Jared M Baeten

Summary

Publications

  1. ncbi request reprint Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
  2. ncbi request reprint A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelines
    R Scott McClelland
    Departments of Medicine, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 41:611-5. 2006
  3. pmc Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    N Engl J Med 367:399-410. 2012
  4. doi request reprint Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 197:1361-8. 2008
  5. pmc Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
  6. ncbi request reprint Micronutrient supplementation increases genital tract shedding of HIV-1 in women: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 37:1657-63. 2004
  7. ncbi request reprint Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Int J STD AIDS 18:202-6. 2007
  8. ncbi request reprint A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 23:1197-200. 2007
  9. ncbi request reprint Vitamin A deficiency and the acute phase response among HIV-1-infected and -uninfected women in Kenya
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
    J Acquir Immune Defic Syndr 31:243-9. 2002
  10. pmc Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
    J Infect Dis 205:358-65. 2012

Detail Information

Publications78

  1. ncbi request reprint Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
    ..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity...
  2. ncbi request reprint A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelines
    R Scott McClelland
    Departments of Medicine, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 41:611-5. 2006
    ..Guidelines for initiating antiretrovirals are based on markers of advanced disease and are not directly linked to markers of HIV-1 transmission such as viral shedding...
  3. pmc Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    N Engl J Med 367:399-410. 2012
    ..Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations...
  4. doi request reprint Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 197:1361-8. 2008
    ..Vaginal infections are common and have been associated with increased risk for acquisition of human immunodeficiency virus type 1 (HIV-1)...
  5. pmc Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
    ..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
  6. ncbi request reprint Micronutrient supplementation increases genital tract shedding of HIV-1 in women: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 37:1657-63. 2004
    ..The potential benefit of micronutrient supplementation in HIV-1-seropositive women should be considered in relation to the potential for increased infectivity...
  7. ncbi request reprint Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Int J STD AIDS 18:202-6. 2007
    ....
  8. ncbi request reprint A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 23:1197-200. 2007
    ..0, p = 0.008). Trends for an increased risk of mortality were also seen. A greater decrease in albumin levels accompanying HIV-1 acquisition may be a marker for changes in early infection associated with more rapid disease progression...
  9. ncbi request reprint Vitamin A deficiency and the acute phase response among HIV-1-infected and -uninfected women in Kenya
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
    J Acquir Immune Defic Syndr 31:243-9. 2002
    ..These results provide possible explanations for the disparity between observational studies and randomized trials of vitamin A for HIV-1 infection...
  10. pmc Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
    J Infect Dis 205:358-65. 2012
    ..Knowledge of factors that affect per-act infectivity of human immunodeficiency virus type 1 (HIV-1) is important for designing HIV-1 prevention interventions and for the mathematical modeling of the spread of HIV-1...
  11. pmc Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study
    Renee Heffron
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Lancet Infect Dis 12:19-26. 2012
    ..We aimed to assess the association between hormonal contraceptive use and risk of HIV-1 acquisition by women and HIV-1 transmission from HIV-1-infected women to their male partners...
  12. pmc Prospective study of vaginal bacterial flora and other risk factors for vulvovaginal candidiasis
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 199:1883-90. 2009
    ..Our objective was to determine the relationship between vaginal bacterial flora and VVC...
  13. pmc An empiric risk scoring tool for identifying high-risk heterosexual HIV-1-serodiscordant couples for targeted HIV-1 prevention
    Erin M Kahle
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 62:339-47. 2013
    ..A simple risk assessment tool could be useful for identifying couples at highest risk for HIV-1 transmission...
  14. pmc Hormonal contraceptive use and risk of HIV-1 disease progression
    Renee Heffron
    Department of Epidemiology, University of Washington, Seattle, Washington 98104, USA
    AIDS 27:261-7. 2013
    ..For HIV-1-infected women, hormonal contraception prevents unintended pregnancy, excess maternal morbidity, and vertical HIV-1 transmission. Hormonal contraceptives are widely used but their effects on HIV-1 disease progression are unclear...
  15. ncbi request reprint Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue, Seattle, WA 98109, USA
    AIDS 18:615-9. 2004
    ..Infection with multiple viral variants was associated with higher plasma HIV-1 RNA levels and faster CD4 T-cell decline...
  16. ncbi request reprint Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohort
    Jared M Baeten
    University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 38:S18-21. 2005
  17. ncbi request reprint HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 195:1177-80. 2007
    ..There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads...
  18. ncbi request reprint Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women
    Jared M Baeten
    Seattle HIV Prevention Trials Unit, Department of Medicine, University of Washington, 9012 Boren Avenue, Seattle, WA 98104, USA
    AIDS 21:1771-7. 2007
    ..A recent study from Uganda and Zimbabwe found that women using hormonal contraception were at increased risk for HIV-1 if they were seronegative for herpes simplex virus type 2 (HSV-2), but not if they were HSV-2 seropositive...
  19. pmc Increased risk of genital ulcer disease in women during the first month after initiating antiretroviral therapy
    Susan M Graham
    Departments of Medicine, Epidemiology and Global Health, University of Washington, Seattle, WA 98104 2499, USA
    J Acquir Immune Defic Syndr 52:600-3. 2009
    ..To better define this risk, we monitored 134 women at ART initiation and monthly thereafter...
  20. ncbi request reprint HIV-1 acquisition and disease progression are associated with decreased high-risk sexual behaviour among Kenyan female sex workers
    R Scott McClelland
    Departments of Medicine, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    AIDS 20:1969-73. 2006
    ..Changes in sexual risk behaviour may occur following HIV-1 infection...
  21. ncbi request reprint High levels of cervical HIV-1 RNA during early HIV-1 infection
    Ludo Lavreys
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    AIDS 20:2389-90. 2006
    ..43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006)...
  22. pmc Quantification of genital human immunodeficiency virus type 1 (HIV-1) DNA in specimens from women with low plasma HIV-1 RNA levels typical of HIV-1 nontransmitters
    Sarah Benki
    Department of Microbiology, University of Washington, Seattle, WA 98109, USA, and Coast Provincial General Hospital, Mombasa, Kenya
    J Clin Microbiol 44:4357-62. 2006
    ..The assay described here can be utilized in future efforts to examine the role of cell-associated HIV-1 in transmission...
  23. pmc Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women
    Paul K Drain
    Department of Medicine, University of Washington, 1959 NE Pacific, A 300 Health Sciences, Box 356340, Seattle, WA 98105, USA
    BMC Infect Dis 6:85. 2006
    ..Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response...
  24. ncbi request reprint Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase response
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Am J Clin Nutr 79:218-25. 2004
    ..The performance of RBP in the context of infection or protein malnutrition, however, has not been evaluated...
  25. pmc HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response
    Anne Piantadosi
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    AIDS 23:579-87. 2009
    ..To evaluate relationships between HIV-1 evolution, including immune evasion, and markers of disease progression during chronic infection...
  26. ncbi request reprint Contribution of HIV-1 infection to acquisition of sexually transmitted disease: a 10-year prospective study
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    J Infect Dis 191:333-8. 2005
    ..Sexually transmitted diseases (STDs) enhance human immunodeficiency virus (HIV)-1 susceptibility, but few studies have examined the reciprocal effect of HIV-1 on STD acquisition...
  27. pmc Incidence and correlates of Chlamydia trachomatis infection in a high-risk cohort of Kenyan women
    Linnet Masese
    Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
    Sex Transm Dis 40:221-5. 2013
    ..Our objective was to evaluate the incidence and correlates of C. trachomatis infection among high-risk Kenyan women...
  28. doi request reprint A prospective study of risk factors for bacterial vaginosis in HIV-1-seronegative African women
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 35:617-23. 2008
    ..Bacterial vaginosis (BV) is common and has been associated with increased HIV-1 susceptibility. The objective of this study was to identify risk factors for BV in African women at high risk for acquiring HIV-1...
  29. pmc Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    BMC Infect Dis 7:63. 2007
    ..However, vitamin E supplementation has also been reported to increase CCR5 expression, which could increase HIV-1 replication. We hypothesized that vitamin E levels at HIV-1 acquisition may influence disease progression...
  30. ncbi request reprint HIV-1 infection alters the retinol-binding protein:transthyretin ratio even in the absence of the acute phase response
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Nutr 136:1624-9. 2006
    ..Our results raise questions about the utility of this measurement given the high prevalence of HIV-1 infection in areas where vitamin A deficiency is common...
  31. ncbi request reprint Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in women
    Ludo Lavreys
    Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:303-11. 2004
    ..These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection...
  32. pmc Correlation between pill counts and biologic effects in an HIV-1 prevention clinical trial: implications for measuring adherence
    DEBORAH J DONNELL
    Department of Global Health, University of Washington, Seattle, USA
    AIDS Behav 17:632-9. 2013
    ..e., fewer pills returned than expected) and when pill counts were missing because bottles were not returned, plasma HIV-1 RNA and GUD effects were diminished, likely indicating periods of non-adherence...
  33. pmc Genital Inflammation Predicts HIV-1 Shedding Independent of Plasma Viral Load and Systemic Inflammation
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Acquir Immune Defic Syndr 61:436-40. 2012
    ..Thus, efforts to decrease HIV-1 transmission must take into account the role of local inflammation, which is not necessarily reflected in plasma measurements...
  34. pmc Using plasma viral load to guide antiretroviral therapy initiation to prevent HIV-1 transmission
    Pamela M Murnane
    Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e51192. 2012
    ..Because the quantity of HIV-1 in plasma is the primary predictor of HIV-1 transmission, consideration of plasma viral load in ART initiation guidelines is warranted...
  35. pmc Outside sexual partnerships and risk of HIV acquisition for HIV uninfected partners in African HIV serodiscordant partnerships
    Patrick Ndase
    Department of Global Health, University of Washington, Seattle, 98104, USA
    J Acquir Immune Defic Syndr 59:65-71. 2012
    ..As African countries scale-up couples HIV testing, little is known about sexual behaviors and HIV risk for HIV-uninfected partners in known HIV-serodiscordant relationships...
  36. doi request reprint A prospective study of contraceptive use among African women in HIV-1 serodiscordant partnerships
    Renee Heffron
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 37:621-8. 2010
    ..Few studies have explored contraceptive use in HIV-1 serodiscordant couples, a population at high risk for HIV-1 transmission...
  37. pmc Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression
    Anne Piantadosi
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 83:10269-74. 2009
    ..Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection...
  38. ncbi request reprint Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 195:698-702. 2007
    ..52-fold (95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women...
  39. ncbi request reprint Higher set point plasma viral load and more-severe acute HIV type 1 (HIV-1) illness predict mortality among high-risk HIV-1-infected African women
    Ludo Lavreys
    Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, WA 98104 2499, USA
    Clin Infect Dis 42:1333-9. 2006
    ..We used data from a prospective cohort study of female sex workers in Mombasa, Kenya, who were followed up monthly from before the date of HIV-1 infection...
  40. ncbi request reprint Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan women
    Ludo Lavreys
    Departments of Epidemiology and Medicine, University of Washington, Seattle 98104 2499, USA
    AIDS 18:2179-84. 2004
    ..To evaluate the relationship between hormonal contraceptive use and the acquisition of cervical sexually transmitted infections (STI) among HIV-1-infected women...
  41. pmc Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
    Jairam R Lingappa
    Department of Global Health, Seattle, WA, USA
    Lancet 375:824-33. 2010
    ..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression...
  42. pmc High-dose valacyclovir decreases plasma HIV-1 RNA more than standard-dose acyclovir in persons coinfected with HIV-1 and HSV-2: a randomized crossover trial
    Tara Perti
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 63:201-8. 2013
    ..We hypothesized that high-dose valacyclovir would further reduce plasma HIV-1 RNA and that the effect would be mediated by greater suppression of HSV shedding...
  43. pmc Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters
    Mary S Campbell
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Infect Dis 207:1166-70. 2013
    ..Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa...
  44. pmc Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1
    Romel D Mackelprang
    Department of Global Health, University of Washington, WA, USA
    J Infect Dis 206:1299-308. 2012
    ..We developed a novel approach for quantifying HIV-1 exposure to identify individuals remaining HIV-1 uninfected despite persistent high exposure...
  45. ncbi request reprint Female-to-male infectivity of HIV-1 among circumcised and uncircumcised Kenyan men
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 191:546-53. 2005
    ..e., infectivity) for circumcised and uncircumcised men, by use of detailed accounts of sexual behavior in a population with multiple partnerships...
  46. pmc Willingness of Kenyan HIV-1 serodiscordant couples to use antiretroviral-based HIV-1 prevention strategies
    Renee Heffron
    Department of Epidemiology, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 61:116-9. 2012
    ..Antiretroviral treatment (ART) and pre-exposure prophylaxis (PrEP) have demonstrated efficacy as new human immunodeficiency virus-1 (HIV-1) prevention approaches for HIV-1 serodiscordant couples...
  47. pmc Characteristics of HIV-1 serodiscordant couples enrolled in a clinical trial of antiretroviral pre-exposure prophylaxis for HIV-1 prevention
    Andrew Mujugira
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e25828. 2011
    ..We describe the trial design and characteristics of the study cohort...
  48. pmc Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression
    Manish Sagar
    Divisions of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    J Virol 77:12921-6. 2003
    ..01) 4 to 24 months after infection compared to women who were infected with a single viral genotype. These studies suggest that early HIV-1 genetic diversity is linked to faster disease progression...
  49. ncbi request reprint Vitamin A supplementation and human immunodeficiency virus type 1 shedding in women: results of a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 185:1187-91. 2002
    ..Vitamin A supplementation is unlikely to decrease the infectivity of women infected with HIV-1...
  50. ncbi request reprint Hormonal contraception and risk of HIV-1 acquisition: results of a 10-year prospective study
    Ludo Lavreys
    Departments of Epidemiology and Medicine, University of Washington, Seattle, WA, USA
    AIDS 18:695-7. 2004
  51. ncbi request reprint Vaginal washing and increased risk of HIV-1 acquisition among African women: a 10-year prospective study
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    AIDS 20:269-73. 2006
    ..No prospective study has examined the risk of HIV-1 acquisition associated with vaginal washing, although intravaginal practices have been identified as potentially important contributors to HIV-1 susceptibility...
  52. pmc Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e12598. 2010
    ....
  53. pmc Efficacy of preexposure prophylaxis for HIV-1 prevention among high-risk heterosexuals: subgroup analyses from a randomized trial
    Pamela M Murnane
    aDepartment of Epidemiology bDepartment of Global Health cDepartment of Medicine, University of Washington, Seattle, Washington, USA dDepartment of Obstetrics and Gynaecology, University of Nairobi eDepartment of Obstetrics and Gynaecology, Kenyatta National Hospital, Nairobi, Kenya fDivision of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD and TB Prevention, CDC Uganda, Entebbe, Uganda gDivision of Infectious Diseases and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland hStatistical Center for HIV AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA iCenters for Disease Control and Prevention, Atlanta, Georgia, USA Members of the Partners PrEP Study Team listed at end of paper
    AIDS 27:2155-60. 2013
    ..One hypothesis proposed for these divergent results is that PrEP efficacy may be reduced in populations with higher HIV-1 incidence...
  54. doi request reprint A Prospective Study of the Effect of Pregnancy on CD4 Counts and Plasma HIV-1 RNA Concentrations of Antiretroviral-Naive HIV-1-Infected Women
    Renee Heffron
    Department of Global Health, University of Washington, Seattle, WA Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya Wits Reproductive Health and HIV Institute WRHI, University of the Witwatersrand, Johannesburg, South Africa Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya Kenya Medical Research Institute, Nairobi, Kenya Department of Reproductive Health, Moi University, Eldoret, Kenya and Departments of Epidemiology and Medicine, University of Washington, Seattle, WA
    J Acquir Immune Defic Syndr 65:231-6. 2014
    ....
  55. pmc HIV-1 prevention for HIV-1 serodiscordant couples
    Kathryn Curran
    International Clinical Research Center, Department of Global Health, University of Washington, Seattle, WA 98104, USA
    Curr HIV/AIDS Rep 9:160-70. 2012
    ....
  56. pmc Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e28632. 2011
    ..To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use...
  57. pmc Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
    C Celum
    Department of Global Health, University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359927, Seattle, WA 98104, USA
    N Engl J Med 362:427-39. 2010
    ..Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1...
  58. pmc Herpes simplex virus type 2 suppressive therapy with acyclovir or valacyclovir does not select for specific HIV-1 resistance in HIV-1/HSV-2 dually infected persons
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, Washington, USA
    J Infect Dis 203:117-21. 2011
    ..No V75I cases were detected (95% confidence interval, 0%-2.2%). These prospective in vivo studies suggest that standard-dose acyclovir or valacyclovir does not select for HIV-1 resistance...
  59. ncbi request reprint Virus load during primary Human Immunodeficiency Virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan women
    Ludo Lavreys
    University of Washington, Seattle, WA, 98104, USA
    Clin Infect Dis 35:77-81. 2002
    ..4 log(10) copies/mL...
  60. pmc A post-trial assessment of factors influencing study drug adherence in a randomized biomedical HIV-1 prevention trial
    Shevin T Jacob
    Department of Medicine, University of Washington, Seattle, WA, USA
    AIDS Behav 15:897-904. 2011
    ....
  61. doi request reprint High Mycoplasma genitalium organism burden is associated with shedding of HIV-1 DNA from the cervix
    Lisa E Manhart
    Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
    J Infect Dis 197:733-6. 2008
    ..genitalium-negative women (adjusted OR, 2.9 [95% confidence interval, 1.1-7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count)...
  62. pmc Daily short message service surveys to measure sexual behavior and pre-exposure prophylaxis use among Kenyan men and women
    Kathryn Curran
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    AIDS Behav 17:2977-85. 2013
    ..87). PrEP adherence was high, missed doses were correlated with sexual abstinence, and unprotected sex was not associated with decreased PrEP adherence...
  63. doi request reprint Sexual behaviour of heterosexual men and women receiving antiretroviral pre-exposure prophylaxis for HIV prevention: a longitudinal analysis
    Kenneth K Mugwanya
    Department of Epidemiology, University of Washington, Seattle, WA, USA Department of Disease Control and Environmental Health, Makerere University, Kampala, Uganda
    Lancet Infect Dis 13:1021-8. 2013
    ..We studied whether the use of pre-exposure prophylaxis in HIV-uninfected men and women in HIV-serodiscordant couples was associated with increased sexual risk behaviour...
  64. pmc Immune response to hepatitis B virus vaccination among HIV-1 infected and uninfected adults in Kenya
    Elizabeth Irungu
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 207:402-10. 2013
    ....
  65. ncbi request reprint Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
    AIDS 16:2073-8. 2002
    ..However, few studies have examined heterosexual HHV-8 transmission, especially among African populations in which HHV-8 is endemic...
  66. pmc Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 198:1804-8. 2008
    ..001]), as was cervical HIV-1 level (-0.35 log10 copies/swab, a 55% decrease [P < .001]). Suppressive HSV-2 therapy has the potential to reduce HIV-1 infectiousness and slow HIV-1 disease progression...
  67. ncbi request reprint Reducing HIV-1 transmission through prevention strategies targeting HIV-1-seropositive individuals
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Antimicrob Chemother 57:163-6. 2006
    ..Further work is urgently needed to develop, test and implement comprehensive strategies for prevention in positives...
  68. pmc Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98195, USA
    Sci Transl Med 3:77ra29. 2011
    ..These data suggest that HIV-1 RNA in genital secretions could be used as a marker of HIV-1 sexual transmission risk...
  69. pmc Performance of the Focus HerpeSelect-2 enzyme immunoassay for the detection of herpes simplex virus type 2 antibodies in seven African countries
    Andrew Mujugira
    Department of Global Health, University of Washington, Seattle, Washington, USA
    Sex Transm Infect 87:238-41. 2011
    ..To compare the performance of the Focus HerpeSelect-2 enzyme immunoassay (EIA) with the gold standard herpes simplex virus (HSV) type 2 western blot, among HIV-1-uninfected men and women in east and southern Africa...
  70. pmc Clinical and virologic response to episodic acyclovir for genital ulcers among HIV-1 seronegative, herpes simplex virus type 2 seropositive African women: a randomized, placebo-controlled trial
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 39:21-4. 2012
    ..1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405)...
  71. pmc Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples
    Jared M Baeten
    University of Washington, WA, USA
    AIDS 24:737-44. 2010
    ....
  72. pmc The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*
    Shevin T Jacob
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA
    Crit Care Med 40:2050-8. 2012
    ..In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers...
  73. ncbi request reprint The influence of hormonal contraceptive use on HIV-1 transmission and disease progression
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 45:360-9. 2007
    ..Safe and effective contraceptive choices are essential for women with and at risk for HIV-1 infection. Thus, understanding the effect, if any, of hormonal contraception on HIV-1 disease among women is a public health priority...
  74. pmc Hormonal contraception and HIV-1 transmission
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Am J Reprod Immunol 65:302-7. 2011
    ..It is clear that hormonal contraceptives are not protective against HIV-1 infection and that dual protection with condoms should be the goal for women using hormonal contraception...
  75. ncbi request reprint Measuring the infectiousness of persons with HIV-1: opportunities for preventing sexual HIV-1 transmission
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
    Curr HIV Res 1:69-86. 2003
    ..Unresolved issues related to optimal measurement techniques for genital HIV-1, promises and limitations of antiretroviral therapy and vaccines to reduce infectiousness, and other intervention strategies still in development are reviewed...
  76. pmc Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence
    Connie Celum
    Departments of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, Washington 98104, USA
    Curr Opin Infect Dis 25:51-7. 2012
    ..Preexposure prophylaxis (PrEP) trials and future directions are summarized...
  77. pmc Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-Infected Persons
    Andrew Mujugira
    Department of Global Health, University of Washington, Seattle, WA, USA
    BMC Res Notes 4:64. 2011
    ..abstract:..
  78. ncbi request reprint Re: distinguishing the temporal association between women's intravaginal practices and risk of human immunodeficiency virus infection: a prospective study of South African women
    R Scott McClelland
    Am J Epidemiol 165:474-5; author reply 475-6. 2007