Malignant blue nevus: a case report and molecular analysisShashi M Ariyanayagam-Baksh
Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA
Am J Dermatopathol 25:21-7. 2003
..No loss of heterozygosity was detected, despite informativeness in seven genes. We suggest that malignant blue nevus may represent a distinct entity with a different molecular pathway to tumorigenesis than that of conventional melanomas...
Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanomaShashi M Ariyanayagam-Baksh
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Mod Pathol 16:992-5. 2003
..Genetic heterogeneity seen in different metastases from the same primary suggests a nonlinear pattern of chromosomal damage, with the development of multiple clones within the primary tumor, each acquiring its own metastatic potential...
Widespread molecular alterations present in stage I non-small cell lung carcinoma fail to predict tumor recurrenceFabien K Baksh
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213, USA
Mod Pathol 16:28-34. 2003
..The approach of investigating a panel of genes for alterations can be applied to any given tumor type, and provides information on patterns of mutations/LOH that can help us better understand the molecular biology of tumorigenesis...
Small-cell neuroendocrine carcinoma displays unique profiles of tumor-suppressor gene loss in relationship to the primary site of formationSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, PA 15213, USA
Hum Pathol 33:927-32. 2002
..These attributes can be effectively used for primary localization of metastatic SCNC, thereby assisting in the diagnosis and classification of this neoplasm...
Absence of Mycobacterium avium subsp. paratuberculosis in the microdissected granulomas of Crohn's diseaseFabien K Baksh
Department of Pathology, Lancaster General Hospital, PA 17604 3555, USA
Mod Pathol 17:1289-94. 2004
..None of the Crohn's disease cases yielded a positive amplification product, failing to support a role for the organism in the pathogenesis of this illness...
Histoplasma phimosis: an uncommon presentation of a not uncommon pathogenShashi M Ariyanayagam-Baksh
Department of Pathology, Lancaster General Hospital, Lancaster, PA 17604 3555, USA
Am J Dermatopathol 29:300-2. 2007
..We present a case of histoplasma posthitis in a 71-year-old man, manifesting with the extremely unusual presentation of phimosis. The diagnosis was confirmed using an immunohistochemical stain...