Uday Bandyopadhyay

Summary

Publications

  1. pmc Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum
    Manish Goyal
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, West Bengal, India
    Nucleic Acids Res 40:1174-90. 2012
  2. ncbi request reprint Redox regulation in malaria: current concepts and pharmacotherapeutic implications
    M Goyal
    Division of Infectious Diseases and Immunology, CSIR Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    Curr Med Chem 19:1475-503. 2012
  3. ncbi request reprint Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer
    Uday Bandyopadhyay
    Department of Physiology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata, 700032, India
    Life Sci 75:2867-78. 2004
  4. doi request reprint Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis
    Sumanta Dey
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    Free Radic Biol Med 46:271-81. 2009
  5. pmc Tryptamine-gallic acid hybrid prevents non-steroidal anti-inflammatory drug-induced gastropathy: correction of mitochondrial dysfunction and inhibition of apoptosis in gastric mucosal cells
    Chinmay Pal
    Division of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    J Biol Chem 287:3495-509. 2012
  6. pmc Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration
    Sumanta Dey
    Division of Infectious Diseases and Immunology, Council of Scientific and Industrial Research Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, West Bengal, India
    J Biol Chem 287:26630-46. 2012
  7. doi request reprint Cysteine-3 and cysteine-4 are essential for the thioredoxin-like oxidoreductase and antioxidant activities of Plasmodium falciparum macrophage migration inhibitory factor
    Athar Alam
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, West Bengal, India
    Free Radic Biol Med 50:1659-68. 2011
  8. doi request reprint Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation
    Pallab Maity
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    J Biol Chem 284:3058-68. 2009
  9. pmc Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor
    Athar Alam
    Division of Infectious Diseases and Immunology, Council of Scientific and Industrial Research CSIR Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    J Biol Chem 287:24844-61. 2012
  10. doi request reprint Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal
    Pallab Maity
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    J Biol Chem 283:14391-401. 2008

Collaborators

  • Ratna Chatterjee
  • Debashis Bandyopadhyay
  • Kunal Bhattacharya
  • Saikat Chakrabarti
  • Russel J Reiter
  • Rahul Kumar
  • Chinmay Pal
  • Sumanta Dey
  • Athar Alam
  • Samik Bindu
  • Manish Goyal
  • Pallab Maity
  • Mohd Shameel Iqbal
  • Souvik Sarkar
  • Ishita Chattopadhyay
  • Kaushik Biswas
  • Ranajit K Banerjee
  • Kalyan Mitra
  • Mithu Guha
  • Susanta Adhikari
  • Chinmoy Banerjee
  • Somnath Mazumder
  • Asim Azhar Siddiqui
  • M Goyal
  • Nakul C Maiti
  • Uttam Pal
  • Milan Kumar Kundu
  • Vinay Choubey
  • Rudranil De
  • M Shameel Iqbal
  • Abhijit Mazumdar
  • Hirekodathakallu V Thulasiram
  • Saikat Haldar
  • Sanjit Kumar Das
  • Mita Chatterjee Debnath
  • Anindyajit Banerjee
  • Kamal Krishna Halder
  • Priyanka Singh
  • Gautam Panda
  • Sajal Kumar Das
  • A Alam
  • Shubham Dutta
  • Nahren Manuel Mascarenhas
  • Nanda Ghoshal
  • Susanta S Adhikari
  • Bithi Nandi
  • Archana Varadaraj
  • Esahak Ali
  • Somenath Roy

Detail Information

Publications29

  1. pmc Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum
    Manish Goyal
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, West Bengal, India
    Nucleic Acids Res 40:1174-90. 2012
    ..ChIP and ChIP ReChIP analyses further confirmed that PfAlba3 binds to the telomeric and subtelomeric regions as well as to var gene promoter...
  2. ncbi request reprint Redox regulation in malaria: current concepts and pharmacotherapeutic implications
    M Goyal
    Division of Infectious Diseases and Immunology, CSIR Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    Curr Med Chem 19:1475-503. 2012
    ..We have also given maximum efforts to enlist currently used redox-active antimalarials, their mode of action and pharmacotherapeutic implications...
  3. ncbi request reprint Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer
    Uday Bandyopadhyay
    Department of Physiology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata, 700032, India
    Life Sci 75:2867-78. 2004
    ..Neem bark extract thus has therapeutic potential for controlling gastric hypersecretion and gastroesophageal and gastroduodenal ulcers...
  4. doi request reprint Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis
    Sumanta Dey
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    Free Radic Biol Med 46:271-81. 2009
    ..Interestingly, mitochondrial (.)OH generation correlates with the activation of both caspase-9 and caspase-3 with the progress of malarial infection, indicating the critical role of (.)OH...
  5. pmc Tryptamine-gallic acid hybrid prevents non-steroidal anti-inflammatory drug-induced gastropathy: correction of mitochondrial dysfunction and inhibition of apoptosis in gastric mucosal cells
    Chinmay Pal
    Division of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    J Biol Chem 287:3495-509. 2012
    ..Thus, SEGA (3a) bears an immense potential to be a novel gastroprotective agent against NSAID-induced gastropathy...
  6. pmc Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration
    Sumanta Dey
    Division of Infectious Diseases and Immunology, Council of Scientific and Industrial Research Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, West Bengal, India
    J Biol Chem 287:26630-46. 2012
    ..Thus, hepatic free heme accumulation, TNFα release, oxidative stress, and NF-κB activation established a link to favor neutrophil infiltration in inducing liver damage during hemolytic conditions in malaria...
  7. doi request reprint Cysteine-3 and cysteine-4 are essential for the thioredoxin-like oxidoreductase and antioxidant activities of Plasmodium falciparum macrophage migration inhibitory factor
    Athar Alam
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, West Bengal, India
    Free Radic Biol Med 50:1659-68. 2011
    ..Altogether, our results suggest that the vicinal Cys-3 and Cys-4 play a critical role in the Trx-like oxidoreductase activity and antioxidant property of PfMIF...
  8. doi request reprint Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation
    Pallab Maity
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    J Biol Chem 284:3058-68. 2009
    ....
  9. pmc Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor
    Athar Alam
    Division of Infectious Diseases and Immunology, Council of Scientific and Industrial Research CSIR Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    J Biol Chem 287:24844-61. 2012
    ..In contrast, epoxyazadiradione inhibited both huMIF and plasmodial MIF, thus bearing an immense therapeutic potential against proinflammatory reactions induced by MIF of both malaria parasites and human...
  10. doi request reprint Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal
    Pallab Maity
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    J Biol Chem 283:14391-401. 2008
    ..This study thus provides the detailed mechanism of antiapoptotic and prosurvival effects of lansoprazole for offering gastroprotection against indomethacin-induced gastropathy...
  11. doi request reprint Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis
    Pallab Maity
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Kolkata, India
    J Pineal Res 46:314-23. 2009
    ..Thus, melatonin has significant anti-apoptotic effects to protect gastric mucosa from NSAID-induced apoptosis and gastropathy, which makes its use as potential therapy against gastric damage during NSAID treatment...
  12. doi request reprint The use of neem for controlling gastric hyperacidity and ulcer
    Pallab Maity
    Division of Infectious Disease and Immunology, Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India
    Phytother Res 23:747-55. 2009
    ..Neem bark extract has the potential for the development of novel medicines for the therapeutic control of gastric hyperacidity and ulcer...
  13. doi request reprint Gallic acid prevents nonsteroidal anti-inflammatory drug-induced gastropathy in rat by blocking oxidative stress and apoptosis
    Chinmay Pal
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India
    Free Radic Biol Med 49:258-67. 2010
    ....
  14. doi request reprint Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent
    Athar Alam
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, West Bengal, India
    Bioorg Med Chem 19:7365-73. 2011
    ..7 cell which are the markers for inflammation. The compound 4b is not cytotoxic as evident from cell viability assay. Hence, the compound 4b has potential to be a novel anti-inflammatory agent...
  15. pmc Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury
    Samik Bindu
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    J Biol Chem 286:39387-402. 2011
    ..Thus, induction and mitochondrial localization of HO-1 are a novel cytoprotective mechanism against MOS-mediated apoptotic tissue injury...
  16. doi request reprint Aryl aryl methyl thio arenes prevent multidrug-resistant malaria in mouse by promoting oxidative stress in parasites
    Manish Goyal
    Division of Infectious Diseases and Immunology, CSIR Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    Free Radic Biol Med 53:129-42. 2012
    ..Efforts have been made to synthesize achiral AAMTAs 17-23 and among them, compound 18 showed significant antimalarial activity in vivo...
  17. ncbi request reprint Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen
    Ishita Chattopadhyay
    Department of Physiology, Indian Institute of Chemical Biology, Kolkata, India
    Free Radic Biol Med 40:1397-408. 2006
    ..Curcumin can also scavenge ()OH in vitro. We suggest that curcumin protects gastric damage by efficient removal of H(2)O(2) and H(2)O(2) -derived ()OH by preventing peroxidase inactivation by indomethacin...
  18. ncbi request reprint Gastroprotective effect of Neem (Azadirachta indica) bark extract: possible involvement of H(+)-K(+)-ATPase inhibition and scavenging of hydroxyl radical
    Uday Bandyopadhyay
    Department of Physiology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    Life Sci 71:2845-65. 2002
    ..It is also well tolerated by rats with no significant adverse effect. It is concluded that Neem bark extract has therapeutic potential for the control of gastric hyperacidity and ulcer...
  19. ncbi request reprint Mechanism of antiulcer effect of Neem (Azadirachta indica) leaf extract: effect on H+-K+-ATPase, oxidative damage and apoptosis
    Ishita Chattopadhyay
    Department of Physiology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700 032, India
    Inflammopharmacology 12:153-76. 2004
    ..Neem leaf extract, thus, offers antiulcer activity by blocking acid secretion through inhibition of H+-K+-ATPase and by preventing oxidative damage and apoptosis...
  20. ncbi request reprint Novel antimalarial drug targets: hope for new antimalarial drugs
    Athar Alam
    Division of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    Expert Rev Clin Pharmacol 2:469-89. 2009
    ..This review will discuss and highlight the current understanding regarding the potential antimalarial drug targets, which could be utilized to develop novel antimalarials...
  21. ncbi request reprint Association of Heme Oxygenase 1 with the Restoration of Liver Function after Damage in Murine Malaria by Plasmodium yoelii
    Sumanta Dey
    Department of Infectious Diseases and Immunology, CSIR Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    Infect Immun 82:3113-26. 2014
    ..Therefore, we propose that selective induction of HO-1 in the liver would be beneficial for the restoration of liver function after parasite clearance. ..
  22. doi request reprint Nonsteroidal anti-inflammatory drug induces proinflammatory damage in gastric mucosa through NF-κB activation and neutrophil infiltration: anti-inflammatory role of heme oxygenase-1 against nonsteroidal anti-inflammatory drug
    Samik Bindu
    Department of Infectious Diseases and Immunology, CSIR Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India
    Free Radic Biol Med 65:456-67. 2013
    ..Thus, NSAID by promoting MOS-induced proinflammatory response damaged gastric mucosa and HO-1 protected NSAID-induced gastric mucosal damage by preventing NF-κB activation and proinflammatory activity. ..
  23. ncbi request reprint Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection
    Mithu Guha
    Division of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Kolkata, West Bengal, India
    J Pineal Res 43:372-81. 2007
    ..Thus, melatonin may well be effective in combating oxidative stress-induced apoptosis and liver damage during malaria infection...
  24. ncbi request reprint A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical
    Kaushik Biswas
    Department of Physiology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700 032, India
    J Biol Chem 278:10993-1001. 2003
    ..Thus, omeprazole plays a significant role in gastroprotection by acting as a potent antioxidant and antiapoptotic molecule...
  25. doi request reprint Redox-active antiparasitic drugs
    Chinmay Pal
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Kolkata, India
    Antioxid Redox Signal 17:555-82. 2012
    ..Thus, identification of affordable and readily available drugs against resistant parasites is of global demand...
  26. ncbi request reprint Smoking and the pathogenesis of gastroduodenal ulcer--recent mechanistic update
    Pallab Maity
    Department of Physiology, Indian Institute of Chemical Biology, Kolkata, India
    Mol Cell Biochem 253:329-38. 2003
    ..It is concluded that gastric mucosal integrity is maintained by an interplay of some aggressive and defensive factors controlling apoptotic cell death and cell proliferation and smoking potentiates ulcer by disturbing this balance...
  27. ncbi request reprint Probing the role of active site histidine residues in the catalytic activity of lacrimal gland peroxidase
    Abhijit Mazumdar
    Department of Physiology, Indian Institute of Chemical Biology, Calcutta
    Mol Cell Biochem 237:21-30. 2002
    ..6 is ascertained and attributed to the histidine residue controlling SCN- binding. LGP has thus two distinctly different essential histidine residues - one regulates compound I formation while the other one controls SCN- binding...
  28. doi request reprint Synthesis of novel heme-interacting acridone derivatives to prevent free heme-mediated protein oxidation and degradation
    Chinmay Pal
    Department of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    Bioorg Med Chem Lett 21:3563-7. 2011
    ..These acridones in vitro block heme-mediated protein oxidation and degradation, markers for heme-induced oxidative stress...
  29. ncbi request reprint Extrathyroidal actions of antithyroid thionamides
    Uday Bandyopadhyay
    Department of Physiology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
    Toxicol Lett 128:117-27. 2002
    ..Thionamides also affect gene expression and modulate the functions of some cell types. A brief account of the chemistry and metabolism of antithyroid thionamides, along with their biological actions are presented...