Laura D Baker

Summary

Publications

  1. pmc Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Arch Neurol 68:51-7. 2011
  2. pmc Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial
    Laura D Baker
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, USA
    Arch Neurol 69:1420-9. 2012
  3. pmc Cognitive response to estradiol in postmenopausal women is modified by high cortisol
    Laura D Baker
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA
    Neurobiol Aging 33:829.e9-20. 2012
  4. pmc High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 28:137-46. 2012
  5. pmc Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease
    Laura D Baker
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    J Alzheimers Dis 22:569-79. 2010
  6. pmc Effects of aerobic exercise on mild cognitive impairment: a controlled trial
    Laura D Baker
    Departments of Psychiatry and BehavioralScience, University of Washington School of Medicine, Seattle, Washington, USA
    Arch Neurol 67:71-9. 2010
  7. ncbi request reprint Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 13:950-8. 2005
  8. pmc Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    Mark A Reger
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:323-31. 2008
  9. ncbi request reprint Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
    Amy Claxton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Alzheimers Dis 35:789-97. 2013
  10. pmc Effects of insulin and octreotide on memory and growth hormone in Alzheimer's disease
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA, USA
    J Alzheimers Dis 18:595-602. 2009

Collaborators

Detail Information

Publications33

  1. pmc Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Arch Neurol 68:51-7. 2011
    ....
  2. pmc Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial
    Laura D Baker
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, USA
    Arch Neurol 69:1420-9. 2012
    ..Previously, we reported favorable cognitive effects of short-term GHRH administration in healthy older adults and provided preliminary evidence to suggest a similar benefit in adults with mild cognitive impairment (MCI)...
  3. pmc Cognitive response to estradiol in postmenopausal women is modified by high cortisol
    Laura D Baker
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA
    Neurobiol Aging 33:829.e9-20. 2012
    ..Our findings indicate that cognitive and physiological responses to estradiol are adversely affected by elevated stress hormone levels of cortisol in healthy postmenopausal women...
  4. pmc High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 28:137-46. 2012
    ..Exercise may thus interact with diet to alter pathological processes that ultimately modify risk of Alzheimer's disease...
  5. pmc Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease
    Laura D Baker
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    J Alzheimers Dis 22:569-79. 2010
    ..Although replication in a larger sample is needed, our findings potentially have important therapeutic implications for a growing number of adults at increased risk of cognitive decline...
  6. pmc Effects of aerobic exercise on mild cognitive impairment: a controlled trial
    Laura D Baker
    Departments of Psychiatry and BehavioralScience, University of Washington School of Medicine, Seattle, Washington, USA
    Arch Neurol 67:71-9. 2010
    ..To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response...
  7. ncbi request reprint Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 13:950-8. 2005
    ..Authors evaluated the effects of the PPAR-gamma agonist rosiglitazone on cognition and plasma levels of the APP derivative beta-amyloid (Abeta) in humans...
  8. pmc Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    Mark A Reger
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:323-31. 2008
    ..These findings suggest that groups with different genetic risks for AD may show differential dose-response curves following intranasal insulin administration...
  9. ncbi request reprint Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
    Amy Claxton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Alzheimers Dis 35:789-97. 2013
    ..Unlike previous studies with young adults, neither men nor women taking intranasal insulin exhibited a significant change in weight over 4 months of treatment...
  10. pmc Effects of insulin and octreotide on memory and growth hormone in Alzheimer's disease
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA, USA
    J Alzheimers Dis 18:595-602. 2009
    ..0299). Thus, insulin and octreotide appear to regulate memory in older adults. APOE epsilon4 genotype modulates responses to insulin and octreotide. Finally, insulin may regulate GH levels during euglycemia...
  11. pmc Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, S 182, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 69:29-38. 2012
    ..To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD)...
  12. pmc Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial
    Angela J Hanson
    Geriatric Research, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Washington, USA
    JAMA Neurol 70:972-80. 2013
    ..Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. However, not much is known about the lipid states of these proteins in human cerebrospinal fluid...
  13. ncbi request reprint Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center GRECC, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108 1532, USA
    Neurobiol Aging 27:38-41. 2006
    ..These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions...
  14. pmc Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
    Jennifer L Bayer-Carter
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 68:743-52. 2011
    ....
  15. pmc Cognitive-behavioral treatment for comorbid insomnia and osteoarthritis pain in primary care: the lifestyles randomized controlled trial
    Michael V Vitiello
    Department ofPsychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Am Geriatr Soc 61:947-56. 2013
    ....
  16. pmc Insulin and sex interactions in older adults with mild cognitive impairment
    Brenna Cholerton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98493, USA
    J Alzheimers Dis 31:401-10. 2012
    ..Future research will help determine whether insulin dysregulation results in differential effects on vascular function and AD pathology as a function of sex and/or APOE genotype...
  17. pmc Neuropathologic correlates of cognition in a population-based sample
    Brenna Cholerton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 9600 Veterans Drive SW, Tacoma, WA 98493, USA
    J Alzheimers Dis 36:699-709. 2013
    ..These findings underscore that cognitive impairment is a complex convergent trait that has important implications for clinical investigation and medical management of older adults. ..
  18. pmc Statin users without an APOE-epsilon4 allele have increased insulin resistance
    Brian T Vanfossen
    GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 19:1149-53. 2010
    ..0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele...
  19. ncbi request reprint Effects of exercise and nutrition on memory in Japanese Americans with impaired glucose tolerance
    G Stennis Watson
    Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, Washington 98108, USA
    Diabetes Care 29:135-6. 2006
  20. ncbi request reprint Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
    Mark A Fishel
    Department of Neurology, University of Washington, Seattle, WA 98108, USA
    Arch Neurol 62:1539-44. 2005
    ..Hyperinsulinemia induces inflammation and is a risk factor for Alzheimer disease. Thus, insulin abnormalities may contribute to Alzheimer disease pathophysiology through effects on the inflammatory network...
  21. ncbi request reprint Insulin, cognition, and dementia
    Brenna Cholerton
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Eur J Pharmacol 719:170-9. 2013
    ....
  22. pmc Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging
    Seth D Friedman
    Department of Radiology, Seattle Children s Hospital, Seattle, Washington 98105, USA
    JAMA Neurol 70:883-90. 2013
    ..Growth hormone-releasing hormone (GHRH) has been previously shown to have cognition-enhancing effects. The role of neurotransmitter changes, measured by proton magnetic resonance spectroscopy, may inform the mechanisms for this response...
  23. ncbi request reprint Insulin and Alzheimer's disease: untangling the web
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Alzheimers Dis 33:S263-75. 2013
    ..Finally, we will discuss the implications of this area for AD therapeutics and prevention...
  24. ncbi request reprint Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Psychoneuroendocrinology 28:809-22. 2003
    ....
  25. ncbi request reprint 17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, the VA Puget Sound Health Care System, Seattle Tacoma, WA, USA
    Am J Geriatr Psychiatry 11:239-44. 2003
    ..The authors evaluated the effects of estrogen administration on plasma concentration of one by-product of APP processing, Abeta40, for postmenopausal women with AD...
  26. ncbi request reprint Short-term improvement in insomnia symptoms predicts long-term improvements in sleep, pain, and fatigue in older adults with comorbid osteoarthritis and insomnia
    Michael V Vitiello
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA Electronic address
    Pain 155:1547-54. 2014
    ..Trial Registration: ClinicalTrials.gov Identifier: NCT01142349. ..
  27. pmc Who benefits from CBT for insomnia in primary care? Important patient selection and trial design lessons from longitudinal results of the Lifestyles trial
    Susan M McCurry
    Department of Psychosocial and Community Health, University of Washington School of Nursing, Seattle, WA
    Sleep 37:299-308. 2014
    ..Evaluate long-term effects of group interventions on sleep and pain outcomes in a primary care population of older adults with osteoarthritis pain and sleep disturbance...
  28. ncbi request reprint The relationship between neuropsychological functioning and driving ability in dementia: a meta-analysis
    Mark A Reger
    Geriatric Research, Education, and Clinical Center GRECC, Veterans Affairs Puget Sound Health Care System VAPSHCS, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, WA, USA
    Neuropsychology 18:85-93. 2004
    ..Other effects were small or nonsignificant. Implications for basing driving recommendations on neuropsychological testing are discussed...
  29. ncbi request reprint Estrogen and Alzheimer's disease: the story so far
    Brenna Cholerton
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle Tacoma, Washington, USA
    Drugs Aging 19:405-27. 2002
    ..These important issues must be addressed in order to establish the role of estrogen for the prevention and treatment of AD in women...
  30. pmc Effects of varying diagnostic criteria on prevalence of mild cognitive impairment in a community based sample
    Emily H Trittschuh
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Alzheimers Dis 25:163-73. 2011
    ..Longitudinal follow-up will determine whether varying diagnostic criteria improves sensitivity and specificity of the MCI diagnosis as a predictor for dementia...
  31. pmc Group interventions for co-morbid insomnia and osteoarthritis pain in primary care: the lifestyles cluster randomized trial design
    Michael Von Korff
    Group Health Research Institute, Seattle, WA 98101, USA
    Contemp Clin Trials 33:759-68. 2012
    ..This hybrid efficacy-effectiveness trial design evaluates whether interventions yield specific benefits for clinical and behavioral outcomes relative to an education only control when implemented in a primary care setting...
  32. pmc Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e9340. 2010
    ....
  33. ncbi request reprint Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1/mac 25) is reduced in human prostate cancer and is inversely related to tumor volume and proliferation index in Lucap 23.12 xenografts
    Marie K Tennant
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Prostate 56:115-22. 2003
    ..Likewise, mice injected with prostate cells over-expressing IGFBP-rP1/mac 25 showed decreased tumor formation and tumor volume...