B Andre

Summary

Country: Belgium

Publications

  1. pmc Systematic mutational analysis of the intracellular regions of yeast Gap1 permease
    Ahmad Merhi
    Physiologie Moléculaire de la Cellule, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS ONE 6:e18457. 2011
  2. pmc K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway
    Elsa Lauwers
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    J Cell Biol 185:493-502. 2009
  3. pmc Machine learning techniques to identify putative genes involved in nitrogen catabolite repression in the yeast Saccharomyces cerevisiae
    Kevin Kontos
    Machine Learning Group, , , , Boulevard du Triomphe CP 212, 1050 Brussels, Belgium
    BMC Proc 2:S5. 2008
  4. ncbi request reprint An overview of membrane transport proteins in Saccharomyces cerevisiae
    B Andre
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    Yeast 11:1575-611. 1995
  5. ncbi request reprint Ubiquitin and the SCF(Grr1) ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae
    F Bernard
    Laboratoire de Physiologie Cellulaire, Université Libre de Bruxelles CP 300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet 10, 6041, Gosselies, Belgium
    FEBS Lett 496:81-5. 2001
  6. pmc Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease
    I Iraqui
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    Mol Cell Biol 19:989-1001. 1999
  7. pmc A family of ammonium transporters in Saccharomyces cerevisiae
    A M Marini
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Cell Biol 17:4282-93. 1997
  8. ncbi request reprint Cloning and expression of the UGA4 gene coding for the inducible GABA-specific transport protein of Saccharomyces cerevisiae
    B Andre
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    Mol Gen Genet 237:17-25. 1993
  9. pmc Transcriptional induction by aromatic amino acids in Saccharomyces cerevisiae
    I Iraqui
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Université Libre de Bruxelles Campus Plaine CP244, B 1050 Brussels, Belgium
    Mol Cell Biol 19:3360-71. 1999
  10. pmc Two mutually exclusive regulatory systems inhibit UASGATA, a cluster of 5'-GAT(A/T)A-3' upstream from the UGA4 gene of Saccharomyces cerevisiae
    B Andre
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    Nucleic Acids Res 23:558-64. 1995

Collaborators

  • A M Marini
  • Martine Prevost
  • G Matassi
  • J Collado-Vides
  • S Scohy
  • E Boles
  • Elsa Lauwers
  • F Bernard
  • Ahmad Merhi
  • I Iraqui
  • Kevin Kontos
  • S Soussi-Boudekou
  • S Biver
  • J O De Craene
  • S Vissers
  • A Urrestarazu
  • D Van Belle
  • Nicolas Gérard
  • J van Helden
  • Christophe Jacob
  • Patrice Godard
  • Jacques van Helden
  • Gianluca Bontempi
  • C Szpirer
  • J Y Springael
  • J Szpirer
  • O Soetens
  • D Talibi
  • J C Jauniaux
  • M Grenson
  • F Muyldermans

Detail Information

Publications25

  1. pmc Systematic mutational analysis of the intracellular regions of yeast Gap1 permease
    Ahmad Merhi
    Physiologie Moléculaire de la Cellule, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS ONE 6:e18457. 2011
    ..The NT of Gap1 contains the acceptor lysines for ubiquitylation and its CT includes a sequence essential to exit from the endoplasmic reticulum (ER)...
  2. pmc K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway
    Elsa Lauwers
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    J Cell Biol 185:493-502. 2009
    ..Our data reveal that K63-linked Ub chains act as a specific signal for MVB sorting, providing further insight into the Ub code of membrane protein trafficking...
  3. pmc Machine learning techniques to identify putative genes involved in nitrogen catabolite repression in the yeast Saccharomyces cerevisiae
    Kevin Kontos
    Machine Learning Group, , , , Boulevard du Triomphe CP 212, 1050 Brussels, Belgium
    BMC Proc 2:S5. 2008
    ..CONCLUSION : These results suggest that our approach can successfully identify potential NCR genes. Hence, the dimensionality of the problem of identifying all genes involved in NCR is drastically reduced...
  4. ncbi request reprint An overview of membrane transport proteins in Saccharomyces cerevisiae
    B Andre
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    Yeast 11:1575-611. 1995
    ..A new research area is anticipated: the functional analysis of many transport proteins whose existence was revealed by genome sequencing...
  5. ncbi request reprint Ubiquitin and the SCF(Grr1) ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae
    F Bernard
    Laboratoire de Physiologie Cellulaire, Université Libre de Bruxelles CP 300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet 10, 6041, Gosselies, Belgium
    FEBS Lett 496:81-5. 2001
    ..This suggests that transduction to these genes of the amino acid signal generated by Ssy1 involves an SCF(Grr1)-catalysed ubiquitination step...
  6. pmc Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease
    I Iraqui
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    Mol Cell Biol 19:989-1001. 1999
    ..The essential role of Grr1p in this amino acid signaling pathway lends further support to the hypothesis that this protein participates in integrating nutrient availability with the cell cycle...
  7. pmc A family of ammonium transporters in Saccharomyces cerevisiae
    A M Marini
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Cell Biol 17:4282-93. 1997
    ..In contrast, expression of either MEP1 or MEP3 requires only Gln3p and is unexpectedly down-regulated in a Nil1p-dependent manner. Analysis of databases suggests that families of NH4+ transporters exist in other organisms as well...
  8. ncbi request reprint Cloning and expression of the UGA4 gene coding for the inducible GABA-specific transport protein of Saccharomyces cerevisiae
    B Andre
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    Mol Gen Genet 237:17-25. 1993
    ..In the absence of the pleiotropic UGA43/DAL80 repressor, UGA4 is constitutively expressed at high level...
  9. pmc Transcriptional induction by aromatic amino acids in Saccharomyces cerevisiae
    I Iraqui
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Université Libre de Bruxelles Campus Plaine CP244, B 1050 Brussels, Belgium
    Mol Cell Biol 19:3360-71. 1999
    ..Finally, we show that Gap1p, the general amino acid permease, and Wap1p (Ycl025p), a newly discovered inducible amino acid permease with broad specificity, are the main aromatic amino acid transporters for catabolic purposes...
  10. pmc Two mutually exclusive regulatory systems inhibit UASGATA, a cluster of 5'-GAT(A/T)A-3' upstream from the UGA4 gene of Saccharomyces cerevisiae
    B Andre
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    Nucleic Acids Res 23:558-64. 1995
    ..The role of UASGATA in the expression of the UGA4 gene is discussed in relation to its sensitivity to the two distinct repression systems...
  11. ncbi request reprint A co-activator of nitrogen-regulated transcription in Saccharomyces cerevisiae
    S Soussi-Boudekou
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Université Libre de Bruxelles Campus Plaine, Brussels, Belgium
    Mol Microbiol 31:753-62. 1999
    ..Ada1/Gan1p thus represents the first reported case of an accessory protein (a co-activator) linking the GATA-binding proteins Gln3p and Nil1p, mediating nitrogen-regulated transcription, to the basal transcription machinery...
  12. ncbi request reprint Genetic analysis of the signalling pathway activated by external amino acids in Saccharomyces cerevisiae
    F Bernard
    Laboratoire de Physiologie Cellulaire, Université Libre de Bruxelles CP300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Mol Microbiol 41:489-502. 2001
    ....
  13. ncbi request reprint Gzf3p, a fourth GATA factor involved in nitrogen-regulated transcription in Saccharomyces cerevisiae
    S Soussi-Boudekou
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    Mol Microbiol 23:1157-68. 1997
    ..In addition, both Uga43p and Gzf3p moderately regulate expression of their own genes. These two proteins seem to be parts of a complex network of GATA factors which probably play a determining role in nitrogen-regulated transcription...
  14. ncbi request reprint From yeast ammonium transporters to Rhesus proteins, isolation and functional characterization
    A M Marini
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, rue des Professeurs Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Transfus Clin Biol 13:95-6. 2006
    ..Using yeast as an expression tool, we have started a structure-function analysis of distinct members from the Mep/Amt/Rh super-family...
  15. ncbi request reprint The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease
    J O De Craene
    Laboratoire de Physiologie Cellulaire, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Professeurs Jeneer et Brachet, 6041 Gosselies, Belgium
    J Biol Chem 276:43939-48. 2001
    ..Npr1 belongs to a subgroup of protein kinases, some of which are reported to exert a positive control on the activity of other permeases. We propose that these kinases also function as regulators of permease trafficking...
  16. ncbi request reprint Physiological role of the putative ammonium transporter RhCG in the mouse
    S Biver
    Laboratoire de Biologie du Developpement, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, rue des Professeurs Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Transfus Clin Biol 13:167-8. 2006
    ..To study the physiological role of RhCG and to test a potential function in ammonium excretion, we have generated mice bearing an invalidation of the corresponding gene...
  17. ncbi request reprint Induction of the 4-aminobutyrate and urea-catabolic pathways in Saccharomyces cerevisiae. Specific and common transcriptional regulators
    S Vissers
    Laboratoire de Microbiologie, Faculte des Sciences, Universite Libre de Bruxelles, Belgium
    Eur J Biochem 187:611-6. 1990
    ..Our results show that the expression of two biochemically distinct nitrogenous catabolisms, as triggered by their respective inducers, seems to involve multiple regulatory factors, some of which are common to the two catabolic pathways...
  18. pmc Nitrogen-regulated ubiquitination of the Gap1 permease of Saccharomyces cerevisiae
    J Y Springael
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Université Libre de Bruxelles Campus Plaine CP244, B 1050 Brussels, Belgium
    Mol Biol Cell 9:1253-63. 1998
    ..We show here that mutant Gap1 permeases affected in these sequences still bind Ub. Furthermore, we provide evidence that only a small fraction of Gap1 is modified by Ub after addition of NH4+ to mutants defective in endocytosis...
  19. ncbi request reprint In vivo N-glycosylation of the mep2 high-affinity ammonium transporter of Saccharomyces cerevisiae reveals an extracytosolic N-terminus
    A M Marini
    Laboratoire de Physiologie Cellulaire, Universite Libre de Bruxelles, CP300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Mol Microbiol 38:552-64. 2000
    ..Mep2 glycosylation is not required for pseudohyphal differentiation in response to ammonium starvation, and its absence causes only a slight reduction in the affinity of the transporter for its substrate...
  20. pmc Cloning and expression of the MEP1 gene encoding an ammonium transporter in Saccharomyces cerevisiae
    A M Marini
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    EMBO J 13:3456-63. 1994
    ..Its main function appears to be to enable cells grown under nitrogen-limiting conditions to incorporate ammonium present at relatively low concentrations in the growth medium...
  21. ncbi request reprint The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast
    A M Marini
    Laboratoire de Physiologie Cellulaire, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Gosselies, Belgium
    Nat Genet 26:341-4. 2000
    ..Our results provide the first experimental evidence for a direct role of RhAG and RhGK in ammonium transport. These findings are of high interest, because no specific ammonium transport system has been characterized so far in human...
  22. pmc Cis- and trans-acting elements determining induction of the genes of the gamma-aminobutyrate (GABA) utilization pathway in Saccharomyces cerevisiae
    D Talibi
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Belgium
    Nucleic Acids Res 23:550-7. 1995
    ..We propose that tight coupling between the UASGABA and UASGATA elements enables the cell to integrate, according to its nitrogen status, the induced expression levels of UGA4...
  23. ncbi request reprint A web site for the computational analysis of yeast regulatory sequences
    J van Helden
    Centro de Investigacion Sobre Fijacion de Nitrogeno, Universidad Nacional Autonoma de Mexico, AP565A, Cuernavaca 62100, Morelos, Mexico
    Yeast 16:177-87. 2000
    ..This widens the scope of the site to the analysis of non-regulatory and/or non-yeast sequences...
  24. ncbi request reprint A genomic view of yeast membrane transporters
    D Van Belle
    Unité de Bioinformatique, Université Libre de Bruxelles CP300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet 10, 6041, Gosselies, Belgium
    Curr Opin Cell Biol 13:389-98. 2001
    ..A complete view of the role of membrane transporters in the metabolism of yeast may not be far off...
  25. ncbi request reprint Positive and negative regulatory elements control the expression of the UGA4 gene coding for the inducible 4-aminobutyric-acid-specific permease in Saccharomyces cerevisiae
    S Vissers
    Laboratoire de Microbiologie, Faculte des Sciences, Universite Libre de Bruxelles, Belgium
    Eur J Biochem 181:357-61. 1989
    ..On the other hand, recessive mutations at the UGA35 gene locus lead to non-inducibility of the UGA regulon. Hence the UGA35 gene product behaves like a second trans-acting positive regulator in addition to UGA3...