Esteban Ballestar

Summary

Publications

  1. doi request reprint Epigenetics lessons from twins: prospects for autoimmune disease
    Esteban Ballestar
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, Avda Gran Via 199 203, 08907, L Hospitalet de Llobregat, Barcelona, Spain
    Clin Rev Allergy Immunol 39:30-41. 2010
  2. pmc Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
    Biola M Javierre
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona 08907, Spain
    Genome Res 20:170-9. 2010
  3. doi request reprint Epigenetic alterations in autoimmune rheumatic diseases
    Esteban Ballestar
    Bellvitge Biomedical Research Institute, Barcelona, Spain
    Nat Rev Rheumatol 7:263-71. 2011
  4. pmc C/EBPa-mediated activation of microRNAs 34a and 223 inhibits Lef1 expression to achieve efficient reprogramming into macrophages
    Javier Rodriguez-Ubreva
    Chromatin and Disease Group, Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Mol Cell Biol 34:1145-57. 2014
  5. doi request reprint Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression
    Lorenzo de la Rica
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    J Autoimmun 41:6-16. 2013
  6. pmc NF-κB directly mediates epigenetic deregulation of common microRNAs in Epstein-Barr virus-mediated transformation of B-cells and in lymphomas
    Roser Vento-Tormo
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, 08908 L Hospitalet de Llobregat, Barcelona, Spain
    Nucleic Acids Res 42:11025-39. 2014
  7. pmc Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation
    Henar Hernando
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, Avda Gran Via 199 203, 08908 L Hospitalet de Llobregat, Barcelona, Spain, Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Universitat Pompeu Fabra UPF, 08003 Barcelona, Spain, Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh, Center for Integrated Protein Science and Adolf Butenandt Institute, Ludwig Maximilians University of Munich, 80336 Munich, Germany and CR UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK
    Nucleic Acids Res 42:249-63. 2014
  8. pmc Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells
    Eric M Kallin
    Gene Regulation, Stem Cells and Cancer Program, Center for Genomic Regulation, and Pompeu Fabra University, Barcelona, Spain
    Mol Cell 48:266-76. 2012
  9. doi request reprint Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells
    Biola M Javierre
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, Barcelona, Spain
    Mol Cancer Res 9:1139-51. 2011
  10. doi request reprint Gains of DNA methylation in myeloid terminal differentiation are dispensable for gene silencing but influence the differentiated phenotype
    Roser Vento-Tormo
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    FEBS J 282:1815-25. 2015

Collaborators

Detail Information

Publications18

  1. doi request reprint Epigenetics lessons from twins: prospects for autoimmune disease
    Esteban Ballestar
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, Avda Gran Via 199 203, 08907, L Hospitalet de Llobregat, Barcelona, Spain
    Clin Rev Allergy Immunol 39:30-41. 2010
    ..The implications of novel strategies to map epigenetic profiles and how the use of MZ twins can contribute to dissect the epigenetic component of autoimmune disease are discussed...
  2. pmc Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
    Biola M Javierre
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona 08907, Spain
    Genome Res 20:170-9. 2010
    ....
  3. doi request reprint Epigenetic alterations in autoimmune rheumatic diseases
    Esteban Ballestar
    Bellvitge Biomedical Research Institute, Barcelona, Spain
    Nat Rev Rheumatol 7:263-71. 2011
    ....
  4. pmc C/EBPa-mediated activation of microRNAs 34a and 223 inhibits Lef1 expression to achieve efficient reprogramming into macrophages
    Javier Rodriguez-Ubreva
    Chromatin and Disease Group, Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Mol Cell Biol 34:1145-57. 2014
    ....
  5. doi request reprint Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression
    Lorenzo de la Rica
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    J Autoimmun 41:6-16. 2013
    ..Our study enabled the identification of novel dysregulated targets in rheumatoid arthritis synovial fibroblasts and generated a new workflow for the integrated analysis of miRNA and epigenetic control...
  6. pmc NF-κB directly mediates epigenetic deregulation of common microRNAs in Epstein-Barr virus-mediated transformation of B-cells and in lymphomas
    Roser Vento-Tormo
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, 08908 L Hospitalet de Llobregat, Barcelona, Spain
    Nucleic Acids Res 42:11025-39. 2014
    ..Our results highlight the relevance of the NF-kB pathway in epigenetically mediated miRNA control in B cell transformation and DLBCL. ..
  7. pmc Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation
    Henar Hernando
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, Avda Gran Via 199 203, 08908 L Hospitalet de Llobregat, Barcelona, Spain, Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Universitat Pompeu Fabra UPF, 08003 Barcelona, Spain, Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh, Center for Integrated Protein Science and Adolf Butenandt Institute, Ludwig Maximilians University of Munich, 80336 Munich, Germany and CR UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK
    Nucleic Acids Res 42:249-63. 2014
    ..Our study describes a novel phenomenon related to transformation of B cells, and highlights its independence of the pure acquisition of proliferation. ..
  8. pmc Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells
    Eric M Kallin
    Gene Regulation, Stem Cells and Cancer Program, Center for Genomic Regulation, and Pompeu Fabra University, Barcelona, Spain
    Mol Cell 48:266-76. 2012
    ..Activation of these target genes was accompanied by rapid increases of promoter hydroxy-methylation. Our observations indicate that Tet2 helps CEBPα rapidly derepress myeloid genes during the conversion of pre-B cells into macrophages...
  9. doi request reprint Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells
    Biola M Javierre
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, Barcelona, Spain
    Mol Cancer Res 9:1139-51. 2011
    ..Our results not only provide the first evidence that LRES can have functional specific effects in cancer but also identify several deregulated Ikaros targets that may contribute to progression in colorectal adenocarcinoma...
  10. doi request reprint Gains of DNA methylation in myeloid terminal differentiation are dispensable for gene silencing but influence the differentiated phenotype
    Roser Vento-Tormo
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    FEBS J 282:1815-25. 2015
    ..Our data give rise to a novel perspective on the functional relevance and mechanisms of the acquisition of DNA methylation in myeloid cell differentiation...
  11. pmc Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes
    Javier Rodriguez-Ubreva
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Nucleic Acids Res 40:1954-68. 2012
    ....
  12. pmc A DNA methylation fingerprint of 1628 human samples
    Agustin F Fernandez
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet, 08908 Barcelona, Catalonia, Spain
    Genome Res 22:407-19. 2012
    ....
  13. doi request reprint Chromatin immunoprecipitation
    Javier Rodriguez-Ubreva
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Methods Mol Biol 1094:309-18. 2014
    ..In this chapter, we provide a brief review of the variations in ChIP assays and a detailed explanation of the basic standard ChIP protocol. ..
  14. doi request reprint Epigenomic deregulation in the immune system
    Virginia C Rodriguez-Cortez
    Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Epigenomics 3:697-713. 2011
    ..It is also discussed how epigenomic analysis can help to understand the molecular basis of these diseases and how this information can be used in the clinical setting...
  15. doi request reprint Epigenetic control of myeloid cell differentiation, identity and function
    Damiana Alvarez-Errico
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, 08908L Hospitalet de Llobregat, Barcelona, Spain
    Nat Rev Immunol 15:7-17. 2015
    ..In this Review, we highlight key epigenetic events controlling myeloid cell biology, focusing on those related to myeloid cell differentiation, the acquisition of myeloid identity and innate immune memory...
  16. ncbi request reprint Environmental triggers and epigenetic deregulation in autoimmune disease
    Biola M Javierre
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Discov Med 12:535-45. 2011
    ....
  17. ncbi request reprint Epigenetic regulation of myogenesis
    Eusebio Perdiguero
    Department of Experimental and Health Sciences, Pompeu Fabra University UPF, CIBER on Neurodegenerative diseases CIBERNED, Barcelona, Spain
    Epigenetics 4:541-50. 2009
    ..These studies are increasing our understanding of how muscle lineage-specific information encoded in chromatin merges with muscle regulatory factors to drive muscle stem cells through transitions during myogenesis...
  18. doi request reprint Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies
    Hiroaki Taniguchi
    Bellvitge Biomedical Research Institute, L Hospitalet, and Institucio Catalana de Recerca i Estudis Avancats, Catalonia, Spain
    Cancer Res 69:8447-54. 2009
    ..These findings suggest that BMAL1 epigenetic inactivation contributes to the development of hematologic malignancies by disrupting the cellular circadian clock...