Kevin T Morgan

Summary

Affiliation: Aventis Pharma

Publications

  1. ncbi request reprint The hepatic transcriptome as a window on whole-body physiology and pathophysiology
    Kevin T Morgan
    Aventis Inc, Bridgewater, New Jersey 08876, USA
    Toxicol Pathol 33:136-45. 2005
  2. ncbi request reprint Complementary roles for toxicologic pathology and mathematics in toxicogenomics, with special reference to data interpretation and oscillatory dynamics
    Kevin T Morgan
    Aventis Pharmaceuticals, Bridgewater, New Jersey, USA
    Toxicol Pathol 32:13-25. 2004
  3. ncbi request reprint Frequent sampling reveals dynamic responses by the transcriptome to routine media replacement in HepG2 cells
    Kevin T Morgan
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 31:448-61. 2003
  4. ncbi request reprint Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells
    Kevin T Morgan
    Aventis Pharmaceuticals, Raleigh, North Carolina 27604, USA
    Toxicol Pathol 30:435-51. 2002
  5. ncbi request reprint Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium
    Susan D Hester
    US Environmental Protection Agency, Research Triangle Park, NC, USA
    Toxicology 187:13-24. 2003
  6. ncbi request reprint Toxicogenomics, drug discovery, and the pathologist
    Gary A Boorman
    Laboratory for Experimental Pathology, Environmental Toxicology Program, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 30:15-27. 2002
  7. ncbi request reprint Correlation of simultaneous differential gene expression in the blood and heart with known mechanisms of adriamycin-induced cardiomyopathy in the rat
    H Roger Brown
    Drug Safety, GlaxoSmithKline, Inc, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:452-69. 2002
  8. ncbi request reprint Normal gene expression in male F344 rat nasal transitional and respiratory epithelium
    Susan D Hester
    US EPA, Research Triangle Park, NC, USA
    Gene 285:301-10. 2002
  9. pmc Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts
    Lynn M Crosby
    Environmental Carcinogenesis Division, National Health Effects and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, USA
    Cancer Cell Int 10:4. 2010
  10. ncbi request reprint Gene expression analysis reveals chemical-specific profiles
    Kevin T Morgan
    Toxicogenomics Mechanisms, GlaxoSmithKline, Inc, Research Triangle Park, NC 27709, USA
    Toxicol Sci 67:155-6. 2002

Detail Information

Publications15

  1. ncbi request reprint The hepatic transcriptome as a window on whole-body physiology and pathophysiology
    Kevin T Morgan
    Aventis Inc, Bridgewater, New Jersey 08876, USA
    Toxicol Pathol 33:136-45. 2005
    ..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through (www.toxpath.org)...
  2. ncbi request reprint Complementary roles for toxicologic pathology and mathematics in toxicogenomics, with special reference to data interpretation and oscillatory dynamics
    Kevin T Morgan
    Aventis Pharmaceuticals, Bridgewater, New Jersey, USA
    Toxicol Pathol 32:13-25. 2004
    ..An understanding of pathology by mathematicians involved in toxicogenomics is equally critical, as both mathematics and pathology are essential for transforming toxicogenomics data sets into useful knowledge...
  3. ncbi request reprint Frequent sampling reveals dynamic responses by the transcriptome to routine media replacement in HepG2 cells
    Kevin T Morgan
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 31:448-61. 2003
    ..To access this file, click on the issue link for 31(4), then select this article. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
  4. ncbi request reprint Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells
    Kevin T Morgan
    Aventis Pharmaceuticals, Raleigh, North Carolina 27604, USA
    Toxicol Pathol 30:435-51. 2002
    ..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
  5. ncbi request reprint Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium
    Susan D Hester
    US Environmental Protection Agency, Research Triangle Park, NC, USA
    Toxicology 187:13-24. 2003
    ..Differential gene expression profiles may provide clues that could be used to define mechanisms involved in FA-induced nasal cancer...
  6. ncbi request reprint Toxicogenomics, drug discovery, and the pathologist
    Gary A Boorman
    Laboratory for Experimental Pathology, Environmental Toxicology Program, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 30:15-27. 2002
    ..In return, you will gain a greater depth of understanding of cell and tissue function, both in health and disease...
  7. ncbi request reprint Correlation of simultaneous differential gene expression in the blood and heart with known mechanisms of adriamycin-induced cardiomyopathy in the rat
    H Roger Brown
    Drug Safety, GlaxoSmithKline, Inc, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:452-69. 2002
    ..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
  8. ncbi request reprint Normal gene expression in male F344 rat nasal transitional and respiratory epithelium
    Susan D Hester
    US EPA, Research Triangle Park, NC, USA
    Gene 285:301-10. 2002
    ..g. ion channels). Such baseline data will contribute to further understanding the normal physiology of these cells and facilitate the interpretation of responses by the nasal epithelial cells to xenobiotic treatment or disease...
  9. pmc Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts
    Lynn M Crosby
    Environmental Carcinogenesis Division, National Health Effects and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, USA
    Cancer Cell Int 10:4. 2010
    ..We hope that our work will stimulate further study of this important phenomenon...
  10. ncbi request reprint Gene expression analysis reveals chemical-specific profiles
    Kevin T Morgan
    Toxicogenomics Mechanisms, GlaxoSmithKline, Inc, Research Triangle Park, NC 27709, USA
    Toxicol Sci 67:155-6. 2002
    ..Hamadeh, Pierre R. Bushel, Supriya Jayadev, Olimpia DiSorbo, Leping Li, Raymond Tennant, Raymond Stoll, J. Carl Barrett, Richard S. Paules, Kerry Blanchard, and Cynthia A. Afshari (pp. 232-240)...
  11. doi request reprint Integrated disinfection by-products (DBP) mixtures research: gene expression alterations in primary rat hepatocyte cultures exposed to DBP mixtures formed by chlorination and ozonation/postchlorination
    Lynn M Crosby
    U S Environmental Protection Agency University of North Carolina Chapel Hill Cooperative Training Program, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 71:1195-215. 2008
    ..A small subset of gene expression changes was identified that was observed in the response of hepatocytes to peroxisome proliferators, phthalate esters, and haloacetic acids, suggesting a peroxisome proliferative response...
  12. ncbi request reprint Effects of minimally toxic levels of carbonyl cyanide P-(trifluoromethoxy) phenylhydrazone (FCCP), elucidated through differential gene expression with biochemical and morphological correlations
    Sabu Kuruvilla
    Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Toxicol Sci 73:348-61. 2003
    ..These results suggest that gene expression changes may provide a sensitive indicator of uncoupling in response to chemical exposure...
  13. ncbi request reprint Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically
    Christine L Merrill
    Department of Microbiology, Pathology and Parasitology, North Carolina State University, Raleigh 27606, USA
    Toxicol Sci 68:93-101. 2002
    ..This is the first report of oxidative stress caused by etomoxir...
  14. pmc Normalization and analysis of DNA microarray data by self-consistency and local regression
    Thomas B Kepler
    Santa Fe Institute, Santa Fe, NM 87501, USA
    Genome Biol 3:RESEARCH0037. 2002
    ..We find that these assumptions are not generally met, and that these simple methods can be improved...
  15. doi request reprint Temporal gene expression profiling indicates early up-regulation of interleukin-6 in isoproterenol-induced myocardial necrosis in rat
    Igor Mikaelian
    Hoffmann La Roche Inc, Non Clinical Drug Safety, Nutley, New Jersey 07110, USA
    Toxicol Pathol 36:256-64. 2008
    ..These results suggest early involvement of Il6 in isoproterenol-induced myocardial necrosis and emphasize the value of early time points in transcriptomic studies...