Giyasettin Baydas

Summary

Publications

  1. ncbi request reprint Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    J Pineal Res 39:346-52. 2005
  2. ncbi request reprint Melatonin prevents oxidative stress and inhibits reactive gliosis induced by hyperhomocysteinemia in rats
    G Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig 23119, Turkey
    Biochemistry (Mosc) 71:S91-5. 2006
  3. doi request reprint Melatonin prevents gestational hyperhomocysteinemia-associated alterations in neurobehavioral developments in rats
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    J Pineal Res 44:181-8. 2008
  4. ncbi request reprint Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig, Turkey
    Free Radic Biol Med 35:797-804. 2003
  5. ncbi request reprint Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes
    G Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, 23119, Turkey
    Biochemistry (Mosc) 69:1001-5. 2004
  6. ncbi request reprint Early changes in glial reactivity and lipid peroxidation in diabetic rat retina: effects of melatonin
    G Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    Acta Diabetol 41:123-8. 2004
  7. ncbi request reprint Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23119, Turkey
    Acta Pharmacol Sin 26:417-22. 2005
  8. ncbi request reprint Effects of thinner exposure on the expression pattern of neural cell adhesion molecules, level of lipid peroxidation in the brain and cognitive function in rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23119, Turkey
    Eur J Pharmacol 512:181-7. 2005
  9. ncbi request reprint Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    Brain Res 1046:187-94. 2005
  10. ncbi request reprint Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig 23119, Turkey
    Exp Neurol 194:175-81. 2005

Detail Information

Publications41

  1. ncbi request reprint Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    J Pineal Res 39:346-52. 2005
    ..Melatonin improves learning and memory deficits and the behavioral responses of rats to melatonin supplementation are age dependent...
  2. ncbi request reprint Melatonin prevents oxidative stress and inhibits reactive gliosis induced by hyperhomocysteinemia in rats
    G Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig 23119, Turkey
    Biochemistry (Mosc) 71:S91-5. 2006
    ....
  3. doi request reprint Melatonin prevents gestational hyperhomocysteinemia-associated alterations in neurobehavioral developments in rats
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    J Pineal Res 44:181-8. 2008
    ..In conclusion, administration of melatonin throughout pregnancy reduces the effects of hyperhomocysteinemia on the development of fetal brain; therefore, it might be beneficial in preventing persistent congenital malformations...
  4. ncbi request reprint Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig, Turkey
    Free Radic Biol Med 35:797-804. 2003
    ..These results suggest that diabetes causes increased glial reactivity possibly due to elevated oxidative stress, and administration of melatonin represents an achievable adjunct therapy for preventing gliosis...
  5. ncbi request reprint Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes
    G Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, 23119, Turkey
    Biochemistry (Mosc) 69:1001-5. 2004
    ..GSH levels were increased by the administration of alpha-LA. This study suggests that alpha-LA prevents neural injury by inhibiting oxidative stress and suppressing reactive gliosis...
  6. ncbi request reprint Early changes in glial reactivity and lipid peroxidation in diabetic rat retina: effects of melatonin
    G Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    Acta Diabetol 41:123-8. 2004
    ..05). In conclusion, glial reactivity is an early pathogenic event in diabetic retina and both reactive gliosis and accumulation of malondialdehyde and 4-hydroxyalkenals are prevented by melatonin supplementation...
  7. ncbi request reprint Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23119, Turkey
    Acta Pharmacol Sin 26:417-22. 2005
    ..To investigate the effect of gabapentin on neural [neuron-specific enolase (NSE)] and glial markers [glial fibrillary acidic protein (GFAP) and S100B] in different brain regions of diabetic rats...
  8. ncbi request reprint Effects of thinner exposure on the expression pattern of neural cell adhesion molecules, level of lipid peroxidation in the brain and cognitive function in rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23119, Turkey
    Eur J Pharmacol 512:181-7. 2005
    ..Almost all studied parameters were reversed in animals which were allowed to recover from thinner inhalation, suggesting that the effects of exposure to thinner, at least for 1 h/day for 45 days, are reversible...
  9. ncbi request reprint Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    Brain Res 1046:187-94. 2005
    ....
  10. ncbi request reprint Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig 23119, Turkey
    Exp Neurol 194:175-81. 2005
    ..Furthermore, this work suggests that the signal to initiate gliosis is mediated, at least indirectly, by free radical formation...
  11. ncbi request reprint Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels
    G Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig 23119, Turkey
    Neuroscience 135:879-86. 2005
    ..We propose that, in addition to its antioxidant properties, melatonin has the ability to protect neuronal cells against apoptosis mediated homocysteine neurotoxicity by modulating apoptosis-regulatory proteins in the hippocampus of rats...
  12. ncbi request reprint Effects of maternal hyperhomocysteinemia induced by high methionine diet on the learning and memory performance in offspring
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, 23119 Elazig, Turkey
    Int J Dev Neurosci 25:133-9. 2007
    ..In conclusion, maternal hyperhomocysteinemia changes the expression pattern of neural cell adhesion molecule and therefore leads to an impairment in the learning performance of the offspring...
  13. ncbi request reprint Melatonin inhibits oxidative stress and apoptosis in fetal brains of hyperhomocysteinemic rat dams
    Giyasettin Baydas
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    J Pineal Res 43:225-31. 2007
    ..In conclusion, therapeutic administration of melatonin protects against the induction of oxidative stress and neural tissue injury and might prevent congenital malformations of fetal brain caused by maternal hyperhomocysteinemia...
  14. ncbi request reprint Altered expression of NCAM in hippocampus and cortex may underlie memory and learning deficits in rats with streptozotocin-induced diabetes mellitus
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23119, Turkey
    Life Sci 73:1907-16. 2003
    ..Altered expression of NCAM in hippocampus may be an important cause of learning and memory deficits that occur in diabetes mellitus...
  15. ncbi request reprint Antioxidant vitamin levels in term and preterm infants and their relation to maternal vitamin status
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig, Turkey
    Arch Med Res 33:276-80. 2002
    ..We aimed to determine the levels of vitamins E, A, and C in maternal and cord blood plasma of term and preterm infants and to investigate the relationships between these levels...
  16. ncbi request reprint Effect of melatonin on oxidative status of rat brain, liver and kidney tissues under constant light exposure
    G Baydas
    Department of Physiology, College of Medicine, Firat Euphrates University, Elazig, Turkey
    Cell Biochem Funct 19:37-41. 2001
    ..Thus, melatonin is not only a direct scavenger of toxic radicals, but also stimulates the antioxidative enzyme GSH-Px activity to detoxify hydroxyl radical produced by constant light exposure...
  17. ncbi request reprint Daily rhythm of glutathione peroxidase activity, lipid peroxidation and glutathione levels in tissues of pinealectomized rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 213119, Turkey
    Neurosci Lett 323:195-8. 2002
    ..In conclusion, pinealectomy which eliminates the melatonin rhythm has a supressor effect on GSH-Px activity levels...
  18. ncbi request reprint Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig, Turkey
    J Pineal Res 32:225-30. 2002
    ..Considering the much lower molar concentration of melatonin compared with vitamin E, melatonin seems to be a more potent antioxidant, especially in the brain and kidney...
  19. ncbi request reprint Effects of certain micronutrients and melatonin on plasma lipid, lipid peroxidation, and homocysteine levels in rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig, Turkey
    Arch Med Res 33:515-9. 2002
    ..In this paper, we aimed to evaluate the effects of vitamin E, vitamin C, vitamin C 6 palmitate (VC6P), lipoic acid, fish oil, and melatonin supplementation on lipid peroxidation, plasma lipid, and homocysteine (Hcy) levels in rats...
  20. ncbi request reprint A novel role for melatonin: regulation of the expression of cell adhesion molecules in the rat hippocampus and cortex
    G Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23119, Turkey
    Neurosci Lett 326:109-12. 2002
    ..Melatonin may be involved in structural remodeling of synaptic connections during memory and learning processes...
  21. ncbi request reprint Altered glial fibrillary acidic protein content and its degradation in the hippocampus, cortex and cerebellum of rats exposed to constant light: reversal by melatonin
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig, Turkey
    J Pineal Res 33:134-9. 2002
    ..These results suggest that melatonin potentially protects both neurons and glial cells from free radicals; melatonin's protective actions are probably related to the antioxidant properties of the indole...
  22. ncbi request reprint Effects of pinealectomy on the levels and the circadian rhythm of plasma homocysteine in rats
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazýg 23119, Turkey
    J Pineal Res 33:151-5. 2002
    ..In conclusion, we speculate that decreasing levels of melatonin during aging lead to hyperhomocysteinemia and a decrease in tGSH and the latter may be one of the factors causing hyperhomocysteinemia in the elderly population...
  23. ncbi request reprint Inhibitory effects of melatonin on neural lipid peroxidation induced by intracerebroventricularly administered homocysteine
    Giyasettin Baydas
    Department of Physiology, Medical School, Firat University, Elazig, Turkey
    J Pineal Res 34:36-9. 2003
    ..It also shows that melatonin could potentially be beneficial in prevention of neurodegeneration caused by hyperhomocysteinemia...
  24. ncbi request reprint Increase of glial fibrillary acidic protein and S-100B in hippocampus and cortex of diabetic rats: effects of vitamin E
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23119, Turkey
    Eur J Pharmacol 462:67-71. 2003
    ....
  25. ncbi request reprint Melatonin protects the central nervous system of rats against toluene-containing thinner intoxication by reducing reactive gliosis
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23110, Turkey
    Toxicol Lett 137:169-74. 2003
    ..In conclusion, melatonin treatment may provide neuroprotection against toluene neurotoxicity by increasing the survival of glial cells possibly by directly scavenging ROS and by indirectly augmenting their antioxidant capacity...
  26. doi request reprint Effects of the neonicotinoid insecticide, clothianidin, on the reproductive organ system in adult male rats
    Ramazan Bal
    Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey
    Drug Chem Toxicol 36:421-9. 2013
    ..In conclusion, CTD had little detectable detrimental effects on the reproductive system of male rats over the measured parameters...
  27. ncbi request reprint Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats
    Ramazan Bal
    Faculty of Medicine, Department of Physiology, Firat University, Elazig, Turkey
    Cell Biochem Funct 30:492-9. 2012
    ..Apoptosis and fragmentation of seminal DNA were higher in rats treated at the two higher doses of imidacloprid. These results show that this compound has a negative effect on sperm and testis of rats...
  28. doi request reprint Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats
    Ramazan Bal
    Department of Physiology, Faculty of Medicine, Firat University, 23119, Elazig, Turkey
    Cell Biol Toxicol 28:187-200. 2012
    ....
  29. ncbi request reprint Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats
    Mehmet Tuzcu
    Department of Biology, Faculty of Science, Firat University, Elazig, Turkey
    Eur J Pharmacol 537:106-10. 2006
    ..These results suggest that oxidative stress may contribute to learning and memory deficits in diabetes and further suggest that antioxidant melatonin and vitamin E can improve cognitive impairment in streptozotocin-induced diabetes...
  30. ncbi request reprint Learning and memory deficits in rats induced by chronic thinner exposure are reversed by melatonin
    Giyasettin Baydas
    Department of Physiology, Firat University, Elazig, Turkey
    J Pineal Res 39:50-6. 2005
    ..This study indicates that treatment with melatonin prevents learning and memory deficits caused by thinner exposure possibly by reducing oxidative stress and regulating neural plasticity...
  31. pmc Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study
    Ramazan Bal
    Department of Biophysics, Firat University, Elazig 23119, Turkey
    J Assoc Res Otolaryngol 10:281-93. 2009
    ....
  32. ncbi request reprint Exogenous leptin increases lipid peroxidation in the mouse brain
    Selim Kutlu
    Department of Physiology, Medical School, Firat University, Elazig, Turkey
    Tohoku J Exp Med 206:233-6. 2005
    ..05). These results indicate that exogenous leptin increases lipid peroxidation and inhibits antioxidant system in the mouse brain. We therefore suggest that leptin may augment oxidative stress in the brain...
  33. doi request reprint Protective effects of nanostructures of hydrated C(60) fullerene on reproductive function in streptozotocin-diabetic male rats
    Ramazan Bal
    Department of Physiology, Faculty of Medicine, Firat University, 23119 Elazig, Turkey
    Toxicology 282:69-81. 2011
    ....
  34. ncbi request reprint Relationship among levels of leptin and zinc, copper, and zinc/copper ratio in plasma of patients with essential hypertension and healthy normotensive subjects
    Halit Canatan
    Department of Medical Biology, Faculty of Medicine, Firat Euphrates University, Elazig 23119, Turkey
    Biol Trace Elem Res 100:117-23. 2004
    ..There was no significant correlations between levels of Cu and leptin or leptin/BMI. In conclusion, in addition to high leptin levels, Zn and the Zn/Cu ratio were lower in patients with EHT compared to NT controls...
  35. doi request reprint Assessing the effects of the neonicotinoid insecticide imidacloprid in the cholinergic synapses of the stellate cells of the mouse cochlear nucleus using whole-cell patch-clamp recording
    Ramazan Bal
    Department of Biophysics, Firat University, Faculty of Medicine, Elazig, Turkey
    Neurotoxicology 31:113-20. 2010
    ..3+/-3.4 pA inward current (n=4). We conclude that exposure to IMI at concentrations >or=10 microM for <1 min can change the membrane properties of neurons that have nAChRs and, as a consequence, their function...
  36. ncbi request reprint Insulin increases homocysteine levels in a dose-dependent manner in diabetic rats
    M Ferit Gursu
    Department of Biochemistry, College of Medicine, Firat University, Elazig, Turkey
    Arch Med Res 33:305-7. 2002
    ..In diabetes mellitus, homocysteine metabolism is altered and as a result, more severe diabetic complications are expected when hyperhomocysteinemia occurs...
  37. doi request reprint Effects of maternal hyperhomocysteinemia induced by methionine intake on oxidative stress and apoptosis in pup rat brain
    Sema T Koz
    Health Institute, Bingol University, 12000 Bingol, Turkey
    Int J Dev Neurosci 28:325-9. 2010
    ..The increased oxidative stress appears to cause apoptosis and cell death. These results may be significant to understand chronic pathology of the complications of hyperhomocysteinemia and congenital malformations of fetuses...
  38. ncbi request reprint A comparison of estrogen and two different doses of calcitonin in ovariectomized rats
    Vural Kavuncu
    Department of Physical Medicine and Rehabilitation, Afyon Kocatepe Universitesi, ANS Uygulama ve Arastirma Hastanesi Fizik Tedavi Klinigi, Afyon 03200, Turkey
    Yonsei Med J 44:508-16. 2003
    ..In the animal model of estrogen depletion, our results suggest that the calcitonin provides an important alternative therapy for postmenopausal osteoporosis...
  39. doi request reprint Electrophysiological properties of ventral cochlear nucleus neurons of the dog
    Ramazan Bal
    Department of Biophysics, Faculty of Medicine, Firat University, 23119 Elazig, Turkey
    Hear Res 256:93-103. 2009
    ..We conclude that the principal neurons of the dog VCN are, as in mouse and cat, distinguishable on the basis of whole-cell patch-clamp recordings...
  40. ncbi request reprint Comparative analysis of plasma leptin levels in both genders of patients with essential hypertension and healthy subjects
    Halit Canatan
    Department of Medical Biology, Faculty of Medicine, Firat Euphrates University, Elazig, Turkey
    Endocr Res 30:95-105. 2004
    ..05). In conclusion, these results support the hypothesis that a possible link exists between leptin and hypertension. Further studies are needed to clarify how increased levels of leptin affects the pathophysiology of hypertension...
  41. ncbi request reprint Homocysteine levels are increased due to lack of melatonin in pinealectomized rats: is there a link between melatonin and homocysteine?
    Giyasettin Baydas
    J Pineal Res 32:63-4. 2002