Motasim Badri

Summary

Publications

  1. ncbi request reprint Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study
    Motasim Badri
    HIV Clinical Research Unit, Somerset Hospital, University of Cape Town, Green Point 8005, Cape Town, South Africa
    Lancet 359:2059-64. 2002
  2. ncbi request reprint When to initiate highly active antiretroviral therapy in sub-Saharan Africa? A South African cost-effectiveness study
    Motasim Badri
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town, South Africa
    Antivir Ther 11:63-72. 2006
  3. pmc Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting
    Motasim Badri
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 8:89. 2008
  4. ncbi request reprint Tuberculosis among HIV-infected patients receiving HAART: long term incidence and risk factors in a South African cohort
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 19:2109-16. 2005
  5. ncbi request reprint Short-term risk of AIDS or death in people infected with HIV-1 before antiretroviral therapy in South Africa: a longitudinal study
    Motasim Badri
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Lancet 368:1254-9. 2006
  6. pmc Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    BMC Infect Dis 7:99. 2007
  7. pmc Cost-effectiveness of highly active antiretroviral therapy in South Africa
    Motasim Badri
    Department of Medicine, Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    PLoS Med 3:e4. 2006
  8. doi request reprint HIV neuropathy in South Africans: frequency, characteristics, and risk factors
    Jean Maritz
    Division of Neurology, Department of Medicine, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Muscle Nerve 41:599-606. 2010
  9. doi request reprint Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study
    Keertan Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology and University of Cape Town Lung Institute, Department of Medicine, Cape Town, South Africa
    Lancet 375:1798-807. 2010
  10. pmc ICU-associated Acinetobacter baumannii colonisation/infection in a high HIV-prevalence resource-poor setting
    Ntobeko B A Ntusi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e52452. 2012

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study
    Motasim Badri
    HIV Clinical Research Unit, Somerset Hospital, University of Cape Town, Green Point 8005, Cape Town, South Africa
    Lancet 359:2059-64. 2002
    ..Studies of the effect of highly active antiretroviral therapy (HAART) on the risk of HIV-1-associated tuberculosis have had variable results. We set out to determine the effect of HAART on the risk of tuberculosis in South Africa...
  2. ncbi request reprint When to initiate highly active antiretroviral therapy in sub-Saharan Africa? A South African cost-effectiveness study
    Motasim Badri
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town, South Africa
    Antivir Ther 11:63-72. 2006
    ..However, cost-effectiveness of initiating treatment at different CD4 count thresholds has not been explored in resource-poor settings...
  3. pmc Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting
    Motasim Badri
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 8:89. 2008
    ..However, the practical utility of CD4 cell count measurements as an alternative monitoring strategy has not been rigorously assessed...
  4. ncbi request reprint Tuberculosis among HIV-infected patients receiving HAART: long term incidence and risk factors in a South African cohort
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 19:2109-16. 2005
    ..To determine the long-term incidence of tuberculosis (TB) and associated risk factors among individuals receiving HAART in South Africa...
  5. ncbi request reprint Short-term risk of AIDS or death in people infected with HIV-1 before antiretroviral therapy in South Africa: a longitudinal study
    Motasim Badri
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Lancet 368:1254-9. 2006
    ..Our aim was to investigate these risks in patients who had no access to ART or who were given zidovudine alone...
  6. pmc Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    BMC Infect Dis 7:99. 2007
    ..We studied determinants of ELISPOT responses among patients with advanced HIV infection (but without active TB) living in a South African community with very high TB notification rates...
  7. pmc Cost-effectiveness of highly active antiretroviral therapy in South Africa
    Motasim Badri
    Department of Medicine, Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    PLoS Med 3:e4. 2006
    ..Little information exists on the impact of highly active antiretroviral therapy (HAART) on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices...
  8. doi request reprint HIV neuropathy in South Africans: frequency, characteristics, and risk factors
    Jean Maritz
    Division of Neurology, Department of Medicine, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Muscle Nerve 41:599-606. 2010
    ..Our findings raise the possibility that the incidence of DSP may be reduced with avoidance of stavudine-containing regimens in older subjects, especially with a history of prior TB infection...
  9. doi request reprint Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study
    Keertan Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology and University of Cape Town Lung Institute, Department of Medicine, Cape Town, South Africa
    Lancet 375:1798-807. 2010
    ....
  10. pmc ICU-associated Acinetobacter baumannii colonisation/infection in a high HIV-prevalence resource-poor setting
    Ntobeko B A Ntusi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e52452. 2012
    ..There are hardly any data about the incidence, risk factors and outcomes of ICU-associated A.baumannii colonisation/infection in HIV-infected and uninfected persons from resource-poor settings like Africa...
  11. pmc Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples
    Keertan Dheda
    Lung Infection and Immunity Unit, Department of Medicine, Division of Pulmonology and Clinical Immunology, UCT Lung Institute, University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e9848. 2010
    ..The utility of LAM in sputum samples has, hitherto, not been evaluated...
  12. pmc Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting
    Keertan Dheda
    Lung Infection and Immunity Unit and CTBRI, UCT Lung Institute and Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e4689. 2009
    ..Detection of LAM antigen has not previously been evaluated in pleural fluid...
  13. doi request reprint Effect of nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy on dysglycemia and insulin sensitivity in South African HIV-infected patients
    Joel A Dave
    Division of Diabetic Medicine and Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 57:284-9. 2011
    ..We examined the prevalence and associated risk factors of dysglycemia and insulin sensitivity in HIV-infected South Africans...
  14. ncbi request reprint Adherence is not a barrier to successful antiretroviral therapy in South Africa
    Catherine Orrell
    Diana, Princess of Wales HIV Research Unit, Somerset Hospital, University of Cape Town, South Africa
    AIDS 17:1369-75. 2003
    ..To determine adherence of an indigent African HIV-infected cohort initiating antiretroviral therapy (ART); to identify predictors of incomplete adherence (< 95%) and virologic failure (> 400 HIV RNA copies/ml)...
  15. ncbi request reprint Usefulness of total lymphocyte count in monitoring highly active antiretroviral therapy in resource-limited settings
    Motasim Badri
    Somerset Hospital, University of Cape Town, South Africa
    AIDS 17:541-5. 2003
    ..To assess the usefulness of total lymphocyte count (TLC) for monitoring HIV-infected patients receiving highly active antiretroviral therapy. DESIGN Observational cohort study...
  16. doi request reprint T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings
    Keertan Dheda
    Division of Pulmonology and Clinical Immunology, Department of Medicine, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa
    Curr Opin Pulm Med 15:188-200. 2009
    ..low TB burden settings. Here we review the evidence supporting the utility of IGRAs in specific subgroups and compare their performance in high-burden vs. low-burden settings...
  17. ncbi request reprint Initiating highly active antiretroviral therapy in sub-Saharan Africa: an assessment of the revised World Health Organization scaling-up guidelines
    Motasim Badri
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town, Observatory, South Africa
    AIDS 18:1159-68. 2004
    ....
  18. doi request reprint Within-subject variability and boosting of T-cell interferon-gamma responses after tuberculin skin testing
    Richard N van Zyl-Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute Department of Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 180:49-58. 2009
    ..Assessment of within-subject IGRA variability will aid in establishing thresholds for conversions and reversions, and interpretation of serial testing results...
  19. pmc Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study
    Phumla Z Sinxadi
    Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, K45 Old Main Building, Groote Schuur Hospital, Observatory, 7925, Cape Town, South Africa
    AIDS Res Ther 7:23. 2010
    ..Stavudine continues to be widely used in resource poor settings despite its toxicity. Our objective was to determine association between plasma stavudine concentrations and lipoatrophy, concentrations of glucose, lactate and triglycerides...
  20. ncbi request reprint The burden and risk factors for adverse drug events in older patients--a prospective cross-sectional study
    Brent Tipping
    The Albertina and Walter Sisulu Institute of Ageing in Africa, Division of Geriatric Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, South Africa
    S Afr Med J 96:1255-9. 2006
    ..To determine the burden and risk factors for adverse drug events (ADEs) in older patients. Design. A prospective cross-sectional study...
  21. pmc The clinical, electrocardiographic and echocardiographic characteristics and long-term outcome of patients with tachycardia-induced cardiomyopathy
    Ashley Chin
    Cardiac Clinic, Groote Schuur Hospital, and Department of Medicine, University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:136-42. 2012
    ..The clinical, electrocardiographic and echocardiographic features and long-term outcome of patients with tachycardia-induced cardiomyopathy (TIC) have not been well described in the past...
  22. doi request reprint Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
    ..w) can safely reduce mortality and morbidity...
  23. pmc Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa
    Karen Shean
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e63057. 2013
    ..However, data about the type, frequency and severity of presumed drug-associated adverse events (AEs) and their association with treatment-related outcomes in patients with XDR-TB are scarce...
  24. pmc A single-blinded trial of methotrexate versus azathioprine as steroid-sparing agents in generalized myasthenia gravis
    Jeannine M Heckmann
    Department of Medicine, Division of Neurology, University of Cape Town, Observatory, Cape Town, 7925, South Africa
    BMC Neurol 11:97. 2011
    ..We evaluated the steroid-sparing efficacy of MTX (17.5 mg weekly) compared with AZA (2.5 mg/kg daily) in subjects recently diagnosed with generalized MG by assessing their average monthly prednisone requirements...
  25. doi request reprint Clinical features, survival experience, and profile of plakophylin-2 gene mutations in participants of the arrhythmogenic right ventricular cardiomyopathy registry of South Africa
    David A Watkins
    Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart Rhythm 6:S10-7. 2009
    ..PKP2 gene mutations are common, have an allele dose effect, and a novel founder effect in white South Africans...
  26. ncbi request reprint CD4 decline and incidence of opportunistic infections in Cape Town, South Africa: implications for prophylaxis and treatment
    Charles B Holmes
    Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 42:464-9. 2006
    ..To determine the rate of CD4 decline and the incidence of opportunistic infections (OIs) among antiretroviral therapy-naive South African HIV-infected patients and inform timing of OI prophylaxis...
  27. ncbi request reprint Reply to Ouattara et al.: past history of tuberculosis is not a risk factor for incident tuberculosis during antiretroviral treatment in South Africa
    Stephen D Lawn
    AIDS 21:388-9. 2007
  28. ncbi request reprint Risk factors for tuberculosis among HIV-infected patients receiving antiretroviral treatment
    Stephen D Lawn
    Am J Respir Crit Care Med 172:1348; author reply 1348-9. 2005