MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcomaDaniel Baumhoer
Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Switzerland
Cancer Genet 205:212-9. 2012
..Our findings indicate a crucial impact of deregulated miRNAs with consecutive changes in gene expression in osteosarcomas, which strongly suggests pathogenetic and potentially therapeutic implications...
- Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma
Daniel Baumhoer
Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Basel, Switzerland
Mod Pathol 25:522-8. 2012
..The disruption of CXCR4/CXCR7/CXCL12 signaling could therefore be crucial in OSs for the migration of tumor cells from bone into circulation and for developing systemic disease...
CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patientsDaniel Baumhoer
Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Basel, Switzerland
Oncotarget 2:970-5. 2011
..0433) and without metastases (p = 0.0108) indicating a favorable prognostic effect. CRIP1 therefore seems to represent a promising new biomarker in osteosarcoma patients which should be considered for a prospective validation...
- Ewing sarcoma of the mandible mimicking an odontogenic abscess - a case report
Martin Gosau
Department of Cranio Maxillo Facial Surgery, University of Munster, Germany
Head Face Med 4:24. 2008
..This case report recapitulates the clinical and histopathological findings in oral ES, demonstrates its sometimes difficult diagnosis and discusses the (dis-)advantages of primary osseous reconstruction in ablative tumour surgery...
- Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer
Manuela Eppenberger
Institute of Pathology, University Hospital of Basel, Basel, Switzerland
BMC Cancer 10:93. 2010
..The aim of this study was to elucidate the role of the VEGF ligand/receptor ratios on tumour progression and metastasis in patients with mismatch repair-proficient colorectal cancer...
- The nature of the characteristic cementum-like matrix deposits in the walls of simple bone cysts
Daniel Baumhoer
Institute of Pathology, University Hospital Basel, Basel, Switzerland
Histopathology 59:390-6. 2011
..Because these deposits are strongly fuchsinophilic in routine van Gieson stains, the aim of this study was to investigate a series of SBCs using immunohistochemistry and electron microscopy...
- Aberrant expression of the human epidermal growth factor receptor 2 oncogene is not a common feature in osteosarcoma
Daniel Baumhoer
Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland
Hum Pathol 42:859-66. 2011
..In conclusion, our study does not support a role for human epidermal growth factor receptor 2 as a prognostic marker in osteosarcoma...
- Tumours of the hand: a review on histology of bone malignancies
D Baumhoer
Institute of Pathology, the Bone Tumour Reference Center and the Reference Registry of DOSAK German Austrian Swiss Working Group for Tumours of the Face and Jaws at the Institute of Pathology, University Hospital Basel, Switzerland
J Hand Surg Eur Vol 35:354-61. 2010
..This review focusses on the histology of these tumours and gives an overview of the main differential diagnoses. Close correlation to radiologic and clinical features usually leads to the correct diagnosis...
- [Warthin tumor with carcinoma: malignant transformation or metastasis?]
D Baumhoer
Institut fur Pathologie, Universitatsspital Basel, Schönbeinstr 40, 4031 Basel, Schweiz
Pathologe 30:457-60. 2009
..PET scans detected a metastasizing carcinoma of the breast, morphologically identical to the WT infiltrates. Care should always be taken when the diagnosis of malignant WT is made to exclude metastatic disease...
- Tubulopapillary hidradenoma-like tumor of the mandible
D Baumhoer
Institute of Pathology, University Hospital Basel, Switzerland
Int J Oral Maxillofac Surg 38:903-7. 2009
..The authors describe an unusual case of an intraosseous tubulopapillary hidradenoma of the mandible that recurred 1 year after initial curettage and required en-bloc resection...
- Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater
Daniel Baumhoer
Institute of Pathology, University of Basel, Basel, Switzerland
Mod Pathol 22:306-13. 2009
..CD24 and S100A4, furthermore, can assist in the differential diagnosis of dysplasia vs invasive carcinoma...
- Immunophenotyping and oncogene amplifications in tumors of the papilla of Vater
Daniel Baumhoer
Institute of Pathology, University of Basel, Schonbeinstrasse 40, 4003 Basel, Switzerland
Virchows Arch 453:579-88. 2008
..Fluorescence in situ hybridization analyses of therapeutic target genes (c-myc, EGFR1, CCND1, HER2) found CCND1 to represent the most frequently amplified gene in our series (7.5%)...
- Patterns of liver infiltration in lymphoproliferative disease
D Baumhoer
Institute of Pathology, University Hospital Basel, Basel, Switzerland
Histopathology 53:81-90. 2008
..Data correlating the form of liver involvement with distinct lymphoma subtypes is, however, scarce. The aim was to review 89 liver biopsies diagnosed with lymphoma infiltration and evaluate the infiltration patterns...
Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literatureDaniel Baumhoer
Institute of Pathology, University of Basel, Schonbeinstrasse 40, 4003 Basel, Switzerland
Virchows Arch 451:923-8. 2007
..Moreover, both cases presented aberrant karyotypes including distinct DNA copy number changes involving chromosome 7 and disclosed DNA aneuploidy...
- [Hereditary bone tumors]
G Jundt
Knochentumor Referenzzentrum am Institut für Pathologie, Universitatsspital Basel, Schönbeinstr 40, 4031, Basel, Schweiz
Pathologe 31:471-6. 2010
..In contrast to sporadically occurring similar tumors, differences in manifestation in time, topography or histology may be present which can aid in the correct recognition of the underlying syndrome...
- Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: a tissue microarray analysis of 4,387 tissue samples
Daniel Baumhoer
Institute of Pathology, University Hospital Basel, Basel, Switzerland
Am J Clin Pathol 129:899-906. 2008
..Furthermore, several other tumors revealed consistent expression of GPC3, including squamous cell carcinoma of the lung (27/50 [54%]), testicular nonseminomatous germ cell tumors (32/62 [52%]), and liposarcoma (15/29 [52%])...
- Glypican-3 expression in primary and recurrent ovarian carcinomas
Sylvia Stadlmann
Institute of Pathology, University Hospital Basel, Basel, Switzerland
Int J Gynecol Pathol 26:341-4. 2007
..In conclusion, our data show that GPC3 is observed in a significant fraction of primary and corresponding recurrent ovarian carcinomas. Glypican-3 may therefore represent a potential target for (second-line) therapy in ovarian cancer...
- Hepatic tumorigenesis in acute hepatic failure
Daniel Baumhoer
Department of Gastroenterology and Endocrinology, , , Germany
Eur J Gastroenterol Hepatol 17:1125-30. 2005
..Our cases indicate hepatic tumorigenesis not as a cause of hepatic failure but either as an event taking place in parallel or as a process being induced by progressive liver failure...
- Comparative genomic hybridization in four angiosarcomas of the female breast
Daniel Baumhoer
Department of Gastroenterology and Endocrinology, , , Germany
Gynecol Oncol 97:348-52. 2005
..However, reviewing the cytogenetic literature on angiosarcomas of different sites, gains at 8q and 20p appear to emerge as the most frequent aberrations in at least a subset of these tumors...
