Aberrant expression of cell cycle regulatory genes predicts overall and disease free survival in malignant pleural mesothelioma patientsAbeer A Bahnassy
Pathology, Department, National Cancer Institute, Cairo University, Egypt
Exp Mol Pathol 93:154-61. 2012
..Since escape from cell cycle checkpoint control is common in several solid tumors, the present study was performed to evaluate the role of some cell cycle regulatory genes in the development and progression of MPM...
Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patientsAbeer A Bahnassy
Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
BMC Gastroenterol 4:22. 2004
..Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer...
- The role of cyclins and cyclin dependent kinases in development and progression of hepatitis C virus-genotype 4-associated hepatitis and hepatocellular carcinoma
Abeer A Bahnassy
Pathology Department, National Cancer Institute, Cairo University, Egypt
Exp Mol Pathol 91:643-52. 2011
..Cyclin D1 and cyclin A are prognostic biomarkers associated with reduced OS in HCC. Cyclin D1 aberration could identify high risk groups of CH patients prone to develop HCC...
The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinomaAbeer A Bahnassy
The Departments of Pathology, National Cancer Institute, Cairo, Egypt
J Egypt Natl Canc Inst 18:292-302. 2006
..This is possibly achieved through an interaction between HPV oncogenic proteins and some cell cycle regulatory genes. However, the exact pathogenetic mechanisms are not well defined yet...
- Epstein-Barr viral infection in extranodal lymphoma of the head and neck: correlation with prognosis and response to treatment
A A Bahnassy
Pathology Department, Menofya University, Cairo, Egypt
Histopathology 48:516-28. 2006
..18% of all lymphoma diagnosed at the National Cancer Institute, Cairo. Although EBV infection is highly associated with lymphoma in immunocompromised patients, the situation in immunocompetent patients is still unclear...
- Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
J Gastroenterol Hepatol 24:416-28. 2009
..Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide strongly linked to hepatitis C virus (HCV) infection. However, the exact pathogenetic mechanisms are still unclear...
- Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with repression of interferon regulatory factor-1
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Eur J Gastroenterol Hepatol 22:450-6. 2010
..This study has been performed to show the expression profile of IRF-1, IRF-3, and IRF-7 in Egyptian patients with HCV-related liver diseases and hepatocellular carcinoma (HCC)...
- Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival
Abeer A Bahnassy
Department of Pathology, National Cancer Institute, Kaser El-Aini School of Medicine, Cairo University, Fom El-Khalig, Cairo 11796, Egypt
Pathol Int 55:53-62. 2005
..mdm2 and c-erbB2 are possible targets for HPV in the p53-independent pathway. However, only advanced stage and aberrant expression of p53 and p21(waf) are independent prognostic markers...
- Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Pathol Int 57:493-501. 2007
..Combined positivity for SV40 and asbestos exposure is an independent prognostic factor in MPM, having a detrimental effect on OS...
- Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Virol J 4:16. 2007
..HCV is one of the major health problems in Egypt, where it is highly prevalent. Genotype 4 is the most common genotype of HCV and its response to treatment is still a controversy...
- The correlation between FHIT, P53 and MMR genes in human papillomavirus-associated cervical carcinoma
Abeer A Bahnassy
Department of Pathology, National Cancer Institute, Cairo University, Egypt
J Egypt Natl Canc Inst 18:191-202. 2006
..We investigated 20 human cervical carcinomas and 15 normal cervical tissues for the correlation between aberrant expression of the FHIT, p53 and MMR genes and their prognostic impact...
- TRUGENE sequencing versus INNO-LiPA for sub-genotyping of HCV genotype-4
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt
J Med Virol 75:412-20. 2005
..This is mainly due to the high diversity of genotype 4, which is the most prevalent genotype in Egypt...
- Characterization of chronic HCV infection-induced apoptosis
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Egypt
Comp Hepatol 10:4. 2011
..abstract:..
- Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Oncol Rep 26:825-31. 2011
....
- p53 mutation in HCV-genotype-4 associated hepatocellular carcinoma in Egyptian patients
Abdel Rahman N Zekri
The Department of Virology and Immunology Unit, National Cancer Institute, El Menoufia School of Medicine, El Menoufia University, Egypt
J Egypt Natl Canc Inst 18:17-29. 2006
..However, no specific pattern for p53 mutations was observed in HCV genotype 4-associated HCC and no significant relation between p53 mutations, HCV-NS3 expressions or any HCV sub-genotype-4 sequence...
- Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer
Hussein M Khaled
Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
BMC Cancer 9:32. 2009
..We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the clinical outcome of patients with muscle invasive bilharzial bladder cancer (MI-BBC)...
- Consensus siRNA for inhibition of HCV genotype-4 replication
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
Virol J 6:13. 2009
..The current study was conducted to assess whether siRNA can inhibit different HCV genotypes with many quasispecies and to assess whether consensus siRNA have the same effect as regular siRNA...
- Mismatch repair genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in the pathogenesis of hepatocellular carcinoma
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Kasr El Aini St, Fom El Khaig, Cairo 11796, Egypt
World J Gastroenterol 11:3020-6. 2005
..Abnormalities in one or more MMR genes are implicated in the development of many cancers. We investigated the role of expression of MMR genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in hepatocellular carcinogenesis...
- Molecular Prognostic Profile of Egyptian HCC Cases Infected with Hepatitis C Virus
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt e mail
Asian Pac J Cancer Prev 13:5433-8. 2012
..cDNA microarrays showed that among the major upregulated genes in HCC are sets. Conclusion: The identified genes could provide a panel of new diagnostic and prognostic aids for HCC...
- Epstein-Barr virus and breast cancer: epidemiological and molecular study on Egyptian and Iraqi women
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11976, Egypt
J Egypt Natl Canc Inst 24:123-31. 2012
..The aim of the current study is to unravel the association between EBV and primary invasive breast cancer (PIBC) in two different Arab populations (Egyptian and Iraqi women)...
- The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer
Mostafa M El-Serafi
Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
Cancer 116:4954-64. 2010
..However, patients with similar disease characteristics exhibit various outcomes, especially in stage II. Therefore, the identification of molecular prognostic markers is needed to predict patient outcomes...
- Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma
Abdel Rahman N Zekri
Virology and Immunology Unit, Cairo University, Cairo, Egypt
J Gastroenterol Hepatol 20:87-94. 2005
....
- Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
BMC Res Notes 1:106. 2008
..Hepatocellular carcinoma (HCC) is a preventable disease rather than a curable one, since there is no well-documented effective treatment modality until now, making the molecular study of this disease mandatory...
- Telomerase expression as complementary prognostic factor in neuroblastoma
Abeer A Bahnassy
The Departments of Pathology, NCI, Cairo University
J Egypt Natl Canc Inst 22:191-200. 2010
..Identification of standard prognostic factors has several limitations. Hence, there is an increasing demand to identify new prognostic factors and tools that help in risk stratification of patients for proper treatment...
