F Qadri

Summary

Affiliation: International Centre for Diarrhoeal Disease Research
Country: Bangladesh

Publications

  1. pmc Evaluation of a typhoid/paratyphoid diagnostic assay (TPTest) detecting anti-Salmonella IgA in secretions of peripheral blood lymphocytes in patients in Dhaka, Bangladesh
    Farhana Khanam
    International Centre for Diarrhoeal Disease Research ICDDR, B, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 7:e2316. 2013
  2. pmc Impact of rapid urbanization on the rates of infection by Vibrio cholerae O1 and enterotoxigenic Escherichia coli in Dhaka, Bangladesh
    Fahima Chowdhury
    International Centre for Diarrheal Disease Research, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e999. 2011
  3. pmc Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection
    Mohammad Arifuzzaman
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e1413. 2011
  4. pmc Knowledge of, attitudes toward, and preventive practices relating to cholera and oral cholera vaccine among urban high-risk groups: findings of a cross-sectional study in Dhaka, Bangladesh
    Tasnuva Wahed
    Centre for Vaccine Sciences, ICDDR, B, Dhaka, Bangladesh
    BMC Public Health 13:242. 2013
  5. doi request reprint Immune responses and protection in children in developing countries induced by oral vaccines
    Firdausi Qadri
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
    Vaccine 31:452-60. 2013
  6. ncbi request reprint Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    J Infect Dis 192:573-9. 2005
  7. pmc Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh
    Firdausi Qadri
    International Centre for Diarrheal Disease Research, Laboratory Sciences Division B, Dhaka 1000, Bangladesh
    Infect Immun 75:3961-8. 2007
  8. pmc Mucosal and systemic immune responses in patients with diarrhea due to CS6-expressing enterotoxigenic Escherichia coli
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Infect Immun 75:2269-74. 2007
  9. ncbi request reprint Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants
    Firdausi Qadri
    ICDDR, B Centre for Health and Population Research, Bangladesh
    Vaccine 25:231-8. 2007
  10. ncbi request reprint Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPOBox 128, Dhaka 1000, Bangladesh
    J Infect Dis 187:1085-96. 2003

Research Grants

Detail Information

Publications101 found, 100 shown here

  1. pmc Evaluation of a typhoid/paratyphoid diagnostic assay (TPTest) detecting anti-Salmonella IgA in secretions of peripheral blood lymphocytes in patients in Dhaka, Bangladesh
    Farhana Khanam
    International Centre for Diarrhoeal Disease Research ICDDR, B, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 7:e2316. 2013
    ..We report the characterization of novel approach utilizing lymphocyte secretions, for diagnosing patients with enteric fever by the TPTest procedure...
  2. pmc Impact of rapid urbanization on the rates of infection by Vibrio cholerae O1 and enterotoxigenic Escherichia coli in Dhaka, Bangladesh
    Fahima Chowdhury
    International Centre for Diarrheal Disease Research, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e999. 2011
    ..The aim of this prospective study was to identify the prevalence and importance of V. cholerae O1 and enterotoxigenic Escherichia coli (ETEC) as causal agents of severe diarrhea in a high diarrhea prone urban area in Dhaka city...
  3. pmc Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection
    Mohammad Arifuzzaman
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e1413. 2011
    ..The aim of this study was to determine the relationship of the Lewis blood group antigens with susceptibility to cholera, as well as severity of disease and immune responses to infection...
  4. pmc Knowledge of, attitudes toward, and preventive practices relating to cholera and oral cholera vaccine among urban high-risk groups: findings of a cross-sectional study in Dhaka, Bangladesh
    Tasnuva Wahed
    Centre for Vaccine Sciences, ICDDR, B, Dhaka, Bangladesh
    BMC Public Health 13:242. 2013
    ..The present study assessed the knowledge of, attitudes toward, and preventive practices relating to cholera and oral cholera vaccine among an urban population residing in a high cholera-prone setting in Dhaka, Bangladesh...
  5. doi request reprint Immune responses and protection in children in developing countries induced by oral vaccines
    Firdausi Qadri
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
    Vaccine 31:452-60. 2013
    ....
  6. ncbi request reprint Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    J Infect Dis 192:573-9. 2005
    ..A lower immunological response against cholera toxin B subunit was detected.CONCLUSIONS. The safety and immunogenicity of this Peru-15 vaccine candidate indicates the usefulness of future studies in Bangladesh, where cholera is endemic...
  7. pmc Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh
    Firdausi Qadri
    International Centre for Diarrheal Disease Research, Laboratory Sciences Division B, Dhaka 1000, Bangladesh
    Infect Immun 75:3961-8. 2007
    ..032 to 0.023). Children with ETEC diarrhea were underweight and growth stunted at the 2-year follow-up period, showing the importance of strategies to prevent and decrease ETEC diarrheal morbidity in children...
  8. pmc Mucosal and systemic immune responses in patients with diarrhea due to CS6-expressing enterotoxigenic Escherichia coli
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Infect Immun 75:2269-74. 2007
    ..Studies are needed to determine if the anti-CS6 responses protect against reinfection and if protective levels of CS6 immunity are induced by vaccination...
  9. ncbi request reprint Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants
    Firdausi Qadri
    ICDDR, B Centre for Health and Population Research, Bangladesh
    Vaccine 25:231-8. 2007
    ..The responses to the reduced dose was lower. These studies demonstrate that Peru-15 at a dose of 2x10(8)cfu is safe and immunogenic in children in Bangladesh...
  10. ncbi request reprint Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPOBox 128, Dhaka 1000, Bangladesh
    J Infect Dis 187:1085-96. 2003
    ..Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting...
  11. pmc Homologous and cross-reactive immune responses to enterotoxigenic Escherichia coli colonization factors in Bangladeshi children
    Firdausi Qadri
    International Centre for Diarhoeal Disease Research, Bangladesh, Laboratory Sciences Division, GPO Box 128, Dhaka 1000, Bangladesh
    Infect Immun 74:4512-8. 2006
    ....
  12. ncbi request reprint Reduced doses of oral killed enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine is safe and immunogenic in Bangladeshi infants 6-17 months of age: dosing studies in different age groups
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 24:1726-33. 2006
    ..05-0.001). This study thus demonstrates that reduced doses of the ETEC vaccine is immunogenic in children and infants as well as safe in infants down to 6 months of age...
  13. pmc Reduction in capsular content and enhanced bacterial susceptibility to serum killing of Vibrio cholerae O139 associated with the 2002 cholera epidemic in Bangladesh
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Infect Immun 73:6577-83. 2005
    ..cholerae O139. Consequently, this assay may be useful in studies of both O139-infected patients and recipients of O139 vaccines...
  14. pmc Antigen-specific immunoglobulin A antibodies secreted from circulating B cells are an effective marker for recent local immune responses in patients with cholera: comparison to antibody-secreting cell responses and other immunological markers
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    Infect Immun 71:4808-14. 2003
    ....
  15. pmc Enterotoxigenic Escherichia coli and Vibrio cholerae diarrhea, Bangladesh, 2004
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Emerg Infect Dis 11:1104-7. 2005
    ..ETEC that produced heat-stable enterotoxin alone was most prevalent, and 78% of strains had colonization factors. Like V. cholerae O1, ETEC can cause epidemic diarrhea...
  16. ncbi request reprint Safety and immunogenicity of an oral, inactivated enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Bangladeshi children 18-36 months of age
    Firdausi Qadri
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 21:2394-403. 2003
    ..003 to <0.001). This study thus shows that the CF-BS-ETEC vaccine is well tolerated in children, 18-36 months of age and gives rise to significant systemic and mucosal IgA antibody responses...
  17. pmc Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139
    Firdausi Qadri
    Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Clin Diagn Lab Immunol 9:221-9. 2002
    ..cholerae O1 and O139...
  18. pmc Enterotoxin-specific immunoglobulin E responses in humans after infection or vaccination with diarrhea-causing enteropathogens
    F Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Infect Immun 68:6077-81. 2000
    ....
  19. pmc Lipopolysaccharide- and cholera toxin-specific subclass distribution of B-cell responses in cholera
    F Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Diagn Lab Immunol 6:812-8. 1999
    ..Vaccines against O1 and O139 cholera ideally should stimulate antibody subclasses that are likely to offer protection...
  20. pmc Prevalence of toxin types and colonization factors in enterotoxigenic Escherichia coli isolated during a 2-year period from diarrheal patients in Bangladesh
    F Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 38:27-31. 2000
    ..This study supports the fact that ETEC is still a major cause of childhood diarrhea in Bangladesh, especially in children up to 3 years of age, and that measures to prevent such infections are needed in developing countries...
  21. ncbi request reprint Safety and immunogenicity of an oral, inactivated enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Bangladeshi adults and children
    F Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 18:2704-12. 2000
    ..These results show that a single dose of the ETEC vaccine may elicit significant mucosal immune responses in both children and adults residing in an ETEC-endemic country such as Bangladesh...
  22. ncbi request reprint Human antibody response to longus type IV pilus and study of its prevalence among enterotoxigenic Escherichia coli in Bangladesh by using monoclonal antibodies
    F Qadri
    Laboratory Sciences Division, ICDDR, B, Dhaka 1000, Bangladesh
    J Infect Dis 181:2071-4. 2000
    ..These studies show that longus is prevalent among ETEC in Bangladesh and that longus gives rise to IgA antibody responses in patients...
  23. pmc Acute dehydrating disease caused by Vibrio cholerae serogroups O1 and O139 induce increases in innate cells and inflammatory mediators at the mucosal surface of the gut
    F Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Gut 53:62-9. 2004
    ..This is being re-evaluated based on available data that natural cholera infection or cholera toxin induces a Th2-type of immune profile and stimulates the humoral immune response, innate cells, and mediators in the host...
  24. pmc Comparison of immune responses in patients infected with Vibrio cholerae O139 and O1
    F Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Infect Immun 65:3571-6. 1997
    ..These results suggest that despite having a polysaccharide capsule, V. cholerae O139 induces systemic and intestine-derived ASC responses in peripheral blood comparable to those seen in patients with V. cholerae O1 disease...
  25. pmc Immune response to the mannose-sensitive hemagglutinin in patients with cholera due to Vibrio cholerae O1 and O0139
    F Qadri
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Clin Diagn Lab Immunol 4:429-34. 1997
    ..In summary, we demonstrated that MSHA is immunogenic, giving rise to both systemic and local antibodies in patients with cholera due to both O1 and O139 serogroups...
  26. pmc Innate immune responses in children and adults with Shigellosis
    R Raqib
    Laboratory Sciences Division, International Centre for Diarrhoeal Diseases Research, Bangladesh, Dhaka, Bangladesh
    Infect Immun 68:3620-9. 2000
    ..In addition, increased production of proinflammatory mediators in the rectum of patients with severe histology suggested contribution of these molecules to the immunopathogenesis of severe colitis caused by shigellae...
  27. pmc Characterization of Aeromonas trota strains that cross-react with Vibrio cholerae O139 Bengal
    M J Albert
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    J Clin Microbiol 33:3119-23. 1995
    ..Studies on bacteria that share somatic antigen with V. cholerae O139 may shed further light on the genesis of V. cholerae O139...
  28. pmc Comparison of the vibriocidal antibody response in cholera due to Vibrio cholerae O139 Bengal with the response in cholera due to Vibrio cholerae O1
    F Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Clin Diagn Lab Immunol 2:685-8. 1995
    ..These findings may explain the basis for the lack of heterologous protection between the two serogroups of V. cholerae. Healthy controls had higher background levels of vibriocidal antibody to V. cholerae O1 than to V. cholerae O139...
  29. doi request reprint Differential expression of enteric neuroimmune-network in invasive and acute watery diarrhoea
    P SarkEr
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Neurogastroenterol Motil 22:70-8, e29. 2010
    ..Neurotransmitters and neuropeptides may play differential roles in invasive and watery diarrhoea...
  30. ncbi request reprint Characterization of enterotoxigenic Escherichia coli from diarrhoeal patients in Bangladesh using phenotyping and genetic profiling
    M Ansaruzzaman
    ICDDR, B International Centre for Diarrhoeal Diseases Research, Bangladesh, Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Med Microbiol 56:217-22. 2007
    ..Three major clonal groups were identified among the ETEC strains in this study, largely based on O-antigenic type, CF expression pattern and toxin profile...
  31. ncbi request reprint Cell surface proteins from Shigella dysenteriae type 1
    F Qadri
    International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka
    Zentralbl Bakteriol 273:287-99. 1990
    ..This method will be useful when immunogenically active proteins free from other cellular components are required for studies...
  32. pmc Antigen-specific memory B-cell responses to Vibrio cholerae O1 infection in Bangladesh
    AARON M HARRIS
    International Centre for Diarrheal Disease Research, Bangladesh, Centre for Health and Population Research, Dhaka, Bangladesh
    Infect Immun 77:3850-6. 2009
    ..cholerae protein antigens. Such memory B cells could mediate anamnestic responses on reexposure to V. cholerae...
  33. pmc Emergence of a new clone of toxigenic Vibrio cholerae O1 biotype El Tor displacing V. cholerae O139 Bengal in Bangladesh
    S M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    J Clin Microbiol 35:624-30. 1997
    ..Further studies are required to assess the epidemic potential of the newly emerged clone of V. cholerae O1 and to understand the mechanism of emergence of new clones of toxigenic V. cholerae...
  34. doi request reprint Isolation of a bacteriophage specific for CS7-expressing strains of enterotoxigenic Escherichia coli
    Y A Begum
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Med Microbiol 59:266-72. 2010
    ..In summary, this study showed the presence of a lytic phage in environmental water that is specific for the CS7 CF of ETEC...
  35. doi request reprint Infection by Helicobacter pylori in Bangladeshi children from birth to two years: relation to blood group, nutritional status, and seasonality
    Taufiqur Rahman Bhuiyan
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Pediatr Infect Dis J 28:79-85. 2009
    ..A birth cohort of 238 children was followed in an urban slum in Dhaka, Bangladesh, to determine incidence, prevalence, and epidemiologic factors related to Helicobacter pylori infection...
  36. pmc A comparison of clinical and immunologic features in children and older patients hospitalized with severe cholera in Bangladesh
    Fahima Chowdhury
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Pediatr Infect Dis J 27:986-92. 2008
    ..Available vaccines provide less protection against cholera than natural infection, particularly in children...
  37. ncbi request reprint Comparison of enterotoxigenic Escherichia coli isolated from surface water and diarrhoeal stool samples in Bangladesh
    Y A Begum
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Can J Microbiol 53:19-26. 2007
    ..The strains showed multiple and similar antibiotic resistance patterns. This study shows that ETEC is prevalent in surface water sources in Bangladesh suggesting a possible reason for the endemicity of this pathogen in Bangladesh...
  38. ncbi request reprint El Tor cholera with severe disease: a new threat to Asia and beyond
    A K Siddique
    Public Health Sciences Division PHSD, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Epidemiol Infect 138:347-52. 2010
    ..However, if cholera due to strains with increased severity spread to other areas where treatment facilities are limited, there are likely to be many more cholera deaths...
  39. ncbi request reprint Role of plasmids in virulence-associated attributes and in O-antigen expression in Shigella dysenteriae type 1 strains
    K Haider
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    J Med Microbiol 33:1-9. 1990
    ..abstract truncated at 250 words)..
  40. pmc Rapid detection of Vibrio cholerae O139 Bengal from stool specimens by PCR
    M J Albert
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    J Clin Microbiol 35:1633-5. 1997
    ..All the 67 V. cholerae O139 culture-positive stool specimens were positive by PCR, and the remaining specimens, which contained either other recognized enteric pathogens or no pathogens, were all negative by PCR...
  41. pmc L-isoleucine-supplemented oral rehydration solution in the treatment of acute diarrhoea in children: a randomized controlled trial
    N H Alam
    Clinical Sciences Division, ICDDR, B GPO Box 128, Dhaka 1000, Bangladesh
    J Health Popul Nutr 29:183-90. 2011
    ..L-isoleucine-supplemented ORS might be beneficial in reducing stool output and ORS intake in children with acute watery diarrhoea. A further study is warranted to substantiate the therapeutic effect of L-isoleucine...
  42. ncbi request reprint Delayed and reduced adaptive humoral immune responses in children with shigellosis compared with in adults
    R Raqib
    International Centre for Diarrhoeal Diseases Research, ICDDR, B, Dhaka, Bangladesh
    Scand J Immunol 55:414-23. 2002
    ..Thus, paediatric patients with shigellosis have reduced and delayed adaptive immune responses compared with adult patients...
  43. pmc Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1
    Channa R Jayasekera
    International Centre for Diarrhoeal Disease Research, Bangladesh
    J Infect Dis 198:1055-61. 2008
    ..The presence of antigen-specific memory B cells may therefore be a more direct measure of protection than serum antibody responses...
  44. doi request reprint Enhanced immunogenicity of an oral inactivated cholera vaccine in infants in Bangladesh obtained by zinc supplementation and by temporary withholding breast-feeding
    Tanvir Ahmed
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 27:1433-9. 2009
    ..This study demonstrates that the vaccine is safe and immunogenic in children under 2 years of age and that simple interventions can enhance immune responses in young children...
  45. doi request reprint Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other muco
    Sohel Shamsuzzaman
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 27:1386-92. 2009
    ..This sets the ground for testing such vaccines in large field trials in Bangladesh and also demonstrates that addition of other vibrio components to the existing cholera vaccine does not alter the responses to the O1 vaccine components...
  46. pmc The major subunit of the toxin-coregulated pilus TcpA induces mucosal and systemic immunoglobulin A immune responses in patients with cholera caused by Vibrio cholerae O1 and O139
    Muhammad Asaduzzaman
    International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka, Bangladesh
    Infect Immun 72:4448-54. 2004
    ..These results demonstrate that TcpA is immunogenic following natural V. cholerae infection and suggest that immune responses to this antigen should be evaluated for potential protection against subsequent life-threatening illness...
  47. pmc Development of immunoglobulin M memory to both a T-cell-independent and a T-cell-dependent antigen following infection with Vibrio cholerae O1 in Bangladesh
    Emily A Kendall
    International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
    Infect Immun 78:253-9. 2010
    ..We did not observe an association between the IgM memory response to LPS and the vibriocidal titer...
  48. pmc Comparison of clinical features and immunological parameters of patients with dehydrating diarrhoea infected with Inaba or Ogawa serotypes of Vibrio cholerae O1
    Ashraful I Khan
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Scand J Infect Dis 42:48-56. 2010
    ..These results suggest that a cholera vaccine based on the Ogawa serotype needs to be further investigated...
  49. pmc Phagocytosis of Vibrio cholerae O139 Bengal by human polymorphonuclear leukocytes
    M J Albert
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Diagn Lab Immunol 6:276-8. 1999
    ..cholerae O139 strains were shown to be only partially resistant, with most strains showing <40% survival. These findings may explain the relative rarity of V. cholerae O139 bacteremia in cholera caused by this organism...
  50. ncbi request reprint Supplementation with zinc, but not vitamin A, improves seroconversion to vibriocidal antibody in children given an oral cholera vaccine
    M John Albert
    International Centre for Diarrhoeal Disease Research, Bangladesh
    J Infect Dis 187:909-13. 2003
    ..Thus, supplementation with zinc improves seroconversion to vibriocidal antibody and, hence, has the potential to improve the efficacy of oral cholera vaccine in children...
  51. doi request reprint Presence of enterotoxigenic Escherichia coli in biofilms formed in water containers in poor households coincides with epidemic seasons in Dhaka
    D Ahmed
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    J Appl Microbiol 114:1223-9. 2013
    ..The objective of this study was to investigate if biofilms may be potential reservoirs for the waterborne pathogen enterotoxigenic Escherichia coli (ETEC) in household water in Dhaka, Bangladesh...
  52. pmc Memory T-cell responses to Vibrio cholerae O1 infection
    Ana A Weil
    International Centre for Diarrheal Disease Research, Dhaka, Bangladesh
    Infect Immun 77:5090-6. 2009
    ..cholerae antigens may be important for the generation and stability of memory B-cell responses. The T-cell proliferative response to VCC was of a higher magnitude than responses observed to other V. cholerae antigens...
  53. pmc Shifting prevalence of major diarrheal pathogens in patients seeking hospital care during floods in 1998, 2004, and 2007 in Dhaka, Bangladesh
    AARON M HARRIS
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Am J Trop Med Hyg 79:708-14. 2008
    ..05). Our findings demonstrate alterations in clinical features and phenotypic changes of major bacterial pathogens in the recent Bangladesh flood...
  54. pmc Concomitant enterotoxigenic Escherichia coli infection induces increased immune responses to Vibrio cholerae O1 antigens in patients with cholera in Bangladesh
    Fahima Chowdhury
    International Centre for Diarrheal Disease Research, Dhaka, Bangladesh
    Infect Immun 78:2117-24. 2010
    ..cholerae O1 infection alone. It is possible that LT or other factors expressed by ETEC may play a role as a mucosal adjuvant in enhancing the immune responses to V. cholerae O1...
  55. ncbi request reprint Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh
    Debasish Saha
    International Centre for Diarrheal Disease Research, Bangladesh
    J Infect Dis 189:2318-22. 2004
    ..No association between baseline vibriocidal titer and protection from V. cholerae O139 infection was found. Our findings suggest that the vibriocidal antibody is an incomplete predictor of protection from V. cholerae infection...
  56. ncbi request reprint Suppressive effect of zinc on antibody response to cholera toxin in children given the killed, B subunit-whole cell, oral cholera vaccine
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Vaccine 22:416-21. 2004
    ..Thus, zinc enhanced vibriocidal antibody response, but suppressed CT-antibody response, suggesting that zinc supplementation has different modulating effects on vibriocidal antibody response and CT-antibody response...
  57. pmc Relatedness of Vibrio cholerae O1/O139 isolates from patients and their household contacts, determined by multilocus variable-number tandem-repeat analysis
    Emily A Kendall
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    J Bacteriol 192:4367-76. 2010
    ..Our results demonstrate that genetically related V. cholerae strains cluster in local outbreaks but also suggest that multiple distinct strains of V. cholerae O1 may circulate simultaneously within a household...
  58. pmc Genomic sequence and receptor for the Vibrio cholerae phage KSF-1phi: evolutionary divergence among filamentous vibriophages mediating lateral gene transfer
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka
    J Bacteriol 187:4095-103. 2005
    ..Since MSHA is present in a wide variety of V. cholerae strains and is presumed to express in the environment, diverse filamentous phages using this receptor are likely to contribute significantly to V. cholerae evolution...
  59. pmc Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh
    Clin Microbiol Rev 18:465-83. 2005
    ..Increases in antimicrobial resistance will dictate the drugs used for the treatment of traveler's diarrhea. Efforts need to be made to improve our understanding of the worldwide importance of ETEC...
  60. ncbi request reprint CD4+ T-cell responses to an oral inactivated cholera vaccine in young children in a cholera endemic country and the enhancing effect of zinc supplementation
    Tanvir Ahmed
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 28:422-9. 2009
    ..001). Our results thus show that oral cholera vaccination induces a Th1 T-cell response in young children, and that the IFN-gamma as well as the vibriocidal antibody responses can be enhanced by zinc supplementation...
  61. pmc Persistence of mucosal mast cells and eosinophils in Shigella-infected children
    Rubhana Raqib
    International Centre for Diarrhoeal Diseases Research, Bangladesh, Dhaka, Bangladesh
    Infect Immun 71:2684-92. 2003
    ..The results suggest that children with shigellosis have a persistent activation of the innate immune response in the convalescent phase, indicating delayed elimination of Shigella antigens compared to adults...
  62. pmc Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 44:4211-3. 2006
    ..All of the El Tor strains of V. cholerae O1 isolated since 2001 produced CT of the classical biotype, while those isolated before 2001 produced CT of the El Tor biotype...
  63. ncbi request reprint Development of Peru-15 (CholeraGarde), a live-attenuated oral cholera vaccine: 1991-2009
    Mohiul Islam Chowdhury
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Mohakhali, Dhaka, 1000, Bangladesh
    Expert Rev Vaccines 8:1643-52. 2009
    ..Phase III studies are being targeted to determine the protective efficacy of CholeraGarde and for further development of a single-dose vaccine that will protect infants and also other age groups from endemic and epidemic cholera...
  64. pmc Children with the Le(a+b-) blood group have increased susceptibility to diarrhea caused by enterotoxigenic Escherichia coli expressing colonization factor I group fimbriae
    Tanvir Ahmed
    Laboratory Sciences Division, ICDDR, B, GPO Box 128, Dhaka 1000, Bangladesh
    Infect Immun 77:2059-64. 2009
    ..001). In contrast, we did not find any association between the Lewis blood group phenotype and diarrhea caused by ETEC expressing CS6 or rotavirus...
  65. pmc Familial aggregation of Vibrio cholerae-associated infection in Matlab, Bangladesh
    Kazi Mizanur Rahman
    Child Health Unit, Public Health Sciences Division, ICDDR, B, GPO Box 128, Dhaka 1000, Bangladesh
    J Health Popul Nutr 27:733-8. 2009
    ..Further analysis of human genetic factors that contribute to susceptibility to cholera may be productive...
  66. pmc Analysis of Salmonella enterica serotype paratyphi A gene expression in the blood of bacteremic patients in Bangladesh
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 4:e908. 2010
    ..Salmonella enterica serotype Paratyphi A is a human-restricted cause of paratyphoid fever, accounting for up to a fifth of all cases of enteric fever in Asia...
  67. doi request reprint The added benefit of zinc supplementation after zinc treatment of acute childhood diarrhoea: a randomized, double-blind field trial
    Charles P Larson
    ICDDR, B, Dhaka, Bangladesh
    Trop Med Int Health 15:754-61. 2010
    ..To determine whether continuing with zinc supplementation after zinc treatment (ZT) of an acute diarrhoea episode will result in additional clinical benefits beyond ZT alone...
  68. doi request reprint Immune responses to Helicobacter pylori infection in Bangladeshi children during their first two years of life and the association between maternal antibodies and onset of infection
    Taufiqur Rahman Bhuiyan
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    J Infect Dis 202:1676-84. 2010
    ....
  69. pmc Use of dipsticks for rapid diagnosis of cholera caused by Vibrio cholerae O1 and O139 from rectal swabs
    N A Bhuiyan
    Laboratory and Clinical Sciences Divisions, International Centre for Diarrhoeal Diseases Research, Bangladesh ICDDR, B, Dhaka 1212, Bangladesh
    J Clin Microbiol 41:3939-41. 2003
    ..The dipsticks represent the first rapid test which has been successfully used to diagnose cholera from rectal swabs, and this would immensely improve surveillance for cholera, especially in remote settings...
  70. pmc Hyperinfectivity of human-passaged Vibrio cholerae can be modeled by growth in the infant mouse
    Ashfaqul Alam
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Infect Immun 73:6674-9. 2005
    ..cholerae as well as the contribution of three type IV pili to the phenotype...
  71. doi request reprint Zinc influences innate immune responses in children with enterotoxigenic Escherichia coli-induced diarrhea
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Nutr 140:1049-56. 2010
    ..Increased responses, including complement C3, phagocytic activity, and changes in T cell phenotypes, suggest that zinc administration enhances innate immunity against ETEC infection in children...
  72. pmc Salmonella enterica serovar Typhi-specific immunoglobulin A antibody responses in plasma and antibody in lymphocyte supernatant specimens in Bangladeshi patients with suspected typhoid fever
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Clin Vaccine Immunol 16:1587-94. 2009
    ..It can be important for use in epidemiological studies, as well as in difficult cases involving fevers of unknown origin...
  73. pmc Zinc treatment to under-five children: applications to improve child survival and reduce burden of disease
    Charles P Larson
    ICDDR, B, Mohakhali, Dhaka 1212, Bangladesh
    J Health Popul Nutr 26:356-65. 2008
    ..Important challenges remain in terms of reaching the poorest families and those living in remote areas of Bangladesh...
  74. pmc Cholera caused by Vibrio cholerae O1 induces T-cell responses in the circulation
    Taufiqur Rahman Bhuiyan
    Immunology Laboratory, Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka 1000, Bangladesh
    Infect Immun 77:1888-93. 2009
    ..cholerae O1. Further studies are needed to determine if such responses are also stimulated after immunization with oral cholera vaccines and if these responses play a role in protection following exposure to cholera...
  75. pmc Antigen-specific memory B-cell responses in Bangladeshi adults after one- or two-dose oral killed cholera vaccination and comparison with responses in patients with naturally acquired cholera
    Mohammad Murshid Alam
    Immunology Unit, Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakali, Dhaka 1212, Bangladesh
    Clin Vaccine Immunol 18:844-50. 2011
    ..These findings may explain in part the relatively short-term protection afforded by oral cholera vaccination compared to natural disease...
  76. pmc Mucosal immunologic responses in cholera patients in Bangladesh
    Taher Uddin
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Dhaka, Bangladesh
    Clin Vaccine Immunol 18:506-12. 2011
    ....
  77. pmc Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection
    Regina C LaRocque
    Division of Infectious Diseases, Gray Jackson 504, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 73:4488-93. 2005
    ..These findings provide a more detailed assessment of the transcriptome of V. cholerae in the human host than previous studies of organisms in stool alone and have implications for cholera control and the design of improved vaccines...
  78. ncbi request reprint Live attenuated oral cholera vaccines
    Edward T Ryan
    Massachusetts General Hospital Tropical and Geographic Medicine Center, Division of Infectious Diseases, Jackson 504 55 Fruit Street, Boston, MA 02114, USA
    Expert Rev Vaccines 5:483-94. 2006
    ..cholerae O139, including CVD 112 and Bengal-15. Live, orally administered, attenuated cholera vaccines are in various stages of development and evaluation...
  79. pmc Type IV longus pilus of enterotoxigenic Escherichia coli: occurrence and association with toxin types and colonization factors among strains isolated in Argentina
    Mariana G Pichel
    Instituto Nacional de Enfermedades Infecciosas, ANLIS Carlos G Malbrán, Buenos Aires, Argentina
    J Clin Microbiol 40:694-7. 2002
    ..The prevalence of longus among ETEC strains in Argentina was comparable to that of colonization factor antigen I (CFA/I), CFA/II, and CFA/IV in other regions of the world...
  80. pmc Host-induced epidemic spread of the cholera bacterium
    D Scott Merrell
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nature 417:642-5. 2002
    ....
  81. ncbi request reprint A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh
    R Bradley Sack
    Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 187:96-101. 2003
    ..These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks...
  82. pmc Transcutaneous immunization with toxin-coregulated pilin A induces protective immunity against Vibrio cholerae O1 El Tor challenge in mice
    Julianne E Rollenhagen
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Infect Immun 74:5834-9. 2006
    ..001). Our results suggest that transcutaneous immunization with TcpA and an immunoadjuvant induces protective anti-TcpA immune responses. Anti-TcpA responses may contribute to an optimal cholera vaccine...
  83. pmc Enterotoxigenic Escherichia coli with STh and STp genotypes is associated with diarrhea both in children in areas of endemicity and in travelers
    Ingrid Bolin
    Department of Microbiology and Immunology, and Göteborg Vaccine Research Institute GUVAX, Goteborg University, Goteborg, Sweden
    J Clin Microbiol 44:3872-7. 2006
    ..Irrespective of ST genotype, the disease symptoms were also similar in both children and travelers...
  84. pmc Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 74:5161-8. 2006
    ..Serovar Typhi antigens identified by IVIAT warrant further evaluation for their contributions to pathogenesis, and they may have diagnostic, therapeutic, or preventive uses...
  85. ncbi request reprint Postgenomic approaches to cholera vaccine development
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, GRJ 504, 55 Fruit Street, Boston, MA 02114, USA
    Expert Rev Vaccines 5:337-46. 2006
    ..This work holds promise for the identification of bacterial targets of protective human immune responses and may contribute to the development of a new generation of cholera vaccines...
  86. pmc Diarrheal epidemics in Dhaka, Bangladesh, during three consecutive floods: 1988, 1998, and 2004
    Brian S Schwartz
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, USA
    Am J Trop Med Hyg 74:1067-73. 2006
    ..Our findings suggest that cholera is the predominant cause of flood-associated diarrheal epidemics in Dhaka, but that other organisms spread by the fecal-oral route also contribute...
  87. pmc Enterotoxigenic Escherichia coli isolated from surface water in urban and rural areas of Bangladesh
    Yasmin A Begum
    J Clin Microbiol 43:3582-3. 2005
  88. pmc Isolation of Escherichia coli bacteriophages from the stool of pediatric diarrhea patients in Bangladesh
    Sandra Chibani-Chennoufi
    Nestle Research Center, Nestec Ltd, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    J Bacteriol 186:8287-94. 2004
    ..Phages with closely related restriction patterns and, in the case of T4-like phages, identical g23 gene sequences were isolated from different patients, suggesting epidemiological links between the patients...
  89. ncbi request reprint In vivo expression of the heat stable (estA) and heat labile (eltB) toxin genes of enterotoxigenic Escherichia coli (ETEC)
    Asa Sjoling
    Institute of Biomedicine, Department of Microbiology and Immunology, Goteborg University, Box 435, 405 30 Goteborg, Sweden
    Microbes Infect 8:2797-802. 2006
    ..We found that estA and eltB are expressed in the in vivo samples but no significant up-or down regulation of the expression levels of either estA or eltB could be determined in vivo as compared to in vitro...
  90. pmc Broad up-regulation of innate defense factors during acute cholera
    Carl Fredrik Flach
    Institute of Biomedicine, Department of Microbiology and Immunology, Goteborg University, Box 435, 40530 Goteborg, Sweden
    Infect Immun 75:2343-50. 2007
    ..Both direct effects of CT on the epithelial cells and changes in the lamina propria cells contribute to this up-regulation...
  91. pmc Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin A-neutralizing antibodies in mice
    Chandrabali Ghose
    Division of Infectious Diseases, Massachusetts General Hospital, Jackson 504, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 75:2826-32. 2007
    ..Our results suggest that transcutaneous immunization with CDA toxoid may be a feasible immunization strategy against C. difficile, an important cause of morbidity and mortality against which current preventative strategies are failing...
  92. doi request reprint Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed country
    Taufiqur Rahman Bhuiyan
    Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    FEMS Immunol Med Microbiol 54:70-9. 2008
    ..pylori, compared with Swedish volunteers. Increased inflammation is present in the duodenum of Bangladeshi volunteers, maybe as a result of frequent exposure to enteric infections in these individuals...
  93. pmc Proteomic analysis of Vibrio cholerae in human stool
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Infect Immun 76:4145-51. 2008
    ..We identified a number of these in vivo expressed proteins as immunogenic during human infection. To our knowledge, this is the first characterization of the proteome of a pathogenic bacteria recovered from a natural host...
  94. pmc Detection of antibodies to toxin-coregulated pili in sera from cholera patients
    Stephen R Attridge
    Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia, Australia
    Infect Immun 72:1824-7. 2004
    ..These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients...
  95. pmc Complexity of rice-water stool from patients with Vibrio cholerae plays a role in the transmission of infectious diarrhea
    Eric J Nelson
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:19091-6. 2007
    ..cholerae. If lytic phage are present, viable counts of V. cholerae drop, stools become DF(-), other microorganisms bloom, and cholera transmission is reduced...
  96. pmc Genes induced late in infection increase fitness of Vibrio cholerae after release into the environment
    Stefan Schild
    Howard Hughes Medical Institute and the Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Cell Host Microbe 2:264-77. 2007
    ..Furthermore, passage through the intestinal tract was necessary to observe this phenotype. Thus, V. cholerae genes expressed prior to exiting the host intestinal tract are advantageous for subsequent life in aquatic environments...
  97. ncbi request reprint Differential expression of intestinal membrane transporters in cholera patients
    Carl Fredrik Flach
    Institute of Biomedicine, Department of Microbiology and Immunology, and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, Goteborg, Sweden
    FEBS Lett 581:3183-8. 2007
    ..The majority of these changes appear to be attempts of the host to counteract the secretory response. Our results also support the concept that epithelial cells are involved in 5-HT signalling during acute cholera...
  98. pmc Sensitive microplate assay for detection of bactericidal antibodies to Vibrio cholerae O139
    Stephen R Attridge
    Department of Molecular Biosciences, University of Adelaide, Adelaide, South Australia 5005, Australia
    Clin Diagn Lab Immunol 9:383-7. 2002
    ..Although infection generated stronger responses than vaccination, the proportion of responders was similar among individuals with low background titers...
  99. ncbi request reprint Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1
    Firoz Ahmed
    Institut Pasteur and CNRS URA 2185, 25 28 Rue du Dr Roux, Paris, France
    Proteins 70:284-8. 2008
  100. pmc Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 73:7422-7. 2005
    ..Based on this epidemiologic evidence, we propose a hypothesis for understanding the association between blood group O and the risk of infection with V. cholerae O1 and O139 as well as the risk of developing severe symptoms once infected...
  101. doi request reprint Development and validation of a mismatch amplification mutation PCR assay to monitor the dissemination of an emerging variant of Vibrio cholerae O1 biotype El Tor
    Masatomo Morita
    National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo, 162 8640, Japan
    Microbiol Immunol 52:314-7. 2008
    ..cholerae O1. This assay will enable easy monitoring of the spread of a new emerging variant of the El Tor biotype of V. cholerae O1...

Research Grants1

  1. Mucosal immune response to oral cholera vaccine Peru 15
    Firdausi Qadri; Fiscal Year: 2007
    ..cholerae. ..