J A Cairns

Summary

Affiliation: Aventis Pharma

Publications

  1. ncbi Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders
    J A Cairns
    Respiratory and Rheumatoid Arthritis Disease Group, Aventis Pharmaceuticals, Bridgewater, NJ 08807, USA
    Pulm Pharmacol Ther 18:55-66. 2005
  2. ncbi Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells
    P Berger
    Immunopharmacology Group, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Appl Physiol 91:1372-9. 2001
  3. ncbi Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression
    J A Cairns
    Immunopharmacology Group, Southampton General Hospital, UK
    J Immunol 156:275-83. 1996
  4. ncbi Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
    J A Cairns
    Immunopharmacology Group, Southampton General Hospital, United Kingdom
    J Clin Invest 99:1313-21. 1997

Collaborators

Detail Information

Publications4

  1. ncbi Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders
    J A Cairns
    Respiratory and Rheumatoid Arthritis Disease Group, Aventis Pharmaceuticals, Bridgewater, NJ 08807, USA
    Pulm Pharmacol Ther 18:55-66. 2005
    ....
  2. ncbi Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells
    P Berger
    Immunopharmacology Group, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Appl Physiol 91:1372-9. 2001
    ..SLIGKV elicited a response on SMCs similar to that of tryptase. Tryptase could provide an important stimulus for SMC proliferation in asthmatic airways, by acting on PAR-2...
  3. ncbi Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression
    J A Cairns
    Immunopharmacology Group, Southampton General Hospital, UK
    J Immunol 156:275-83. 1996
    ..Tryptase may play a critical role in epithelial repair and in the recruitment of granulocytes following mast cell activation...
  4. ncbi Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
    J A Cairns
    Immunopharmacology Group, Southampton General Hospital, United Kingdom
    J Clin Invest 99:1313-21. 1997
    ..Our findings suggest that the release of tryptase from activated mast cells may provide a signal for abnormal fibrosis in inflammatory disease...