Research Topics

Genomes and Genes


Julie Bakker


Country: Belgium


  1. Bakker J, Brock O. Early oestrogens in shaping reproductive networks: evidence for a potential organisational role of oestradiol in female brain development. J Neuroendocrinol. 2010;22:728-35 pubmed publisher
  2. Staphorsius A, Kreukels B, Cohen Kettenis P, Veltman D, Burke S, Schagen S, et al. Puberty suppression and executive functioning: An fMRI-study in adolescents with gender dysphoria. Psychoneuroendocrinology. 2015;56:190-9 pubmed publisher
    ..These findings suggest that (1) GnRHa treatment had no effect on ToL performance in adolescents with GD, and (2) pubertal hormones may induce sex-atypical brain activations during EF in adolescents with GD. ..
  3. Desroziers E, Brock O, Bakker J. Potential contribution of progesterone receptors to the development of sexual behavior in male and female mice. Horm Behav. 2017;90:31-38 pubmed publisher
    ..Taken together, these results suggest a role for PR and thus perhaps progesterone in the development of lordosis behavior in female mice. By contrast, no obvious role for PR can be discerned in the development of male sexual behavior. ..
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    Bakker J, Honda S, Harada N, Balthazart J. The aromatase knock-out mouse provides new evidence that estradiol is required during development in the female for the expression of sociosexual behaviors in adulthood. J Neurosci. 2002;22:9104-12 pubmed
    ..Together, these findings demonstrate that estrogen is required for normal female development. The concept that the female brain develops in the absence of any hormonal stimulation should therefore be reconsidered. ..
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    Bakker J, Baillien M, Honda S, Harada N, Balthazart J. Relationships between aromatase activity in the brain and gonads and behavioural deficits in homozygous and heterozygous aromatase knockout mice. J Neuroendocrinol. 2004;16:483-90 pubmed
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    Bakker J, De Mees C, Douhard Q, Balthazart J, Gabant P, Szpirer J, et al. Alpha-fetoprotein protects the developing female mouse brain from masculinization and defeminization by estrogens. Nat Neurosci. 2006;9:220-6 pubmed
    ..These results clearly demonstrate that prenatal estrogens masculinize and defeminize the brain and that AFP protects the female brain from these effects of estrogens. ..
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    Bakker J, De Mees C, Szpirer J, Szpirer C, Balthazart J. Exposure to oestrogen prenatally does not interfere with the normal female-typical development of odour preferences. J Neuroendocrinol. 2007;19:329-34 pubmed
    ..Furthermore, the presence of a strong male-directed odour preference in AFP-KO females suggests a postnatal contribution of oestrogens to the development of preferences to investigate opposite-sex odours. ..