Cui Gai Bai
Shi Y, Dai D, Li J, Dong Y, Jiang Y, Li H, et al
. Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines. Molecules. 2016;21:514 pubmed publisher
..SFN, 3d and 14c significantly induced the activation of caspase-3, and reduced the ALDH? subpopulation in the SUM159 cell line, while the marketed drug doxrubicin(DOX) increased the ALDH? subpopulation. ..
Li H, He D, Zhao X, Sun T, Zhang Q, Bai C, et al
. Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells. Bioorg Med Chem Lett. 2018;28:700-706 pubmed publisher
..8.98 μM). Compounds 15a and 24a also inhibited colony formation in MCF-7 cells and inhibited cell migration in the cell wound scratch assay in B16BL6 cells. Moreover, hydroxyl compounds 15a and 24a had low toxicity in vivo. ..
Jiang Y, Li H, Li X, Lu J, Zhang Q, Bai C, et al
. Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis. Bioorg Med Chem Lett. 2018;28:737-741 pubmed publisher
..Compound 8b also did not cause appreciable toxicity in mice after 5 weeks at a daily dose of 200 mg/kg. ..
Li Y, Wang J, Pan C, Meng F, Chu X, Ding Y, et al
. Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib. Bioorg Med Chem Lett. 2016;26:1419-27 pubmed publisher
..These findings suggest that these compounds are able to inhibit leukemia stem-like cells. ..