurol 10:35. 2010
    ..e., represents "automatic" subcortical processing) or is a sufficient sign of consciousness and higher order cortical processing...
  8. ncbi Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state
    Melanie Boly
    Cyclotron Research Center, University of Liege, Liege, Belgium
    Arch Neurol 61:233-8. 2004
    ..The minimally conscious state (MCS) is a recently defined clinical condition; it differs from the persistent vegetative state (PVS) by the presence of inconsistent, but clearly discernible, behavioral evidence of consciousness...
  9. doi A French validation study of the Coma Recovery Scale-Revised (CRS-R)
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Brain Inj 22:786-92. 2008
    ....
  10. ncbi Perception of pain in the minimally conscious state with PET activation: an observational study
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Lancet Neurol 7:1013-20. 2008
    ..Therefore, better understanding of cerebral noxious processing in these patients is of clinical, therapeutic, and ethical relevance...
  11. pmc Interaction between hippocampal and striatal systems predicts subsequent consolidation of motor sequence memory
    Geneviève Albouy
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    PLoS ONE 8:e59490. 2013
    ..The latter process appears to be supported by a reorganisation of cerebral activity in hippocampo-neocortical networks after sleep...
  12. ncbi Metabolic activity in external and internal awareness networks in severely brain-damaged patients
    Aurore Thibaut
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, 4000 Liege, Belgium
    J Rehabil Med 44:487-94. 2012
    ..This study measured brain metabolism in both networks in patients with severe brain damage...
  13. pmc Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients
    Audrey Vanhaudenhuyse
    Coma Science Group, Cyclotron Research Centre, University of Liege, Allee du 6 Aout, B30, Liege, Belgium
    Brain 133:161-71. 2010
    ..Future prospective studies in a larger patient population are needed in order to evaluate the prognostic value of the presented methodology...
  14. doi Detecting consciousness in a total locked-in syndrome: an active event-related paradigm
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurocase 15:271-7. 2009
    ..This study shows that our active event-related paradigm allowed to identify voluntary brain activity in a patient who would behaviorally be diagnosed as comatose...
  15. doi Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness
    Pierre Boveroux
    Department of Anesthesia and Intensive Care Medicine, University of Liege, Liege, Belgium
    Anesthesiology 113:1038-53. 2010
    ..Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness...
  16. doi Is there anybody in there? Detecting awareness in disorders of consciousness
    Athena Demertzi
    Coma Science Group, Neurology Department, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Expert Rev Neurother 8:1719-30. 2008
    ....
  17. doi [Neuroimaging technique: a diagnostic tool to detect altered states of consciousness]
    Marie Thonnard
    Coma Science Group, Centre de Recherches du Cyclotron, Université et Centre Hospitalier Universitaire de Liège, Sart Tilman, B30, 4000 Liege, Belgique
    Med Sci (Paris) 27:77-81. 2011
    ..The implementation of these methods in clinical routine could permit to reduce the current high rate of misdiagnosis (40%)...
  18. doi The Nociception Coma Scale: a new tool to assess nociception in disorders of consciousness
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Sart Tilman, Liege, Belgium
    Pain 148:215-9. 2010
    ..e., VS or MCS). The NCS constitutes a sensitive clinical tool for assessing nociception in severely brain-injured patients. This scale constitutes the first step to a better management of patients recovering from coma...
  19. pmc Sleep transforms the cerebral trace of declarative memories
    Steffen Gais
    Cyclotron Research Center, University of Liege, Allée du 6 août 8, B30, 4000 Liege, Belgium
    Proc Natl Acad Sci U S A 104:18778-83. 2007
    ..Six months after learning, memories activated the mPFC more strongly when they were encoded before sleep, showing that sleep leads to long-lasting changes in the representation of memories on a systems level...
  20. doi Two distinct neuronal networks mediate the awareness of environment and of self
    Audrey Vanhaudenhuyse
    University of Liege, Liege, Belgium
    J Cogn Neurosci 23:570-8. 2011
    ....
  21. doi Brain function in physiologically, pharmacologically, and pathologically altered states of consciousness
    Pierre Boveroux
    Department of Neurology, Coma Science Group, University of Liege, Liege, Belgium
    Int Anesthesiol Clin 46:131-46. 2008
  22. doi Neuroimaging after coma
    Luaba Tshibanda
    Coma Science Group, Cyclotron Research Center, University and University Hospital of Liège, Sart Tilman, B30 Liège, Belgium
    Neuroradiology 52:15-24. 2010
    ....
  23. ncbi Reaching across the abyss: recent advances in functional magnetic resonance imaging and their potential relevance to disorders of consciousness
    Andrea Soddu
    Coma Science Group, Cyclotron Research Centre, University of Liege, Belgium
    Prog Brain Res 177:261-74. 2009
    ..In particular, we discuss the potential provided by assessment of these slow spontaneous BOLD fluctuations as a novel tool in assessing the cognitive state and chances of recovery from brain pathologies underlying DOCs...
  24. doi Brain functional integration decreases during propofol-induced loss of consciousness
    Jessica Schrouff
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 57:198-205. 2011
    ..They stress the important role played by parietal and frontal areas in the generation of consciousness...
  25. doi Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness
    Andrea Soddu
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Hum Brain Mapp 33:778-96. 2012
    ..We here aimed to identify the DMN in the challenging patient population of disorders of consciousness encountered following coma...
  26. doi Neural correlates of performance variability during motor sequence acquisition
    Geneviève Albouy
    Cyclotron Research Centre, University of Liege, B30, Sart Tilman, B 4000, Liege, Belgium
    Neuroimage 60:324-31. 2012
    ..Our results suggest that these dynamic large-scale interactions represent a cornerstone in the implementation of consistent motor behavior in humans...
  27. ncbi Response to comment on "preserved feedforward but impaired top-down processes in the vegetative state"
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
    Science 334:1203. 2011
    ..We welcome the opportunity to provide more details about our methods and results and to resolve their concerns. We substantiate our interpretation of the results and provide a point-by-point response to the issues raised...
  28. doi "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients
    Christophe L Phillips
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 56:797-808. 2011
    ..Therefore, RVM classification of cerebral metabolic images obtained in coma survivors could become a useful tool for the automated PET-based diagnosis of altered states of consciousness...
  29. ncbi Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients
    Marie Aurelie Bruno
    Coma Science Group, Cyclotron Research Center, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    J Neurol 259:1087-98. 2012
    ..MCS+ patients showed preserved metabolism and functional connectivity in language networks arguably reflecting some additional higher order or extended consciousness albeit devoid of clinical verbal or nonverbal expression...
  30. pmc Hierarchical clustering of brain activity during human nonrapid eye movement sleep
    Melanie Boly
    Cyclotron Research Centre, University of Liege, 4000 Liege, Belgium
    Proc Natl Acad Sci U S A 109:5856-61. 2012
    ..Such modifications in brain connectivity, possibly driven by sleep ultraslow oscillations, could hinder the brain's ability to integrate information and account for decreased consciousness during NREM sleep...
  31. ncbi Neuroimaging activation studies in the vegetative state: predictors of recovery?
    Haibo Di
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Belgium
    Clin Med 8:502-7. 2008
    ..The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness...
  32. doi Nociception coma scale-revised scores correlate with metabolism in the anterior cingulate cortex
    Camille Chatelle
    1University of Liege, Liege, Belgium
    Neurorehabil Neural Repair 28:149-52. 2014
    ..The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possible pain perception in patients with disorders of consciousness...
  33. ncbi Theoretical approaches to the diagnosis of altered states of consciousness
    Melanie Boly
    Coma Science Group, Cyclotron Research Center and Neurology Department, University of Liege, CHU Sart Tilman Hospital, Liege, Belgium
    Prog Brain Res 177:383-98. 2009
    ..Nevertheless, we argue that some of the predictions of the theory are potentially testable using available imaging techniques...
  34. doi Consciousness and cerebral baseline activity fluctuations
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Liege, Belgium
    Hum Brain Mapp 29:868-74. 2008
    ..We place these findings in light of recent findings on the architecture of spontaneous BOLD fluctuations in the awake human brain, and discuss the possible origins of the observed baseline brain activity fluctuations...
  35. doi Consciousness and responsiveness: lessons from anaesthesia and the vegetative state
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege and CHU Sart Tilman, Liege, Belgium
    Curr Opin Anaesthesiol 26:444-9. 2013
    ..The aim of this article is to review recent behavioural and neuroimaging studies in anaesthesia and the vegetative state...
  36. ncbi Magnetic resonance spectroscopy and diffusion tensor imaging in coma survivors: promises and pitfalls
    Luaba Tshibanda
    Coma Science Group, Cyclotron Research Center and Neurology Department, University and University Hospital of Liège, Belgium
    Prog Brain Res 177:215-29. 2009
    ..This review will focus on the interest of comatose patients MRI multimodal assessment with MRS and DTI. It will emphasize the advantages and pitfalls of these techniques in particular in predicting the coma survivors' outcome...
  37. ncbi Naloxone-insensitive epidural placebo analgesia in a chronic pain patient
    Ron Kupers
    PET Unit and Section of Surgical Pathophysiology, Rigshospitalet, Copenhagen, Denmark, and Neurology Department, University of Liege, Liege, Belgium
    Anesthesiology 106:1239-42. 2007
  38. pmc Tracking the recovery of consciousness from coma
    Steven Laureys
    Cyclotron Research Center and Department of Neurology, University of Liege, Liege, Belgium
    J Clin Invest 116:1823-5. 2006
    ..This case shows that old dogmas need to be oppugned, as recovery with meaningful reduction in disability continued in this case for nearly 2 decades after extremely severe traumatic brain injury...
  39. ncbi What is it like to be vegetative or minimally conscious?
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 20:609-13. 2007
    ..Here we review current possibilities and limitations of clinical and para-clinical assessment of chronic disorders of consciousness...
  40. pmc Brain connectivity in pathological and pharmacological coma
    Quentin Noirhomme
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège Liège, Belgium
    Front Syst Neurosci 4:160. 2010
    ..These results suggest that conscious awareness critically depends on the functional integrity of thalamo-cortical and cortico-cortical frontoparietal connectivity within and between "intrinsic" and "extrinsic" brain networks...
  41. pmc Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    BMC Neurol 9:35. 2009
    ..In this study, we compared consensus-based diagnoses of VS and MCS to those based on a well-established standardized neurobehavioral rating scale, the JFK Coma Recovery Scale-Revised (CRS-R)...
  42. ncbi Brain function in the vegetative state
    Steven Laureys
    Cyclotron Research Center, Department of Neurology, CHU Sart Tilman, University of Liege, Liege, Belgium
    Acta Neurol Belg 102:177-85. 2002
    ....
  43. pmc Sleep-related hippocampo-cortical interplay during emotional memory recollection
    Virginie Sterpenich
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    PLoS Biol 5:e282. 2007
    ..After sleep deprivation, recollection of negative, potentially dangerous, memories recruits an alternate amygdalo-cortical network, which would keep track of emotional information despite sleep deprivation...
  44. doi Cognitive function in the locked-in syndrome
    Caroline Schnakers
    Cyclotron Research Center, University of Liege, Belgium
    J Neurol 255:323-30. 2008
    ..Classically, communication remains possible by means of spared vertical eye movements and/or blinking. To allow assessing cognitive functions in LIS patients, we propose here a neuropsychological testing based on eye-coded communication...
  45. doi Influence of anesthesia on cerebral blood flow, cerebral metabolic rate, and brain functional connectivity
    Vincent Bonhomme
    University Department of Anesthesia and ICM, CHR Citadelle, Belgium
    Curr Opin Anaesthesiol 24:474-9. 2011
    ..To describe recent studies exploring brain function under the influence of hypnotic anesthetic agents, and their implications on the understanding of consciousness physiology and anesthesia-induced alteration of consciousness...
  46. pmc Spontaneous neural activity during human slow wave sleep
    Thien Thanh Dang-Vu
    Cyclotron Research Centre, University of Liege, B4000 Liege, Belgium
    Proc Natl Acad Sci U S A 105:15160-5. 2008
    ....
  47. ncbi Residual cognitive function in comatose, vegetative and minimally conscious states
    Steven Laureys
    Cyclotron Research Centre, University of Liege, Belgium
    Curr Opin Neurol 18:726-33. 2005
    ..In addition to novel behavioural 'consciousness-scales', the role of para-clinical markers of consciousness, such as event related potentials and functional neuroimaging is reviewed...
  48. ncbi Measuring consciousness in severely damaged brains
    Olivia Gosseries
    Coma Science Group, Cyclotron Research Center and Neurology Department, University of Liege, and University Hospital of Liege, 4000 Liege, Belgium email
    Annu Rev Neurosci 37:457-78. 2014
    ..The promise of such theoretically based markers is illustrated by recent findings that used a perturbational approach to assess the levels of consciousness. Further research on the contents of consciousness in DOC is also needed. ..
  49. ncbi Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine
    Arnaud Fumal
    Department of Neurology, University of Liege, Liege, Belgium
    Brain 129:543-50. 2006
    ..The latter is known to occur in drug dependence and could predispose subgroups of migraineurs to recurrent analgesic overuse...
  50. ncbi Human cognition during REM sleep and the activity profile within frontal and parietal cortices: a reappraisal of functional neuroimaging data
    Pierre Maquet
    Cyclotron Research Centre, University of Lièege Sart Tilman, 4000 Liege, Belgium
    Prog Brain Res 150:219-27. 2005
    ....