Behzad Baradaran



  1. Noorolyai S, Shajari N, Baghbani E, Sadreddini S, Baradaran B. The relation between PI3K/AKT signalling pathway and cancer. Gene. 2019;698:120-128 pubmed publisher
    ..In this review, we consider about the phosphoinositide 3-kinases family and mechanisms of PI3K-Akt stimulation in cancer. ..
  2. Jahanafrooz Z, Motamed N, Rinner B, Mokhtarzadeh A, Baradaran B. Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator. Life Sci. 2018;213:236-247 pubmed publisher
    ..The goal of the treatments is to make it possible to eliminate the tumor with the minimum side effects and cure the patient in the early stage cancer. Therefore, plant extracts such as silibinin can be included in the treatments. ..
  3. Rezapour Firouzi S, Arefhosseini S, Ebrahimi Mamaghani M, Baradaran B, Sadeghihokmabad E, Torbati M, et al. Activity of liver enzymes in multiple sclerosis patients with Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention. Complement Ther Med. 2014;22:986-93 pubmed publisher
  4. Hemmatzadeh M, Mohammadi H, Karimi M, Musavishenas M, Baradaran B. Differential role of microRNAs in the pathogenesis and treatment of Esophageal cancer. Biomed Pharmacother. 2016;82:509-19 pubmed publisher
    ..In this review, the oncogenic, tumor suppressive, and drug resistance related roles of miRNAs, and their involvement in the pathogenesis and treatment of esophageal cancer were summarized. ..
  5. Mohammadi A, Mansoori B, Baradaran B. The role of microRNAs in colorectal cancer. Biomed Pharmacother. 2016;84:705-713 pubmed publisher
    ..This review summarizes the potential roles of microRNAs as potential biomarkers for CRC diagnosis, and treatment. ..
  6. Mohammadi A, Mansoori B, Baradaran P, Baradaran S, Baradaran B. Anacyclus Pyrethrum Extract Exerts Anticancer Activities on the Human Colorectal Cancer Cell Line (HCT) by Targeting Apoptosis, Metastasis and Cell Cycle Arrest. J Gastrointest Cancer. 2017;48:333-340 pubmed publisher
    ..These results indicate that Anacyclus pyrethrum extract can successfully induce apoptosis in HCT cells. Therefore, it could be used as a novel therapeutic candidate for colorectal cancer treatment. ..
  7. Esmailzadeh S, Mansoori B, Mohammadi A, Shanehbandi D, Baradaran B. siRNA-Mediated Silencing of HMGA2 Induces Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma. J Gastrointest Cancer. 2017;48:156-163 pubmed publisher
    ..These results propose that HMGA2 might play an important role in the progression of colorectal carcinoma and might be a potential therapeutic target for trigger apoptosis and cell cycle arrest in colorectal carcinoma. ..
  8. Mansoori B, Mohammadi A, Shirjang S, Baghbani E, Baradaran B. Micro RNA 34a and Let-7a Expression in Human Breast Cancers is Associated with Apoptotic Expression Genes. Asian Pac J Cancer Prev. 2016;17:1887-90 pubmed
  9. Rezapour Firouzi S, Arefhosseini S, Ebrahimi Mamaghani M, Baradaran B, Sadeghihokmabad E, Mostafaei S, et al. Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complement Ther Med. 2015;23:652-7 pubmed publisher
    ..The co-supplemented hemp seed and evening primrose oils with Hot nature diet can have beneficial effects in improving clinical symptoms and signs in RRMS patients which were confirmed by regulation of surface-membrane enzymes. ..

More Information


  1. Goldar S, Baradaran B, Shekari Khaniani M, Azadmehr A, Derakhshan S, Mohammadi A, et al. Extracts of Scrophularia frigida Boiss display potent antitumor effects in human breast cancer cells by inducing apoptosis and inhibition of expression of the human epidermal growth factor receptor 2. Cell Mol Biol (Noisy-le-grand). 2016;62:83-89 pubmed
    ..Taken together, the results obtained indicate that S. frigida Boiss extracts may contain effective compounds that can be used as a therapeutic anticancer agent. ..
  2. Mohammadi A, Mansoori B, Baradaran P, Khaze V, Aghapour M, Farhadi M, et al. Urtica dioica Extract Inhibits Proliferation and Induces Apoptosis and Related Gene Expression of Breast Cancer Cells In Vitro and In Vivo. Clin Breast Cancer. 2017;17:463-470 pubmed publisher
    ..These results suggest that U. dioica extract can decrease the growth of breast tumors and induce apoptosis in tumor cells; thus, it might represent an ideal therapeutic tool for breast cancer. ..
  3. Karimi L, Mansoori B, Shanebandi D, Mohammadi A, Aghapour M, Baradaran B. Function of microRNA-143 in different signal pathways in cancer: New insights into cancer therapy. Biomed Pharmacother. 2017;91:121-131 pubmed publisher
    ..In this study, an overview of the miRNA-143 function in different signaling pathways in cancer will be provided. ..
  4. Davudian S, Mansoori B, Shajari N, Mohammadi A, Baradaran B. BACH1, the master regulator gene: A novel candidate target for cancer therapy. Gene. 2016;588:30-7 pubmed publisher
  5. Tavanafar F, Safaralizadeh R, Hosseinpour Feizi M, Mansoori B, Shanehbandi D, Mohammadi A, et al. Restoration of miR-143 expression could inhibit migration and growth of MDA-MB-468 cells through down-regulating the expression of invasion-related factors. Biomed Pharmacother. 2017;91:920-924 pubmed publisher
  6. Davudian S, Shajari N, Kazemi T, Mansoori B, Salehi S, Mohammadi A, et al. BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes. Biomed Pharmacother. 2016;84:191-198 pubmed publisher
    ..Collectively, these results suggest that BACH1 may function as an oncogenic driver in colon cancer and may represent as a potential target of gene therapy for CRC treatment. ..
  7. Montazami N, Aghapour M, Farajnia S, Baradaran B. New insights into the mechanisms of multidrug resistance in cancers. Cell Mol Biol (Noisy-le-grand). 2015;61:70-80 pubmed
    ..In this review, we briefly look inside the recent mechanisms of chemotherapeutic resistance, the MDR1 gene expression in tumors and some novel inhibition-based approaches. ..
  8. Salehi S, Mansoori B, Mohammadi A, Davoudian S, Musavi Shenas S, Shajari N, et al. An analysis of suppressing migratory effect on human urinary bladder cancer cell line by silencing of snail-1. Biomed Pharmacother. 2017;96:545-550 pubmed publisher
    ..These results propose that snail-1 plays a major role in the progression and migration of urinary bladder cancer, and can be a potential therapeutic target for target therapy of invasive urinary bladder cancer. ..
  9. Aletaha M, Mansoori B, Mohammadi A, Fazeli M, Baradaran B. Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line. Biomed Pharmacother. 2017;88:34-42 pubmed publisher
    ..0001), cell cycle arrest (p=0.03) and induces apoptosis (p<0.0001) and reduces the expression of miR-21 (P=0.0014). Our results suggest that the bach1 can be considered as a potent adjuvant in breast cancer therapy. ..
  10. Hajjari S, Mehdizadeh M, Sadigh Eteghad S, Shanehbandi D, Teimourian S, Baradaran B. Secretases-related miRNAs in Alzheimer's disease: new approach for biomarker discovery. Neurol Sci. 2017;38:1921-1926 pubmed publisher
    ..Therefore, in this paper, we review the miRNAs involved in APP cleavage pathways and the formation of A? in order to evaluate the potential diagnostic biomarkers in AD. ..
  11. Ghaderi S, Alidadiani N, Dilaver N, Heidari H, Parvizi R, Rahbarghazi R, et al. Role of glycogen synthase kinase following myocardial infarction and ischemia-reperfusion. Apoptosis. 2017;22:887-897 pubmed publisher
    ..In this review, we have opted to focus on GSK3β interactions with mitochondria in ischemic heart disease and expand on the therapeutic interventions. ..
  12. Baradaran P, Mohammadi A, Mansoori B, Baradaran S, Baradaran B. Growth inhibitory effect of Scrophularia oxysepala extract on mouse mammary carcinoma 4T1 cells in vitro and in vivo systems. Biomed Pharmacother. 2017;85:718-724 pubmed publisher
    ..Thus it may represent an ideal therapeutic tool for breast cancer. ..
  13. Mohammadi A, Mansoori B, Aghapour M, Baradaran B. Urtica dioica dichloromethane extract induce apoptosis from intrinsic pathway on human prostate cancer cells (PC3). Cell Mol Biol (Noisy-le-grand). 2016;62:78-83 pubmed
    ..These results indicate that dichloromethanolic extract of Urtica dioica can successfully induce apoptosis in PC3 cells. Therefore, it could be used as a novel therapeutic candidate for prostate tumor treatment. ..
  14. Karimi M, Mohammadi H, Hemmatzadeh M, Mohammadi A, Rafatpanah H, Baradaran B. Role of the HTLV-1 viral factors in the induction of apoptosis. Biomed Pharmacother. 2017;85:334-347 pubmed publisher
    ..Here we have reviewed by prior research how the apoptosis pathways are suppressed by the Tax and HBZ and new drugs which have been designed to deal with this suppression. ..
  15. Shomali N, Mansoori B, Mohammadi A, Shirafkan N, Ghasabi M, Baradaran B. MiR-146a functions as a small silent player in gastric cancer. Biomed Pharmacother. 2017;96:238-245 pubmed publisher
  16. Shirafkan N, Mansoori B, Mohammadi A, Shomali N, Ghasbi M, Baradaran B. MicroRNAs as novel biomarkers for colorectal cancer: New outlooks. Biomed Pharmacother. 2018;97:1319-1330 pubmed publisher
  17. Mansoori B, Mohammadi A, Hashemzadeh S, Shirjang S, Baradaran A, Asadi M, et al. Urtica dioica extract suppresses miR-21 and metastasis-related genes in breast cancer. Biomed Pharmacother. 2017;93:95-102 pubmed publisher
    ..Moreover, our findings demonstrated that the extract could decrease miR-21 expression, which substantially lessens the overexpressed MMP1, MMP9, MMP13, vimentin, and CXCR4 and increases E-cadherin in the tumoral group. ..
  18. Mohammadi A, Mansoori B, Baradaran B. Regulation of miRNAs by herbal medicine: An emerging field in cancer therapies. Biomed Pharmacother. 2017;86:262-270 pubmed publisher
  19. Mohammadi A, Mansoori B, Aghapour M, Shirjang S, Nami S, Baradaran B. The Urtica dioica extract enhances sensitivity of paclitaxel drug to MDA-MB-468 breast cancer cells. Biomed Pharmacother. 2016;83:835-842 pubmed publisher
    ..Also, Urtica dioica extract substantially increased sensitivity of breast cancer cells to paclitaxel. Therefore, it can be used as a potential candidate for treatment of breast cancer with paclitaxel. ..
  20. Mohammadi A, Mansoori B, Aghapour M, Baradaran P, Shajari N, Davudian S, et al. The Herbal Medicine Utrica Dioica Inhibits Proliferation of Colorectal Cancer Cell Line by Inducing Apoptosis and Arrest at the G2/M Phase. J Gastrointest Cancer. 2016;47:187-95 pubmed publisher
    ..Taken together, our experiment showed that subjecting HCT-116 cells to dichloromethane extract of nettle (U. dioica), increases turnover of these cells. Thus, it may be a useful agent in the treatment of colorectal cancer. ..
  21. Goldar S, Khaniani M, Derakhshan S, Baradaran B. Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev. 2015;16:2129-44 pubmed