Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetesLaura D Baker
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
Arch Neurol 68:51-7. 2011
....
Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trialLaura D Baker
Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, USA
Arch Neurol 69:1420-9. 2012
..Previously, we reported favorable cognitive effects of short-term GHRH administration in healthy older adults and provided preliminary evidence to suggest a similar benefit in adults with mild cognitive impairment (MCI)...
Cognitive response to estradiol in postmenopausal women is modified by high cortisolLaura D Baker
Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA
Neurobiol Aging 33:829.e9-20. 2012
..Our findings indicate that cognitive and physiological responses to estradiol are adversely affected by elevated stress hormone levels of cortisol in healthy postmenopausal women...
- High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment
Laura D Baker
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 28:137-46. 2012
..Exercise may thus interact with diet to alter pathological processes that ultimately modify risk of Alzheimer's disease...
- Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease
Laura D Baker
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
J Alzheimers Dis 22:569-79. 2010
..Although replication in a larger sample is needed, our findings potentially have important therapeutic implications for a growing number of adults at increased risk of cognitive decline...
- Effects of aerobic exercise on mild cognitive impairment: a controlled trial
Laura D Baker
Departments of Psychiatry and BehavioralScience, University of Washington School of Medicine, Seattle, Washington, USA
Arch Neurol 67:71-9. 2010
..To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response...
- Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
Mark A Reger
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 13:323-31. 2008
..These findings suggest that groups with different genetic risks for AD may show differential dose-response curves following intranasal insulin administration...
- Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
G Stennis Watson
Geriatric Research, Education, and Clinical Center, Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Am J Geriatr Psychiatry 13:950-8. 2005
..Future confirmation in a larger study is needed to fully demonstrate rosiglitazone's therapeutic potential...
- Effects of insulin and octreotide on memory and growth hormone in Alzheimer's disease
G Stennis Watson
Geriatric Research, Education, and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA, USA
J Alzheimers Dis 18:595-602. 2009
..0299). Thus, insulin and octreotide appear to regulate memory in older adults. APOE epsilon4 genotype modulates responses to insulin and octreotide. Finally, insulin may regulate GH levels during euglycemia...
- Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
Suzanne Craft
Geriatric Research, Education, and Clinical Center, S 182, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 69:29-38. 2012
..To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD)...
- Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
Jennifer L Bayer-Carter
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 68:743-52. 2011
....
- Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease
G Stennis Watson
Geriatric Research, Education, and Clinical Center (GRECC, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108-1532, USA
Neurobiol Aging 27:38-41. 2006
..These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions...
- Statin users without an APOE-epsilon4 allele have increased insulin resistance
Brian T Vanfossen
GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 19:1149-53. 2010
..0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele...
- Effects of exercise and nutrition on memory in Japanese Americans with impaired glucose tolerance
G Stennis Watson
Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, Washington 98108, USA
Diabetes Care 29:135-6. 2006
- Insulin and sex interactions in older adults with mild cognitive impairment
Brenna Cholerton
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98493, USA
J Alzheimers Dis 31:401-10. 2012
..Future research will help determine whether insulin dysregulation results in differential effects on vascular function and AD pathology as a function of sex and/or APOE genotype...
- Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype
Suzanne Craft
Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
Psychoneuroendocrinology 28:809-22. 2003
....
- 17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study
Laura D Baker
Geriatric Research, Education, and Clinical Center, the VA Puget Sound Health Care System, Seattle/Tacoma, WA, USA
Am J Geriatr Psychiatry 11:239-44. 2003
..This finding suggests that the hormone may serve as an Abeta-lowering agent for HRT-naïve AD women, which may, in turn, have ultimate ramifications for the progression of AD pathology...
- Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
Mark A Fishel
Department of Neurology, University of Washington, Seattle, WA 98108, USA
Arch Neurol 62:1539-44. 2005
..05). CONCLUSION: Moderate hyperinsulinemia can elevate inflammatory markers and Abeta42 in the periphery and the brain, thereby potentially increasing the risk of Alzheimer disease...
- The relationship between neuropsychological functioning and driving ability in dementia: a meta-analysis
Mark A Reger
Geriatric Research, Education, and Clinical Center GRECC, Veterans Affairs Puget Sound Health Care System VAPSHCS, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, WA, USA
Neuropsychology 18:85-93. 2004
..Other effects were small or nonsignificant. Implications for basing driving recommendations on neuropsychological testing are discussed...
- Estrogen and Alzheimer's disease: the story so far
Brenna Cholerton
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle/Tacoma, Washington, USA
Drugs Aging 19:405-27. 2002
..These important issues must be addressed in order to establish the role of estrogen for the prevention and treatment of AD in women...
- Effects of varying diagnostic criteria on prevalence of mild cognitive impairment in a community based sample
Emily H Trittschuh
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
J Alzheimers Dis 25:163-73. 2011
..Longitudinal follow-up will determine whether varying diagnostic criteria improves sensitivity and specificity of the MCI diagnosis as a predictor for dementia...
- Group interventions for co-morbid insomnia and osteoarthritis pain in primary care: the lifestyles cluster randomized trial design
Michael Von Korff
Group Health Research Institute, Seattle, WA 98101, USA
Contemp Clin Trials 33:759-68. 2012
..This hybrid efficacy-effectiveness trial design evaluates whether interventions yield specific benefits for clinical and behavioral outcomes relative to an education only control when implemented in a primary care setting...
- Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT
Thomas J Montine
Department of Pathology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e9340. 2010
....
- Insulin and Alzheimer's disease: untangling the web
Suzanne Craft
Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
J Alzheimers Dis 33:S263-75. 2013
..Finally, we will discuss the implications of this area for AD therapeutics and prevention...
- Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1/mac 25) is reduced in human prostate cancer and is inversely related to tumor volume and proliferation index in Lucap 23.12 xenografts
Marie K Tennant
Department of Medicine, University of Washington, Seattle, Washington, USA
Prostate 56:115-22. 2003
..Likewise, mice injected with prostate cells over-expressing IGFBP-rP1/mac 25 showed decreased tumor formation and tumor volume...
