Babasaheb P Bandgar

Summary

Publications

  1. doi Synthesis and biological evaluation of a novel series of pyrazole chalcones as anti-inflammatory, antioxidant and antimicrobial agents
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem 17:8168-73. 2009
  2. doi Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem Lett 20:730-3. 2010
  3. doi Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem 18:1364-70. 2010
  4. doi Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, India
    Bioorg Med Chem 18:6149-55. 2010
  5. doi Synthesis of novel carbazole chalcones as radical scavenger, antimicrobial and cancer chemopreventive agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra
    J Enzyme Inhib Med Chem 28:593-600. 2013
  6. doi Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India
    Bioorg Med Chem Lett 23:912-6. 2013
  7. doi Synthesis and biological evaluation of ester prodrugs of Benzafibrate as orally active hypolipidemic agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India
    Eur J Med Chem 57:217-24. 2012
  8. ncbi Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India
    Bioorg Med Chem Lett 22:5839-44. 2012
  9. doi Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413255, Maharashtra, India
    Bioorg Med Chem 20:5649-57. 2012
  10. ncbi Synthesis and biological evaluation of orally active hypolipidemic agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    J Med Chem 54:5915-26. 2011

Collaborators

Detail Information

Publications22

  1. doi Synthesis and biological evaluation of a novel series of pyrazole chalcones as anti-inflammatory, antioxidant and antimicrobial agents
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem 17:8168-73. 2009
    ..Toxicity of the compounds was evaluated theoretically and experimentally and revealed to be nontoxic except 3d and 3j...
  2. doi Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem Lett 20:730-3. 2010
    ..Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2...
  3. doi Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem 18:1364-70. 2010
    ....
  4. doi Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, India
    Bioorg Med Chem 18:6149-55. 2010
    ..All four 3,5-diaryl pyrazole derivatives were active as tyrosinase inhibitors (2a, 2d, 2h and 2l), and belonging to competitive inhibitors. Interestingly, they all manifested simple reversible slow-binding inhibition against diphenolase...
  5. doi Synthesis of novel carbazole chalcones as radical scavenger, antimicrobial and cancer chemopreventive agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra
    J Enzyme Inhib Med Chem 28:593-600. 2013
    ..All the compounds were subjected for absorption, distribution, metabolism and excretion (ADME) predictions by computational method and found that these molecules could be considered as potential candidates for oral drug development...
  6. doi Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India
    Bioorg Med Chem Lett 23:912-6. 2013
    ..Among the synthesized compounds, compounds 9b, 9d and 9f, were found to be active anti-inflammatory agents in addition to having potent antioxidant activity...
  7. doi Synthesis and biological evaluation of ester prodrugs of Benzafibrate as orally active hypolipidemic agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India
    Eur J Med Chem 57:217-24. 2012
    ..4. On the basis of in vivo studies, prodrug 7 emerged as new potent hypolipidemic agent...
  8. ncbi Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India
    Bioorg Med Chem Lett 22:5839-44. 2012
    ..Molecular docking result, along with the biological assay data, suggested that compound 5c was a potential anti-inflammatory agent...
  9. doi Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413255, Maharashtra, India
    Bioorg Med Chem 20:5649-57. 2012
    ..Compounds 7a, 7d, 7e, 7g, and 7k were found to be potent inhibitors of tyrosinase (IC(50) = 14.01-17.52 μM). These results suggest the possible use of these compounds for the design and development of novel XO and tyrosinase inhibitors...
  10. ncbi Synthesis and biological evaluation of orally active hypolipidemic agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    J Med Chem 54:5915-26. 2011
    ..4. On the basis of in vivo studies, prodrugs 1c and 1d emerged as potent hypolipidemic agents...
  11. doi Synthesis and biological evaluation of orally active prodrugs of indomethacin
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded 431 606, India
    J Med Chem 54:1191-201. 2011
    ..Prodrugs 1a and 1c emerged as potent anti-inflammatory agents with a lesser potential for ulcer than the parent drug indomethacin...
  12. doi Synthesis, characterization, and biological evaluation of novel diclofenac prodrugs
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    J Med Chem 54:1202-10. 2011
    ..4 and 3.0. Diclofenac prodrugs 4, 5, 6 were found to be crystalline in nature (analyzed by PXRD). Prodrug 4 was found to be a superior candidate for the treatment of chronic inflammatory diseases...
  13. doi Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413255, MS, India
    Eur J Med Chem 45:3223-7. 2010
    ..Interestingly, all compounds have shown good antimicrobial activity. Compounds 4d, 4e and 4f showed excellent antimicrobial activity as compared with standard drugs...
  14. doi Silica-supported fluoroboric acid (HBF(4)-SiO(2)) catalyzed highly productive synthesis of thiomorpholides as activators of l-asparaginase as well as the antioxidant agent
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem 18:3618-24. 2010
    ....
  15. doi Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-alpha and IL-6 inhibitors with antioxidant activity
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem Lett 20:2292-6. 2010
    ..Amongst the tested compounds, 16a, 17g, 18f, 18g, 19g and 20e were found to possess significant antioxidant activity...
  16. doi Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413255, India
    Eur J Med Chem 45:2629-33. 2010
    ..None of the compound was found to be cytotoxic in CCK-8 cells at 10 microM concentration. Whereas compounds 5b, 5d, 5e and 5i showed very good antibacterial activity and compounds 5a, 5b, 5e and 5i showed good antifungal activity...
  17. doi Synthesis and biological screening of a combinatorial library of beta-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents
    Babasaheb P Bandgar
    Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, India
    Bioorg Med Chem 18:2060-5. 2010
    ..Some of the compounds 4d, 4e, 4a, 4i and 4b revealed promising antimicrobial activity at MIC 50-100 microg/mL against selected pathogenic bacteria and fungi...
  18. doi Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra, India
    J Enzyme Inhib Med Chem 27:267-74. 2012
    ..Compounds 7h, 7t, 7l, 7i, and 7e have shown good antibacterial activity, whereas compounds 7j, 7f, 7o, 7h, and 7t exhibited significant antifungal activity...
  19. ncbi Synthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents
    Laxman K Adsul
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, Maharashtra, India
    J Enzyme Inhib Med Chem 28:1316-23. 2013
    ..All the compounds were subjected for ADME predictions by computational method...
  20. doi Design, synthesis, characterization and anti-inflammatory evaluation of novel pyrazole amalgamated flavones
    Hemant V Chavan
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India
    Bioorg Med Chem Lett 23:1315-21. 2013
    ..The keto and phenolic -OH are major factors that are prominently involved in interaction with COX-2 active site...
  21. doi Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase
    Shrikant S Gawande
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Bahirji Smarak Mahavidyalaya, Basmathnagar 431512, Hingoli Dist, Maharashtra, India
    Bioorg Med Chem 21:2772-7. 2013
    ..Preliminary structure-activity relationships (SAR) analysis suggested that further development of such compounds might be of interest, as it manifests simple reversible slow binding inhibition against monophenolase and diphenolase...
  22. doi Synthesis and biological evaluation of asymmetric indole curcumin analogs as potential anti-inflammatory and antioxidant agents
    Babasaheb P Bandgar
    Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur, India
    J Enzyme Inhib Med Chem 29:7-11. 2014
    ..Amongst the tested compounds, 5c, 5b, 5j and 5g were found to possess excellent reducing activity and 5b, 5c and 5h were moderate DPPH (1,1-diphenyl-2-picryl hydrazine) radical scavengers...