T Ebner


Affiliation: Women's General Hospital
Country: Austria


  1. request reprint
    Ebner T, Moser M, Sommergruber M, Puchner M, Wiesinger R, Tews G. Developmental competence of oocytes showing increased cytoplasmic viscosity. Hum Reprod. 2003;18:1294-8 pubmed
    ..05). Our data suggest that cytoplasm of higher viscosity delays development up to cleavage stage and impairs optimal development. Injection funnel persistence was found to be a negative prognostic marker of preimplantation development. ..
  2. Ebner T, Balaban B, Moser M, Shebl O, Urman B, Ata B, et al. Automatic user-independent zona pellucida imaging at the oocyte stage allows for the prediction of preimplantation development. Fertil Steril. 2010;94:913-20 pubmed publisher
    ..This knowledge might further help to reduce both the time in culture and the number of concepti considered for transfer. ..
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    Ebner T, Vanderzwalmen P, Shebl O, Urdl W, Moser M, Zech N, et al. Morphology of vitrified/warmed day-5 embryos predicts rates of implantation, pregnancy and live birth. Reprod Biomed Online. 2009;19:72-8 pubmed
    ..05), which was negatively related. Accurate scoring of warmed blastocysts (within the first 2 h) allows for prediction of pregnancy outcome, and thus will help to further reduce the number of transferred embryos. ..
  4. Ebner T, Oppelt P, Wöber M, Staples P, Mayer R, Sonnleitner U, et al. Treatment with Ca2+ ionophore improves embryo development and outcome in cases with previous developmental problems: a prospective multicenter study. Hum Reprod. 2015;30:97-102 pubmed publisher
    ..The present approach is exclusively for overcoming cleavage arrest. No funding received. T.E. reports fees from Gynemed, outside the submitted work. All co-authors have no interest to declare. ..
  5. Ebner T, Maurer M, Oppelt P, Mayer R, Duba H, Costamoling W, et al. Healthy twin live-birth after ionophore treatment in a case of theophylline-resistant Kartagener syndrome. J Assist Reprod Genet. 2015;32:873-7 pubmed publisher
    ..The future will show if routine application of A23187 in Kartagener or primary cilia dyskinesis patients will be of benefit. ..
  6. Ebner T, Filicori M, Tews G, Parmegiani L. A plea for a more physiological ICSI. Andrologia. 2012;44 Suppl 1:2-19 pubmed publisher
    ..Furthermore, novel non-invasive imaging techniques can be valid tools for helping in the morphological selection of ICSI spermatozoa. ..
  7. Ebner T, Shebl O, Holzer S, Oppelt P, Petek E, Schappacher Tilp G, et al. Viability of cumulus cells is associated with basal AMH levels in assisted reproduction. Eur J Obstet Gynecol Reprod Biol. 2014;183:59-63 pubmed publisher
    ..g. apoptosis, may impair outer cumulus cells first. Age-corrected AMH reflects quality of these outer cumulus cells. AMH; Corona radiata cells; DNA fragmentation; Outer cumulus cells; SCD test. ..
  8. request reprint
    Ebner T, Moser M, Sommergruber M, Gaiswinkler U, Wiesinger R, Puchner M, et al. Presence, but not type or degree of extension, of a cytoplasmic halo has a significant influence on preimplantation development and implantation behaviour. Hum Reprod. 2003;18:2406-12 pubmed
    ..In addition, the developmental advantage of pattern 0 is confirmed. ..
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    Ebner T, Shebl O, Moser M, Sommergruber M, Tews G. Developmental fate of ovoid oocytes. Hum Reprod. 2008;23:62-6 pubmed
    ..The quality of blastocysts was not affected at any stage in ovoid concepti (P > 0.05). Ovoid oocytes with abnormal cleavage pattern show delayed preimplantation development, probably due to a reduced number of cell-to-cell contacts. ..

More Information


  1. Ebner T, Tritscher K, Mayer R, Oppelt P, Duba H, Maurer M, et al. Quantitative and qualitative trophectoderm grading allows for prediction of live birth and gender. J Assist Reprod Genet. 2016;33:49-57 pubmed publisher
    ..The presented correlation of TE with outcome indicates that TE scoring could replace ICM scoring in terms of priority. This would automatically require a rethinking process in terms of blastocyst selection and cryopreservation strategy. ..
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    Ebner T, Moser M, Sommergruber M, Tews G. Selection based on morphological assessment of oocytes and embryos at different stages of preimplantation development: a review. Hum Reprod Update. 2003;9:251-62 pubmed
    ..In addition, multiple selection at different stages of development will be required to filter out the correct 'candidate' embryo which will result in a healthy newborn. ..
  3. Ebner T, Montag M, Montag M, van der Ven K, van der Ven H, Ebner T, et al. Live birth after artificial oocyte activation using a ready-to-use ionophore: a prospective multicentre study. Reprod Biomed Online. 2015;30:359-65 pubmed publisher
    ..In total, 99% of the patients had an improved outcome with A23187 application resulting in a 28% live birth rate (35 babies). These data suggest that artificial oocyte activation using a ready-to-use compound is an efficient method. ..
  4. Ebner T, Shebl O, Moser M, Mayer R, Arzt W, Tews G. Group culture of human zygotes is superior to individual culture in terms of blastulation, implantation and life birth. Reprod Biomed Online. 2010;21:762-8 pubmed publisher
    ..As far as is known, this is the first evidence that grouping embryos improves preimplantation development in human and it is recommended that culture volume should be reduced or embryo density increased. ..
  5. request reprint
    Ebner T, Moser M, Shebl O, Sommergruber M, Gaiswinkler U, Tews G. Morphological analysis at compacting stage is a valuable prognostic tool for ICSI patients. Reprod Biomed Online. 2009;18:61-6 pubmed
    ..Blastocysts deriving from grade C1/C4 embryos led to a higher pregnancy rate as compared with the C2/C3 counterparts (P < 0.05). This modified score allows for adequate prediction of both blastocyst formation/quality and pregnancy. ..
  6. Ebner T, Montag M. Artificial oocyte activation: evidence for clinical readiness. Reprod Biomed Online. 2016;32:271-3 pubmed publisher
    ..As epigenetic consequences or differences in gene expression have not been studied to date, artificial oocyte activation has to be considered as experimental and should only be applied with a proper indication. ..
  7. Krause I, Pohler U, Grosse S, Shebl O, Petek E, Chandra A, et al. Characterization of the injection funnel during intracytoplasmic sperm injection reflects cytoplasmic maturity of the oocyte. Fertil Steril. 2016;106:1101-1106 pubmed publisher
    ..Precise evaluation of the injection funnel may help to explain deviations from expected ICSI outcome and could also assist in optimizing controlled ovarian hyperstimulation. ..
  8. Ebner T, Oppelt P, Radler E, Allerstorfer C, Habelsberger A, Mayer R, et al. Morphokinetics of vitrified and warmed blastocysts predicts implantation potential. J Assist Reprod Genet. 2017;34:239-244 pubmed publisher
    ..Time-lapse imaging of vitrified-warmed blastocysts offers additional selection criteria allowing for prediction of implantation potential. As a consequence, cumulative pregnancy rate could be increased and time-to-pregnancy reduced. ..
  9. Ebner T, Höggerl A, Oppelt P, Radler E, Enzelsberger S, Mayer R, et al. Time-lapse imaging provides further evidence that planar arrangement of blastomeres is highly abnormal. Arch Gynecol Obstet. 2017;296:1199-1205 pubmed publisher
    ..This indicates that planar embryos are rather abnormal and should only be considered for transfer if no other embryos are available. ..