- Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disordersJ A Cairns
Respiratory and Rheumatoid Arthritis Disease Group, Aventis Pharmaceuticals, Bridgewater, NJ 08807, USA
Pulm Pharmacol Ther 18:55-66. 2005....
- Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cellsP Berger
Immunopharmacology Group, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
J Appl Physiol 91:1372-9. 2001..SLIGKV elicited a response on SMCs similar to that of tryptase. Tryptase could provide an important stimulus for SMC proliferation in asthmatic airways, by acting on PAR-2...
- Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expressionJ A Cairns
Immunopharmacology Group, Southampton General Hospital, UK
J Immunol 156:275-83. 1996..Tryptase may play a critical role in epithelial repair and in the recruitment of granulocytes following mast cell activation...
- Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblastsJ A Cairns
Immunopharmacology Group, Southampton General Hospital, United Kingdom
J Clin Invest 99:1313-21. 1997..Our findings suggest that the release of tryptase from activated mast cells may provide a signal for abnormal fibrosis in inflammatory disease...