Thomas G Beach

Summary

Publications

  1. pmc Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 117:169-74. 2009
  2. pmc Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Am J Pathol 173:483-93. 2008
  3. pmc Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
    Thomas G Beach
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neuropathol 117:613-34. 2009
  4. pmc Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia
    Alex E Roher
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 7:436-44. 2011
  5. pmc Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Biomarkers 14:493-501. 2009
  6. pmc Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains
    Douglas G Walker
    Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Exp Neurol 240:190-204. 2013
  7. pmc Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 5:18-29. 2009
  8. pmc The influence of Apolipoprotein E genotype on regional pathology in Alzheimer's disease
    Marwan N Sabbagh
    The Cleo Robert Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA
    BMC Neurol 13:44. 2013
  9. pmc Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson's disease subjects
    Chera L Maarouf
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Neurol Res 34:669-76. 2012
  10. pmc Brain biochemistry in autopsied patients with essential tremor
    Holly A Shill
    Banner Sun Health Research Institute, Sun City, Arizona, USA
    Mov Disord 27:113-7. 2012

Collaborators

Detail Information

Publications55

  1. pmc Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 117:169-74. 2009
    ..It is concluded that olfactory bulb LTS accurately predicts the presence of LTS in other brain regions. It is suggested that olfactory bulb biopsy be considered to confirm the diagnosis in PD subjects being assessed for surgical therapy...
  2. pmc Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Am J Pathol 173:483-93. 2008
    ....
  3. pmc Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
    Thomas G Beach
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neuropathol 117:613-34. 2009
    ..It is suggested that the proposed staging system would improve on its predecessors by allowing classification of a much greater proportion of cases...
  4. pmc Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia
    Alex E Roher
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 7:436-44. 2011
    ..To assess this hypothesis, it is vital to rigorously establish the measures of AVD that are most strongly associated with an AD diagnosis...
  5. pmc Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Biomarkers 14:493-501. 2009
    ..For the discrimination of AD from NADD subjects, measurement of Abeta1-42 alone was superior...
  6. pmc Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains
    Douglas G Walker
    Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Exp Neurol 240:190-204. 2013
    ..By comparing two brain regions, we showed higher accumulation of insoluble pS129-α-synuclein in cingulate cortex, where histological deposits occur first, than in temporal cortex in samples with advanced (stage IV) LB pathology...
  7. pmc Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 5:18-29. 2009
    ..We evaluated the amounts of amyloid beta (Abeta)) peptides in the central nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Abeta plasma levels and Alzheimer's disease (AD) pathology...
  8. pmc The influence of Apolipoprotein E genotype on regional pathology in Alzheimer's disease
    Marwan N Sabbagh
    The Cleo Robert Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA
    BMC Neurol 13:44. 2013
    ..Although several studies have shown significant differences in AD pathology among ϵ4 carriers and non-carriers, few have characterized these differences in terms of brain region and neuropathological score frequency...
  9. pmc Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson's disease subjects
    Chera L Maarouf
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Neurol Res 34:669-76. 2012
    ..We sought to discover potential biomarkers in the cerebrospinal fluid (CSF) of neuropathologically confirmed PD cases...
  10. pmc Brain biochemistry in autopsied patients with essential tremor
    Holly A Shill
    Banner Sun Health Research Institute, Sun City, Arizona, USA
    Mov Disord 27:113-7. 2012
    ..The hypothesis that essential tremor represents early Parkinson's disease was not supported, as striatal dopaminergic markers were not reduced compared with control subjects...
  11. pmc Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets
    Tyler A Kokjohn
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Biochim Biophys Acta 1812:1508-14. 2011
    ....
  12. pmc Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Mol Med 14:184-94. 2008
    ....
  13. ncbi request reprint BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains
    Boris Decourt
    Haldeman Laboratory of Molecular Diagnostics and Therapeutics, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Curr Alzheimer Res 10:309-15. 2013
    ..Our data suggest that brain BACEl levels may be influenced by the apolipoprotein E genotype before the onset of AD, providing an alternative explanation for the lower amyloid beta 42 levels in CSF in ND and AD subjects...
  14. pmc The distribution of phosphorylated tau in spinal cords of Alzheimer's disease and non-demented individuals
    Brittany N Dugger
    Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 34:529-36. 2013
    ..The presence of significant spinal cord p-tau-immunoreactive pathology has important implications for both the pathogenesis and clinical manifestations of AD...
  15. ncbi request reprint Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles
    Thomas G Beach
    W H Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 113:13-21. 2007
    ..The results suggest that the statistical association between intracranial atherosclerosis and AD is not an artifact of diagnostic misclassification or of unequal distribution of the apolipoprotein E-epsilon4 allele...
  16. pmc Submandibular gland biopsy for the diagnosis of Parkinson disease
    Thomas G Beach
    Banner Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neuropathol Exp Neurol 72:130-6. 2013
    ..This would be particularly advantageous for subject selection in early-stage clinical trials for invasive therapies or for verifying other biomarker studies...
  17. pmc Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease
    Jesse M Hunter
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    J Alzheimers Dis 27:361-76. 2011
    ..Understanding the strengths and limitations of Tg mouse AD models through rigorous biochemical, pathological, and functional analyses will facilitate the derivation of models that better approximate human sporadic AD...
  18. pmc Correlation of clinical features with argyrophilic grains at autopsy
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Alzheimer Dis Assoc Disord 23:229-33. 2009
    ..AGs can occur with or without neurodegenerative conditions and can occur in the absence of significant cognitive decline. AGs are not clearly associated with any single comorbid health condition...
  19. pmc Reduced clinical and postmortem measures of cardiac pathology in subjects with advanced Alzheimer's Disease
    Thomas G Beach
    Banner Sun Health Research Institute, Sun City, AZ, USA
    BMC Geriatr 11:3. 2011
    ..Autopsy studies of cardiac disease in AD have been few and inconclusive. In this report, clinical and gross anatomic measures of cardiac disease were compared in deceased human subjects with and without AD...
  20. pmc Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 119:689-702. 2010
    ..Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest...
  21. pmc Parkinson disease with dementia: comparing patients with and without Alzheimer pathology
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Harold Civin Laboratory of Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Alzheimer Dis Assoc Disord 23:295-7. 2009
    ..PDD-AD and PDD+AD have similar degrees of dementia and approximately half of PDD subjects have enough AD pathology to attain a neuropathologic diagnosis of AD. PDD can develop in the absence of significant Alzheimer pathology...
  22. ncbi request reprint Interaction of cardiovascular disease and neurodegeneration: transcranial Doppler ultrasonography and Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City AZ 85351, USA
    Neurol Res 28:672-8. 2006
    ..In this study, we examine the arteries of the circle of Willis by transcranial Doppler (TCD) ultrasonography...
  23. pmc Neurochemical profile of dementia pugilistica
    Tyler A Kokjohn
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurotrauma 30:981-97. 2013
    ..Understanding the precise threshold of damage needed for the induction of pathology in DP and TBI is vital...
  24. pmc Quantitative appraisal of ventricular cerebrospinal fluid biomarkers in neuropathologically diagnosed Parkinson's disease cases lacking Alzheimer's disease pathology
    Chera L Maarouf
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Biomark Insights 8:19-28. 2013
    ..Our results suggest coexistent AD CSF biomarkers within the PD group notwithstanding that it was selected to minimize AD neuropathological lesions...
  25. pmc Transcranial doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's disease
    Alex E Roher
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 7:445-55. 2011
    ..Multiple lines of evidence suggest that cardiovascular co-morbidities hasten the onset of Alzheimer's disease (AD) or accelerate its course...
  26. ncbi request reprint TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 46:10317-27. 2007
    ..However, given the phylogenetic distance and the differences in APP processing and Abeta chemistry between Tg mice and AD, caution should be applied in projecting mouse therapeutic interventions onto human subjects...
  27. pmc Cerebral blood flow in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Vasc Health Risk Manag 8:599-611. 2012
    ....
  28. pmc Frequency of Alzheimer's disease pathology at autopsy in patients with clinical normal pressure hydrocephalus
    Danielle Cabral
    The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 7:509-13. 2011
    ..Uncovering the extent to which AD and NPH co-occur has implications for diagnosis and treatment of NPH. Autopsy studies of patients with NPH during their lifetime would elucidate the frequency of such comorbidities...
  29. pmc Striatal amyloid plaque density predicts Braak neurofibrillary stage and clinicopathological Alzheimer's disease: implications for amyloid imaging
    Thomas G Beach
    Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 28:869-76. 2012
    ..Validation of this hypothesis will require autopsy studies of subjects that had amyloid imaging during life...
  30. pmc Neuropathology and amyloid-β spectrum in a bapineuzumab immunotherapy recipient
    Alex E Roher
    Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 24:315-25. 2011
    ..These results suggest that, in this particular case, bapineuzumab immunotherapy neither resulted in detectable clearance of amyloid plaques nor prevented further cognitive impairment...
  31. ncbi request reprint Atherosclerosis of cerebral arteries in Alzheimer disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, Ariz 85351, USA
    Stroke 35:2623-7. 2004
    ..Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia...
  32. ncbi request reprint Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers
    Thomas G Beach
    Sun Health Research Institute, Sun City, Arizona 85372, USA
    J Neuropathol Exp Neurol 63:329-37. 2004
    ..Further studies are needed to ascertain the molecular basis of Marinesco body formation; preliminary studies indicate that proteasome dysfunction can lead to similar abnormalities in cultured cells...
  33. pmc The biochemical aftermath of anti-amyloid immunotherapy
    Chera L Maarouf
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Mol Neurodegener 5:39. 2010
    ..These patients were compared to 6 non-immunized AD cases and 5 non-demented control (NDC) cases...
  34. doi request reprint Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies
    Lih Fen Lue
    Laboratory of Neuroregeneration, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Brain Pathol 22:745-56. 2012
    ..Therefore, identifying the underlying mechanisms driving these changes could be crucial to understanding the pathogenesis of LB disorders...
  35. ncbi request reprint Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 114:419-24. 2007
    ....
  36. pmc Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
    Chera L Maarouf
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Mol Neurodegener 3:20. 2008
    ..In addition, the levels of Abeta40/42 peptides were quantified by ELISA...
  37. ncbi request reprint Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid
    Amanda J Newell
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Neurosci Lett 350:178-80. 2003
    ..Results for Abeta42 showed a similar trend. The results indicate that age-related decreases of neprilysin could lead to increased brain concentrations of Abeta, plaque formation, and AD...
  38. ncbi request reprint Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects
    Thomas G Beach
    Banner Sun Health Research Institute, 10515W Santa Fe Drive, Sun City, AZ 85351, United States Electronic address
    Neurosci Lett 571:34-8. 2014
    ..There were no stained nerve fibers or other specific staining in any of the non-PD or non-DLB subjects. It is possible that at least some of the observed visual function impairments in PD subjects might be due to α-synucleinopathy. ..
  39. ncbi request reprint Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease
    Walter Kalback
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
    Neurol Res 26:525-39. 2004
    ..Our data strongly suggest that severe hemodynamic disturbances contribute to sporadic AD and support the numerous observations indicating cardiovascular system participation in the pathogenesis of these dementias...
  40. pmc Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
    Chera L Maarouf
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Curr Alzheimer Res 6:399-406. 2009
    ..The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias...
  41. ncbi request reprint Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Arterioscler Thromb Vasc Biol 23:2055-62. 2003
    ..We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer's disease (AD)...
  42. ncbi request reprint Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging
    Marwan N Sabbagh
    Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Arch Neurol 63:1771-6. 2006
    ..Decreased neocortical nicotinic receptor binding is characteristic of AD but has not been investigated in subjects with MCI...
  43. pmc Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis
    R Lyle Patton
    The Longtine Center for Molecular Biology and Genetics, W H Civin Laboratory for Neuropathology, M D Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Am J Pathol 169:1048-63. 2006
    ..This may allow Abeta mobilization under conditions in which drainage and degradation of these toxic peptides is efficient...
  44. pmc The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007
    Thomas G Beach
    Sun Health Research Institute, Sun City, 85351, USA
    Cell Tissue Bank 9:229-45. 2008
    ....
  45. pmc Evaluation of alpha-synuclein immunohistochemical methods used by invited experts
    Thomas G Beach
    Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 116:277-88. 2008
    ..Some methods, however, achieved relatively high sensitivities with optimized formic acid protocols combined with a hydrolytic step. One method was developed that allows high sensitivity with commercially available reagents...
  46. doi request reprint Pathology in essential tremor
    Holly A Shill
    Banner Sun Health Research Institute, Sun City, AZ, USA
    Parkinsonism Relat Disord 18:S135-7. 2012
    ..This paper will review those findings and put them into context with clinical studies in ET and findings in neurodegenerative disorders such as Parkinson's disease...
  47. pmc Postmortem interval effect on RNA and gene expression in human brain tissue
    Alex C Birdsill
    Civin Laboratory for Neuropathology, Brain and Body Donation Program, Banner Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Cell Tissue Bank 12:311-8. 2011
    ..For tissue derived from autopsy, a short PMI optimizes its utility for molecular research...
  48. ncbi request reprint Essential tremor is not associated with cerebellar Purkinje cell loss
    Claire Symanski
    Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, Arizona, USA
    Mov Disord 29:496-500. 2014
    ..02; 95% confidence interval [CI]: -0.30-0.34). PC counts were not associated with tremor duration (r = 0.06; 95% CI: -0.21-0.32). These data demonstrate that ET is not associated with cerebellar PC loss...
  49. pmc Bid signal pathway components are identified in the temporal cortex with Parkinson disease
    Hong Jiang
    Sun Health Research Institute, Sun City, AZ, USA
    Neurology 79:1767-73. 2012
    ....
  50. doi request reprint Alzheimer's disease and the "Valley Of Death": not enough guidance from human brain tissue?
    Thomas G Beach
    Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 33:S219-33. 2013
    ..To optimize the promise of these new technologies, however, it is critical that brain banks are rejuvenated by enhanced governmental and/or private support...
  51. doi request reprint Physiologic origins of age-related beta-amyloid deposition
    Thomas G Beach
    Sun Health Research Institute, Sun City, Ariz 85351, USA
    Neurodegener Dis 5:143-5. 2008
    ..Brain beta-amyloid (Abeta) deposition is an extremely common accompaniment of aging in humans and many other mammalian species. We hypothesized that normal physiological changes of aging cause Abeta deposition...
  52. ncbi request reprint Hippocampal sclerosis dementia with tauopathy
    Thomas G Beach
    W H Civin Laboratory for Neuropathology, Sun Health Research Institute, Sun City, Ariz 85372, USA
    Brain Pathol 13:263-78. 2003
    ..The results suggest that most cases of HS dementia are sporadic multisystem tauopathies; we suggest the term "hippocampal sclerosis dementia with tauopathy" (HSDT) for these...
  53. pmc Positron emission tomography and neuropathologic estimates of fibrillar amyloid-β in a patient with Down syndrome and Alzheimer disease
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, 101515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Arch Neurol 68:1461-6. 2011
    ..The extent to which the most frequently used PET ligands can be used to detect fibrillar Aβ in patients with Down syndrome remains to be determined...
  54. pmc Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010
    Thomas G Beach
    Banner Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neuropathol Exp Neurol 71:266-73. 2012
    ..The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies...
  55. pmc Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Mol Med 9:112-22. 2003
    ..This failure of fluid drainage has implications for therapeutic strategies to treat Alzheimer's disease...