Robert Barouki

Summary

Publications

  1. pmc Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss
    Min Ji Kim
    INSERM, UMR S, Universite Paris Descartes, Centre Universitaire des Saints Peres, France
    Environ Health Perspect 119:377-83. 2011
  2. pmc Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells
    Min Ji Kim
    INSERM UMR S 747, Universite Paris Descartes, Centre Universitaire des Saints Peres, Paris, France
    Environ Health Perspect 120:508-14. 2012
  3. pmc Toxicological function of adipose tissue: focus on persistent organic pollutants
    Michele La Merrill
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Environ Health Perspect 121:162-9. 2013
  4. doi request reprint [Can xenobiotics accumulated in adipose tissue contribute to a carcinogenic risk?]
    Robert Barouki
    INSERM UMR S 747, Centre Universitaire des Saints Peres, Universite Paris Descartes, Hopital Necker Enfants Malades, AP HP, 45, rue des Saints Pères, 75015 Paris, France
    Ann Endocrinol (Paris) 74:154-5. 2013
  5. doi request reprint The aryl hydrocarbon receptor system
    Robert Barouki
    INSERM UMR, Universite Paris Descartes, Paris, France
    Drug Metabol Drug Interact 27:3-8. 2012
  6. pmc Developmental origins of non-communicable disease: implications for research and public health
    Robert Barouki
    INSERM UMR S, Universite Paris Descartes, France
    Environ Health 11:42. 2012
  7. ncbi request reprint Linking long-term toxicity of xeno-chemicals with short-term biological adaptation
    Robert Barouki
    INSERM UMR S 747, Universite Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, Service de Biochimie Métabolique, Paris, France
    Biochimie 92:1222-6. 2010
  8. pmc Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor
    Robert Barouki
    INSERM UMR S 747, Paris, France
    Cell Adh Migr 4:72-6. 2010
  9. ncbi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2
    Ariane Ambolet-Camoit
    INSERM UMR S 747, 75006 Paris, France
    Toxicol Sci 115:501-12. 2010
  10. doi request reprint Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation
    Stéphane Pierre
    INSERM UMR S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 Rue des Saints Peres, 75006 Paris, France
    Biochem Pharmacol 81:304-13. 2011

Collaborators

Detail Information

Publications25

  1. pmc Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss
    Min Ji Kim
    INSERM, UMR S, Universite Paris Descartes, Centre Universitaire des Saints Peres, France
    Environ Health Perspect 119:377-83. 2011
    ..In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear...
  2. pmc Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells
    Min Ji Kim
    INSERM UMR S 747, Universite Paris Descartes, Centre Universitaire des Saints Peres, Paris, France
    Environ Health Perspect 120:508-14. 2012
    ..Epidemiological studies emphasize the possible role of persistent organic pollutants (POPs) in obesity and the metabolic syndrome. These pollutants are stored in adipose tissue (AT)...
  3. pmc Toxicological function of adipose tissue: focus on persistent organic pollutants
    Michele La Merrill
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Environ Health Perspect 121:162-9. 2013
    ..Adipose tissue (AT) is involved in several physiological functions, including metabolic regulation, energy storage, and endocrine functions...
  4. doi request reprint [Can xenobiotics accumulated in adipose tissue contribute to a carcinogenic risk?]
    Robert Barouki
    INSERM UMR S 747, Centre Universitaire des Saints Peres, Universite Paris Descartes, Hopital Necker Enfants Malades, AP HP, 45, rue des Saints Pères, 75015 Paris, France
    Ann Endocrinol (Paris) 74:154-5. 2013
    ..These complex interactions between adipose tissue and environmental pollutants have implications in obesity that need to be further studied...
  5. doi request reprint The aryl hydrocarbon receptor system
    Robert Barouki
    INSERM UMR, Universite Paris Descartes, Paris, France
    Drug Metabol Drug Interact 27:3-8. 2012
    ..A holistic approach should provide a better understanding of the biology of this receptor in addition to providing new avenues for the identification of specific toxicity mechanisms...
  6. pmc Developmental origins of non-communicable disease: implications for research and public health
    Robert Barouki
    INSERM UMR S, Universite Paris Descartes, France
    Environ Health 11:42. 2012
    ....
  7. ncbi request reprint Linking long-term toxicity of xeno-chemicals with short-term biological adaptation
    Robert Barouki
    INSERM UMR S 747, Universite Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, Service de Biochimie Métabolique, Paris, France
    Biochimie 92:1222-6. 2010
    ..Altogether, The hypothesis presented here proposes that one mechanism for long-term toxicity stems from cumulative side effects due to the repeated activity of adaptive pathways triggered by acute intoxication...
  8. pmc Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor
    Robert Barouki
    INSERM UMR S 747, Paris, France
    Cell Adh Migr 4:72-6. 2010
    ..We will put our studies in perspective with other observations made by several groups...
  9. ncbi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2
    Ariane Ambolet-Camoit
    INSERM UMR S 747, 75006 Paris, France
    Toxicol Sci 115:501-12. 2010
    ....
  10. doi request reprint Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation
    Stéphane Pierre
    INSERM UMR S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 Rue des Saints Peres, 75006 Paris, France
    Biochem Pharmacol 81:304-13. 2011
    ..Remarkably, our studies also suggest that SOS1 induction leads to functional effects similar to those elicited by the well-characterized oncogenic Ras mutations...
  11. ncbi request reprint Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione
    Joan Tordjman
    INSERM U530, Universite Paris Descartes, F 75006, Paris, France
    J Biol Chem 282:23591-602. 2007
    ..Our data identify cAspAT as a new member of glyceroneogenesis, transcriptionally regulated by TZD via the control of RORalpha expression by PPARgamma in adipocytes...
  12. ncbi request reprint The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein
    Robert Barouki
    INSERM, UMR S 747, 75270 Paris Cedex 06, France
    FEBS Lett 581:3608-15. 2007
    ..In this review, we will attempt to summarize the studies supporting the implication of the AhR in those endogenous cellular processes...
  13. doi request reprint Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex
    Jean Marc Blouin
    INSERM UMR S 747, Universite Paris Descartes, Centre Universitaire des Saints Peres, Paris, France
    Int J Cancer 128:2591-601. 2011
    ....
  14. ncbi request reprint Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor
    Erwan Guyot
    INSERM UMR S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 Rue des Saints Peres, 75006 Paris, France
    Biochem Pharmacol 83:627-32. 2012
    ..It also acts by activating the AhR. However, in contrast with traditional AhR agonists, it does not induce cyp1A1 transcription. (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile is therefore a specific AhR modulator targeting PON1...
  15. doi request reprint Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin
    Stéphane Pierre
    INSERM UMR S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, Paris, France
    Toxicol Sci 137:114-24. 2014
    ..Finally, we confirmed that Snai2 is a direct transcriptional target of TCDD in the human hepatocarcinoma cell line, HepG2. The AhR ligand, TCDD, induces hepatic fibrosis by directly regulating profibrotic pathways. ..
  16. ncbi request reprint Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4
    Alexandre Marchand
    INSERM UMR S 747, Universite Paris Descartes, 45 Rue des Saints Peres, 75270 Paris, France
    J Biol Chem 281:19124-33. 2006
    ..Increased secretion of IGFBP-1 during hepatic ER stress may thus constitute a signal to modulate cell growth and metabolism and induce a systemic adaptive response...
  17. doi request reprint The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications
    Erwan Guyot
    INSERM UMR S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 Rue des Saints Peres, 75006 Paris, France
    Drug Discov Today 18:479-86. 2013
    ..Finally, we suggest several promising perspectives for the pharmacological modulation of these responses...
  18. ncbi request reprint Induction of the paraoxonase-1 gene expression by resveratrol
    Cédric Gouédard
    INSERM UMR S 490, Universite Rene Descartes, Paris, France
    Arterioscler Thromb Vasc Biol 24:2378-83. 2004
    ..It is able to interact with transcriptional modulators such as the estrogen receptor alpha (ERalpha). We investigated the effect of resveratrol on the PON-1 gene expression...
  19. pmc Oculomotor deficits in aryl hydrocarbon receptor null mouse
    Aline Chevallier
    INSERM UMR S 747, Toxicologie Pharmacologie et Signalisation Cellulaire, Centre Universitaire des Saints Peres, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    PLoS ONE 8:e53520. 2013
    ..Given the many common features between both AhR mouse and human infantile nystagmus syndromes, the AhR-/- mice might give insights into the developmental mechanisms which lead to congenital eye disorders...
  20. pmc A head and neck cancer tumor response-specific gene signature for cisplatin, 5-fluorouracil induction chemotherapy fails with added taxanes
    Celine Tomkiewicz
    INSERM, UMR S, Centre Universitaire des Saints Peres, Paris, France
    PLoS ONE 7:e47170. 2012
    ....
  21. doi request reprint ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes
    Laurent Magne
    INSERM UMR S 747, Paris, France
    J Hepatol 54:729-37. 2011
    ..The aim of this study was to assess the effect of alcohol on the ISR signaling pathway in human liver cells and to define the role of cytochrome P450 2E1 (CYP2E1) in this response...
  22. ncbi request reprint Characterisation of a human liver cystathionine beta synthase mRNA sequence corresponding to the c.[833T>C;844_845ins68] mutation in CBS gene
    Jean François Chassé
    INSERM UMR S 747, 45 Rue des Saints Peres, 75270, Paris Cedex 06, France
    Mol Cell Biochem 332:183-7. 2009
    ..We have determined the sequence of the liver mRNA corresponding to the CBS c.[833T>C;844_845ins68] gene. We have shown that a novel splicing event could account for the modification in protein and possibly in enzyme activity...
  23. ncbi request reprint NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner
    Julien Diana
    Institut National de la Santé et de la Recherche Médicale U561, Hôpital Cochin St Vincent de Paul, Paris, France
    Immunity 30:289-99. 2009
    ..Thus, this study identifies pDCs as an essential partner of iNKT cells for mounting an efficient, nondeleterious antiviral response in peripheral tissue...
  24. ncbi request reprint Opposite regulation of the rat and human cytosolic aspartate aminotransferase genes by fibrates
    Celine Tomkiewicz
    UMRS Unit 490 INSERM, Centre Universitaire des Saints Peres, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Biochem Pharmacol 67:213-25. 2004
    ..Co-transfection assays suggested that, in humans, the PPARalpha was also involved in the increase in expression of the cAspAT gene due to fibrates, without the presence of a canonical PPAR responsive element...
  25. ncbi request reprint Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins
    Cédric Gouédard
    Institut National de la Santé et de la Recherche Médicale Unité 490, Centre Universitaire des Saints Peres, Paris, France
    Mol Pharmacol 63:945-56. 2003
    ..Regarding the toxicological aspects, the induction achieved with fenofibric acid, although limited, could increase organophosphate metabolism and may be relevant in certain conditions for protective treatments...