David A Sack

Summary

Affiliation: International Centre for Diarrhoeal Disease Research
Country: Bangladesh

Publications

  1. pmc Reemergence of epidemic Vibrio cholerae O139, Bangladesh
    Shah M Faruque
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Emerg Infect Dis 9:1116-22. 2003
  2. pmc Cholera in Mozambique, variant of Vibrio cholerae
    M Ansaruzzaman
    Emerg Infect Dis 10:2057-9. 2004
  3. ncbi request reprint Cholera
    David A Sack
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Dhaka, Bangladesh
    Lancet 363:223-33. 2004
  4. ncbi request reprint Improved indicators of infant mortality for integrated primary healthcare programmes
    D A Sack
    ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    J Health Popul Nutr 18:61-8. 2000
  5. ncbi request reprint Randomised, double-blind, safety and efficacy of a killed oral vaccine for enterotoxigenic E. Coli diarrhoea of travellers to Guatemala and Mexico
    David A Sack
    Vaccine Testing Unit, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Vaccine 25:4392-400. 2007
  6. ncbi request reprint A novel serovar of Shigella dysenteriae from patients with diarrhoea in Bangladesh
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 56:654-8. 2007
  7. ncbi request reprint Antibiotic resistance and genetic diversity of Shigella sonnei isolated from patients with diarrhoea between 1999 and 2003 in Bangladesh
    Kaisar A Talukder
    ICDDR, B, Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 55:1257-63. 2006
  8. doi request reprint Characteristics of a pandemic clone of O3 : K6 and O4 : K68 Vibrio parahaemolyticus isolated in Beira, Mozambique
    M Ansaruzzaman
    ICDDR, B International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka 1212, Bangladesh
    J Med Microbiol 57:1502-7. 2008
  9. ncbi request reprint An improved technique for isolation of environmental Vibrio cholerae with epidemic potential: monitoring the emergence of a multiple-antibiotic-resistant epidemic strain in Bangladesh
    Shah M Faruque
    Molecular Genetics Laboratory, Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    J Infect Dis 193:1029-36. 2006
  10. pmc Pandemic serovars (O3:K6 and O4:K68) of Vibrio parahaemolyticus associated with diarrhea in Mozambique: spread of the pandemic into the African continent
    M Ansaruzzaman
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Clin Microbiol 43:2559-62. 2005

Detail Information

Publications91

  1. pmc Reemergence of epidemic Vibrio cholerae O139, Bangladesh
    Shah M Faruque
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Emerg Infect Dis 9:1116-22. 2003
    ..These findings emphasize the need for continuous monitoring of the new epidemic strains...
  2. pmc Cholera in Mozambique, variant of Vibrio cholerae
    M Ansaruzzaman
    Emerg Infect Dis 10:2057-9. 2004
  3. ncbi request reprint Cholera
    David A Sack
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Dhaka, Bangladesh
    Lancet 363:223-33. 2004
    ..Appropriate case management has reduced deaths from diarrhoeal disease by an estimated 3 million per year compared with 20 years ago. Vaccination was thought to have no role for cholera, but new oral vaccines are showing great promise...
  4. ncbi request reprint Improved indicators of infant mortality for integrated primary healthcare programmes
    D A Sack
    ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    J Health Popul Nutr 18:61-8. 2000
    ..S.A. The results of these examples demonstrate that the new indicators are more sensitive than traditional measures when describing infant mortality, and may better reflect the perception in infant mortality status in the community...
  5. ncbi request reprint Randomised, double-blind, safety and efficacy of a killed oral vaccine for enterotoxigenic E. Coli diarrhoea of travellers to Guatemala and Mexico
    David A Sack
    Vaccine Testing Unit, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Vaccine 25:4392-400. 2007
    ..We conclude that the new oral ETEC vaccine reduces the rate of more severe episodes of traveller's diarrhoea (TD) due to VPO-ETEC, but it did not reduce the overall rate of ETEC diarrhoea or of travellers' diarrhoea due to other causes...
  6. ncbi request reprint A novel serovar of Shigella dysenteriae from patients with diarrhoea in Bangladesh
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 56:654-8. 2007
    ..coli serotype reference strains. It is therefore proposed that these isolates represent a new provisional serovar of S. dysenteriae, type strain KIVI 162...
  7. ncbi request reprint Antibiotic resistance and genetic diversity of Shigella sonnei isolated from patients with diarrhoea between 1999 and 2003 in Bangladesh
    Kaisar A Talukder
    ICDDR, B, Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 55:1257-63. 2006
    ..It can be concluded that endemic strains of Shigella sonnei isolated from patients in Bangladesh are diverse in their genetic pattern...
  8. doi request reprint Characteristics of a pandemic clone of O3 : K6 and O4 : K68 Vibrio parahaemolyticus isolated in Beira, Mozambique
    M Ansaruzzaman
    ICDDR, B International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka 1212, Bangladesh
    J Med Microbiol 57:1502-7. 2008
    ..The O3 : K58 (n=8), O4 : K13 (n=6), O3 : KUT (n=1) and O8 : K41 (n=1) strains showed unique characteristics different from the pandemic clone...
  9. ncbi request reprint An improved technique for isolation of environmental Vibrio cholerae with epidemic potential: monitoring the emergence of a multiple-antibiotic-resistant epidemic strain in Bangladesh
    Shah M Faruque
    Molecular Genetics Laboratory, Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    J Infect Dis 193:1029-36. 2006
    ..cholerae occurs in the human host and leads to the start of an epidemic cycle dominated by a single clone of V. cholerae that spreads rapidly through environmental waters...
  10. pmc Pandemic serovars (O3:K6 and O4:K68) of Vibrio parahaemolyticus associated with diarrhea in Mozambique: spread of the pandemic into the African continent
    M Ansaruzzaman
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Clin Microbiol 43:2559-62. 2005
    ..This is the first report of the isolation of pandemic strains of V. parahaemolyticus in sub-Saharan Africa and clearly indicates that the pandemic of V. parahaemolyticus has spread into the African continent...
  11. ncbi request reprint Pandemic strains of O3:K6 Vibrio parahaemolyticus in the aquatic environment of Bangladesh
    M Sirajul Islam
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO 128, Dhaka 1000, Bangladesh
    Can J Microbiol 50:827-34. 2004
    ..This is the first report on the isolation of pandemic O3:K6 strains of V. parahaemolyticus from the aquatic environment of Bangladesh...
  12. pmc Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 101:2123-8. 2004
    ..cholerae strains and thus promotes the rare, multiple-gene transfer events needed to assemble the critical combination of genes required for pandemic spread...
  13. ncbi request reprint Genetic diversity of El Tor strains of Vibrio cholerae O1 with hybrid traits isolated from Bangladesh and Mozambique
    Mohammad Ansaruzzaman
    Laboratory Sciences Division, Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Dhaka 1000, Bangladesh
    Int J Med Microbiol 297:443-9. 2007
    ....
  14. doi request reprint Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other muco
    Sohel Shamsuzzaman
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 27:1386-92. 2009
    ..This sets the ground for testing such vaccines in large field trials in Bangladesh and also demonstrates that addition of other vibrio components to the existing cholera vaccine does not alter the responses to the O1 vaccine components...
  15. pmc Toxigenic Vibrio cholerae in the aquatic environment of Mathbaria, Bangladesh
    Munirul Alam
    International Center for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
    Appl Environ Microbiol 72:2849-55. 2006
    ..The biofilm community is concluded to be an additional reservoir of cholera bacteria in the aquatic environment between seasonal epidemics of cholera in Bangladesh...
  16. pmc Diverse CTX phages among toxigenic Vibrio cholerae O1 and O139 strains isolated between 1994 and 2002 in an area where cholera is endemic in Bangladesh
    Suraia Nusrin
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 42:5854-6. 2004
    ....
  17. pmc Pathogenic potential of environmental Vibrio cholerae strains carrying genetic variants of the toxin-coregulated pilus pathogenicity island
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Infect Immun 71:1020-5. 2003
    ..cholerae encode biologically active gene products. Detection of functional homologs of the TCP island genes in environmental strains may have implications for understanding the origin and evolution of virulence genes of V. cholerae...
  18. pmc Viable but nonculturable Vibrio cholerae O1 in biofilms in the aquatic environment and their role in cholera transmission
    Munirul Alam
    International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Proc Natl Acad Sci U S A 104:17801-6. 2007
    ..cholerae cells freshly discharged into the environment are significantly less robust than cells adapted to environmental conditions...
  19. doi request reprint Methodology and lessons-learned from the efficacy clinical trial of the pentavalent rotavirus vaccine in Bangladesh
    K Zaman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh
    Vaccine 30:A94-100. 2012
    ..This is the first vaccine trial in rural Bangladesh with online data entry. The study was well accepted in the community and was completed successfully...
  20. ncbi request reprint Genetic relatedness of ciprofloxacin-resistant Shigella dysenteriae type 1 strains isolated in south Asia
    Kaisar A Talukder
    Enteric Microbiology Laboratory, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Antimicrob Chemother 54:730-4. 2004
    ..The aim of the present study was to determine the clonal relationships of ciprofloxacin-resistant Shigella dysenteriae type 1 strains isolated from south Asia, and S. dysenteriae 1 strains associated with epidemics in 1978, 1984 and 1994...
  21. ncbi request reprint Surveillance of rotavirus in a rural diarrhoea treatment centre in Bangladesh, 2000-2006
    K Zaman
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Mohakhali, Dhaka 1212, Bangladesh
    Vaccine 27:F31-4. 2009
    ..Rotavirus is an important cause of childhood diarrhoea in rural Bangladesh and this burden may be reduced with a rotavirus vaccination programme...
  22. ncbi request reprint Genetic characteristics of Matlab variants of Vibrio cholerae O1 that are hybrids between classical and El Tor biotypes
    Ashrafus Safa
    Laboratory Sciences Division, Enteric Microbiology Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 55:1563-9. 2006
    ..The genetic relatedness of Matlab variants to the V. cholerae strains recently isolated in Mozambique is another important observation of this study, which underscores the epidemiological significance of Matlab variants...
  23. pmc Temporal shifts in the dominance of serotypes of Shigella dysenteriae from 1999 to 2002 in Dhaka, Bangladesh
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, Dhaka 1000, Bangladesh
    J Clin Microbiol 41:5053-8. 2003
    ..All the strains harboring the 140-MDa plasmid were positive for the ipaH gene, had Congo red binding abilities, and were positive by the Sereny test, demonstrating their invasive properties...
  24. pmc Prevalence of virulence genes and cytolethal distending toxin production in Campylobacter jejuni isolates from diarrheal patients in Bangladesh
    Kaisar A Talukder
    Enteric Microbiology Laboratory, Laboratory Sciences Division, ICDDR, B, GPO Box 128, Dhaka 1000, Bangladesh
    J Clin Microbiol 46:1485-8. 2008
    ..5%), cdtA (97.5%), cdtB (97.5%), cdtC (97.5%), and wlaN (7.5%) genes was detected in C. jejuni by PCR. All C. jejuni strains but one produced cytolethal distending toxin in a HeLa cell assay...
  25. ncbi request reprint Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants
    Firdausi Qadri
    ICDDR, B Centre for Health and Population Research, Bangladesh
    Vaccine 25:231-8. 2007
    ..The responses to the reduced dose was lower. These studies demonstrate that Peru-15 at a dose of 2x10(8)cfu is safe and immunogenic in children in Bangladesh...
  26. pmc Seasonal cholera caused by Vibrio cholerae serogroups O1 and O139 in the coastal aquatic environment of Bangladesh
    Munirul Alam
    International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Appl Environ Microbiol 72:4096-104. 2006
    ..cholerae O139 have been demonstrated. Based on the results of this study, the coastal ecosystem of the Bay of Bengal is concluded to be a significant reservoir for the epidemic serogroups of V. cholerae...
  27. pmc Characterization of a novel P[25],G11 human group a rotavirus
    Mustafizur Rahman
    ICDDR, B, Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 43:3208-12. 2005
    ..This lack of high sequence similarity in the VP4 gene indicates that the Dhaka6 isolate represents a new group A rotavirus P genotype, to which we propose assignment of the designation P[25]...
  28. pmc Critical factors influencing the occurrence of Vibrio cholerae in the environment of Bangladesh
    Anwar Huq
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA
    Appl Environ Microbiol 71:4645-54. 2005
    ..g., plankton population blooms. The new information on the ecology of V. cholerae is proving useful in developing environmental models for the prediction of cholera epidemics...
  29. pmc Prevalence of G2P[4] and G12P[6] rotavirus, Bangladesh
    Mustafizur Rahman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Emerg Infect Dis 13:18-24. 2007
    ..1%) during this season. Because recently licensed rotavirus vaccines include only the P[8] specificity, it is unknown how the vaccines will perform in settings where non-P[8] types are prevalent...
  30. pmc Shigella dysenteriae type 1-specific bacteriophage from environmental waters in Bangladesh
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Appl Environ Microbiol 69:7028-31. 2003
    ..dysenteriae type 1 was isolated from three phage-positive samples. The results of this study suggest that phage SF-9 may have epidemiological applications in tracing the presence of S. dysenteriae type 1 in environmental waters...
  31. pmc Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 44:4211-3. 2006
    ..All of the El Tor strains of V. cholerae O1 isolated since 2001 produced CT of the classical biotype, while those isolated before 2001 produced CT of the El Tor biotype...
  32. pmc Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 103:6350-5. 2006
    ..The results of this study support a model of cholera transmission in which in vivo-formed biofilms contribute to enhanced infectivity and environmental persistence of pathogenic V. cholerae...
  33. pmc New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 40:3296-9. 2002
    ..Furthermore, the existence of such novel strains may have implications for the development of a cholera vaccine...
  34. pmc Antigen-specific immunoglobulin A antibodies secreted from circulating B cells are an effective marker for recent local immune responses in patients with cholera: comparison to antibody-secreting cell responses and other immunological markers
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    Infect Immun 71:4808-14. 2003
    ....
  35. ncbi request reprint Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka, 1000, Bangladesh
    Curr Microbiol 52:108-11. 2006
    ..In fluoroquinolone-resistant strains, double mutations (Ser83-->Leu, Asp87-->Asn or Gly) and a single mutation (Ser80-->Ile) were detected in the QRDRs of gyrA and parC, respectively...
  36. pmc Reduction in capsular content and enhanced bacterial susceptibility to serum killing of Vibrio cholerae O139 associated with the 2002 cholera epidemic in Bangladesh
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Infect Immun 73:6577-83. 2005
    ..cholerae O139. Consequently, this assay may be useful in studies of both O139-infected patients and recipients of O139 vaccines...
  37. doi request reprint Surveillance for invasive Streptococcus pneumoniae disease among hospitalized children in Bangladesh: antimicrobial susceptibility and serotype distribution
    Samir K Saha
    Department of Microbiology, Bangladesh Institute of Child Health, Dhaka Shishu Hospital, Dhaka, Bangladesh
    Clin Infect Dis 48:S75-81. 2009
    ..Vaccines offer the prospect of primary disease prevention of pneumococcal disease in childhood. For introduction of such vaccines in developing countries, information about disease epidemiology is necessary...
  38. ncbi request reprint Isolation and characterization of provisional serovar Shigella boydii E16553 from diarrhoeal patients in Bangladesh
    M Ansaruzzaman
    International Center for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 54:477-80. 2005
    ..boydii 19...
  39. ncbi request reprint Reduced doses of oral killed enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine is safe and immunogenic in Bangladeshi infants 6-17 months of age: dosing studies in different age groups
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 24:1726-33. 2006
    ..05-0.001). This study thus demonstrates that reduced doses of the ETEC vaccine is immunogenic in children and infants as well as safe in infants down to 6 months of age...
  40. pmc Effect of transport at ambient temperature on detection and isolation of Vibrio cholerae from environmental samples
    Munirul Alam
    International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Appl Environ Microbiol 72:2185-90. 2006
    ..cholerae from freshwater ecosystems can be achieved by holding samples at the ambient temperature, an observation that has significant implications for tracking this pathogen in diverse aquatic environments...
  41. pmc Enterotoxigenic Escherichia coli and Vibrio cholerae diarrhea, Bangladesh, 2004
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Emerg Infect Dis 11:1104-7. 2005
    ..ETEC that produced heat-stable enterotoxin alone was most prevalent, and 78% of strains had colonization factors. Like V. cholerae O1, ETEC can cause epidemic diarrhea...
  42. pmc Reduction of cholera in Bangladeshi villages by simple filtration
    Rita R Colwell
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 100:1051-5. 2003
    ..005) compared with the control...
  43. pmc Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 102:1702-7. 2005
    ..Our data support the conclusion that cholera phages can influence cholera seasonality and may also play a role in emergence of new V. cholerae pandemic serogroups or clones...
  44. pmc CTXphi-independent production of the RS1 satellite phage by Vibrio cholerae
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 100:1280-5. 2003
    ..cholerae strains. This study also shows that filamentous phages can package diverse DNA elements and thus may play a role in horizontal transfer of more genes than previously appreciated...
  45. pmc Detection and characterization of human group C rotaviruses in Bangladesh
    Mustafizur Rahman
    ICDDR, B, Centre for Health and Population Research, Mohakhali, Dhaka, Bangladesh
    J Clin Microbiol 43:4460-5. 2005
    ..Phylogenetic analysis suggested that all human group C rotaviruses, including the strains isolated in our study, clustered in a monophyletic branch, which was distantly related to the branch comprised of animal group C rotaviruses...
  46. pmc Isolation of Shigella dysenteriae type 1 and S. flexneri strains from surface waters in Bangladesh: comparative molecular analysis of environmental Shigella isolates versus clinical strains
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Appl Environ Microbiol 68:3908-13. 2002
    ....
  47. pmc Prevalence of the pandemic genotype of Vibrio parahaemolyticus in Dhaka, Bangladesh, and significance of its distribution across different serotypes
    N A Bhuiyan
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    J Clin Microbiol 40:284-6. 2002
    ..A marker (open reading frame ORF8) for a filamentous phage previously thought to correspond to the pandemic genotype was found to have a poor correlation with the pandemic genotype...
  48. ncbi request reprint Getting serious about cholera
    David A Sack
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    N Engl J Med 355:649-51. 2006
  49. pmc Comparative safety and immunogenicity of two attenuated enterotoxigenic Escherichia coli vaccine strains in healthy adults
    Robin McKenzie
    Center for Immunization Research, Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, 624 N Broadway, HH, Rm 203, Baltimore, MD 21205, USA
    Infect Immun 74:994-1000. 2006
    ..Based on its superior immunogenicity, which was comparable to that of a virulent ETEC strain and other ETEC vaccine candidates, PTL-003 will be developed further as a component of a live, oral attenuated ETEC vaccine...
  50. doi request reprint Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial
    K Zaman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Lancet 376:615-23. 2010
    ..We assessed the clinical efficacy of live oral pentavalent rotavirus vaccine for prevention of severe rotavirus gastroenteritis in infants in Bangladesh and Vietnam...
  51. pmc Evaluation of enrichment method for the detection of Vibrio cholerae O1 using a rapid dipstick test in Bangladesh
    Christine M George
    Department of International Health Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Trop Med Int Health 19:301-7. 2014
    ..To evaluate the specificity of the Crystal VC dipstick test for detecting cholera...
  52. ncbi request reprint Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    J Infect Dis 192:573-9. 2005
    ..A lower immunological response against cholera toxin B subunit was detected.CONCLUSIONS. The safety and immunogenicity of this Peru-15 vaccine candidate indicates the usefulness of future studies in Bangladesh, where cholera is endemic...
  53. ncbi request reprint The Practice of Jhum Cultivation and its Relationship to Plasmodium falciparum Infection in the Chittagong Hill Districts of Bangladesh
    Sean R Galagan
    Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Centre for Population, Urbanization and Climate Change, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Am J Trop Med Hyg 91:374-83. 2014
    ..These results confirm that jhum cultivation is an independent risk factor for malaria infection and underscore the need for malaria testing and treatment services to reach remote populations in the Chittagong Hill Districts. ..
  54. ncbi request reprint Changing trend of persistent diarrhoea in young children over two decades: observations from a large diarrhoeal disease hospital in Bangladesh
    Sumon Kumar Das
    International Centre for Diarrheal Disease Research, Bangladesh Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Acta Paediatr 101:e452-7. 2012
    ..We studied the changing trend and factors associated with persistent diarrhoea (PD) in under-five children presenting to a large diarrhoeal disease hospital in urban Dhaka, Bangladesh, over the last two decades...
  55. pmc Refinement of a human challenge model for evaluation of enterotoxigenic Escherichia coli vaccines
    Clayton Harro
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Clin Vaccine Immunol 18:1719-27. 2011
    ..After the second challenge, participants exhibited blunted anti-LPS and -LTB responses but a booster response to CFA/I. This ETEC model should prove useful in the future evaluation of ETEC vaccine candidates...
  56. pmc Emergence and evolution of Vibrio cholerae O139
    Shah M Faruque
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 100:1304-9. 2003
    ..cholerae, not only in the Ganges Delta region of India and Bangladesh, but also in other areas of endemic and epidemic cholera...
  57. ncbi request reprint Safety and immunogenicity of an oral, inactivated enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Bangladeshi children 18-36 months of age
    Firdausi Qadri
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 21:2394-403. 2003
    ..003 to <0.001). This study thus shows that the CF-BS-ETEC vaccine is well tolerated in children, 18-36 months of age and gives rise to significant systemic and mucosal IgA antibody responses...
  58. doi request reprint Malnutrition levels among vaccinated and unvaccinated children between 2 and 3 years of age following enrollment in a randomized clinical trial with the pentavalent rotavirus vaccine (PRV) in Bangladesh
    Andrea J Feller
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Vaccine 30:A101-5. 2012
    ..Regardless of the impact on malnutrition indicators, rotavirus vaccines are an important intervention for reducing morbidity and mortality in children in developing countries...
  59. pmc Typing of human rotaviruses: nucleotide mismatches between the VP7 gene and primer are associated with genotyping failure
    Mustafizur Rahman
    ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    Virol J 2:24. 2005
    ..9%) of the rotavirus strains isolated in 2002 could not be G-typed using the routinely used primer set. To investigate the reason why the strains were untypeable, nucleotide sequencing of the VP7 genes was performed...
  60. doi request reprint Zinc treatment for 5 or 10 days is equally efficacious in preventing diarrhea in the subsequent 3 months among Bangladeshi children
    Dewan S Alam
    Health Systems and Infectious Diseases Division, International Centre for Diarrheal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh
    J Nutr 141:312-5. 2011
    ..These findings suggest that among Bangladeshi children, a 5-d zinc treatment for ACD is as efficacious as 10 d in preventing diarrhea in the subsequent 3 mo...
  61. pmc Global dissemination of Vibrio parahaemolyticus serotype O3:K6 and its serovariants
    G Balakrish Nair
    Enteric Microbiology Unit, Laboratory Sciences Division, ICDDR, B Center for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    Clin Microbiol Rev 20:39-48. 2007
    ..This review traces the genesis, virulence features, molecular characteristics, serotype variants, environmental occurrence, and global spread of this unique clone of V. parahaemolyticus...
  62. pmc Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19
    Robin McKenzie
    Department of Medicine, Johns Hopkins University, Johns Hopkins Bayview Medical Center, MD, USA
    J Infect Dis 204:60-4. 2011
    ..These studies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suitability of the LT|CS17-ETEC challenge model for interventional trials...
  63. pmc Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research Bangladesh, Centre for Health and Population Research, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 103:9178-83. 2006
    ....
  64. ncbi request reprint Antidiarrheal effects of L-histidine-supplemented rice-based oral rehydration solution in the treatment of male adults with severe cholera in Bangladesh: a double-blind, randomized trial
    Golam H Rabbani
    Clinical Sciences Division, Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    J Infect Dis 191:1507-14. 2005
    ..Because of the antisecretory potential of L-histidine in the intestinal tract, its antidiarrheal effects were determined in cholera...
  65. pmc Achieving the millennium development goals for health and nutrition in Bangladesh: key issues and interventions--an introduction
    David A Sack
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street E5036, Baltimore, Maryland 21205, USA
    J Health Popul Nutr 26:253-60. 2008
  66. pmc Nutrition: basis for healthy children and mothers in Bangladesh
    A S G Faruque
    Clinical Sciences Division, ICDDR, B, GPO Box 128, Dhaka 1000, Mohakhali, Bangladesh
    J Health Popul Nutr 26:325-39. 2008
    ....
  67. ncbi request reprint Diarrhoea in elderly people: aetiology, and clinical characteristics
    Abu S G Faruque
    From the Clinical Sciences Division, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    Scand J Infect Dis 36:204-8. 2004
    ..Early initiation of oral or i.v. rehydration therapy, prompt referral, and immediate clinical diagnosis for assessment of the need for antibiotic therapy might be beneficial for the elderly...
  68. ncbi request reprint Symptomatic hyponatremia during treatment of dehydrating diarrheal disease with reduced osmolarity oral rehydration solution
    Nur H Alam
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research Bangladesh, Mohakhali, Dhaka, Bangladesh
    JAMA 296:567-73. 2006
    ....
  69. ncbi request reprint Rotavirus-specific subclass antibody and cytokine responses in Bangladeshi children with rotavirus diarrhoea
    Tasnim Azim
    ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    J Med Virol 69:286-95. 2003
    ..The immune responses described are relevant to future vaccine trials, as immune responses in vaccinees should mimic those in natural infection...
  70. ncbi request reprint A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh
    R Bradley Sack
    Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 187:96-101. 2003
    ..These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks...
  71. pmc RS1 element of Vibrio cholerae can propagate horizontally as a filamentous phage exploiting the morphogenesis genes of CTXphi
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Infect Immun 70:163-70. 2002
    ..The results of this study showed for the first time that RS1 element, which encodes a site-specific recombination system in V. cholerae, can propagate horizontally as a filamentous phage, exploiting the morphogenesis genes of CTXPhi...
  72. pmc Phenotypic and genotypic characterization of serologically atypical strains of Shigella flexneri type 4 isolated in Dhaka, Bangladesh
    Kaisar A Talukder
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 40:2490-7. 2002
    ..This study concluded that two different clones of atypical S. flexneri type 4 exist and strongly suggests that these are new subserotypes of S. flexneri that await further serological classification...
  73. pmc Mapping hypoendemic, seasonal malaria in rural Bandarban, Bangladesh: a prospective surveillance
    Wasif A Khan
    ICDDR, B International Centre for Diarrhoeal Disease Research, Clinical Sciences Division
    Malar J 10:124. 2011
    ....
  74. ncbi request reprint Rapid diagnosis of active tuberculosis by detecting antibodies from lymphocyte secretions
    Rubhana Raqib
    International Center for Diarrhoeal Disease Research, Bangladesh
    J Infect Dis 188:364-70. 2003
    ..Patients with active TB had higher BCG- or PPD-specific IgG antibody responses than patients without TB or healthy subjects (P=.001). This method can be used as a quick diagnostic aid to facilitate rapid detection of TB cases...
  75. pmc Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 102:6119-24. 2005
    ..cholerae and, hence, the collapse of the epidemic. Thus, in vivo phage amplification in patients and subsequent phage predation in the environment may explain the self-limiting nature of seasonal cholera epidemics in Bangladesh...
  76. pmc Phenotypic and genotypic characterization of provisional serotype Shigella flexneri 1c and clonal relationships with 1a and 1b strains isolated in Bangladesh
    Kaisar A Talukder
    Enteric Laboratory, Laboratory Sciences Division, International Centre for Diarrhoeal Diseases Research, Bangladesh
    J Clin Microbiol 41:110-7. 2003
    ..Furthermore, the high rate of prevalence of serotype 1c necessitates the commercial production of antibody against this subserotype to allow the determination of the actual burden of shigellosis caused by provisional serotype 1c...
  77. pmc Use of antibodies in lymphocyte secretions for detection of subclinical tuberculosis infection in asymptomatic contacts
    Rubhana Raqib
    ICDDR, B Centre for Health and Population Research, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh
    Clin Diagn Lab Immunol 11:1022-7. 2004
    ..The method may also allow discrimination between effective treatment of active infection and suboptimal response to therapy...
  78. ncbi request reprint Invasive pneumococcal disease burden and implications for vaccine policy in urban Bangladesh
    W Abdullah Brooks
    ICDDR, B, Mohakhali, Dhaka, Bangladesh
    Am J Trop Med Hyg 77:795-801. 2007
    ..9%, 82.4%, 14.7%, and 24.1%, respectively. Current conjugate vaccines should substantially reduce IPD, childhood pneumonia, and antimicrobial resistance in Bangladesh...
  79. ncbi request reprint Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPOBox 128, Dhaka 1000, Bangladesh
    J Infect Dis 187:1085-96. 2003
    ..Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting...
  80. ncbi request reprint Multilocus sequence typing (MLST) analysis of Vibrio cholerae O1 El Tor isolates from Mozambique that harbour the classical CTX prophage
    Je Hee Lee
    International Vaccine Institute, San 4 8 Bongcheon 7 Dong, Kwanak gu, Seoul, 151 818, Republic of Korea
    J Med Microbiol 55:165-70. 2006
    ..The possible origin of these isolates and the presence of the tandem repeat of the classical prophage in them implicate the presence of the classical CTX phage...
  81. ncbi request reprint Efficacy calculation in randomized trials: global or local measures?
    Michael Emch
    Department of Geography, Saunders Hall, University of North Carolina, Chapel Hill, NC 27599 3220 USA
    Health Place 13:238-48. 2007
    ..Local efficacy measures can help public health practitioners make better decisions about when and where to vaccinate populations. The concepts offered in this study are pertinent for any health intervention trial, not just vaccines...
  82. ncbi request reprint An unusual cluster of dysentery due to Shigella dysenteriae type 4 in Dhaka, Bangladesh
    Kaisar A Talukder
    J Med Microbiol 54:511-3. 2005
  83. ncbi request reprint Impending concentrated HIV epidemic among injecting drug users in Central Bangladesh
    Tasnim Azim
    Int J STD AIDS 15:280-2. 2004
  84. ncbi request reprint Relationship between neighbourhood-level killed oral cholera vaccine coverage and protective efficacy: evidence for herd immunity
    Michael Emch
    Department of Geography, Saunders Hall, Campus Box 3220, University of North Carolina Chapel Hill, 27599 3220, USA
    Int J Epidemiol 35:1044-50. 2006
    ....
  85. ncbi request reprint Therapy of travelers' diarrhea with rifaximin on various continents
    Robert Steffen
    Division of Communicable Diseases, Institute of Social and Preventive Medicine of the University, Zurich, Switzerland
    Am J Gastroenterol 98:1073-8. 2003
    ..Our aim was to compare the efficacy and safety of rifaximin, a virtually nonabsorbed antibiotic, 600 and 1200 mg per day, with placebo in patients with travelers' diarrhea...
  86. ncbi request reprint The effect of rainfall on the incidence of cholera in Bangladesh
    Masahiro Hashizume
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Epidemiology 19:103-10. 2008
    ..The incidence of cholera in Bangladesh shows clear seasonality, suggesting that weather factors could play a role in its epidemiology. We estimated the effects of rainfall on the incidence of cholera in Dhaka, Bangladesh...
  87. pmc Emergence of multidrug-resistant strain of Vibrio cholerae O1 in Bangladesh and reversal of their susceptibility to tetracycline after two years
    Abu S G Faruque
    J Health Popul Nutr 25:241-3. 2007
  88. ncbi request reprint When should cholera vaccine be used in cholera-endemic areas?
    David A Sack
    J Health Popul Nutr 21:299-303. 2003
  89. ncbi request reprint O3:K6 serotype of Vibrio parahaemolyticus identical to the global pandemic clone associated with diarrhea in Peru
    Ana I Gil
    Instituto de Investigacion Nutricional, Av La Molina 1885, Lima 12, Peru, AP 18 091, Lima 18, Peru
    Int J Infect Dis 11:324-8. 2007
    ..To determine if the Vibrio parahaemolyticus O3:K6 global pandemic clone has spread into Peru...
  90. ncbi request reprint Enteroaggregative Escherichia coli diarrhea in travelers: response to rifaximin therapy
    Rosa M Infante
    Center for Infectious Diseases, The University of Texas Houston School of Public Health and Medical School, Houston, Texas, USA
    Clin Gastroenterol Hepatol 2:135-8. 2004
    ..We have recently shown that enteroaggregative Escherichia coli (EAEC) strains commonly cause travelers' diarrhea. The study was designed to determine whether U.S. travelers with EAEC diarrhea responded to rifaximin therapy...
  91. ncbi request reprint Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis
    Mohammad Ali
    International Vaccine Institute, Seoul, Korea
    Lancet 366:44-9. 2005
    ..We reanalysed data from a field trial in Bangladesh to ascertain whether there is evidence of indirect protection from killed oral cholera vaccines...