Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsiesKai Erik Uleberg
Pathology Department, Stavanger University Hospital, Armauer Hansen Road 20, Stavanger, Norway
Proteome Sci 9:36. 2011
..abstract:..
Proliferation is the strongest prognosticator in node-negative breast cancer: significance, error sources, alternatives and comparison with molecular prognostic markersJan P A Baak
Department of Pathology, Stavanger University Hospital, P O Box 8100, Stavanger 4068, Norway
Breast Cancer Res Treat 115:241-54. 2009
....
Prospective multicenter evaluation of the morphometric D-score for prediction of the outcome of endometrial hyperplasiasJ P Baak
Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands
Am J Surg Pathol 25:930-5. 2001
..S. $50 per case)...
- Prognostic relevance of androgen receptor detection in operable breast cancer
Håvard Søiland
Department of Surgery, Stavanger University Hospital, Stavanger, Norway
J Surg Oncol 98:551-8. 2008
..Different determination methods and cut-off levels hamper interpretation and comparisons of studies. Long-term prognostic evaluation of different AR assays in patients comprising operable breast cancers is scarce...
- D2-40/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients
Einar Gudlaugsson
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Mod Pathol 24:502-11. 2011
..In conclusion, T(1-2)N(0)M(0) invasive breast cancer patients ≥55 years with phosphohistone H3≥13, D2-40+/p63- defined lymph vessel invasion identifies a subgroup with a high risk of distant metastases...
- Metachronous cancer development in patients with sporadic colorectal adenomas-multivariate risk model with independent and combined value of hTERT and survivin
Kjetil Søreide
Department of Pathology, Stavanger University Hospital, P O Box 8100, 4068 Stavanger, Norway
Int J Colorectal Dis 23:389-400. 2008
..We sought to validate biomarkers predictive of metachronous colorectal cancer (mCRC) in patients with sporadic colorectal adenomas, using 374 consecutive patients from a large defined population...
- DNA cytometric features in biopsies of TaT1 urothelial cell cancer predict recurrence and stage progression more accurately than stage, grade, or treatment modality
Jan P A Baak
Department of Pathology, SIR Hospital, Stavanger, Norway
Urology 61:1266-72. 2003
..CONCLUSIONS: DNA image cytometric features predict recurrence and stage progression in TaT1 UCC biopsies more accurately than classic prognostic factors, independent of treatment modality...
- A protein profile study to discriminate CIN lesions from normal cervical epithelium
Kai Erik Uleberg
Pathology Department, Stavanger University Hospital, Armauer Hansen Road 20, PO Box 8100, 4068 Stavanger, Norway
Cell Oncol (Dordr) 34:443-50. 2011
....
- The prognostic value of the orphan nuclear receptor DAX-1 (NROB1) in node-negative breast cancer
Hui Zhang
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Anticancer Res 31:443-9. 2011
..DAX-1 inhibits oestrogen receptor (ER) activities and aromatase P450 expression. The prognostic effect of DAX-1 expression in breast cancer was investigated...
- In patients younger than age 55 years with lymph node-negative breast cancer, proliferation by mitotic activity index is prognostically superior to adjuvant!
Tone Hoel Lende
Stavanger University Hospital, Stavanger, Norway
J Clin Oncol 29:852-8. 2011
..We compared the accuracy of the online program Adjuvant!, the Norwegian Breast Cancer Group (NBCG) guidelines, and the proliferation factor mitotic activity index (MAI) in patients with lymph node (LN) -negative disease (pN0)...
- Ki67 predicts progression in early CIN: validation of a multivariate progression-risk model
Arnold-Jan Kruse
Department of Pathology, Rogaland Central Hospital, Norway and Free University, 4068 Stavanger, Norway
Cell Oncol 26:13-20. 2004
..Routine application of the quantitative Ki67-model in CIN1 and CIN2 was well reproducible. In conclusion, the results confirm that quantitative Ki67 features have strong prognostic value for progression in early CIN lesions...
- Microsatellite instability and DNA ploidy in colorectal cancer: potential implications for patients undergoing systematic surveillance after resection
Kjetil Søreide
Department of General and Gastroenterological Surgery, Stavanger University Hospital, Stavanger, Norway
Cancer 115:271-82. 2009
..The objective of the current study was to investigate the effect of microsatellite instability (MSI) and DNA ploidy on surveillance after surgery...
- Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer--possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients
Håvard Søiland
Department of Surgery, Stavanger University Hospital, Norway
Acta Oncol 48:514-21. 2009
..Hence, the co-expression of ApoD may therefore identify clinical relevant subgroups of ERalpha positive breast cancer patients...
- LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer
Emiel A M Janssen
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Cell Oncol 31:335-43. 2009
..The mitotic activity index (MAI) is a strong prognosticator in node-negative invasive breast cancer patients. Recently, a correlation between the MAI and specific chromosomal aberrations at chromosome 1p was described...
- In lymph node-negative invasive breast carcinomas, specific chromosomal aberrations are strongly associated with high mitotic activity and predict outcome more accurately than grade, tumour diameter, and oestrogen receptor
Emiel A M Janssen
Department of Pathology, Central Hospital for Rogaland, Stavanger, Norway
J Pathol 201:555-61. 2003
..In conclusion, loss of 1p is associated with a high MAI. A gain of 3q is a stronger predictor of recurrence than grade, MAI, and other features in invasive breast cancers...
- Comparing the prognostic value of PTEN and Akt expression with the Mitotic Activity Index in adjuvant chemotherapy-treated node-negative breast cancer patients aged <55 years
Emiel A M Janssen
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Cell Oncol 29:25-35. 2007
..Cell proliferation, especially the Mitotic Activity Index (MAI), is strongly prognostic in lymph node-negative (LNneg) invasive breast cancer. However, its prognostic value has not been compared with the value of Akt and PTEN expression...
- Interaction of epithelial biomarkers, local immune response and condom use in cervical intraepithelial neoplasia 2-3 regression
Ane Cecilie Munk
Department of Gynecology and Obstetrics, Stavanger University Hospital, Stavanger, Norway
Gynecol Oncol 127:489-94. 2012
..The aim of this study was to investigate whether punch-biopsy derived immunohistochemical biomarkers, local immune response, CIN lesion size and condom use are independently correlated to regression of CIN2-3...
- The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer
Kristin Jonsdottir
Department of Pathology, Stavanger University Hospital, PO Box 8100, 4068 Stavanger, Norway
Breast Cancer Res Treat 135:381-90. 2012
..In conclusion, MARCKSL1 has strong prognostic value in lymph node-negative breast cancer patients, especially in those with high proliferation...
- Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions
Jan P A Baak
Departments of Pathology, Stavanger University Hospital, Stavanger, Norway
Am J Surg Pathol 29:1062-6. 2005
..HSILs with combined negativity/low positivity for p53 and pRb protein in small histologic biopsies are highly likely to persist, contrasting those in which one of these cell cycle regulators is strongly positive (p53 > 15%; pRb > 40%)...
- Quantitative molecular parameters to identify low-risk and high-risk early CIN lesions: role of markers of proliferative activity and differentiation and Rb availability
Arnold-Jan Kruse
Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
Int J Gynecol Pathol 23:100-9. 2004
..57). Increased RbDeep can reduce proliferation, including its upward spread. Combined quantitation of Ki67, Rb, CK13, and CK14 gives accurate information about the progression risk of early CIN lesions...
- Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients
Kjetil Soreide
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Cell Oncol 29:301-13. 2007
..We assessed whether differential expression of cell-cycle and apoptosis-regulating proteins and a monotonous population of elongated cells (MPECs) in colorectal adenomas could predict metachronous CRC...
- The prognostic value of the proliferation marker phosphohistone H3 (PPH3) in luminal, basal-like and triple negative phenotype invasive lymph node-negative breast cancer
Ivar Skaland
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Cell Oncol 31:261-71. 2009
..Prognostic comparison of phosphohistone-H3 (PPH3) with Cytokeratin 5/6 and/or 14 positive (=basal-CK), triple (ER, PR, HER2)-negative (=TNP) and basal-like (=TNP and basal-CK positive) phenotype in invasive breast cancers...
- Prospective multicenter validation confirms the prognostic superiority of the endometrial carcinoma prognostic index in international Federation of gynecology and obstetrics stage 1 and 2 endometrial carcinoma
Jan P A Baak
Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
J Clin Oncol 21:4214-21. 2003
..CONCLUSION: In endometrial carcinoma, DNA-ploidy is prognostic in hysterectomy and not in curettage samples. The ECPI is prognostically much stronger than the classic features widely used for therapy triage in pFIGO-1 and -2...
- Prospective multicenter validation of the independent prognostic value of the mitotic activity index in lymph node-negative breast cancer patients younger than 55 years
Jan P A Baak
Department of Pathology and Epidemiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
J Clin Oncol 23:5993-6001. 2005
..To validate the independent strong prognostic value of mitotic activity index (MAI) in lymph node (LN) -negative invasive breast cancer patients younger than 55 years in a nationwide multicenter prospective study...
- Phosphohistone H3 expression has much stronger prognostic value than classical prognosticators in invasive lymph node-negative breast cancer patients less than 55 years of age
Ivar Skaland
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Mod Pathol 20:1307-15. 2007
..Phosphohistone H3 is by far the strongest prognostic variable in early invasive node-negative breast cancer patients less than 55 years old with long-term follow-up...
- The prognostic value of molecular biomarkers in tissue removed by curettage from FIGO stage 1 and 2 endometrioid type endometrial cancer
Anita Steinbakk
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Am J Obstet Gynecol 200:78.e1-8. 2009
..To analyze the prognostic value of molecular biomarkers in curettages of endometrioid endometrial cancer pathologic FIGO stages 1 and 2...
- Comparison of different commercial methods for HPV detection in follow-up cytology after ASCUS/LSIL, prediction of CIN2-3 in follow up biopsies and spontaneous regression of CIN2-3
Irene T Ovestad
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Gynecol Oncol 123:278-83. 2011
..Different Human Papilloma Virus (HPV) tests are currently used. An integrated comparison of the Amplicor, Cobas4800, PreTect HPV-Proofer and APTIMA HPV tests has not been done...
- Apolipoprotein D predicts adverse outcome in women >or=70 years with operable breast cancer
Håvard Søiland
Department of Surgery, Stavanger University Hospital, Stavanger, Norway
Breast Cancer Res Treat 113:519-28. 2009
..6; 95% CI = 2.3-40.4). The potential relevance of ApoD in this increasingly frequent group of breast cancer patients should be further explored...
- Low- and high-risk CIN 1 and 2 lesions: prospective predictive value of grade, HPV, and Ki-67 immuno-quantitative variables
Arnold-Jan Kruse
Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
J Pathol 199:462-70. 2003
..In conclusion, Ki-67 immuno-quantitation of small biopsies showing CIN 1 or CIN 2 has strong independent prognostic value for progression...
- Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ
Arnold Jan Kruse
Department of Pathology, Stavanger University Hospital, PO Box 8100, 4068 Stavanger, Norway
Hum Pathol 39:573-8. 2008
....
- Prospective multicenter comparison of proliferation and other prognostic factors in lymph node negative lobular invasive breast cancer
Einar Gudlaugsson
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Breast Cancer Res Treat 121:35-40. 2010
..0001). In multivariate analysis only subtype and MAI but none of the other characteristics had independent prognostic value. Histologic subtype and MAI have independent prognostic value in node negative invasive lobular cancers...
- The prognostic value of proliferation in lymph-node-negative breast cancer patients is age dependent
Jan P A Baak
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands, and Department of Pathology, Stavanger University Hospital, P O Box 8100, 4068 Stavanger, Norway
Eur J Cancer 43:527-35. 2007
..006) for patients aged 55-70 years, while over 70 years, MAI was not significant (P=.11). The prognostic value of proliferation was age-dependent. Prognostic breast cancer studies must clearly indicate the age group being studied...
- Androgen receptor determination in breast cancer: a comparison of the dextran-coated charcoal method and quantitative immunohistochemical analysis
Håvard Søiland
Department of Surgery, Stavanger University Hospital, Stavanger, The Netherlands
Appl Immunohistochem Mol Morphol 16:362-70. 2008
..Thus, AR determination by charc-AR is inaccurate due to evaluation of both normal and cancer cells. IHC is more sensitive and specific than charc-AR in WS samples, but not when applied to single or a few TMA samples...
- Local immune response in the microenvironment of CIN2-3 with and without spontaneous regression
Irene Tveiterås Øvestad
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Mod Pathol 23:1231-40. 2010
..In conclusion, in non-HPV-16 CIN2-3 lesions, assessing stromal immune cells can be a useful prognostic indicator of regression or persistence...
- Prognostic differences of World Health Organization-assessed mitotic activity index and mitotic impression by quick scanning in invasive ductal breast cancer patients younger than 55 years
Ivar Skaland
Department of Pathology, Stavanger University Hospital, Box 8100, 4068 Stavanger, Norway
Hum Pathol 39:584-90. 2008
....
- Consistent condom use increases the regression rate of cervical intraepithelial neoplasia 2-3
Ane Cecilie Munk
Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger, Norway
PLoS ONE 7:e45114. 2012
....
- Cervical intraepithelial neoplasia grade 3 lesions can regress
Ane Cecilie Munk
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
APMIS 115:1409-14. 2007
..001). These results favour the hypothesis that CIN3 can regress, and do not support the "curative punch biopsy" theory...
- The relationship between syntactic structure analysis features, histological grade and high-risk HPV DNA in cervical intraepithelial neoplasia
Arnold-Jan Kruse
Department of Pathology, Rogaland Central Hospital (SiR, Stavanger, Norway
Cell Oncol 26:135-41. 2004
....
- Comparison of apolipoprotein D determination methods in breast cancer
Håvard Søiland
Department of Surgery, Stavanger University Hospital, Stavanger, Norway
Anticancer Res 28:1151-60. 2008
..Apolipoprotein D (ApoD) is a promising prognostic and predictive factor in breast cancer, but the analysis methods and results vary...
- Validating the prognostic value of proliferation measured by Phosphohistone H3 (PPH3) in invasive lymph node-negative breast cancer patients less than 71 years of age
Ivar Skaland
Department of Pathology, Stavanger University Hospital, Box 8100, 4068, Stavanger, Norway
Breast Cancer Res Treat 114:39-45. 2009
..PPH3 is robust as it showed high inter-observer reproducibility and was prognostic over wide range of thresholds around 13 and is the strongest prognostic variable in invasive node-negative breast cancer patients less than 71 years old...
- Biologic profiling of lymph node negative breast cancers by means of microRNA expression
Emiel A M Janssen
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Mod Pathol 23:1567-76. 2010
..The current study shows that estrogen receptor negativity and cytokeratin 5 and 6 expression are important, and specific biological processes in lymph node negative breast cancer, as microRNA signatures are strongest in these subgroups...
- Evaluation of 5 different labeled polymer immunohistochemical detection systems
Ivar Skaland
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Appl Immunohistochem Mol Morphol 18:90-6. 2010
..We conclude that there are significant differences in sensitivity, specificity, costs, and total assay time in the immunohistochemical detection systems currently in use...
- Digital image analysis improves the quality of subjective HER-2 expression scoring in breast cancer
Ivar Skaland
Department of Pathology, Stavanger University Hospital, Stavanger, The Netherlands
Appl Immunohistochem Mol Morphol 16:185-90. 2008
..To compare HER-2 scoring reproducibility by subjective and digital image analysis (DIA) scores with each other and with fluorescence in situ hybridization (FISH) assessed HER-2 amplification...
- Mitotic activity and bone marrow micrometastases have independent prognostic value in node positive breast cancer patients
Bjørnar Gilje
Department of Haematology and Oncology, Stavanger University Hospital, Stavanger, Norway
Breast Cancer Res Treat 128:137-46. 2011
..2-50) and LN-positive (HR 6.0, CI 1.4 to 26.4) patients with regard to breast cancer-specific survival. A combination of MAI and BM DTC detection identified both LN-negative and LN-positive breast cancer patients with poor prognosis...
- Prognostic value of proliferative activity and nuclear morphometry for progression in TaT1 urothelial cell carcinomas of the urinary bladder
Marco G W Bol
Department of Pathology, SIR Hospital, Stavanger, Norway
Urology 60:1124-30. 2002
....
- Success predictors of adjuvant chemotherapy in node-negative breast cancer patients under 55 years
Emiel A M Janssen
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Cell Oncol 28:295-303. 2006
..0001; HR=0.32, 95% CI 0.18-0.58). CONCLUSION: MAI is the strongest predictor of adjuvant systemic chemotherapy success. In patients with MAI < 3 (31% of all patients), ASCT does not improve survival...
- Comparison of the effect of different techniques for measurement of Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer
Einar Gudlaugsson
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Histopathology 61:1134-44. 2012
..We compared the reproducibility and prognostic value of different Ki67 sampling and measurement methods...
- Multivariate prognostic evaluation of the mitotic activity index and fibrotic focus in node-negative invasive breast cancers
Jan P A Baak
Department of Pathology, Stavanger University Hospital, Armauer Hansensveg 20, P O Box 8100, 4068 Stavanger, Norway
Eur J Cancer 41:2093-101. 2005
..The FF may be important as it has additional prognostic value to the MAI in the small subgroup of invasive ductal or mixed-ductal breast cancer patients with combined MAI < 10 and an FF > 1/3 of the tumour area...
- Evaluation of MIB-1-positive cell clusters as a diagnostic marker for cervical intraepithelial neoplasia
Arnold-Jan Kruse
Department of Pathology, Stavanger, Norway
Am J Surg Pathol 26:1501-7. 2002
..When tangentially cut parabasal cells and inflammatory cells are carefully excluded, MIB-C is a strong diagnostic adjunct in distinguishing CIN from normal or benign cervical squamoepithelial lesions...
- Correlation of grade of urothelial cell carcinomas and DNA histogram features assessed by flow cytometry and automated image cytometry
Marco G W Bol
Department of Pathology, SIR Hospital, Stavanger, Norway
Anal Cell Pathol 25:147-53. 2003
..CONCLUSIONS: The adapted fully automated DNA ICM works very well for UCs. Low CV DNA ICM histograms are obtained in a time comparable to FCM. The DNA ICM results have stronger discriminative power than DNA FCM for grade in TaT1 UCs...
- Prognostic value and reproducibility of koilocytosis in cervical intraepithelial neoplasia
Arnold-Jan Kruse
Department of Pathalogy, Rogaland Central Hospital, Stavanger, Norway
Int J Gynecol Pathol 22:236-9. 2003
..Therefore, other more objective and better reproducible criteria are required to extract the potentially important prognostic information contained in the microscopic image of CIN 1 and 2 lesions...
- The effect of different DNA isolation methods on the outcome of high-risk HPV testing
Irene T Oevestad
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Indian J Pathol Microbiol 50:733-9. 2007
..In conclusion both the manual and standard MPLC DNA isolation methods give good HPV results. The standard MPLC is the fastest DNA isolation method...
- Quantitative assessment of gastric antrum atrophy shows restitution to normal histology after Helicobacter pylori eradication
Nicole C T van Grieken
Department of Gastroenterology, Free University Medical Center, Amsterdam, The Netherlands
Digestion 69:27-33. 2004
..pylori eradication. The cases with difficult-to-classify grades of atrophy showed significantly lower VPGLs and higher VPIs than the reference cases...
- Use of biomarkers in the evaluation of CIN grade and progression of early CIN
Jan P A Baak
Department of Pathology, Stavanger University Hospital, Norway
Methods Mol Med 119:85-99. 2005
....
- Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers
Kristin Jonsdottir
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
PLoS ONE 7:e48692. 2012
..Previously it has been shown that miR-18a/b, miR-25, miR-29c and miR-106b correlate to high proliferation...
- Emerging concepts of apolipoprotein D with possible implications for breast cancer
Håvard Søiland
Department of Surgery, Stavanger University Hospital, Stavanger, University of Bergen, Norway
Cell Oncol 29:195-209. 2007
..The triangular relationship between oestrogen receptor, tamoxifen and ApoD should be further explored...
- Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha)
Reinhard Bos
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Oncogene 22:8948-51. 2003
..The cases with amplification in BCL-6 showed an increased (25%) incidence of BCL-6 protein overexpression. Thus, this study is the first to show that BCL-6 oncogene activation plays a role in cancers other than lymphomas...
- Further testing of morphometric grading in T(A,1) urothelial carcinomas of the urinary bladder and the additional value of p53 immunoquantitation
Marco G W Bol
Department of Pathology, SIR Hospital, Stavanger, Norway
Anal Quant Cytol Histol 24:114-20. 2002
..CONCLUSION: The value of MNA-10, MAI and Ki-67 for grading in T(A,1) urothelial carcinomas of the urinary bladder was confirmed. p53 Did not improve overall grading classification of this combination...
- Confocal DNA cytometry: a contour-based segmentation algorithm for automated three-dimensional image segmentation
Jeroen A M Belien
Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
Cytometry 49:12-21. 2002
..So far, these measurements have been performed manually, which is quite time-consuming...
- Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer
Mariël Brinkhuis
Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands
Anal Cell Pathol 24:17-23. 2002
..Further studies are required to elucidate the biological background of the strong prognostic value of mean nuclear area in advanced ovarian cancer...
- A monotonous population of elongated cells (MPECs) in colorectal adenoma indicates a high risk of metachronous cancer
Kjetil Soreide
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Am J Surg Pathol 30:1120-9. 2006
..Dysplasia grade and histologic growth pattern had no additional value. Thus, colorectal adenomas with subsequent metachronous cancer development can be identified more accurately with MPECs than with classical prognostic factors...
- The framework of pathology: good laboratory practice by quantitative and molecular methods
Jan P A Baak
Department of Pathology, Central Hospital of Rogaland, Norway
J Pathol 198:277-83. 2002
..Pathologists should focus on carefully reacting to new clinical needs, using GLP criteria. Reproducibility and predictive accuracy should be major themes in any pathology practice...
- Barrett's adenocarcinomas resemble adenocarcinomas of the gastric cardia in terms of chromosomal copy number changes, but relate to squamous cell carcinomas of the distal oesophagus with respect to the presence of high-level amplifications
Marjan M Weiss
Department of Gastroenterology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
J Pathol 199:157-65. 2003
..With respect to Barrett's cancer, the chromosomal aberrations more closely reflect the adenocarcinoma phenotype than the squamous origin of the epithelium...
- Improved objectivity of grading of T(A,1) transitional cell carcinomas of the urinary bladder by quantitative nuclear and proliferation related features
M G Bol
Department of Pathology, Medical Centre Alkmaar, Alkmaar 1814JD, The Netherlands
J Clin Pathol 54:854-9. 2001
..The similarity of the classification results of the learning set and test set are encouraging and this quantitative pathological grading model should be applied in a prospective study...
- Ki-67 immunoquantitation in cervical intraepithelial neoplasia (CIN): a sensitive marker for grading
A J Kruse
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
J Pathol 193:48-54. 2001
..It is concluded that Ki-67 immunoquantitation is a useful diagnostic adjunct to distinguish different CIN grades and may also be a sensitive biological indicator of progression of seemingly low-grade CIN...
- Experience with a dynamic inexpensive video-conferencing system for frozen section telepathology
J P Baak
Department of Pathology, University Hospital VU, Amsterdam, The Netherlands
Anal Cell Pathol 21:169-75. 2000
..To evaluate the feasibility of an inexpensive, generally applicable video-conferencing system for frozen section telepathology (TP)...
- Relationship between the presence of oncogenic HPV DNA assessed by polymerase chain reaction and Ki-67 immunoquantitative features in cervical intraepithelial neoplasia
A J Kruse
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
J Pathol 195:557-62. 2001
..Thus, routine QP-grading may be used to correct the subjective grade assessed by non-expert pathologists...
- Nuclear cytometric changes in breast carcinogenesis
E C Mommers
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
J Pathol 193:33-9. 2001
..This provides evidence for a progression from usual to atypical ductal hyperplasia and then to invasive cancer, through different routes for well-differentiated and poorly differentiated lesions...
- Automated selection of the most epithelium-rich areas in gynecologic tumor sections
N W Schipper
Department of Pathology, Free University, Amsterdam, The Netherlands
Anal Quant Cytol Histol 13:395-402. 1991
..abstract truncated at 250 words)..
- Prognostic value of morphometry in patients with normal breast tissue or usual ductal hyperplasia of the breast
E C Mommers
Department of Pathology, Free University Hospital, 1007 MB Amsterdam, The Netherlands
Int J Cancer 95:282-5. 2001
..It is worthwhile studying this further in independent groups of patients with long-term follow-up...
