D J P Barker

Summary

Publications

  1. doi request reprint The obstetric origins of health for a lifetime
    David J P Barker
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    Clin Obstet Gynecol 56:511-9. 2013
  2. doi request reprint Human growth and chronic disease: a memorial to Jim Tanner
    David J P Barker
    Medical School, University of Southampton, UK
    Ann Hum Biol 39:335-41. 2012
  3. doi request reprint Placental programming of chronic diseases, cancer and lifespan: a review
    D J P Barker
    MRC Lifecourse Epidemiology Unit, Medical School, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Placenta 34:841-5. 2013
  4. doi request reprint The shape of the placental surface at birth and colorectal cancer in later life
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, Oregon MRC Lifecourse Epidemiology Unit University of Southampton, Southampton General Hospital, UK
    Am J Hum Biol 25:566-8. 2013
  5. pmc Maternal cotyledons at birth predict blood pressure in childhood
    D Barker
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Placenta 34:672-5. 2013
  6. doi request reprint Foetal and childhood growth and asthma in adult life
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, OR, USA
    Acta Paediatr 102:732-8. 2013
  7. doi request reprint The intrauterine origins of Hodgkin's lymphoma
    David J P Barker
    Heart Research Center, Oregon Health and Science University, OR, USA
    Cancer Epidemiol 37:321-3. 2013
  8. doi request reprint The placental origins of sudden cardiac death
    David J P Barker
    Heart Research Center and Moore Institute, Oregon Health and Science University, Portland, OR, USA
    Int J Epidemiol 41:1394-9. 2012
  9. doi request reprint Resource allocation in utero and health in later life
    D J P Barker
    Medical School, University of Southampton, UK
    Placenta 33:e30-4. 2012
  10. doi request reprint A possible link between the pubertal growth of girls and prostate cancer in their sons
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Am J Hum Biol 24:406-10. 2012

Collaborators

Detail Information

Publications43

  1. doi request reprint The obstetric origins of health for a lifetime
    David J P Barker
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    Clin Obstet Gynecol 56:511-9. 2013
    ....
  2. doi request reprint Human growth and chronic disease: a memorial to Jim Tanner
    David J P Barker
    Medical School, University of Southampton, UK
    Ann Hum Biol 39:335-41. 2012
    ..Memorial to Jim Tanner...
  3. doi request reprint Placental programming of chronic diseases, cancer and lifespan: a review
    D J P Barker
    MRC Lifecourse Epidemiology Unit, Medical School, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Placenta 34:841-5. 2013
    ..We also need to understand why, compared to other placental mammals, the human placenta is so variable in its morphology and functional capacity...
  4. doi request reprint The shape of the placental surface at birth and colorectal cancer in later life
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, Oregon MRC Lifecourse Epidemiology Unit University of Southampton, Southampton General Hospital, UK
    Am J Hum Biol 25:566-8. 2013
    ..In this study, we examine how colorectal cancer is related to maternal and placental characteristics...
  5. pmc Maternal cotyledons at birth predict blood pressure in childhood
    D Barker
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Placenta 34:672-5. 2013
    ..Because the number of cotyledons is correlated with the surface area, we hypothesized that fewer cotyledons would be associated with higher blood pressure...
  6. doi request reprint Foetal and childhood growth and asthma in adult life
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, OR, USA
    Acta Paediatr 102:732-8. 2013
    ..Here, we examine whether asthma in adult life is associated with reduced body size at birth and poor living conditions in childhood...
  7. doi request reprint The intrauterine origins of Hodgkin's lymphoma
    David J P Barker
    Heart Research Center, Oregon Health and Science University, OR, USA
    Cancer Epidemiol 37:321-3. 2013
    ..Our hypothesis was that the disease would be associated with markers of poor fetal growth, specifically small body size or small placental size at birth...
  8. doi request reprint The placental origins of sudden cardiac death
    David J P Barker
    Heart Research Center and Moore Institute, Oregon Health and Science University, Portland, OR, USA
    Int J Epidemiol 41:1394-9. 2012
    ..We hypothesized that placental size would be associated with sudden cardiac death...
  9. doi request reprint Resource allocation in utero and health in later life
    D J P Barker
    Medical School, University of Southampton, UK
    Placenta 33:e30-4. 2012
    ..There is not a separate cause for each different disease. Which chronic disease originates during development may depend more on timing than on qualitative differences in experience...
  10. doi request reprint A possible link between the pubertal growth of girls and prostate cancer in their sons
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Am J Hum Biol 24:406-10. 2012
    ..We speculated that high maternal estrogen concentrations during pregnancy initiate hormonal cancers in their daughters. Here, we examine the association between the mothers' intercristal diameters and prostate cancer in their sons...
  11. doi request reprint Growth and chronic disease: findings in the Helsinki Birth Cohort
    David J P Barker
    MRC Epidemiology Resource Centre University of Southampton, Southampton General Hospital, Southampton, UK
    Ann Hum Biol 36:445-58. 2009
    ..Those who later develop stroke grow slowly in fetal life, infancy and during childhood. We also review how the growth of girls during infancy, childhood and at puberty influences chronic disease in the next generation...
  12. doi request reprint The prenatal origins of lung cancer. II. The placenta
    David J P Barker
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Am J Hum Biol 22:512-6. 2010
    ..We suggest that each led to low amino acid-normal glucose transfer to the fetus, reflected in a newborn baby that was short in relation to its weight...
  13. doi request reprint How boys grow determines how long they live
    David J P Barker
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Am J Hum Biol 23:412-6. 2011
    ..There is, however, a caveat. Tall adult stature may be the result of rapid "compensatory" growth following a setback. Compensatory growth is known to reduce the lifespan of animals, possibly because it is disorganized...
  14. doi request reprint The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Eur J Heart Fail 12:819-25. 2010
    ..Here we examine the association between body and placental size at birth and later chronic heart failure...
  15. doi request reprint The lifespan of men and the shape of their placental surface at birth
    D J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Placenta 32:783-7. 2011
    ..We here examine the size and shape of their placentas at birth to gain further insight into their path of fetal growth...
  16. doi request reprint Sir Richard Doll Lecture. Developmental origins of chronic disease
    D J P Barker
    Medical School, University of Southampton, Southampton, UK
    Public Health 126:185-9. 2012
    ..Not only will this prevent chronic disease, but it will produce new generations who have better health and well-being through their lives...
  17. doi request reprint The surface area of the placenta and hypertension in the offspring in later life
    David J P Barker
    MRC Epidemiology Resource Centre University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Dev Biol 54:525-30. 2010
    ..In better-nourished mothers the placental surface may expand to compensate for fetal undernutrition. Growth along the minor axis of the surface may be more nutritionally sensitive than growth along the major axis...
  18. doi request reprint Sex differences in birth size and intergenerational effects of intrauterine exposure to Ramadan in Saudi Arabia
    S H Alwasel
    Fetal Programming of Disease Research Chair, Zoology Department, College of Science, King Saud University, Saudi Arabia
    Am J Hum Biol 23:651-4. 2011
    ..In Europe, boys and girls have different body proportions at birth. We examined newborn babies in Saudi Arabia to determine the sex differences and whether fetal growth differed if the mother was in utero during Ramadan...
  19. doi request reprint The breadth of the placental surface but not the length is associated with body size at birth
    S H Alwasel
    Zoology Department, College of Science and Centre of Excellence in Biotechnology Research, King Saud University, Saudi Arabia
    Placenta 33:619-22. 2012
    ..Mothers who are short in stature are known to have lower rates of protein turnover in pregnancy. In these circumstances the ability of the placenta to transfer amino acids to the fetus may be critical...
  20. doi request reprint Growth in childhood predicts hip fracture risk in later life
    M K Javaid
    MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK
    Osteoporos Int 22:69-73. 2011
    ..2-fold increase in hip fracture risk compared with those in the highest quarter (p < 0.001). These data point to a relationship between childhood growth and fracture risk during later life...
  21. ncbi request reprint Fetal origins of adult disease: strength of effects and biological basis
    D J P Barker
    Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
    Int J Epidemiol 31:1235-9. 2002
    ....
  22. pmc Growth of girls who later develop coronary heart disease
    T Forsen
    Southampton General Hospital, Tremona Road, Southampton, UK
    Heart 90:20-4. 2004
    ..To determine the path of growth of girls who later develop coronary heart disease...
  23. doi request reprint Secular increase in placental weight in Saudi Arabia
    S H Alwasel
    Fetal Programming of Disease Research Chair, Zoology Dept, College of Science, King Saud University, Riyadh, Saudi Arabia
    Placenta 32:391-4. 2011
    ..We also found that, over the four years of the study, placental weight increased by 29 g per year. We have now extended our data collection in order to examine this trend in more detail...
  24. pmc The developmental origins of well-being
    D J P Barker
    Division for Developmental Origins of Adult Health and Disease, University of Southampton, Mailpoint 95, Southampton General Hospital, Southampton SO16 6YD, UK
    Philos Trans R Soc Lond B Biol Sci 359:1359-66. 2004
    ..A new vision of optimal early human development is emerging, which takes account of health and well-being throughout life...
  25. ncbi request reprint Cohort profile: the Hertfordshire cohort study
    H E Syddall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 34:1234-42. 2005
  26. ncbi request reprint The developmental origins of adult disease
    D J P Barker
    University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
    J Am Coll Nutr 23:588S-595S. 2004
    ..A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes...
  27. ncbi request reprint Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study
    H E Syddall
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Epidemiol 161:1074-80. 2005
    ..Overall, a one-standard-deviation increase in birth weight reduced all-cause mortality risk by age 75 years by 0.86% for both men and women...
  28. pmc Mother's lifetime nutrition and the size, shape and efficiency of the placenta
    N R Winder
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Placenta 32:806-10. 2011
    ..Studies have shown that the shape and size of the placenta at birth predict blood pressure in later life. The influences that determine placental morphology are largely unknown. We have examined the role of mother's body size...
  29. doi request reprint Constraints on food choices of women in the UK with lower educational attainment
    M Barker
    Food Choice Group, MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Public Health Nutr 11:1229-37. 2008
    ..The present study aimed to identify factors that influence the food choices of women with lower educational attainment and how women could be helped to improve those choices...
  30. pmc Infant growth and income 50 years later
    D J P Barker
    DOHaD Division, University of Southampton, UK
    Arch Dis Child 90:272-3. 2005
    ..One interpretation of this is that biological processes linked to slow infant growth may lead to lifelong impairment of cognitive function...
  31. doi request reprint Intergenerational effects of in utero exposure to Ramadan in Tunisia
    S H Alwasel
    Fetal Programming of Disease Research Chair, Zoology Department, College of Science, King Saud University, Saudi Arabia
    Am J Hum Biol 25:341-3. 2013
    ..In a series of newborn babies in Saudi Arabia, those whose mothers had been in utero during Ramadan differed from those whose mothers had not been in utero during Ramadan. These were unexpected findings and require replication...
  32. ncbi request reprint The origins of the developmental origins theory
    D J P Barker
    DOHaD Division, University of Southampton, UK
    J Intern Med 261:412-7. 2007
    ..The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward...
  33. ncbi request reprint The developmental origins of adult disease
    D J P Barker
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Eur J Epidemiol 18:733-6. 2003
  34. ncbi request reprint Coronary heart disease: a disorder of growth
    D J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Horm Res 59:35-41. 2003
    ....
  35. ncbi request reprint Coronary heart disease: a disorder of growth
    S M Robinson
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Proc Nutr Soc 61:537-42. 2002
    ..These effects are compounded by accelerated weight gain, which may represent 'compensatory growth' in childhood...
  36. ncbi request reprint Obesity and early life
    D J P Barker
    University of Southampton, Southampton, UK
    Obes Rev 8:45-9. 2007
  37. ncbi request reprint Altered regional blood flow in the fetus: the origins of cardiovascular disease?
    D J P Barker
    Division of Developmental Origins of Adult Health and Disease, University of Southampton, Southampton, United Kingdom
    Acta Paediatr 93:1559-60. 2004
    ..A fetal response to hypoxia and other adverse influences is to redistribute blood flow in order to "spare" the brain. This, however, is associated with reduced growth of the liver and kidneys...
  38. ncbi request reprint The developmental origins of chronic adult disease
    D J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom
    Acta Paediatr Suppl 93:26-33. 2004
    ..These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth...
  39. doi request reprint Changes in placental size during Ramadan
    S H Alwasel
    Fetal Programming of Diseases Research, Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia
    Placenta 31:607-10. 2010
    ..Little is known about the effects of this altered lifestyle on placental development...
  40. ncbi request reprint Commentary: Developmental origins of raised serum cholesterol
    D J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 32:876-7. 2003
  41. pmc Different indices of fetal growth predict bone size and volumetric density at 4 years of age
    Nicholas C Harvey
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Bone Miner Res 25:920-7. 2010
    ..These results suggest a discordance between influences on skeletal size and volumetric density...
  42. ncbi request reprint Components in the interpretation of the high mortality in the county of Finnmark
    D J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
    Int J Epidemiol 31:309-10. 2002
  43. ncbi request reprint Impact of educational attainment on the quality of young women's diets
    S M Robinson
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
    Eur J Clin Nutr 58:1174-80. 2004
    ..This study examines the influence of sociodemographic and anthropometric factors on the quality of the diets of young women in the UK...