Fernando Barbosa

Summary

Publications

  1. pmc A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs
    Fernando Barbosa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Environ Health Perspect 113:1669-74. 2005
  2. doi request reprint Vitamin D receptor haplotypes affect lead levels during pregnancy
    Vania B Rezende
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13081 970, Campinas, SP, Brazil
    Sci Total Environ 408:4955-60. 2010
  3. doi request reprint Inorganic and methylmercury levels in plasma are differentially associated with age, gender, and oxidative stress markers in a population exposed to mercury through fish consumption
    Maria Fernanda Hornos Carneiro
    a Laboratório de Toxicologia e Essencialidade de Metais, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Monte Alegre, Ribeirao Preto, SP, Brazil
    J Toxicol Environ Health A 77:69-79. 2014
  4. doi request reprint Intron 4 polymorphism of the endothelial nitric oxide synthase (eNOS) gene is associated with decreased NO production in a mercury-exposed population
    Kátia Cristina de Marco
    Department of Clinical, Toxicological and Food Science Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Sci Total Environ 414:708-12. 2012
  5. doi request reprint Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats
    Gustavo Rafael Mazzaron Barcelos
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe, s no, Ribeirao Preto, Sao Paulo, CEP 14040 903, Brazil
    Arch Toxicol 85:1151-7. 2011
  6. ncbi request reprint Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects
    Vania B Rezende
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13081 970 Campinas, SP, Brazil
    Arch Toxicol 82:29-36. 2008
  7. doi request reprint Evaluation of protective effects of fish oil against oxidative damage in rats exposed to methylmercury
    Denise Grotto
    Departamento de Analises Clinicas, Toxicológicas e Bromatológicas Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de Sao Paulo, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Ecotoxicol Environ Saf 74:487-93. 2011
  8. doi request reprint Mercury exposure increases circulating net matrix metalloproteinase (MMP)-2 and MMP-9 activities
    Anna L B Jacob-Ferreira
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Basic Clin Pharmacol Toxicol 105:281-8. 2009
  9. doi request reprint Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo
    Gustavo Rafael Mazzaron Barcelos
    Departament of Clinical, Toxicologic and Bromatologic Analyses, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Environ Mol Mutagen 53:535-41. 2012
  10. doi request reprint Evaluation of seasonal dietary exposure to arsenic, cadmium and lead in schoolchildren through the analysis of meals served by public schools of Ribeirão Preto, Brazil
    Letícia Ramos Nacano
    a Laboratório de Toxicologia e Essencialidade de Metais, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Monte Alegre, Ribeirao Preto, Sao Paulo, Brazil
    J Toxicol Environ Health A 77:367-74. 2014

Collaborators

  • Jose E Tanus-Santos
  • Denise Grotto
  • Carlos J S Passos
  • Juliana Mara Serpeloni
  • Tatiana Emanuelli
  • Raquel Fernanda Gerlach
  • Karin Broberg
  • Melanie Lemire
  • Donna Mergler
  • Ana C T Zanchi
  • Riccardo Lacchini
  • Maria C D Saraiva
  • Myriam Fillion
  • Maria Fernanda Hornos Carneiro
  • Gustavo Rafael Mazzaron Barcelos
  • Kátia Cristina de Marco
  • Vania B Rezende
  • Anna L B Jacob-Ferreira
  • Marcelo F Montenegro
  • Jairo L Rodrigues
  • Bruno L Batista
  • Samuel S de Souza
  • Juliana Valentini
  • Jefferson H Amaral
  • Andréia Ávila Soares de Oliveira
  • Glauce Regina Costa de Almeida
  • Valeria C Sandrim
  • Lusânia Maria Greggi Antunes
  • Bruno Lemos Batista
  • Claudia Ramos Rhoden
  • Letícia Ramos Nacano
  • Vivian da Silva Santos
  • Ilce Mara de Syllos Colus
  • Gilberto Úbida Leite Braga
  • André van Helvoort Lengert
  • Solange Cristina Garcia
  • Siegfried Knasmuller
  • Vanessa Cristina de Oliveira Souza
  • Silvana M Quintana
  • Rosangela M M Sawan
  • Elen Rizzi
  • Marcelo Freitas Montenegro
  • Maria da Conceição Pereira Saraiva
  • Francisco José Krug
  • Jaime Aparecido Cury
  • Maria da Luz Rosário de Sousa
  • Viviane Elisângela Gomes
  • Marilesia Ferreira de Souza
  • Rossana Batista de Oliveira Godoy Camargo
  • Gustavo Henrique de Almeida Teixeira
  • Marcelo Tempesta de Oliveira
  • Rodolfo de Freitas
  • Fabio Sidonio de B Evangelista
  • Karin Schläwicke Engström
  • Andres Dobal Campiglia
  • Alexandre Ferro Aissa
  • Gilberto Úbila Leite Braga
  • Jairo Kenupp Bastos
  • Bruno Alves Rocha
  • Juliana M O Souza
  • José Pedro Friedmann Angeli
  • Gilberto U Braga
  • Gabriela Ramos Chagas
  • Juliana Tanara Vicentini
  • Maurício Bianchini Moresco
  • Sergio Luis Amantea
  • Samuel S Souza
  • Raquel Tonello
  • Solange C Garcia
  • Jonas Sertorio
  • Giselle A S Leite
  • Vanessa C de Oliveira Souza
  • Juliana Vicentini
  • Lusiane M Bendhack
  • Gabriel Maisonnave Arisi
  • Karla Fernandes
  • Michele M Castro
  • Norberto Garcia-Cairasco
  • Alceu A Jordao
  • Luciano Tormen
  • Juliana A Nunes
  • Adilson J Curtius
  • Carolina de Souza Guerra
  • Marília Afonso Rabelo Buzalaf

Detail Information

Publications49

  1. pmc A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs
    Fernando Barbosa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Environ Health Perspect 113:1669-74. 2005
    ....
  2. doi request reprint Vitamin D receptor haplotypes affect lead levels during pregnancy
    Vania B Rezende
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13081 970, Campinas, SP, Brazil
    Sci Total Environ 408:4955-60. 2010
    ..These findings may have major implications for Pb toxicity because they may help to predict the existence of a group of subjects that is genetically less prone to Pb toxicity during pregnancy...
  3. doi request reprint Inorganic and methylmercury levels in plasma are differentially associated with age, gender, and oxidative stress markers in a population exposed to mercury through fish consumption
    Maria Fernanda Hornos Carneiro
    a Laboratório de Toxicologia e Essencialidade de Metais, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Monte Alegre, Ribeirao Preto, SP, Brazil
    J Toxicol Environ Health A 77:69-79. 2014
    ..Further, plasma Me-Hg was markedly correlated with adverse effects to a greater extent than plasma I-Hg and may be considered a valuable, reliable internal dose biomarker for Hg in chronically Me-Hg- exposed individuals. ..
  4. doi request reprint Intron 4 polymorphism of the endothelial nitric oxide synthase (eNOS) gene is associated with decreased NO production in a mercury-exposed population
    Kátia Cristina de Marco
    Department of Clinical, Toxicological and Food Science Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Sci Total Environ 414:708-12. 2012
    ..Taken together, our results show that the 27 nt repeat polymorphism of the intron 4 in the eNOS gene increases susceptibility to cardiovascular diseases after MeHg exposure by modulating nitric oxide levels...
  5. doi request reprint Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats
    Gustavo Rafael Mazzaron Barcelos
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe, s no, Ribeirao Preto, Sao Paulo, CEP 14040 903, Brazil
    Arch Toxicol 85:1151-7. 2011
    ..In summary, our results indicate that consumption of QC-rich foods may protect Hg-exposed humans against the adverse health effects of the metal...
  6. ncbi request reprint Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects
    Vania B Rezende
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13081 970 Campinas, SP, Brazil
    Arch Toxicol 82:29-36. 2008
    ....
  7. doi request reprint Evaluation of protective effects of fish oil against oxidative damage in rats exposed to methylmercury
    Denise Grotto
    Departamento de Analises Clinicas, Toxicológicas e Bromatológicas Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de Sao Paulo, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Ecotoxicol Environ Saf 74:487-93. 2011
    ..This protection seems not to be related to antioxidant defenses or mercury re-distribution in rat tissues. It is probably due to the anti-inflammatory effects of fish oil...
  8. doi request reprint Mercury exposure increases circulating net matrix metalloproteinase (MMP)-2 and MMP-9 activities
    Anna L B Jacob-Ferreira
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Basic Clin Pharmacol Toxicol 105:281-8. 2009
    ..These findings provide a new insight into the possible biological mechanisms of Hg toxicity, particularly in cardiovascular diseases...
  9. doi request reprint Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo
    Gustavo Rafael Mazzaron Barcelos
    Departament of Clinical, Toxicologic and Bromatologic Analyses, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Environ Mol Mutagen 53:535-41. 2012
    ..Our results indicate that consumption of BIX and NOR may protect humans against the adverse health effects caused by exposure to organic mercury...
  10. doi request reprint Evaluation of seasonal dietary exposure to arsenic, cadmium and lead in schoolchildren through the analysis of meals served by public schools of Ribeirão Preto, Brazil
    Letícia Ramos Nacano
    a Laboratório de Toxicologia e Essencialidade de Metais, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Monte Alegre, Ribeirao Preto, Sao Paulo, Brazil
    J Toxicol Environ Health A 77:367-74. 2014
    ..9 μg, 0.9 μg, and 0.6 μg for As, Cd, and Pb, respectively. These findings are below the toxicological reference values provided by the European Food Safety Authority (EFSA) and the World Health Organization (WHO). ..
  11. doi request reprint Polymorphisms in glutathione-related genes modify mercury concentrations and antioxidant status in subjects environmentally exposed to methylmercury
    Gustavo Rafael Mazzaron Barcelos
    Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Avenida do Café s no, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil Electronic address
    Sci Total Environ 463:319-25. 2013
    ..Persons with GSTM1*0 had higher CAT activity in the blood than those with GSTM1. Our data thus indicate that some GSH-related polymorphisms, such as GSTM1 and GCLM may modify MeHg metabolism and Hg-related antioxidant effects...
  12. doi request reprint Antigenotoxic properties of chlorophyll b against cisplatin-induced DNA damage and its relationship with distribution of platinum and magnesium in vivo
    Juliana Mara Serpeloni
    Department of Clinical, Toxicologic, and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Toxicol Environ Health A 76:345-53. 2013
    ..Thus, our results indicate that consumption of CLb-rich foods may diminish the adverse health effects induced by cDDP exposure...
  13. doi request reprint Evaluation of the concentration of nonessential and essential elements in chicken, pork, and beef samples produced in Brazil
    Bruno Lemos Batista
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    J Toxicol Environ Health A 75:1269-79. 2012
    ..However, high levels were detected for the nonessential element cesium (Cs), mainly in beef samples, an observation that deserves future studies to identify the source of contamination and potential adverse consequences...
  14. doi request reprint Background values for essential and toxic elements in children's nails and correlation with hair levels
    Maria Fernanda Hornos Carneiro
    Laboratorio de Toxicologia e Essencialidade de Metais, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe s n, Monte Alegre, 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Biol Trace Elem Res 144:339-50. 2011
    ..Additionally, we also showed weak to strong correlations between Cu, Mg, Mn, Se, and Zn levels in nails and hair...
  15. doi request reprint Sub-chronic exposure to methylmercury at low levels decreases butyrylcholinesterase activity in rats
    Juliana Valentini
    Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Basic Clin Pharmacol Toxicol 106:95-9. 2010
    ..This preliminary finding highlights a possible mechanism for MeHg to reduce BuChE activity in plasma. Additionally, this enzyme could be an auxiliary biomarker on the evaluation of MeHg exposure...
  16. doi request reprint A common matrix metalloproteinase (MMP)-2 polymorphism affects plasma MMP-2 levels in subjects environmentally exposed to mercury
    Anna L B Jacob-Ferreira
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Sci Total Environ 409:4242-6. 2011
    ..These findings suggest a significant interaction between the C(-1306)T polymorphism and Hg exposure, possibly increasing the risk of developing diseases in subjects with the C allele...
  17. doi request reprint Manioc flour consumption as a risk factor for lead poisoning in the Brazilian Amazon
    Maria Fernanda Hornos Carneiro
    Laboratorio de Toxicologia e Essencialidade de Metais, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Monte Alegre, Ribeirao Preto, SP, Brazil
    J Toxicol Environ Health A 76:206-16. 2013
    ..Manioc flour intake may thus present considerable risk of Pb exposure in this region. Risk management strategies and further studies on adverse effects in this population are needed...
  18. doi request reprint Should we measure serum or plasma lead concentrations?
    Vania B Rezende
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil
    J Trace Elem Med Biol 24:147-51. 2010
    ..We have also examined the effects of sample standing time on Pb concentrations measured in serum, heparin plasma, and EDTA plasma...
  19. doi request reprint A functional matrix metalloproteinase (MMP)-9 polymorphism modifies plasma MMP-9 levels in subjects environmentally exposed to mercury
    Anna L B Jacob-Ferreira
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Sci Total Environ 408:4085-92. 2010
    ..These findings suggest a significant interaction between the (CA)(n) polymorphism and low levels of Hg exposure, possibly increasing the risk of developing diseases in subjects with H alleles...
  20. doi request reprint Fluoride increases lead concentrations in whole blood and in calcified tissues from lead-exposed rats
    Rosangela M M Sawan
    School of Dentistry of Ribeirao Preto, University of Sao Paulo FORP USP, Av do Cafe S N, 14040 904, Ribeirao Preto, SP, Brazil
    Toxicology 271:21-6. 2010
    ....
  21. ncbi request reprint Environmental exposure to methylmercury is associated with a decrease in nitric oxide production
    Kátia Cristina de Marco
    Department of Clinical, Toxicological and Food Science Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Basic Clin Pharmacol Toxicol 106:411-5. 2010
    ..1, p < 0.001). Our findings constitute preliminary clinical evidence that exposure to MeHg may cause inhibitory effects on the production of endothelial nitric oxide...
  22. doi request reprint Determination of the effects of eNOS gene polymorphisms (T-786C and Glu298Asp) on nitric oxide levels in a methylmercury-exposed population
    Kátia Cristina de Marco
    Depto de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    J Toxicol Environ Health A 74:1323-33. 2011
    ..Polymorphisms did not seem to influence this effect. Our findings suggest that eNOS gene polymorphisms (T-786C and Glu298Asp) are not associated with an increased risk for cardiovascular diseases in MeHg-exposed subjects...
  23. doi request reprint Assessment of how pregnancy modifies plasma lead and plasma/whole blood lead ratio in ALAD 1-1 genotype women
    Marcelo Freitas Montenegro
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Basic Clin Pharmacol Toxicol 102:347-51. 2008
    ..We can now better appreciate how pregnancy affects foetal exposure to Pb without the influence of this important genetic factor...
  24. ncbi request reprint Ethnicity affects the distribution of delta-aminolevulinic acid dehydratase (ALAD) genetic variants
    Marcelo F Montenegro
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil FMRP USP, Av Bandeirantes, 3900, Monte Alegre, CEP 14049 900, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 367:192-5. 2006
    ..We examined the distribution of genetic variants of the G177C ALAD polymorphism in black and white Brazilians...
  25. doi request reprint A simple method for methylmercury, inorganic mercury and ethylmercury determination in plasma samples by high performance liquid chromatography-cold-vapor-inductively coupled plasma mass spectrometry
    Samuel S de Souza
    Laboratorio de Toxicologia e Essencialidade de Metais, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Anal Chim Acta 761:11-7. 2013
    ..For the first time to our knowledge, levels of different species of Hg in plasma samples from riverside populations exposed to MeHg were determined...
  26. doi request reprint Evaluation of glutathione S-transferase GSTM1 and GSTT1 polymorphisms and methylmercury metabolism in an exposed Amazon population
    Gustavo Rafael Mazzaron Barcelos
    Department of Clinical, Toxicological and Bromatological Analyses, School of Phamaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Toxicol Environ Health A 75:960-70. 2012
    ..There appeared to be no evidence of an effect of polymorphisms on GSH levels. Therefore, our data suggest that GST polymorphisms may be associated with MeHg detoxification...
  27. ncbi request reprint An interethnic comparison of the distribution of vitamin D receptor genotypes and haplotypes
    Vania B Rezende
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13081 970, Campinas, SP, Brazil
    Clin Chim Acta 384:155-9. 2007
    ..We examined the distribution of genetic variants of 3 VDR polymorphisms (BsmI, ApaI and FokI) and haplotypes in black and white Brazilians. We have also compared our results with those from the HapMap project...
  28. ncbi request reprint Low levels of methylmercury induce DNA damage in rats: protective effects of selenium
    Denise Grotto
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe s n, Campus Universitário da USP, 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Arch Toxicol 83:249-54. 2009
    ..Our findings demonstrated the oxidative and genotoxic properties of MeHg, even at low doses. Moreover, Se co-administration reestablished GSH-Px activity and reduced DNA damage...
  29. ncbi request reprint Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population
    Andréia Ávila Soares de Oliveira
    Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Avenida do Cafe s n, 14040 903 Ribeirao Preto, SP, Brazil
    Biomed Res Int 2014:940952. 2014
    ..Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning. ..
  30. doi request reprint A plateau detected in lead accumulation in subsurface deciduous enamel from individuals exposed to lead may be useful to identify children and regions exposed to higher levels of lead
    Glauce Regina Costa de Almeida
    Department of Morphology, Stomatology and Physiology, Dental School of Ribeirao Preto, University of Sao Paulo FORP USP, Av do Cafe, S N, Monte Alegre, CEP 14040 904, Ribeirao Preto, SP, Brazil
    Environ Res 107:264-70. 2008
    ..The threshold of 600 microg/g of lead in subsurface enamel was tentatively settled here after the plateau seen in exposed children, and enabled us to identify locations with more children exposed to a higher amount of lead...
  31. doi request reprint Low concentrations of selenium and zinc in nails are associated with childhood asthma
    Maria Fernanda Hornos Carneiro
    Laboratorio de Toxicologia e Essencialidade de Metais, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe s n, Monte Alegre, 14040 903, Ribeirao Preto, SP, Brazil
    Biol Trace Elem Res 144:244-52. 2011
    ..Taken together, our results clearly demonstrated an association between concentrations of selenium and zinc and childhood asthma and the usefulness of nail as a noninvasive matrix to detect minerals imbalance in asthma patients...
  32. doi request reprint The relationship between blood and serum lead levels in peripartum women and their respective umbilical cords
    Jefferson H Amaral
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Ribeirao Preto, SP, Brazil
    Basic Clin Pharmacol Toxicol 107:971-5. 2010
    ..Moreover, the similar %Pb-S/Pb-B in pregnant women and in the umbilical cords shows that the foetuses are directly exposed to the rapidly exchangeable Pb fraction found in their mothers...
  33. doi request reprint Speciation of arsenic in rice and estimation of daily intake of different arsenic species by Brazilians through rice consumption
    Bruno L Batista
    Laboratorio de Toxicologia e Essencialidade de Metais, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Monte Alegre, Ribeirao Preto, SP, Brazil
    J Hazard Mater 191:342-8. 2011
    ..Moreover, rice samples harvested in the state of Rio Grande do Sul presented more fractions of inorganic arsenic than rice in Minas Gerais or Goiás, which could lead to different risks of arsenic exposure...
  34. doi request reprint Identification and distribution of mercury species in rat tissues following administration of thimerosal or methylmercury
    Jairo L Rodrigues
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto FCFRP, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, USP, Avenida do Café, S N, Monte Alegre, Ribeirao Preto, SP 14040 903, Brazil
    Arch Toxicol 84:891-6. 2010
    ..Thus, Met-Hg is not an appropriate reference for assessing the risk from exposure to TM-derived Hg. It also adds new data for further studies in the evaluation of TM toxicity...
  35. ncbi request reprint Matrix metalloproteinase-9 activity in plasma correlates with plasma and whole blood lead concentrations
    Fernando Barbosa
    Department of Clinical, Toxicological and Food Science Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Av do Cafe S N, S P 14040 903, Ribeirao Preto, SP, Brazil
    Basic Clin Pharmacol Toxicol 98:559-64. 2006
    ..A causal relationship, however, remains to be proved...
  36. doi request reprint Assessment of trace elements in scalp hair of a young urban population in Brazil
    Maria Fernanda Hornos Carneiro
    Laboratorio de Toxicologia e Essencialidade de Metais, Depto de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe s n, Monte Alegre, 14040 903, Ribeirao Preto, SP, Brazil
    Biol Trace Elem Res 143:815-24. 2011
    ..The overall findings of the present study, with respect to the estimated chemical elements, are of prime importance in the evaluation of reference values for determining environmental effects on children living in urban areas...
  37. doi request reprint Evidence of early involvement of matrix metalloproteinase-2 in lead-induced hypertension
    Elen Rizzi
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Arch Toxicol 83:439-49. 2009
    ..In conclusion, lead exposure increases BP and vascular MMP-2, which is blunted by doxycycline. This observation suggests that MMP-2 may play a role in lead-induced increases in BP...
  38. ncbi request reprint Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms
    Denise Grotto
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14040 903, Brazil
    Arch Toxicol 83:653-62. 2009
    ....
  39. doi request reprint Methylmercury and inorganic mercury determination in blood by using liquid chromatography with inductively coupled plasma mass spectrometry and a fast sample preparation procedure
    Jairo L Rodrigues
    Laboratorio de Toxicologia e Essencialidade de Metais, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Talanta 80:1158-63. 2010
    ..Finally, after the application of the proposed method, we demonstrated an interesting in vivo ethylmercury conversion to inorganic mercury...
  40. doi request reprint Açaí (Euterpe oleracea Mart.): a tropical fruit with high levels of essential minerals-especially manganese-and its contribution as a source of natural mineral supplementation
    Vivian da Silva Santos
    a Laboratório de Toxicologia e Essencialidade de Metais, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciências Farmacêuticas de Ribeirao Preto FCFRP USP, Ribeirao Preto, SP, Brazil
    J Toxicol Environ Health A 77:80-9. 2014
    ..However, due to the expressive levels of Mn, further studies are necessary to evaluate potential adverse effects associated with açaí consumption. ..
  41. doi request reprint Pre and post-natal exposure to ambient level of air pollution impairs memory of rats: the role of oxidative stress
    Ana C T Zanchi
    Laboratory of Experimental Air Pollution Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Inhal Toxicol 22:910-8. 2010
    ..006) and an improvement in habituation memories when compared to other groups. Therefore, exposure to air pollution during both those periods impairs short-term discriminative memory and cortical oxidative stress may mediate this process...
  42. ncbi request reprint A polymorphism in the delta-aminolevulinic acid dehydratase gene modifies plasma/whole blood lead ratio
    Marcelo F Montenegro
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Arch Toxicol 80:394-8. 2006
    ..48+/-0.02, respectively; both P<0.0001). The higher %Pb-P/Pb-B ratios in carriers of the ALAD-2 allele compared with noncarriers indicate that ALAD 1-2/2-2 subjects are probably at increased health risks associated with lead exposure...
  43. ncbi request reprint eNOS genotype-dependent correlation between whole blood lead and plasma nitric oxide products concentrations
    Fernando Barbosa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Nitric Oxide 14:58-64. 2006
    ....
  44. ncbi request reprint Lead contents in the surface enamel of deciduous teeth sampled in vivo from children in uncontaminated and in lead-contaminated areas
    Glauce Regina Costa de Almeida
    Department of Morphology, Estomatology and Physiology, Dental School of Ribeirao Preto, University of Sao Paulo FORP USP, Av do Cafe, S N, Monte Alegre, CEP 14040 904, Ribeirao Preto SP, Brazil
    Environ Res 104:337-45. 2007
    ....
  45. doi request reprint Simultaneous determination of Cd, Cu, Mn, Ni, Pb and Zn in nail samples by inductively coupled plasma mass spectrometry (ICP-MS) after tetramethylammonium hydroxide solubilization at room temperature: comparison with ETAAS
    Bruno L Batista
    Laboratorio de Toxicologia e Essencialidade de Metais, Depto de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Avenida do Cafe s n, Monte Alegre 14040 903, Ribeirao Preto SP, Brazil
    Talanta 76:575-9. 2008
    ..For validation purposes, six ordinary nail samples were solubilized and then directly analyzed by ICP-MS and ETAAS, with no statistical difference between the two techniques at 95% level on applying the t-test...
  46. ncbi request reprint Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects
    Fernando Barbosa
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ave do Café s n, Monte Alegre, 14049 903 Ribeirao Preto, SP, Brazil
    Arch Toxicol 80:633-7. 2006
    ..Taken together, these results suggest that salivary lead may not be used as a biomarker to diagnose lead exposure nor as a surrogate of plasma lead levels at least for low to moderately lead exposed population...
  47. ncbi request reprint Clinical evidence for lead-induced inhibition of nitric oxide formation
    Fernando Barbosa
    Department of Clinical, Toxicological and Food Science Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, Av do Cafe, S N, 14040 903 Ribeirao Preto, SP, Brazil
    Arch Toxicol 80:811-6. 2006
    ..These findings suggest a significant inhibitory effect of lead exposure on NO formation and provide clinical evidence for a biological mechanism possibly involved the association between lead exposure and increased cardiovascular risk...
  48. ncbi request reprint In vivo studies on lead content of deciduous teeth superficial enamel of preschool children
    Viviane Elisângela Gomes
    Department of Community Dentistry, Dental School of Piracicaba, State University of Campinas, CEP 13414 018, Piracicaba, SP, Brazil
    Sci Total Environ 320:25-35. 2004
    ..9 microm gave more reliable results for comparisons between groups. To our knowledge, this study is the first to use an enamel microbiopsy to characterize a large sample of young children in vivo for lead monitoring in teeth...
  49. ncbi request reprint Contrasting effects of age on the plasma/whole blood lead ratio in men and women with a history of lead exposure
    Fernando Barbosa
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciências Farmacêuticas de Ribeirao Preto FCFRP USP, Ave do café, S N, Monte Alegre, 14040 903 Ribeirao Preto, SP, Brazil
    Environ Res 102:90-5. 2006
    ..Moreover, sex might play an important role in the metabolism of lead, implying further consideration on the kinetic models constructed of lead toxicity...