A M Andrianov

Summary

Affiliation: National Academy of Sciences of Belarus
Country: Belarus

Publications

  1. ncbi Human immunodeficiency virus-1 gp120 V3 loop for anti-acquired immune deficiency syndrome drug discovery: computer-aided approaches to the problem solving
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus 375 17 2678263 375 17 2241214
    Expert Opin Drug Discov 6:419-35. 2011
  2. ncbi Discovery of novel promising targets for anti-AIDS drug developments by computer modeling: application to the HIV-1 gp120 V3 loop
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich str 5 2, 220141 Minsk, Belarus
    J Chem Inf Model 51:2760-7. 2011
  3. ncbi Computational model of the HIV-1 subtype A V3 loop: study on the conformational mobility for structure-based anti-AIDS drug design
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 27:179-93. 2009
  4. ncbi Immunophilins and HIV-1 V3 loop for structure-based anti-AIDS drug design
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 26:445-54. 2009
  5. ncbi Determining the invariant structure elements of the HIV-1 variable V3 loops: insight into the HIV-MN and HIV-Haiti isolates
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 26:247-54. 2008
  6. ncbi Computational anti-AIDS drug design based on the analysis of the specific interactions between immunophilins and the HIV-1 gp120 V3 loop. Application to the FK506-binding protein
    A M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 26:49-56. 2008
  7. ncbi Structural analysis of the HIV-1 gp120 V3 loop: application to the HIV-Haiti isolates
    A M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich St 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 24:597-608. 2007
  8. ncbi Determination of structurally conservative amino acids of the HIV-1 protein gp120 V3 loop as promising targets for drug design by protein engineering approaches
    A M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, 220141, Belarus
    Biochemistry (Mosc) 71:906-14. 2006
  9. ncbi Conformational preferences of the HIV-1 principal neutralizing determinant
    A M Andrianov
    Institute of Bioorganic Chemistry, Belarus Academy of Sciences, ac Kuprevich St, 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 23:267-82. 2005
  10. ncbi Dual spatial folds and different local structures of the HIV-1 immunogenic crown in various virus isolates
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich St, 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 22:159-70. 2004

Detail Information

Publications17

  1. ncbi Human immunodeficiency virus-1 gp120 V3 loop for anti-acquired immune deficiency syndrome drug discovery: computer-aided approaches to the problem solving
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus 375 17 2678263 375 17 2241214
    Expert Opin Drug Discov 6:419-35. 2011
    ....
  2. ncbi Discovery of novel promising targets for anti-AIDS drug developments by computer modeling: application to the HIV-1 gp120 V3 loop
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich str 5 2, 220141 Minsk, Belarus
    J Chem Inf Model 51:2760-7. 2011
    ..It is evident that these conserved V3 segments represent potential HIV-1 vulnerable spots and, therefore, provide a blueprint for the design of novel, potent and broad antiviral agents able to stop the HIV's spread...
  3. ncbi Computational model of the HIV-1 subtype A V3 loop: study on the conformational mobility for structure-based anti-AIDS drug design
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 27:179-93. 2009
    ..From the data on molecular docking, synthetic analogs of the CycA and FKBP peptides were suggested being suitable frameworks for making a reality of the V3-based anti-HIV-1 drug projects...
  4. ncbi Immunophilins and HIV-1 V3 loop for structure-based anti-AIDS drug design
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 26:445-54. 2009
    ....
  5. ncbi Determining the invariant structure elements of the HIV-1 variable V3 loops: insight into the HIV-MN and HIV-Haiti isolates
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 26:247-54. 2008
    ....
  6. ncbi Computational anti-AIDS drug design based on the analysis of the specific interactions between immunophilins and the HIV-1 gp120 V3 loop. Application to the FK506-binding protein
    A M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 26:49-56. 2008
    ....
  7. ncbi Structural analysis of the HIV-1 gp120 V3 loop: application to the HIV-Haiti isolates
    A M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich St 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 24:597-608. 2007
    ..The implications are discussed in conjunction with the literature data on the biological activity of the individual amino acids for the HIV-1 gp120 V3 loop...
  8. ncbi Determination of structurally conservative amino acids of the HIV-1 protein gp120 V3 loop as promising targets for drug design by protein engineering approaches
    A M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, 220141, Belarus
    Biochemistry (Mosc) 71:906-14. 2006
    ....
  9. ncbi Conformational preferences of the HIV-1 principal neutralizing determinant
    A M Andrianov
    Institute of Bioorganic Chemistry, Belarus Academy of Sciences, ac Kuprevich St, 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 23:267-82. 2005
    ..The implications are discussed in conjunction with the data on the experimental observations for the HIV-1 principal neutralizing determinant...
  10. ncbi Dual spatial folds and different local structures of the HIV-1 immunogenic crown in various virus isolates
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich St, 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 22:159-70. 2004
    ..The results are discussed in the light of literature data on HIV-1 neutralizing epitope structure...
  11. ncbi 3D structure model of the principal neutralizing epitope of Minnesota HIV-1 isolate
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, Belarus Academy of Sciences, Kuprevich St, 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 21:577-90. 2004
    ....
  12. ncbi Structure and polymorphism of the principal neutralization site of Thailand HIV-1 isolate
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, Belarus Academy of Sciences, Kuprevich St, 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 20:603-13. 2003
    ....
  13. ncbi Global and local structural properties of the principal neutralizing determinant of the HIV-1 envelope protein gp120
    A M Andrianov
    Institute of Bioorganic Chemistry, Belarus Academy of Sciences, Minsk, Republic of Belarus
    J Biomol Struct Dyn 16:931-53. 1999
    ..These data allow to suppose that binding properties of this site are determined by the structural motif which forms the conformation of a double beta-turn and appears common for all hexapeptide structures...
  14. ncbi [Structure and conformational properties of the HIV Thailand gp120 immunodominant epitope]
    A M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences, Minsk, 220141 Belarus
    Mol Biol (Mosk) 36:715-24. 2002
    ..The results are discussed in the light of literature data on HIV-1 IDE structure...
  15. ncbi [Model of three dimensional structure of the immunodominant epitope of gp120 HIV(Thailand)]
    A M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, ul. Akademika Kuprevicha 5/2, Minsk, 220141 Belarus
    Biofizika 48:628-34. 2003
    ..The results obtained are discussed in connection with the literature data on the structure of the HIV-1 principal neutralizing determinant...
  16. ncbi Spatial structure model of the CD4 receptor-binding site of the HIV envelope protein gp120
    A M Andrianov
    Institute of Bioorganic Chemistry, Belarus Academy of Sciences, Minsk, Republic of Belarus
    J Biomol Struct Dyn 15:1101-13. 1998
    ....
  17. ncbi Local structural properties of the V3 loop of Thailand HIV-1 isolate
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, Belarus Academy of Sciences, Kuprevich St, 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 19:973-89. 2002
    ..The results obtained are discussed in conjunction with the data on the structure for the HIV-1 PND reported in literature...