Abeer A Bahnassy

Summary

Publications

  1. doi request reprint Aberrant expression of cancer stem cell markers (CD44, CD90, and CD133) contributes to disease progression and reduced survival in hepatoblastoma patients: 4-year survival data
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt Electronic address
    Transl Res 165:396-406. 2015
  2. ncbi request reprint Differential expression of p53 family proteins in colorectal adenomas and carcinomas: Prognostic and predictive values
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Histol Histopathol 29:207-16. 2014
  3. doi request reprint Aberrant expression of cell cycle regulatory genes predicts overall and disease free survival in malignant pleural mesothelioma patients
    Abeer A Bahnassy
    Pathology, Department, National Cancer Institute, Cairo University, Egypt
    Exp Mol Pathol 93:154-61. 2012
  4. pmc Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    BMC Gastroenterol 4:22. 2004
  5. doi request reprint The role of cyclins and cyclin dependent kinases in development and progression of hepatitis C virus-genotype 4-associated hepatitis and hepatocellular carcinoma
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Egypt
    Exp Mol Pathol 91:643-52. 2011
  6. ncbi request reprint Epstein-Barr viral infection in extranodal lymphoma of the head and neck: correlation with prognosis and response to treatment
    A A Bahnassy
    Pathology Department, Menofya University, Cairo, Egypt
    Histopathology 48:516-28. 2006
  7. ncbi request reprint The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma
    Abeer A Bahnassy
    The Departments of Pathology, National Cancer Institute, Cairo, Egypt
    J Egypt Natl Canc Inst 18:292-302. 2006
  8. doi request reprint Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 24:416-28. 2009
  9. ncbi request reprint Molecular prognostic profile of Egyptian HCC cases infected with hepatitis C virus
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt
    Asian Pac J Cancer Prev 13:5433-8. 2012
  10. doi request reprint Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with repression of interferon regulatory factor-1
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Eur J Gastroenterol Hepatol 22:450-6. 2010

Collaborators

Detail Information

Publications30

  1. doi request reprint Aberrant expression of cancer stem cell markers (CD44, CD90, and CD133) contributes to disease progression and reduced survival in hepatoblastoma patients: 4-year survival data
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt Electronic address
    Transl Res 165:396-406. 2015
    ..Moreover, complete surgical resection and systemic chemotherapy are essential to achieve good response and prolonged survival, especially in early stage patients. ..
  2. ncbi request reprint Differential expression of p53 family proteins in colorectal adenomas and carcinomas: Prognostic and predictive values
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Histol Histopathol 29:207-16. 2014
    ..We studied the contribution of p53 family proteins and their isoforms to the development and progression of colorectal carcinoma in relation to VEGF...
  3. doi request reprint Aberrant expression of cell cycle regulatory genes predicts overall and disease free survival in malignant pleural mesothelioma patients
    Abeer A Bahnassy
    Pathology, Department, National Cancer Institute, Cairo University, Egypt
    Exp Mol Pathol 93:154-61. 2012
    ..Since escape from cell cycle checkpoint control is common in several solid tumors, the present study was performed to evaluate the role of some cell cycle regulatory genes in the development and progression of MPM...
  4. pmc Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    BMC Gastroenterol 4:22. 2004
    ..Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer...
  5. doi request reprint The role of cyclins and cyclin dependent kinases in development and progression of hepatitis C virus-genotype 4-associated hepatitis and hepatocellular carcinoma
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Egypt
    Exp Mol Pathol 91:643-52. 2011
    ..009). Cyclins A, E, CDK2 expression was associated with fibrosis in CH (p=0.004, p=0.02, p=0.012). Reduced OS was (ADD) associated with cyclin D1 and cyclin A, grade, stage and metastasis (p=0.001, p=0.02, p=0.018, p=0.01, p=0.001)...
  6. ncbi request reprint Epstein-Barr viral infection in extranodal lymphoma of the head and neck: correlation with prognosis and response to treatment
    A A Bahnassy
    Pathology Department, Menofya University, Cairo, Egypt
    Histopathology 48:516-28. 2006
    ..18% of all lymphoma diagnosed at the National Cancer Institute, Cairo. Although EBV infection is highly associated with lymphoma in immunocompromised patients, the situation in immunocompetent patients is still unclear...
  7. ncbi request reprint The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma
    Abeer A Bahnassy
    The Departments of Pathology, National Cancer Institute, Cairo, Egypt
    J Egypt Natl Canc Inst 18:292-302. 2006
    ..This is possibly achieved through an interaction between HPV oncogenic proteins and some cell cycle regulatory genes. However, the exact pathogenetic mechanisms are not well defined yet...
  8. doi request reprint Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 24:416-28. 2009
    ..Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide strongly linked to hepatitis C virus (HCV) infection. However, the exact pathogenetic mechanisms are still unclear...
  9. ncbi request reprint Molecular prognostic profile of Egyptian HCC cases infected with hepatitis C virus
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt
    Asian Pac J Cancer Prev 13:5433-8. 2012
    ..This study provides complete genetic profile for Egyptian HCC. Genome-wide analyses were performed to identify the predictive signatures...
  10. doi request reprint Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with repression of interferon regulatory factor-1
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Eur J Gastroenterol Hepatol 22:450-6. 2010
    ..This study has been performed to show the expression profile of IRF-1, IRF-3, and IRF-7 in Egyptian patients with HCV-related liver diseases and hepatocellular carcinoma (HCC)...
  11. ncbi request reprint Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival
    Abeer A Bahnassy
    Department of Pathology, National Cancer Institute, Kaser El Aini School of Medicine, Cairo University, Fom El Khalig, Cairo 11796, Egypt
    Pathol Int 55:53-62. 2005
    ..mdm2 and c-erbB2 are possible targets for HPV in the p53-independent pathway. However, only advanced stage and aberrant expression of p53 and p21(waf) are independent prognostic markers...
  12. pmc Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Virol J 4:16. 2007
    ..HCV is one of the major health problems in Egypt, where it is highly prevalent. Genotype 4 is the most common genotype of HCV and its response to treatment is still a controversy...
  13. ncbi request reprint Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Pathol Int 57:493-501. 2007
    ..Combined positivity for SV40 and asbestos exposure is an independent prognostic factor in MPM, having a detrimental effect on OS...
  14. ncbi request reprint The correlation between FHIT, P53 and MMR genes in human papillomavirus-associated cervical carcinoma
    Abeer A Bahnassy
    Department of Pathology, National Cancer Institute, Cairo University, Egypt
    J Egypt Natl Canc Inst 18:191-202. 2006
    ..We investigated 20 human cervical carcinomas and 15 normal cervical tissues for the correlation between aberrant expression of the FHIT, p53 and MMR genes and their prognostic impact...
  15. ncbi request reprint TRUGENE sequencing versus INNO-LiPA for sub-genotyping of HCV genotype-4
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt
    J Med Virol 75:412-20. 2005
    ..This is mainly due to the high diversity of genotype 4, which is the most prevalent genotype in Egypt...
  16. pmc Dynamic interplay between CXCL levels in chronic hepatitis C patients treated by interferon
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    Virol J 10:218. 2013
    ..Pretreatment predictors of SVR to interferon therapy have not been fully investigated yet. The current study assesses a group of chemokines that may predict treatment response in Egyptian patients with chronic HCV infection...
  17. doi request reprint Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Oncol Rep 26:825-31. 2011
    ....
  18. pmc Characterization of chronic HCV infection-induced apoptosis
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Egypt
    Comp Hepatol 10:4. 2011
    ..abstract:..
  19. ncbi request reprint p53 mutation in HCV-genotype-4 associated hepatocellular carcinoma in Egyptian patients
    Abdel Rahman N Zekri
    The Department of Virology and Immunology Unit, National Cancer Institute, El Menoufia School of Medicine, El Menoufia University, Egypt
    J Egypt Natl Canc Inst 18:17-29. 2006
    ..However, no specific pattern for p53 mutations was observed in HCV genotype 4-associated HCC and no significant relation between p53 mutations, HCV-NS3 expressions or any HCV sub-genotype-4 sequence...
  20. pmc Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer
    Hussein M Khaled
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    BMC Cancer 9:32. 2009
    ..We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the clinical outcome of patients with muscle invasive bilharzial bladder cancer (MI-BBC)...
  21. doi request reprint Epstein-Barr virus and breast cancer: epidemiological and molecular study on Egyptian and Iraqi women
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11976, Egypt
    J Egypt Natl Canc Inst 24:123-31. 2012
    ..The aim of the current study is to unravel the association between EBV and primary invasive breast cancer (PIBC) in two different Arab populations (Egyptian and Iraqi women)...
  22. pmc Consensus siRNA for inhibition of HCV genotype-4 replication
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    Virol J 6:13. 2009
    ..The current study was conducted to assess whether siRNA can inhibit different HCV genotypes with many quasispecies and to assess whether consensus siRNA have the same effect as regular siRNA...
  23. pmc Mismatch repair genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in the pathogenesis of hepatocellular carcinoma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Kasr El Aini St, Fom El Khaig, Cairo 11796, Egypt
    World J Gastroenterol 11:3020-6. 2005
    ..Abnormalities in one or more MMR genes are implicated in the development of many cancers. We investigated the role of expression of MMR genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in hepatocellular carcinogenesis...
  24. ncbi request reprint Telomerase expression as complementary prognostic factor in neuroblastoma
    Abeer A Bahnassy
    The Departments of Pathology, NCI, Cairo University
    J Egypt Natl Canc Inst 22:191-200. 2010
    ..Identification of standard prognostic factors has several limitations. Hence, there is an increasing demand to identify new prognostic factors and tools that help in risk stratification of patients for proper treatment...
  25. doi request reprint The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer
    Mostafa M El-Serafi
    Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
    Cancer 116:4954-64. 2010
    ..However, patients with similar disease characteristics exhibit various outcomes, especially in stage II. Therefore, the identification of molecular prognostic markers is needed to predict patient outcomes...
  26. ncbi request reprint IL28B rs12979860 gene polymorphism in Egyptian patients with chronic liver disease infected with HCV
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, Faculty of Medicine, National Cancer Institute, Cairo University, Cairo, Egypt e mail
    Asian Pac J Cancer Prev 15:7213-8. 2014
    ..Although the IL28B gene polymorphism has been shown to modify the course of chronic HCV infection, this has not been properly assessed in the Egyptian population...
  27. ncbi request reprint Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 20:87-94. 2005
    ....
  28. pmc Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    BMC Res Notes 1:106. 2008
    ..Hepatocellular carcinoma (HCC) is a preventable disease rather than a curable one, since there is no well-documented effective treatment modality until now, making the molecular study of this disease mandatory...
  29. ncbi request reprint Promotor methylation: does it affect response to therapy in chronic Hepatitis C (G4) or fibrosis?
    Abdel Rahman N Zekri
    Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Ann Hepatol 13:518-24. 2014
    ..The present study assessed the impact of promoter methylation (PM) of some genes on the antiviral response to antiviral therapy and it's relation to the presence of fibrosis in HCV-4 infected patients from Egypt...
  30. pmc Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease
    Abeer A Bahnassy
    Abeer A Bahnassy, Molecular Pathology Unit, Pathology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt
    World J Gastroenterol 20:18240-8. 2014
    ..To assess the role of circulating tumor cells (CTCs) and cancer stem cells (CSCs) in hepatitis C virus (HCV)-associated liver disease...