Mark A Babizhayev

Summary

Publications

  1. ncbi request reprint Efficacy of N-acetylcarnosine in the treatment of cataracts
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of Newcastle, Delaware, USA
    Drugs R D 3:87-103. 2002
  2. ncbi request reprint Current ocular drug delivery challenges for N-acetylcarnosine: novel patented routes and modes of delivery, design for enhancement of therapeutic activity and drug delivery relationships
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, County of New Castle, Delaware USA
    Recent Pat Drug Deliv Formul 3:229-65. 2009
  3. ncbi request reprint Olfactory dysfunction and cognitive impairment in age-related neurodegeneration: prevalence related to patient selection, diagnostic criteria and therapeutic treatment of aged clients receiving clinical neurology and community-based care
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Curr Clin Pharmacol 6:236-59. 2011
  4. ncbi request reprint Hydration properties of the molecular chaperone alpha-crystallin in the bovine lens
    M A Babizhayev
    Innovation Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Biochemistry (Mosc) 68:1145-55. 2003
  5. ncbi request reprint Therapeutic uses of drug-carrier systems for imidazole-containing dipeptide compounds that act as pharmacological chaperones and have significant impact on the treatment of chronic diseases associated with increased oxidative stress and the formation of a
    Mark A Babizhayev
    Innovative Vision Products, Inc, USA and Moscow Helmholtz Research Institute for Eye Diseases, Moscow, Russian Federation
    Crit Rev Ther Drug Carrier Syst 27:85-154. 2010
  6. ncbi request reprint NMR spin-echo studies of hydration properties of the molecular chaperone alpha-crystallin in the bovine lens
    Mark A Babizhayev
    Moscow Helmholtz Research Institute of Eye Diseases, 14 19 Sadovaya Chernogryazskaya, Moscow, Russian Federation
    Biochim Biophys Acta 1598:46-54. 2002
  7. ncbi request reprint Senescent phenotype of trabecular meshwork cells displays biomarkers in primary open-angle glaucoma
    M A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    Curr Mol Med 11:528-52. 2011
  8. doi request reprint N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the n
    Mark A Babizhayev
    Innovative Vision Products, New Castle, Delaware, USA
    Am J Ther 16:517-33. 2009
  9. ncbi request reprint State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatm
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Curr Clin Pharmacol 4:4-37. 2009
  10. ncbi request reprint N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    J Drug Target 17:36-63. 2009

Detail Information

Publications41

  1. ncbi request reprint Efficacy of N-acetylcarnosine in the treatment of cataracts
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of Newcastle, Delaware, USA
    Drugs R D 3:87-103. 2002
    ..To evaluate the effects of 1% N-acetylcarnosine (NAC) solution on lens clarity over 6 and 24 months in patients with cataracts...
  2. ncbi request reprint Current ocular drug delivery challenges for N-acetylcarnosine: novel patented routes and modes of delivery, design for enhancement of therapeutic activity and drug delivery relationships
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, County of New Castle, Delaware USA
    Recent Pat Drug Deliv Formul 3:229-65. 2009
    ..The biologically significant applications of carnosine mimetics including those in ophthalmology were patented by Dr. Babizhayev and the alliance Groups (WO 2004/028536 A1; WO 94/19325; WO 95/12581; WO 2004/064866 A1)...
  3. ncbi request reprint Olfactory dysfunction and cognitive impairment in age-related neurodegeneration: prevalence related to patient selection, diagnostic criteria and therapeutic treatment of aged clients receiving clinical neurology and community-based care
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Curr Clin Pharmacol 6:236-59. 2011
    ..The olfactory system, anatomically, is right in the middle of the part of the brain that's very important for memory. There are strong neural connections between the two." ~ Donald Wilson...
  4. ncbi request reprint Hydration properties of the molecular chaperone alpha-crystallin in the bovine lens
    M A Babizhayev
    Innovation Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Biochemistry (Mosc) 68:1145-55. 2003
    ....
  5. ncbi request reprint Therapeutic uses of drug-carrier systems for imidazole-containing dipeptide compounds that act as pharmacological chaperones and have significant impact on the treatment of chronic diseases associated with increased oxidative stress and the formation of a
    Mark A Babizhayev
    Innovative Vision Products, Inc, USA and Moscow Helmholtz Research Institute for Eye Diseases, Moscow, Russian Federation
    Crit Rev Ther Drug Carrier Syst 27:85-154. 2010
    ....
  6. ncbi request reprint NMR spin-echo studies of hydration properties of the molecular chaperone alpha-crystallin in the bovine lens
    Mark A Babizhayev
    Moscow Helmholtz Research Institute of Eye Diseases, 14 19 Sadovaya Chernogryazskaya, Moscow, Russian Federation
    Biochim Biophys Acta 1598:46-54. 2002
    ..These results shed new light on structural properties of alpha-crystallin and have important implications for understanding the mechanism of the chaperone-like action of this protein in the lens and non-ocular tissues...
  7. ncbi request reprint Senescent phenotype of trabecular meshwork cells displays biomarkers in primary open-angle glaucoma
    M A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    Curr Mol Med 11:528-52. 2011
    ....
  8. doi request reprint N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the n
    Mark A Babizhayev
    Innovative Vision Products, New Castle, Delaware, USA
    Am J Ther 16:517-33. 2009
    ....
  9. ncbi request reprint State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatm
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Curr Clin Pharmacol 4:4-37. 2009
    ..Besides, histidine-containing dipeptides are believed to act as cytosolic buffering agents...
  10. ncbi request reprint N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    J Drug Target 17:36-63. 2009
    ..The present invention provides the potent inhibitors of protein glycation and AGEs formation, which are particularly advantageous for eyedrop delivery in the prevention and treatment of diabetes- and age-related pathologies...
  11. ncbi request reprint Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases
    Mark A Babizhayev
    Innovative Vision Products, Inc Delaware, USA
    Drug Metabol Drug Interact 24:275-323. 2009
    ....
  12. doi request reprint Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware, USA
    Cell Biochem Funct 29:183-206. 2011
    ..Combined in ophthalmic formulations with N-acetylcarnosine, mitochondria-targeted antioxidants are promising to become investigated as a potential tool for treating a number of ROS-related ocular diseases, including human cataracts...
  13. doi request reprint Biologic activities of molecular chaperones and pharmacologic chaperone imidazole-containing dipeptide-based compounds: natural skin care help and the ultimate challenge: implication for adaptive responses in the skin
    Mark A Babizhayev
    Innovation Vision Products, Inc, New Castle, DE, USA
    Am J Ther 19:e69-89. 2012
    ....
  14. ncbi request reprint Ocular drug metabolism of the bioactivating antioxidant N-acetylcarnosine for vision in ophthalmic prodrug and codrug design and delivery
    Mark A Babizhayev
    Innovative Vision Products, Silverside Road, Suite, County of New Castle, Delaware, USA markbabizhayev mail ru
    Drug Dev Ind Pharm 34:1071-89. 2008
    ....
  15. doi request reprint Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware, USA
    J Dermatolog Treat 23:345-84. 2012
    ....
  16. doi request reprint Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous
    Mark A Babizhayev
    Innovation Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, DE 19810, USA
    Fundam Clin Pharmacol 25:139-62. 2011
    ..Telomere length in the human crystalline lens cells is a reflection of aging, cataractogenesis, and lifespan in biogerontological studies...
  17. ncbi request reprint Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, Delaware 19810, USA
    Life Sci 78:2343-57. 2006
    ..The biologically significant applications of carnosine mimetics were patented by Dr. Babizhayev and the alliance Groups (WO 2004/028536 A1; WO 94/19325; WO 95/12581; WO 2004/064866 A1)...
  18. doi request reprint Designation of imidazole-containing dipeptides as pharmacological chaperones
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, Delaware, USA
    Hum Exp Toxicol 30:736-61. 2011
    ..Current efforts are being directed towards exploring therapeutic approaches of pharmacological targeting and human drug delivery for chaperone molecules based on innovative patented strategies...
  19. doi request reprint Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, Delaware 19810, USA
    Drug Test Anal 4:468-85. 2012
    ..Patented N-acetylcarnosine lubricant eye-drop formula was marketed as numerous human biological brands reaching important distribution networks on over 550 000 bottles sold. Nature Does Nothing Uselessly. -Aristotle..
  20. doi request reprint New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a s
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE, USA
    Am J Ther 17:373-89. 2010
    ....
  21. ncbi request reprint Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, Delaware, USA
    Drugs R D 5:125-39. 2004
    ..These data showed that N-acetylcarnosine is effective in the management of age-related cataract reversal and prevention both in human and in canine eyes...
  22. doi request reprint Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, DE, USA
    Am J Ther 18:e209-26. 2011
    ....
  23. ncbi request reprint Novel intraocular and systemic absorption drug delivery and efficacy of N-acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    Fundam Clin Pharmacol 26:644-78. 2012
    ..The discovery of naturally occurring carnosine derivatives introduces N-acetylcarnosine and carcinine as effective medical treatment for sight-threatening eye disorders...
  24. ncbi request reprint Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Recent Pat Drug Deliv Formul 6:107-48. 2012
    ....
  25. doi request reprint Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye d
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, New Castle, DE 19810, USA
    Fundam Clin Pharmacol 26:86-117. 2012
    ..The developed therapy is a prominent management care of the glaucomatous neurodegeneration...
  26. ncbi request reprint Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, Delaware 19810, USA
    Drugs R D 6:345-69. 2005
    ....
  27. ncbi request reprint Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy
    Mark A Babizhayev
    Innovation Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Front Biosci (Landmark Ed) 15:934-56. 2010
    ....
  28. ncbi request reprint Water-structuring technology with the molecular chaperone proteins: indicated application of the α-crystallin domains and imidazole-containing peptidomimetics in cosmetic skin care systems or dermatological therapeutic drug carrier formulations
    Mark A Babizhayev
    Innovative Vision Products, Inc, New Castle, DE, USA
    Crit Rev Ther Drug Carrier Syst 28:203-53. 2011
    ..The proposed biotechnology results in a superior therapeutic treatment using the studied skin-rejuvenating, water-structuring, visible smoothing, and revitalizing beauty-performance agents to meet current challenges in skin care...
  29. ncbi request reprint Image analysis and glare sensitivity in human age-related cataracts
    Mark A Babizhayev
    Innovative Vision Products Inc, Ivanovskaya 20, Moscow, Russian Federation
    Clin Exp Optom 86:157-72. 2003
    ....
  30. ncbi request reprint Non-hydrolyzed in digestive tract and blood natural L-carnosine peptide ("bioactivated Jewish penicillin") as a panacea of tomorrow for various flu ailments: signaling activity attenuating nitric oxide (NO) production, cytostasis, and NO-dependent inhibit
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, DE 19810, USA
    J Basic Clin Physiol Pharmacol 24:1-26. 2013
    ....
  31. doi request reprint Cataract halos: a driving hazard in aging populations. Implication of the Halometer DG test for assessment of intraocular light scatter
    Mark A Babizhayev
    Innovative Vision Products Inc, 3511 Silverside Road, Suite 105, County of New Castle, DE 19810, USA
    Appl Ergon 40:545-53. 2009
    ..The authors examined this visual impairment using a new Halometer DG test in the eyes of older adult drivers with and without cataract...
  32. ncbi request reprint Rejuvenation of visual functions in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye drops
    Mark A Babizhayev
    Innovative Vision Products, Inc Moscow Division, Ivanovskaya 20, Suite 74, Moscow 127434, Russian Federation
    Rejuvenation Res 7:186-98. 2004
    ..The developed ophthalmic drug NAC formula showed potential for the non-surgical treatment of age-related cataracts...
  33. ncbi request reprint Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants
    Mark A Babizhayev
    Innovative Vision Products, Inc, Moscow Division, Ivanovskaya 20, Suite 74 Moscow 127434 Russian Federation
    Recent Pat Drug Deliv Formul 7:216-56. 2013
    ....
  34. ncbi request reprint Advanced drug delivery of N-acetylcarnosine (N-acetyl-beta-alanyl-L-histidine), carcinine (beta-alanylhistamine) and L-carnosine (beta-alanyl-L-histidine) in targeting peptide compounds as pharmacological chaperones for use in tissue engineering, human di
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, Delaware 19810, USA
    Recent Pat Drug Deliv Formul 4:198-230. 2010
    ....
  35. pmc N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware, USA
    Clin Interv Aging 4:31-50. 2009
    ..Only the natural L-isomeric form of NAC raw material was specifically synthesized at the cGMP facility and employed for the manufacturing of Can-C eye drops...
  36. doi request reprint Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, DE, USA
    Am J Ther 19:e25-47. 2012
    ....
  37. ncbi request reprint L-carnosine modulates respiratory burst and reactive oxygen species production in neutrophil biochemistry and function: may oral dosage form of non-hydrolized dipeptide L-carnosine complement anti-infective anti-influenza flu treatment, prevention and sel
    Mark A Babizhayev
    Innovative Vision Products, Inc, Moscow Office Ivanovskaya 20, Suite 74 Moscow, 127434, Russia
    Curr Clin Pharmacol 9:93-115. 2014
    ....
  38. doi request reprint Smoking and health: association between telomere length and factors impacting on human disease, quality of life and life span in a large population-based cohort under the effect of smoking duration
    Mark A Babizhayev
    Innovative Vision Products, County of New Castle, DE 19810, USA
    Fundam Clin Pharmacol 25:425-42. 2011
    ..We conclude that a better therapeutic or nutritional maintenance of TL may confer healthy aging in smokers and exceptional longevity in regularly ROS-exposed human survivors...
  39. ncbi request reprint Coated with nanomaterials intraocular lenses, ophthalmic and human body implantable devices with high catalytic antioxidant activities: a new nanotechnology strategy of peroxidase cellular enzyme mimics increasing the biocompatibility and therapeutic depl
    Mark A Babizhayev
    Innovative Vision Products Inc, 3511 Silverside Road, Suite 105, County of New Castle, Delaware 19810, USA
    Recent Pat Drug Deliv Formul 7:39-65. 2013
    ....
  40. ncbi request reprint 3D molecular modeling, free radical modulating and immune cells signaling activities of the novel peptidomimetic L-glutamyl-histamine: possible immunostimulating role
    Mark A Babizhayev
    Innovative Vision Products Inc, Delaware, USA
    Peptides 26:551-63. 2005
    ..The cited abilities and further obtained in vivo results make Immudilin ((INCI: glutamylamidoethyl imidazole, aqueous solution), L-Glu-Hist) a useful immunoregulatory agent...
  41. ncbi request reprint Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs
    Andrea Guiotto
    Institute of Biomolecular Chemistry of CNR, Department of Chemical Sciences, University of Padua, Via F Marzolo, 1 35131 Padova, Italy
    Bioorg Med Chem 15:6158-63. 2007
    ..The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress...