Joydeep Basu

Summary

Publications

  1. doi Functional evaluation of primary renal cell/biomaterial neo-kidney augment prototypes for renal tissue engineering
    Joydeep Basu
    Tengion Inc, Winston Salem, NC 27103, USA
    Cell Transplant 20:1771-90. 2011
  2. doi Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms
    Joydeep Basu
    Tengion, Inc, Winston Salem, North Carolina, USA
    Toxicol Pathol 43:115-25. 2015
  3. doi Regeneration of rodent small intestine tissue following implantation of scaffolds seeded with a novel source of smooth muscle cells
    Joydeep Basu
    Tengion Inc, 3929 Westpoint Boulevard, Suite G, Winston Salem, NC 27103, USA
    Regen Med 6:721-31. 2011
  4. doi Regeneration of native-like neo-urinary tissue from nonbladder cell sources
    Joydeep Basu
    Bioprocess Research and Assay Development, Tengion Inc, Winston Salem, North Carolina 27103, USA
    Tissue Eng Part A 18:1025-34. 2012
  5. doi Extension of bladder-based organ regeneration platform for tissue engineering of esophagus
    Joydeep Basu
    Tengion Inc, 3929 Westpoint Blvd, Suite G, Winston Salem, NC 27103, USA
    Med Hypotheses 78:231-4. 2012
  6. pmc Organ specific regenerative markers in peri-organ adipose: kidney
    Joydeep Basu
    Bioprocess Research and Assay Development, Tengion Inc, 3929 Westpoint Blvd, Suite G, Winston Salem, NC 27103, USA
    Lipids Health Dis 10:171. 2011
  7. doi Expansion of the human adipose-derived stromal vascular cell fraction yields a population of smooth muscle-like cells with markedly distinct phenotypic and functional properties relative to mesenchymal stem cells
    Joydeep Basu
    Bioprocess Research and Assay Development, Tengion Inc, Winston Salem, North Carolina 27103, USA
    Tissue Eng Part C Methods 17:843-60. 2011
  8. doi Platform technologies for tubular organ regeneration
    Joydeep Basu
    Bioprocess Research and Assay Development, Tengion Inc, 3929 Westpoint Blvd, Suite G, Winston Salem, NC 27103, USA
    Trends Biotechnol 28:526-33. 2010
  9. doi Tissue engineering of esophagus and small intestine in rodent injury models
    Joydeep Basu
    Tengion Inc, Winston Salem, NC, USA
    Methods Mol Biol 1001:311-24. 2013
  10. ncbi Molecular characterization of the regenerative response induced by intrarenal transplantation of selected renal cells in a rodent model of chronic kidney disease
    Christopher W Genheimer
    Bioprocess Research and Assay Development, Tengion, Inc, Winston Salem, NC 27103, USA
    Cells Tissues Organs 196:374-84. 2012

Collaborators

Detail Information

Publications21

  1. doi Functional evaluation of primary renal cell/biomaterial neo-kidney augment prototypes for renal tissue engineering
    Joydeep Basu
    Tengion Inc, Winston Salem, NC 27103, USA
    Cell Transplant 20:1771-90. 2011
    ..Conditioned medium was observed to attenuate TGF-β-induced epithelial-mesenchymal transition (EMT) in vitro in a human proximal tubular cell line (HK2)...
  2. doi Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms
    Joydeep Basu
    Tengion, Inc, Winston Salem, North Carolina, USA
    Toxicol Pathol 43:115-25. 2015
    ..In this symposium, we introduced cell-based therapies as an emerging product class to the Society of Toxicologic Pathology (STP) and highlighted key challenges for consideration during product biosafety evaluation. ..
  3. doi Regeneration of rodent small intestine tissue following implantation of scaffolds seeded with a novel source of smooth muscle cells
    Joydeep Basu
    Tengion Inc, 3929 Westpoint Boulevard, Suite G, Winston Salem, NC 27103, USA
    Regen Med 6:721-31. 2011
    ..To apply an organ regeneration platform technology of autologous smooth muscle cell/biomaterial combination products, previously demonstrated to be successful for urinary tissue regeneration, to the regeneration of the small intestine...
  4. doi Regeneration of native-like neo-urinary tissue from nonbladder cell sources
    Joydeep Basu
    Bioprocess Research and Assay Development, Tengion Inc, Winston Salem, North Carolina 27103, USA
    Tissue Eng Part A 18:1025-34. 2012
    ..The ability to create urologic structures de novo from scaffolds seeded by autologous adipose- or peripheral blood-derived SMCs will greatly facilitate the translation of urologic tissue engineering technologies into clinical practice...
  5. doi Extension of bladder-based organ regeneration platform for tissue engineering of esophagus
    Joydeep Basu
    Tengion Inc, 3929 Westpoint Blvd, Suite G, Winston Salem, NC 27103, USA
    Med Hypotheses 78:231-4. 2012
    ..By implication, such regenerative constructs may potentially be used to mediate the regeneration of any laminarly organized tubular organ...
  6. pmc Organ specific regenerative markers in peri-organ adipose: kidney
    Joydeep Basu
    Bioprocess Research and Assay Development, Tengion Inc, 3929 Westpoint Blvd, Suite G, Winston Salem, NC 27103, USA
    Lipids Health Dis 10:171. 2011
    ..To characterize this topographical association, we explored the potential of cells isolated from the stromal vascular fraction (SVF) of kidney sourced adipose to express key renal associated factors...
  7. doi Expansion of the human adipose-derived stromal vascular cell fraction yields a population of smooth muscle-like cells with markedly distinct phenotypic and functional properties relative to mesenchymal stem cells
    Joydeep Basu
    Bioprocess Research and Assay Development, Tengion Inc, Winston Salem, North Carolina 27103, USA
    Tissue Eng Part C Methods 17:843-60. 2011
    ....
  8. doi Platform technologies for tubular organ regeneration
    Joydeep Basu
    Bioprocess Research and Assay Development, Tengion Inc, 3929 Westpoint Blvd, Suite G, Winston Salem, NC 27103, USA
    Trends Biotechnol 28:526-33. 2010
    ..We focus on identifying the elements of this platform that have facilitated the transition of tubular organ regeneration from academic proof-of-concept to commercial viability...
  9. doi Tissue engineering of esophagus and small intestine in rodent injury models
    Joydeep Basu
    Tengion Inc, Winston Salem, NC, USA
    Methods Mol Biol 1001:311-24. 2013
    ..Here, we describe how such constructs may be applied to catalyze regeneration of esophagus and small intestine in preclinical rodent models...
  10. ncbi Molecular characterization of the regenerative response induced by intrarenal transplantation of selected renal cells in a rodent model of chronic kidney disease
    Christopher W Genheimer
    Bioprocess Research and Assay Development, Tengion, Inc, Winston Salem, NC 27103, USA
    Cells Tissues Organs 196:374-84. 2012
    ....
  11. doi Increased urothelial cell detection in the primary bladder smooth muscle cell cultures with dual MACS/qRT-PCR approach
    Chistopher W Genheimer
    Bioprocess Research and Assay Development, Tengion Inc, Winston Salem, NC 27103, USA
    Appl Immunohistochem Mol Morphol 19:184-9. 2011
    ....
  12. pmc Fabrication of a multi-layer three-dimensional scaffold with controlled porous micro-architecture for application in small intestine tissue engineering
    Toyin Knight
    Tengion, Inc, Winston Salem, NC, USA
    Cell Adh Migr 7:267-74. 2013
    ..This data shows the ability of the components of multi-layered scaffolds to influence cell behavior, and demonstrates the potential for these scaffolds to promote desired tissue outcomes in vivo. ..
  13. doi Migration assay to evaluate cellular interactions with biomaterials for tissue engineering/regenerative medicine applications
    Kelly I Guthrie
    Tengion Inc, Winston Salem, NC, USA
    Methods Mol Biol 1001:189-96. 2013
    ..Principles of tissue engineering, Academic Press, 2007; Mieszawska and Kaplan. BMC Biol 8:59, 2010; Matragotri and Lahann J. Nat Mater 8:15-23, 2009)...
  14. doi Smooth muscle phenotypic diversity is mediated through alterations in myocardin gene splicing
    Roger M Ilagan
    Tengion, Inc, Science and Technology, Winston Salem, North Carolina, USA
    J Cell Physiol 226:2702-11. 2011
    ..Together, these data suggest that MYOCD ΔExon 11 may participate in modulating SMC phenotype, potentially acting as a dominant-negative repressor of contraction-related genes...
  15. doi Cross-linked gelatin microspheres with continuously tunable degradation profiles for renal tissue regeneration
    Monica A Serban
    Tengion, Inc, Winston Salem, NC, USA
    Biotechnol Appl Biochem 61:75-81. 2014
    ..These data would indicate that the production of gelatin-based microbeads with tunable degradation profiles might be applicable toward the development of products that catalyze regeneration of kidney and other solid organs. ..
  16. doi Potency evaluation of tissue engineered and regenerative medicine products
    Kelly Guthrie
    Process Research and Translation, Tengion, Inc, 3929 Westpoint Blvd, Suite G, Winston Salem, NC 27103, USA
    Trends Biotechnol 31:505-14. 2013
    ..As the pipeline for TE/RM product candidates expands through 2014 and beyond, the establishment of a defined framework for potency assays will facilitate successful translational outcomes. ..
  17. doi Developmental engineering the kidney: leveraging principles of morphogenesis for renal regeneration
    Joydeep Basu
    Tengion, Inc, Winston Salem, North Carolina 27103, USA joydeep
    Birth Defects Res C Embryo Today 96:30-8. 2012
    ..Ultimately, such methodologies may facilitate the establishment of clinically relevant therapeutic strategies for regeneration of renal structure and function, greatly impacting treatment regimens for chronic kidney disease...
  18. doi Construction of a tubular scaffold that mimics J-shaped stress/strain mechanics using an innovative electrospinning technique
    Harry Scott Rapoport
    Bioprocess Research and Assay Development, Tengion, Inc, Winston Salem, NC 27103, USA
    Tissue Eng Part C Methods 18:567-74. 2012
    ..3±1.9 MJ/m(3). The ability to employ different materials and different formation parameters utilizing this technique promises the ability to match complex stress-strain behaviors in soft tissues with a high degree of fidelity...
  19. doi Linear measurement of cell contraction in a capillary collagen gel system
    Roger Ilagan
    Tengion, Inc, Bioprocess Research and Development, Winston Salem, NC 27103, USA
    Biotechniques 48:153-5. 2010
    ..In addition, capillary tube gels require significantly fewer cells and far less reagents than standard methods...
  20. doi Regenerative medicine of the gastrointestinal tract
    Joydeep Basu
    1Tengion, Inc, Winston Salem, North Carolina, USA
    Toxicol Pathol 42:82-90. 2014
    ..These will be discussed in the context of an overall mechanism of adult regeneration potentially applicable by the tissue engineering and regenerative medicine industry for continued development of hollow neo-organ products. ..
  21. doi Cell-based therapeutic products: potency assay development and application
    Joydeep Basu
    Process Research and Translation, Tengion, Inc, 3929 Westpoint Blvd, Suite G, Winston Salem, NC 27103, USA
    Regen Med 9:497-512. 2014
    ..We present perspectives regarding potency assay development for these products as illustrated by our experiences in process R&D of cryopreserved hepatocytes (Incara Pharmaceuticals) and selected renal cells (Tengion). ..