The intrauterine origins of Hodgkin's lymphomaDavid J P Barker
Heart Research Center, Oregon Health and Science University, USA MRC Lifecourse Epidemiology Unit University of Southampton, Southampton General Hospital, UK Chair of Fetal Programming, King Saud University, Saudi Arabia Electronic address
Cancer Epidemiol 37:321-3. 2013
..We speculate that Hodgkin's lymphoma is initiated by two events in fetal life. One, which is an immune event, is associated with prolonged gestation, while the other is associated with growth faltering...
- The placental origins of sudden cardiac death
David J P Barker
Heart Research Center and Moore Institute, Oregon Health and Science University, Portland, OR, USA
Int J Epidemiol 41:1394-9. 2012
..We hypothesized that placental size would be associated with sudden cardiac death...
- Resource allocation in utero and health in later life
D J P Barker
Medical School, University of Southampton, UK
Placenta 33:e30-4. 2012
..There is not a separate cause for each different disease. Which chronic disease originates during development may depend more on timing than on qualitative differences in experience...
- A possible link between the pubertal growth of girls and prostate cancer in their sons
David J P Barker
Heart Research Center, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
Am J Hum Biol 24:406-10. 2012
..We speculated that high maternal estrogen concentrations during pregnancy initiate hormonal cancers in their daughters. Here, we examine the association between the mothers' intercristal diameters and prostate cancer in their sons...
- The surface area of the placenta and hypertension in the offspring in later life
David J P Barker
MRC Epidemiology Resource Centre University of Southampton, Southampton General Hospital, Southampton, UK
Int J Dev Biol 54:525-30. 2010
..In better-nourished mothers the placental surface may expand to compensate for fetal undernutrition. Growth along the minor axis of the surface may be more nutritionally sensitive than growth along the major axis...
- The prenatal origins of lung cancer. II. The placenta
David J P Barker
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
Am J Hum Biol 22:512-6. 2010
..We suggest that each led to low amino acid-normal glucose transfer to the fetus, reflected in a newborn baby that was short in relation to its weight...
- The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood
David J P Barker
Heart Research Center, Oregon Health and Science University, Portland, OR 97201 3098, USA
Eur J Heart Fail 12:819-25. 2010
..Here we examine the association between body and placental size at birth and later chronic heart failure...
- How boys grow determines how long they live
David J P Barker
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
Am J Hum Biol 23:412-6. 2011
..There is, however, a caveat. Tall adult stature may be the result of rapid "compensatory" growth following a setback. Compensatory growth is known to reduce the lifespan of animals, possibly because it is disorganized...
- The lifespan of men and the shape of their placental surface at birth
D J P Barker
Heart Research Center, Oregon Health and Science University, Portland, OR 97201 3098, USA
Placenta 32:783-7. 2011
..We here examine the size and shape of their placentas at birth to gain further insight into their path of fetal growth...
- Sir Richard Doll Lecture. Developmental origins of chronic disease
D J P Barker
Medical School, University of Southampton, Southampton, UK
Public Health 126:185-9. 2012
..Not only will this prevent chronic disease, but it will produce new generations who have better health and well-being through their lives...
- Growth and chronic disease: findings in the Helsinki Birth Cohort
David J P Barker
MRC Epidemiology Resource Centre University of Southampton, Southampton General Hospital, Southampton, UK
Ann Hum Biol 36:445-58. 2009
..Those who later develop stroke grow slowly in fetal life, infancy and during childhood. We also review how the growth of girls during infancy, childhood and at puberty influences chronic disease in the next generation...
- Sex differences in birth size and intergenerational effects of intrauterine exposure to Ramadan in Saudi Arabia
S H Alwasel
Fetal Programming of Disease Research Chair, Zoology Department, College of Science, King Saud University, Saudi Arabia
Am J Hum Biol 23:651-4. 2011
..In Europe, boys and girls have different body proportions at birth. We examined newborn babies in Saudi Arabia to determine the sex differences and whether fetal growth differed if the mother was in utero during Ramadan...
- Growth in childhood predicts hip fracture risk in later life
M K Javaid
MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK
Osteoporos Int 22:69-73. 2011
..2-fold increase in hip fracture risk compared with those in the highest quarter (p < 0.001). These data point to a relationship between childhood growth and fracture risk during later life...
Fetal origins of adult disease: strength of effects and biological basisD J P Barker
Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
Int J Epidemiol 31:1235-9. 2002
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Growth of girls who later develop coronary heart diseaseT Forsen
Southampton General Hospital, Tremona Road, Southampton, UK
Heart 90:20-4. 2004
..To determine the path of growth of girls who later develop coronary heart disease...
- Secular increase in placental weight in Saudi Arabia
S H Alwasel
Fetal Programming of Disease Research Chair, Zoology Dept, College of Science, King Saud University, Riyadh, Saudi Arabia
Placenta 32:391-4. 2011
..We also found that, over the four years of the study, placental weight increased by 29 g per year. We have now extended our data collection in order to examine this trend in more detail...
- The developmental origins of adult disease
D J P Barker
University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
J Am Coll Nutr 23:588S-595S. 2004
..A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes...
- The developmental origins of well-being
D J P Barker
Division for Developmental Origins of Adult Health and Disease, University of Southampton, Mailpoint 95, Southampton General Hospital, Southampton SO16 6YD, UK
Philos Trans R Soc Lond B Biol Sci 359:1359-66. 2004
..A new vision of optimal early human development is emerging, which takes account of health and well-being throughout life...
- Cohort profile: the Hertfordshire cohort study
H E Syddall
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Int J Epidemiol 34:1234-42. 2005
- Constraints on food choices of women in the UK with lower educational attainment
M Barker
Food Choice Group, MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Public Health Nutr 11:1229-37. 2008
..The present study aimed to identify factors that influence the food choices of women with lower educational attainment and how women could be helped to improve those choices...
- Infant growth and income 50 years later
D J P Barker
DOHaD Division, University of Southampton, UK
Arch Dis Child 90:272-3. 2005
..One interpretation of this is that biological processes linked to slow infant growth may lead to lifelong impairment of cognitive function...
- The breadth of the placental surface but not the length is associated with body size at birth
S H Alwasel
Zoology Department, College of Science and Centre of Excellence in Biotechnology Research, King Saud University, Saudi Arabia
Placenta 33:619-22. 2012
..Mothers who are short in stature are known to have lower rates of protein turnover in pregnancy. In these circumstances the ability of the placenta to transfer amino acids to the fetus may be critical...
- Mother's lifetime nutrition and the size, shape and efficiency of the placenta
N R Winder
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
Placenta 32:806-10. 2011
..Studies have shown that the shape and size of the placenta at birth predict blood pressure in later life. The influences that determine placental morphology are largely unknown. We have examined the role of mother's body size...
- The developmental origins of adult disease
D J P Barker
MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
Eur J Epidemiol 18:733-6. 2003
- Coronary heart disease: a disorder of growth
S M Robinson
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Proc Nutr Soc 61:537-42. 2002
..These effects are compounded by accelerated weight gain, which may represent 'compensatory growth' in childhood...
- Coronary heart disease: a disorder of growth
D J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
Horm Res 59:35-41. 2003
....
- The origins of the developmental origins theory
D J P Barker
DOHaD Division, University of Southampton, UK
J Intern Med 261:412-7. 2007
..The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward...
- Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study
H E Syddall
Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Am J Epidemiol 161:1074-80. 2005
..Overall, a one-standard-deviation increase in birth weight reduced all-cause mortality risk by age 75 years by 0.86% for both men and women...
- Obesity and early life
D J P Barker
University of Southampton, Southampton, UK
Obes Rev 8:45-9. 2007
- The developmental origins of chronic adult disease
D J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom
Acta Paediatr Suppl 93:26-33. 2004
..These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth...
- Altered regional blood flow in the fetus: the origins of cardiovascular disease?
D J P Barker
Division of Developmental Origins of Adult Health and Disease, University of Southampton, Southampton, United Kingdom
Acta Paediatr 93:1559-60. 2004
..CONCLUSION: The long-term consequences of fetal redistribution of blood flow are unknown, but preliminary evidence suggests that there is an increased risk of coronary heart disease and hypertension in later life...
- Changes in placental size during Ramadan
S H Alwasel
Fetal Programming of Diseases Research, Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia
Placenta 31:607-10. 2010
..Little is known about the effects of this altered lifestyle on placental development...
- Commentary: Developmental origins of raised serum cholesterol
D J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Int J Epidemiol 32:876-7. 2003
- Different indices of fetal growth predict bone size and volumetric density at 4 years of age
Nicholas C Harvey
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
J Bone Miner Res 25:920-7. 2010
..These results suggest a discordance between influences on skeletal size and volumetric density...
- Impact of educational attainment on the quality of young women's diets
S M Robinson
MRC Environmental Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
Eur J Clin Nutr 58:1174-80. 2004
..This study examines the influence of sociodemographic and anthropometric factors on the quality of the diets of young women in the UK...
- Components in the interpretation of the high mortality in the county of Finnmark
D J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
Int J Epidemiol 31:309-10. 2002
