Cedric Blanpain

Summary

Country: Belgium

Publications

  1. pmc Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis
    Alexandra Van Keymeulen
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, Brussels B 1070, Belgium
    J Cell Biol 187:91-100. 2009
  2. pmc Tracing epithelial stem cells during development, homeostasis, and repair
    Alexandra Van Keymeulen
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, B 1070 Bruxelles, Belgium
    J Cell Biol 197:575-84. 2012
  3. pmc Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation
    Antoine Bondue
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, B1070 Bruxelles, Belgium
    J Cell Biol 192:751-65. 2011
  4. ncbi request reprint Unravelling stem cell dynamics by lineage tracing
    Cedric Blanpain
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Brussels, Belgium
    Nat Rev Mol Cell Biol 14:489-502. 2013
  5. doi request reprint Tracing the cellular origin of cancer
    Cedric Blanpain
    Universite Libre de Bruxelles, IRIBHM and WELBIO, Brussels, Belgium
    Nat Cell Biol 15:126-34. 2013
  6. doi request reprint Stem cells assessed
    Cedric Blanpain
    Walloon Excellence in Life Science and Biotechnology, Interdisciplinary Research Institute, Universite Libre de Bruxelles, 808, Route de Lennik, BatC, C6 130, 1070 Brussels, Belgium
    Nat Rev Mol Cell Biol 13:471-6. 2012
  7. ncbi request reprint [Epidermal stem cells]
    C Blanpain
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Campus Hospitalo Facultaire Erasme, Bruxelles, Belgique
    Bull Mem Acad R Med Belg 162:418-24; discussion 424-6. 2007
  8. doi request reprint DNA-damage response in tissue-specific and cancer stem cells
    Cedric Blanpain
    Universite Libre de Bruxelles, IRIBHM, B1070 Bruxelles, Belgium
    Cell Stem Cell 8:16-29. 2011
  9. ncbi request reprint [Impact of beta-catenin signaling pathway on stem cell differentiation in the skin]
    Cedric Blanpain
    Institut de Recherche Interdisciplinaire IRIBHM, Universite Libre de Bruxelles, 808 Route de Lennik, Batiment C, 1070 Bruxelles, Belgique
    Med Sci (Paris) 23:34-6. 2007
  10. doi request reprint Identification of the cell lineage at the origin of basal cell carcinoma
    Khalil Kass Youssef
    Universite Libre de Bruxelles ULB, IRIBHM, Brussels B 1070, Belgium
    Nat Cell Biol 12:299-305. 2010

Collaborators

Detail Information

Publications37

  1. pmc Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis
    Alexandra Van Keymeulen
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, Brussels B 1070, Belgium
    J Cell Biol 187:91-100. 2009
    ..Our study demonstrates that MCs arise from the epidermis by an Atoh1-dependent mechanism and opens new avenues for study of MC functions in sensory perception, neuroendocrine signaling, and MC carcinoma...
  2. pmc Tracing epithelial stem cells during development, homeostasis, and repair
    Alexandra Van Keymeulen
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, B 1070 Bruxelles, Belgium
    J Cell Biol 197:575-84. 2012
    ..This technique has been instrumental in characterizing the origin and heterogeneity of epithelial SCs, their tissue location, and their differentiation potential under physiological conditions and during tissue regeneration...
  3. pmc Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation
    Antoine Bondue
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, B1070 Bruxelles, Belgium
    J Cell Biol 192:751-65. 2011
    ..Our study identifies the early MCPs residing at the top of the cellular hierarchy of cardiovascular lineages during ESC differentiation...
  4. ncbi request reprint Unravelling stem cell dynamics by lineage tracing
    Cedric Blanpain
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Brussels, Belgium
    Nat Rev Mol Cell Biol 14:489-502. 2013
    ..These are powerful techniques to address new questions and paradigms in transgenic mouse models and other model systems. ..
  5. doi request reprint Tracing the cellular origin of cancer
    Cedric Blanpain
    Universite Libre de Bruxelles, IRIBHM and WELBIO, Brussels, Belgium
    Nat Cell Biol 15:126-34. 2013
    ....
  6. doi request reprint Stem cells assessed
    Cedric Blanpain
    Walloon Excellence in Life Science and Biotechnology, Interdisciplinary Research Institute, Universite Libre de Bruxelles, 808, Route de Lennik, BatC, C6 130, 1070 Brussels, Belgium
    Nat Rev Mol Cell Biol 13:471-6. 2012
    ....
  7. ncbi request reprint [Epidermal stem cells]
    C Blanpain
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Campus Hospitalo Facultaire Erasme, Bruxelles, Belgique
    Bull Mem Acad R Med Belg 162:418-24; discussion 424-6. 2007
  8. doi request reprint DNA-damage response in tissue-specific and cancer stem cells
    Cedric Blanpain
    Universite Libre de Bruxelles, IRIBHM, B1070 Bruxelles, Belgium
    Cell Stem Cell 8:16-29. 2011
    ..Finally, we will discuss how similar mechanisms operate in cancer stem cells (CSCs) and can mediate resistance to chemo- and radiotherapy...
  9. ncbi request reprint [Impact of beta-catenin signaling pathway on stem cell differentiation in the skin]
    Cedric Blanpain
    Institut de Recherche Interdisciplinaire IRIBHM, Universite Libre de Bruxelles, 808 Route de Lennik, Batiment C, 1070 Bruxelles, Belgique
    Med Sci (Paris) 23:34-6. 2007
  10. doi request reprint Identification of the cell lineage at the origin of basal cell carcinoma
    Khalil Kass Youssef
    Universite Libre de Bruxelles ULB, IRIBHM, Brussels B 1070, Belgium
    Nat Cell Biol 12:299-305. 2010
    ..Our studies uncover the cells at the origin of BCC in mice and demonstrate that expression of differentiation markers in tumour cells is not necessarily predictive of the cancer initiating cells...
  11. ncbi request reprint Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
    Panagiota A Sotiropoulou
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles ULB, 808, Route de Lennik, BatC, C6 130, 1070 Brussels, Belgium
    Nat Cell Biol 12:572-82. 2010
    ..Because NHEJ is an error-prone mechanism, this novel characteristic of adult SCs may have important implications in cancer development and ageing...
  12. doi request reprint Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
    Khalil Kass Youssef
    IRIBHM, Universite Libre de Bruxelles ULB, 808 Route de Lennik, 1070 Brussels, Belgium
    Nat Cell Biol 14:1282-94. 2012
    ..Deletion of β-catenin in adult SmoM2-expressing cells prevents EHFP reprogramming and tumour initiation. Finally, human basal cell carcinomas also express genes of the Wnt signalling and EHFP signatures...
  13. pmc Identifying the cellular origin of squamous skin tumors
    Gaelle Lapouge
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Proc Natl Acad Sci U S A 108:7431-6. 2011
    ..Our studies demonstrate that different epidermal lineages including bulge SC are competent to initiate papilloma formation and that multiple genetic hits in the context of oncogenic KRas are required for the development of invasive SCC...
  14. ncbi request reprint Distinct contribution of stem and progenitor cells to epidermal maintenance
    Guilhem Mascre
    Universite Libre de Bruxelles, IRIBHM, Brussels B 1070, Belgium
    Nature 489:257-62. 2012
    ..After wounding, only stem cells contribute substantially to the repair and long-term regeneration of the tissue, whereas committed progenitor cells make a limited contribution...
  15. doi request reprint Distinct stem cells contribute to mammary gland development and maintenance
    Alexandra Van Keymeulen
    Universite Libre de Bruxelles, IRIBHM, Brussels B 1070, Belgium
    Nature 479:189-93. 2011
    ....
  16. pmc Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness
    Gaelle Lapouge
    IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    EMBO J 31:4563-75. 2012
    ..Our results illustrate the progressive increase of squamous skin TPCs with tumour progression and invasiveness and reveal that serial transplantation may be required to define the long-term renewal potential of TPCs...
  17. ncbi request reprint Multipotent and unipotent progenitors contribute to prostate postnatal development
    Marielle Ousset
    Universite Libre de Bruxelles ULB, IRIBHM, Brussels B 1070, Belgium
    Nat Cell Biol 14:1131-8. 2012
    ..Our results uncover the cellular hierarchy acting during prostate development and will be instrumental in defining the cellular origin and the mechanisms underlying prostate cancer initiation...
  18. ncbi request reprint Defining the mode of tumour growth by clonal analysis
    Gregory Driessens
    Universite Libre de Bruxelles, IRIBHM, Brussels B 1070, Belgium
    Nature 488:527-30. 2012
    ..This study presents the first experimental evidence for the existence of CSCs during unperturbed solid tumour growth...
  19. pmc BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny
    Panagiota A Sotiropoulou
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, Brussels, Belgium
    Genes Dev 27:39-51. 2013
    ..Our data reveal a major difference in the requirement of BRCA1 between different types of epidermal SCs and progenitors and during the different activation stages of adult HF SCs...
  20. doi request reprint Unravelling cancer stem cell potential
    Benjamin Beck
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Universite Libre de Bruxelles ULB, 808 Route de Lennik, 1070 Brussels, Belgium
    Nat Rev Cancer 13:727-38. 2013
    ..In this Opinion article, we discuss the different parallels that can be drawn between adult SCs and CSCs in solid tumours. ..
  21. doi request reprint A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours
    Benjamin Beck
    IRIBHM, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Nature 478:399-403. 2011
    ..Finally, deletion of Nrp1 in normal epidermis prevents skin tumour initiation. These results may have important implications for the prevention and treatment of skin cancers...
  22. ncbi request reprint Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration
    Cedric Blanpain
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Universite Libre de Bruxelles, Brussels B 1070, Belgium Walloon Excellence in Life Sciences and Biotechnology WELBIO, Universite Libre de Bruxelles ULB, Brussels B 1070, Belgium
    Science 344:1242281. 2014
    ..We also discuss the implications of cellular plasticity for regenerative medicine and for cancer. ..
  23. doi request reprint Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification
    Antoine Bondue
    Universite Libre de Bruxelles, IRIBHM, B 1070 Brussels, Belgium
    Cell Stem Cell 3:69-84. 2008
    ..Our results demonstrate that Mesp1 acts as a key regulatory switch during cardiovascular specification, residing at the top of the hierarchy of the gene network responsible for cardiovascular cell-fate determination...
  24. pmc Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin
    Jelle van den Ameele
    IRIBHM Institute for Interdisciplinary Research, Universite Libre de Bruxelles, Campus Erasme, Brussels B 1070, Belgium
    EMBO Rep 13:355-62. 2012
    ..These results place Eomes upstream of the Mesp1-dependent programme of cardiogenesis, and at the intersection of mesodermal and endodermal specification, depending on the levels of Activin/Nodal signalling...
  25. ncbi request reprint Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3
    Cedric Govaerts
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, B 1070 Bruxelles, Belgium
    J Biol Chem 278:1892-903. 2003
    ..We therefore suggest that transmembrane helices 2 and 3 contain important structural elements for the activation mechanism of chemokine receptors, and possibly other related receptors as well...
  26. pmc Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies
    Cedric Blanpain
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Mol Biol Cell 13:723-37. 2002
    ..These results suggest the existence of multiple active conformations of CCR5 and indicate that CCR5 oligomers are involved in an internalization process that is distinct from that induced by the receptor's agonists...
  27. pmc Epidermal homeostasis: a balancing act of stem cells in the skin
    Cedric Blanpain
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, 808, Route de Lennik, 1070 Bruxelles, Belgium
    Nat Rev Mol Cell Biol 10:207-17. 2009
    ..Interestingly, the basic mechanisms and signalling pathways that orchestrate epithelial morphogenesis in the skin are reused during adult life to regulate skin homeostasis...
  28. pmc Development and homeostasis of the skin epidermis
    Panagiota A Sotiropoulou
    IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    Cold Spring Harb Perspect Biol 4:a008383. 2012
    ..Deregulation of the signaling pathways controlling the balance between renewal and differentiation often leads to cancer formation...
  29. ncbi request reprint Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension
    Cedric Blanpain
    Service de Genetique Medicale, Universite Libre de Bruxelles, 808 Lennik, B 1070 Brussels, Belgium
    Cardiovasc Res 60:518-28. 2003
    ..A mouse model incriminates the serotonin 5-HT(2B) receptor but contrasts with other models where this receptor has been shown to mediate pulmonary arterial relaxation via nitric oxide production...
  30. ncbi request reprint SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
    Soufiane Boumahdi
    Universite Libre de Bruxelles, IRIBHM, Brussels B 1070, Belgium
    Nature 511:246-50. 2014
    ..We demonstrate that SOX2, by marking and regulating the functions of skin tumour-initiating cells and CSCs, establishes a continuum between tumour initiation and progression in primary skin tumours. ..
  31. pmc A blizzard of stem cells in Santa Fe
    Khalil Kass Youssef
    Interdisciplinary Research Institute IRIBHM of the Université Libre de Bruxelles, Brussels, Belgium
    EMBO Rep 12:485-7. 2011
    ..The organizers gathered together an impressive panel of speakers to discuss various aspects of stem-cell biology from early development to adult homeostasis, as well as the implications of stem cells for human diseases...
  32. doi request reprint Mesp1: a key regulator of cardiovascular lineage commitment
    Antoine Bondue
    Interdisciplinary Research Institute, Universite Libre de Bruxelles, 808, Route de Lennik, BatC, C6 130, 1070 Bruxelles, Belgium
    Circ Res 107:1414-27. 2010
    ..In addition, these findings will be very useful to boost the production of cardiovascular cells for cellular therapy, drug and toxicity screening...
  33. doi request reprint The majority of multipotent epidermal stem cells do not protect their genome by asymmetrical chromosome segregation
    Panagiota A Sotiropoulou
    Research Institute, Universite Libre de Bruxelles, Interdisciplinary Brussels, Belgium
    Stem Cells 26:2964-73. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  34. ncbi request reprint CCR5 and HIV infection
    Cedric Blanpain
    IRIBHN, Universite Libre de Bruxelles, Brussels, Belgium
    Receptors Channels 8:19-31. 2002
    ..Modified chemokines, monoclonal antibodies and small chemical antagonists, as well as a number of gene therapy approaches have been developed in this frame...
  35. pmc Mechanisms regulating epidermal stem cells
    Benjamin Beck
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    EMBO J 31:2067-75. 2012
    ..In this review, we will discuss the importance of these papers to our understanding of the mechanisms that control epidermal SC functions...
  36. ncbi request reprint The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle
    Cedric Blanpain
    Institute of Interdisciplinary Research, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    J Biol Chem 278:5179-87. 2003
    ....
  37. ncbi request reprint A dominant role of the hair follicle stem cell niche in regulating melanocyte stemness
    Cedric Blanpain
    Universite Libre de Bruxelles, IRIBHM, 1070 Brussels, Belgium
    Cell Stem Cell 6:95-6. 2010
    ..In this issue of Cell Stem Cell, Nishimura et al. (2010) show that hair follicle stem cells, by expressing high levels of TGF-beta2, regulate the quiescence, the stemness, and the long-term renewal of melanocyte stem cells...