Adile Ayati

Summary

Publications

  1. ncbi request reprint Stereoselective synthesis and in vitro antifungal evaluation of (E)- and (Z)-imidazolylchromanone oxime ethers
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran
    Arch Pharm (Weinheim) 335:318-24. 2002
  2. pmc Antinociceptive properties of new coumarin derivatives bearing substituted 3,4-dihydro-2H-benzothiazines
    Masoumeh Alipour
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14176, Iran
    Daru 22:9. 2014
  3. doi request reprint Current developments of coumarin-based anti-cancer agents in medicinal chemistry
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Electronic address
    Eur J Med Chem 102:611-30. 2015
  4. doi request reprint Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Electronic address
    Eur J Med Chem 93:539-63. 2015
  5. pmc Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety
    Negar Mohammadhosseini
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Daru 20:16. 2012
  6. doi request reprint Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Electronic address
    Eur J Med Chem 68:185-91. 2013
  7. doi request reprint Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Eur J Med Chem 66:480-8. 2013
  8. pmc Synthesis, in vitro antifungal evaluation and in silico study of 3-azolyl-4-chromanone phenylhydrazones
    Adile Ayati
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Daru 20:46. 2012
  9. doi request reprint Synthesis and evaluation of 2(3H)-thiazole thiones as tyrosinase inhibitors
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Arch Pharm (Weinheim) 345:629-37. 2012
  10. doi request reprint Conformationally constrained analogs of N-substituted piperazinylquinolones: synthesis and antibacterial activity of N-(2,3-dihydro-4-hydroxyimino-4H-1-benzopyran-3-yl)-piperazinylquinolones
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Arch Pharm (Weinheim) 342:405-11. 2009

Collaborators

  • A Foroumadi
  • Farideh Siavoshi
  • S Rajabalian
  • S J Hosseinimehr
  • Gholamreza Dehghan
  • Mahmoud Reza Heidari
  • Abbas Shafiee
  • Massoud Amanlou
  • Shahla Mansouri
  • Kazem Mohammad
  • Mohammad Sharifzadeh
  • M Abdollahi
  • Sussan K Ardestani
  • Piyush Kumar
  • Mohammad R Zarrindast
  • Saeed Emami
  • Nasrin Samadi
  • Azar Tahghighi
  • Mohammad Ali Faramarzi
  • Mehraban Falahati
  • Negar Mohammadhosseini
  • Abbas Kebriaeezadeh
  • Bahram Letafat
  • Farzad Kobarfard
  • Siavoush Dastmalchi
  • Eskandar Alipour
  • Nematollah Ahangar
  • Mohammad Hassan Moshafi
  • Alireza Aliabadi
  • Masoumeh Alipour
  • Hamid Irannejad
  • Farzane Rezazade Marznaki
  • Sepideh Razmi
  • Ali Banifatemi
  • Reza Khorasani
  • Ensieh Lotfali
  • Mohammad A Faramarzi
  • Javad Mirzaei
  • Mina Behrouzi-Fardmoghadam
  • Zahra Ghanbarimasir
  • Sakineh Dadashpour
  • Seyedeh Farnaz Ghasemi-Niri
  • Saeed Fallah-Benakohal
  • Mehdi Khoobi
  • Shahaboddin Shojapour
  • Sepide Razmi
  • Sussan Kabudanian Ardestani
  • Ebrahim Ghafouri
  • Zahra Alipanahi
  • Parham Foroumadi
  • Mohammad Mahdavi
  • Kami Shahrbandi
  • Nika Khoshnevis
  • Ahmad Ali Enayati
  • Zahra Esmaeeli
  • Arsalan Pashapour
  • Roohollah Fateh
  • Maryam Omrani
  • Maedeh Sorkhi
  • Mahtab Ashrafi-Khozani
  • Javid Shahbazi Mojarrad
  • Soughra Pashangzadeh
  • Motahare Kazemi-Najafabadi
  • Azadeh Yahya-Meymandi
  • Amir Soheil Negahbani
  • Mohsen Vosooghi
  • Maryam Nakhjiri
  • Fazel Shamsa
  • Seyed Nasser Ostad
  • Jamshid Davoodi
  • Mehran Behdad
  • Somaye Sharifynia
  • Soltan Ahmed Ebrahimi
  • Mohammad Reza Khoshayand
  • Fatemeh Poorrajab
  • Mohsen Ebrahimi
  • Shirin Farahyar
  • Ali Asadipour
  • Fatemeh Safari
  • Seyed Mohammad Taghdisi
  • Shahram Akhlaghpoor
  • Mohammad Jafar Zamani
  • Kayvan Moshiri

Detail Information

Publications53

  1. ncbi request reprint Stereoselective synthesis and in vitro antifungal evaluation of (E)- and (Z)-imidazolylchromanone oxime ethers
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran
    Arch Pharm (Weinheim) 335:318-24. 2002
    ..Detailed stereoselective synthesis, spectroscopic, and biological data are reported...
  2. pmc Antinociceptive properties of new coumarin derivatives bearing substituted 3,4-dihydro-2H-benzothiazines
    Masoumeh Alipour
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14176, Iran
    Daru 22:9. 2014
    ..The clinical use of NSAIDs as traditional analgesics is associated with side effects such as gastrointestinal lesions and nephrotoxicity. Therefore, the discovery of new safer drugs represents a challenging goal for such a research area...
  3. doi request reprint Current developments of coumarin-based anti-cancer agents in medicinal chemistry
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Electronic address
    Eur J Med Chem 102:611-30. 2015
    ..This review article covers the current developments of coumarin-based anticancer agents and also discusses the structure-activity relationship of the most potent compounds. ..
  4. doi request reprint Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Electronic address
    Eur J Med Chem 93:539-63. 2015
    ..This review addresses the most significant synthetic methods reported on 4-chromanone-derived compounds and consequently emphasizes on the biological relevance of such compounds. ..
  5. pmc Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety
    Negar Mohammadhosseini
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Daru 20:16. 2012
    ..In the present study, we synthesized a new series of levofloxacin derivatives and evaluated their antibacterial activities...
  6. doi request reprint Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Electronic address
    Eur J Med Chem 68:185-91. 2013
    ..19 μg/mL). Its activity was 4-8 times more than that of standard drug norfloxacin. The molecular docking study of compound 2b further supported the molecular basis of the designed compounds...
  7. doi request reprint Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Eur J Med Chem 66:480-8. 2013
    ..The favorable drug-like property of compound 4c makes 3-(1,2,4-triazol-1-yl)flavanone prototype as a promising lead for the future development of azole antifungal agents. ..
  8. pmc Synthesis, in vitro antifungal evaluation and in silico study of 3-azolyl-4-chromanone phenylhydrazones
    Adile Ayati
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Daru 20:46. 2012
    ..In continuation of our work, we incorporated phenylhydrazone moiety instead of oxime ether fragment in azolylchromanone derivatives...
  9. doi request reprint Synthesis and evaluation of 2(3H)-thiazole thiones as tyrosinase inhibitors
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Arch Pharm (Weinheim) 345:629-37. 2012
    ..The in silico ADME-Tox screening revealed that the drug-likeness and drug-score values of the most potent compound 4a were significantly higher than those of kojic acid...
  10. doi request reprint Conformationally constrained analogs of N-substituted piperazinylquinolones: synthesis and antibacterial activity of N-(2,3-dihydro-4-hydroxyimino-4H-1-benzopyran-3-yl)-piperazinylquinolones
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Arch Pharm (Weinheim) 342:405-11. 2009
    ..Among these derivatives, ciprofloxacin counterpart 9c, highly inhibited the tested Gram-positive bacteria, superior to that of the reference drugs, and displayed antibacterial activity at non-cytotoxic concentrations...
  11. doi request reprint 3-imidazolyl-substituted flavans as potential antifungal agents: synthesis, stereochemical properties, and antifungal activity
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Arch Pharm (Weinheim) 342:541-5. 2009
    ....
  12. doi request reprint Design of conformationally constrained azole antifungals: efficient synthesis and antifungal activity of trans-3-imidazolylflavanones
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Chem Biol Drug Des 73:388-95. 2009
    ..Generally, 3'-chloro- analog of 3-imidazolylflavanone 3c exhibited better profile of antifungal activity against strains of fungi tested, superior than reference drug fluconazole...
  13. ncbi request reprint Synthesis and antibacterial activity of quinolone-based compounds containing a coumarin moiety
    Saeed Emami
    Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari, Iran
    Arch Pharm (Weinheim) 341:42-8. 2008
    ..Generally, in both gram-positive and gram-negative bacteria, better results are obtained with cyclopropyl at the N-1 position of the quinolone ring and 2-oxo- on the ethyl spacer of coumarin and piperazine rings...
  14. ncbi request reprint 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari 48175, Iran
    Bioorg Med Chem Lett 18:141-6. 2008
    ..The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations...
  15. doi request reprint Synthesis and antifungal activity of 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanone derivatives: exploring the scaffold flexibility
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Chem Biol Drug Des 78:979-87. 2011
    ..However, among the synthesized compounds, 1-[2-(2,4-dichlorobenzyloxy)phenyl]-2-(1H-imidazol-1-yl)ethanone hydrochloride (2g) showed comparable or more potent antifungal activity in comparison with fluconazole as a standard drug...
  16. doi request reprint Imidazolylchromanone oxime ethers as potential anticonvulsant agents: Anticonvulsive evaluation in PTZ-kindling model of epilepsy and SAR study
    Saeed Emami
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Bioorg Med Chem Lett 21:655-9. 2011
    ..SAR studies showed that introduction of a chlorine atom to the 7-position and/or a methyl group to the 2-position of the chroman ring resulted in an improvement of anti-seizure efficacy in O-(2,4-dichlorobenzyl) oxime series...
  17. ncbi request reprint Azolylchromans as a novel scaffold for anticonvulsant activity
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Bioorg Med Chem Lett 16:1803-6. 2006
    ..Among these compounds, 7-chloro-3-(1H-imidazol-1-yl)chroman-4-one and 3-(1H-1,2,4-triazol-1-yl)chroman-4-one exhibited significant action in delaying seizures as well as effective protection against PTZ-induced seizures and deaths...
  18. ncbi request reprint Kojic acid and its manganese and zinc complexes as potential radioprotective agents
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Bioorg Med Chem Lett 17:45-8. 2007
    ..The results of in vivo radioprotection showed that these compounds exhibited significant radioprotective effects against lethal dose of gamma-irradiation in mice...
  19. doi request reprint Synthesis and anti-leishmanial activity of 5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amines containing N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] moieties
    Azar Tahghighi
    Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
    Eur J Med Chem 50:124-8. 2012
    ..The most active compound against promostigotes was found to be 4-methylbenzyl analog 3i, which significantly decreases the number of intracellular amastigotes per macrophage, percentage of macrophage infectivity and infectivity index...
  20. ncbi request reprint (E)- and (Z)-1,2,4-triazolylchromanone oxime ethers as conformationally constrained antifungals
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, PO Box 48175 861, Sari, Iran
    Bioorg Med Chem 12:3971-6. 2004
    ..Many of these derivatives exhibit high activity against Candida albicans, Saccharomyces cerevisiae, Aspergillus niger and Microsporum gypseum...
  21. doi request reprint Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain
    Alireza Foroumadi
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Bioorg Med Chem Lett 18:3315-20. 2008
    ..pylori, however, nitroimidazoles 6c and 7c were found to be more promising compounds because of their respectable anti-H. pylori activity besides less cytotoxic effects...
  22. ncbi request reprint 2-Substituted-5-nitroheterocycles: in vitro anti-Helicobacter pylori activity and structure-activity relationship study
    Alireza Foroumadi
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Med Chem 5:529-34. 2009
    ..The Structure-activity relationship of this series indicates that both the structure of the nitroaryl scaffold and the C-2 attached residue have dramatic impact on anti-Helicobacter pylori activity...
  23. doi request reprint Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines
    Mina Behrouzi-Fardmoghadam
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Bioorg Med Chem 16:4509-15. 2008
    ..In general, 5-nitrofuran derivatives were more active than the corresponding 5-nitrothiophene analogues...
  24. ncbi request reprint Stereoselective synthesis and antifungal activity of (Z)-trans-3-azolyl-2-methylchromanone oxime ethers
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, PO Box 48175 861 Sari, Iran
    Bioorg Med Chem 12:5881-9. 2004
    ..Many of these derivatives exhibit high activity against Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum...
  25. doi request reprint Chromene-based synthetic chalcones as potent antileishmanial agents: synthesis and biological activity
    Alireza Foroumadi
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Chem Biol Drug Des 75:590-6. 2010
    ..The obtained results from in vitro biological assays indicated that chloro-substituted 1-(6-methoxy-2H-chromen-3-yl)-3-phenylpropen-1-ones exhibited excellent activity against Leishmania major at non-cytotoxic concentrations...
  26. ncbi request reprint Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones
    Alireza Foroumadi
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Bioorg Med Chem Lett 15:4536-9. 2005
    ..Some of these derivatives exhibit comparable or better activity against Gram-positive bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis, than ciprofloxacin, norfloxacin and enoxacine as reference drugs...
  27. doi request reprint Synthesis and antileishmanial activity of novel 5-(5-nitrofuran-2-y1)-1,3,4-thiadiazoles with piperazinyl-linked benzamidine substituents
    Azar Tahghighi
    Department of Medicinal Chemistry, School of Pharmacy and Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Eur J Med Chem 46:2602-8. 2011
    ..08 μM in promastigote model. This compound showed a very low level of toxicity against macrophages (CC50=785 μM), with the highest selectivity index (SI=78.5) among the tested compounds...
  28. doi request reprint Anticonvulsant and antiepileptogenic effects of azolylchromanones on lithium-pilocarpine induced seizures and pentylenetetrazole-kindling model of epilepsy
    Abbas Kebriaeezadeh
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Biomed Pharmacother 62:208-11. 2008
    ....
  29. doi request reprint 5-Nitroimidazole-based 1,3,4-thiadiazoles: heterocyclic analogs of metronidazole as anti-Helicobacter pylori agents
    Mohammad Hassan Moshafi
    Department of Microbiology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
    Arch Pharm (Weinheim) 344:178-83. 2011
    ..Compound 6f containing the 3,5-dimethylpiperazinyl moiety at the 2-position of the 5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazole skeleton was the most potent compound tested at low concentrations...
  30. ncbi request reprint 5,7-Dihydroxychromone-2-carboxylic acid and it's transition-metal (Mn and Zn) chelates as non-thiol radioprotective agents
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Eur J Med Chem 43:557-61. 2008
    ..Amifostine provides effective radiation protection when administrated immediately prior to radiation exposure, but administration of DHCCA, even 24 h prior to gamma irradiation, provides a significant protection...
  31. doi request reprint 1-[(2-arylthiazol-4-yl)methyl]azoles as a new class of anticonvulsants: design, synthesis, in vivo screening, and in silico drug-like properties
    Nematollah Ahangar
    Department of Toxicology and Pharmacology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Chem Biol Drug Des 78:844-52. 2011
    ....
  32. ncbi request reprint Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones
    Alireza Foroumadi
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Bioorg Med Chem Lett 17:6764-9. 2007
    ..Compounds having catechol moiety exhibited potent antioxidant activities in all tested methods and they were more active than the reference drug, Trolox...
  33. ncbi request reprint Structural features of new quinolones and relationship to antibacterial activity against Gram-positive bacteria
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Mini Rev Med Chem 6:375-86. 2006
    ....
  34. doi request reprint New 5-(nitroheteroaryl)-1,3,4-thiadiazols containing acyclic amines at C-2: synthesis and SAR study for their antileishmanial activity
    Azar Tahghighi
    Department of Medicinal Chemistry, School of Pharmacy and Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    J Enzyme Inhib Med Chem 28:843-52. 2013
    ..The most active derivatives were hydroxypropylamino- and methoxypropylamino- analogs of 5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazole (compounds 29 and 32, respectively) with highest selectivity index (SI >12). ..
  35. ncbi request reprint Radioprotective effects of kojic acid against mortality induced by gamma irradiation in mice
    Seyed J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Saudi Med J 30:490-3. 2009
    ..To evaluate the protective effects of kojic acid on mortality induced by gamma irradiation in mice. The efficacy was compared with amifostine as a reference radioprotector...
  36. ncbi request reprint Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring
    Alireza Foroumadi
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Eur J Med Chem 42:985-92. 2007
    ..Some of them exhibited significant inhibitory activity against Gram-positive bacteria...
  37. ncbi request reprint Synthesis and in vitro leishmanicidal activity of 2-(1-methyl-5-nitro-1H-imidazol-2-yl)-5-substituted-1,3,4-thiadiazole derivatives
    Alireza Foroumadi
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Tehran University of Medical Science, Tehran 14174, Iran
    Eur J Med Chem 40:1346-50. 2005
    ..The leishmanicidal data revealed that compounds 3a-g had strong and much better leishmanicidal activity than the reference drug pentostam. Compound 3c (piperazine analog) was the most active compound (IC50=0.19 microM)...
  38. doi request reprint The importance of triazole scaffold in the development of anticonvulsant agents
    Adile Ayati
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Med Chem 109:380-92. 2016
    ..In this article, we have tried to summarize the latest efforts which have been made in the design and development of triazole-derived anticonvulsant agents. ..
  39. ncbi request reprint Antituberculosis agents. V. Synthesis, evaluation of in vitro antituberculosis activity and cytotoxicity of some 2-(5-nitro-2-furyl)-1,3,4-thiadiazole derivatives
    Alireza Foroumadi
    Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Iran
    Farmaco 57:765-9. 2002
    ..78 microg ml(-1)). Also, the cytotoxic effects indicate that compound 5b was the least toxic compound...
  40. ncbi request reprint Synthesis and antibacterial activity of new 7-piperazinyl-quinolones containing a functionalized 2-(furan-3-yl)ethyl moiety
    Alireza Foroumadi
    Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Arch Pharm (Weinheim) 340:47-52. 2007
    ....
  41. ncbi request reprint Synthesis and antibacterial activity of nitroaryl thiadiazole-levofloxacin hybrids
    Alireza Foroumadi
    Department of Microbiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
    Arch Pharm (Weinheim) 339:621-4. 2006
    ....
  42. ncbi request reprint Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety
    Alireza Foroumadi
    Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Bioorg Med Chem Lett 16:3499-503. 2006
    ..Ciprofloxacin derivatives, containing a N-(chloro-substituted phenethyl) residue, showed in vitro Gram-positive and Gram-negative activity generally comparable or superior to that of reference quinolones...
  43. ncbi request reprint Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives
    Alireza Foroumadi
    Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Bioorg Med Chem Lett 15:4488-92. 2005
    ..The SAR of this series indicates that both the structure of the benzyl unit and the S or SO(2) linker dramatically impact antibacterial activity...
  44. doi request reprint Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery
    Adile Ayati
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Med Chem 97:699-718. 2015
    ..This article is also intended to help researches for finding potential future directions on the development of more potent and specific analogs of thiazole-based compounds for various biological targets. ..
  45. doi request reprint Straightforward synthesis of thiazoline-incorporated chalconoids from phenacyl halides
    Adile Ayati
    Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Mol Divers 17:41-7. 2013
    ..This chemistry provides a new library of compounds basically originated from phenacyl halides as building blocks, with potential activity for biomedical screening...
  46. doi request reprint Synthesis and biological evaluation of 2-phenylthiazole-4-carboxamide derivatives as anticancer agents
    Alireza Aliabadi
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Eur J Med Chem 45:5384-9. 2010
    ..Also, 3-fluoro analog showed good cytotoxic activity profile against all cell lines with IC(50) values less than 10 μg/mL...
  47. doi request reprint Synthesis and in-vitro antibacterial activity of 5-substituted 1-methyl-4-nitro-1H-imidazoles
    Bahram Letafat
    Department of Chemistry and Islamshar Young Researchers Club, Islamic Azad University, Islamshahr Branch, Tehran, Iran
    Arch Pharm (Weinheim) 341:497-501. 2008
    ..pylori (MIC = 2 microg/mL). It was also demonstrated that their corresponding activities were four times larger than that of metronidazole...
  48. doi request reprint Stereospecific deuteration of alpha-furanosyl azomycin nucleosides: a model reaction for tritium radiolabeling
    Piyush Kumar
    Department of Oncologic Imaging, Cross Cancer Institute, 11560 University Avenue Edmonton, Alta, Canada
    Bioorg Med Chem Lett 18:3256-60. 2008
    ....
  49. doi request reprint Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines and related compounds
    Javad Mirzaei
    School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
    Eur J Med Chem 43:1575-80. 2008
    ..Nitrofuran analog 7b containing thiomorpholine S,S-dioxide moiety was the most potent compound tested...
  50. ncbi request reprint Functionalized N(2-oxyiminoethyl) piperazinyl quinolones as new cytotoxic agents
    Saeed Rajabalian
    Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
    J Pharm Pharm Sci 10:153-8. 2007
    ..Thus, as part of a continuing search for potential anticancer drug candidates in the N-substituted piperazinyl quinolones series, the cytotoxicity evaluation of functionalized N-(2-oxyiminoethyl) piperazinyl quinolones was our interest...
  51. ncbi request reprint Synthesis and antibacterial activity of new N-[2-(thiophen-3-yl)ethyl] piperazinyl quinolones
    Bahram Letafat
    Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran
    Chem Pharm Bull (Tokyo) 55:894-8. 2007
    ....
  52. ncbi request reprint Synthesis and antibacterial activity of N-[5-(chlorobenzylthio)-1,3,4-thiadiazol-2-yl] piperazinyl quinolone derivatives
    Alireza Foroumadi
    Pharmaceutical Sciences Research Center Tehran University of Medical Sciences, Tehran, Iran
    Arch Pharm Res 30:138-45. 2007
    ..06 microg/mL). The structure-activity relationship (SAR) study revealed that the position of chlorine atom on benzyl moiety would dramatically affect the antibacterial activities of the synthesized compounds...
  53. ncbi request reprint Synthesis and antibacterial activity of N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] and N-[2-[5-(methylthio)thiophen-2-yl]-2-(oxyimino)ethyl]piperazinylquinolone derivatives
    Alireza Foroumadi
    Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran
    Bioorg Med Chem 14:3421-7. 2006
    ..Among these derivatives, ciprofloxacin derivative 5a, containing N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] residue, showed significant improvement of potency against staphylococci, maintaining Gram-negative coverage...