Stefan Westermann

Summary

Country: Austria

Publications

  1. pmc Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes
    Fabienne Lampert
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Cell Biol 200:21-30. 2013
  2. pmc The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex
    Fabienne Lampert
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Cell Biol 189:641-9. 2010
  3. doi request reprint Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans
    Stefan Westermann
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Trends Cell Biol 23:260-9. 2013
  4. ncbi request reprint Structures and functions of yeast kinetochore complexes
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Biochem 76:563-91. 2007
  5. pmc Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex
    Peter Hornung
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    J Mol Biol 405:548-59. 2011
  6. doi request reprint A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast
    Eva Kiermaier
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Cell Biol 11:1109-15. 2009
  7. ncbi request reprint The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720 3202, USA
    Nature 440:565-9. 2006
  8. ncbi request reprint Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex
    Stefan Westermann
    Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 17:277-90. 2005
  9. pmc Architecture and flexibility of the yeast Ndc80 kinetochore complex
    Hong Wei Wang
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    J Mol Biol 383:894-903. 2008
  10. pmc A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors
    Francesca Malvezzi
    Research Institute of Molecular Pathology IMP, Vienna 1030, Austria
    EMBO J 32:409-23. 2013

Collaborators

Detail Information

Publications20

  1. pmc Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes
    Fabienne Lampert
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Cell Biol 200:21-30. 2013
    ..Our experiments shed light on how microtubule couplers cooperate and impose important constraints on structural models for outer kinetochore assembly...
  2. pmc The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex
    Fabienne Lampert
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Cell Biol 189:641-9. 2010
    ..These findings can explain how the force harvested by Dam1 is transmitted to the rest of the kinetochore via the Ndc80 complex...
  3. doi request reprint Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans
    Stefan Westermann
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Trends Cell Biol 23:260-9. 2013
    ..Together, these findings contribute to a unified view of how centromeric chromatin functions as a regulated scaffold for kinetochore assembly...
  4. ncbi request reprint Structures and functions of yeast kinetochore complexes
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Biochem 76:563-91. 2007
    ..Here we review the current understanding of kinetochore function in budding yeast and draw comparisons to recent findings in other organisms...
  5. pmc Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex
    Peter Hornung
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    J Mol Biol 405:548-59. 2011
    ..Ndc80 and Ctf19 complexes do not compete for binding to the Mtw1 complex, suggesting that Mtw1 can bridge the microtubule-binding components of the kinetochore to the inner centromere...
  6. doi request reprint A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast
    Eva Kiermaier
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Cell Biol 11:1109-15. 2009
    ..Thus, we have built a simplified chromosome segregation system by directly recruiting a microtubule force-transducing component to DNA...
  7. ncbi request reprint The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720 3202, USA
    Nature 440:565-9. 2006
    ..The Dam1 ring complex is a molecular device that can translate the force generated by microtubule depolymerization into movement along the lattice to facilitate chromosome segregation...
  8. ncbi request reprint Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex
    Stefan Westermann
    Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 17:277-90. 2005
    ..These observations suggest a mechanism by which the kinetochore can recognize and stay attached to the plus ends of microtubules...
  9. pmc Architecture and flexibility of the yeast Ndc80 kinetochore complex
    Hong Wei Wang
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    J Mol Biol 383:894-903. 2008
    ..We hypothesize that the kink in Ndc80 is essential for correct kinetochore geometry and could be part of a tension-sensing mechanism at the kinetochore...
  10. pmc A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors
    Francesca Malvezzi
    Research Institute of Molecular Pathology IMP, Vienna 1030, Austria
    EMBO J 32:409-23. 2013
    ..Together, our data provide structural insights into the modular binding mechanism of the Ndc80 complex to its centromere recruiters...
  11. ncbi request reprint Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
    Nat Struct Mol Biol 14:721-6. 2007
    ..One of Ipl1's roles might be to fine-tune the coupling of the microtubule interaction with the conformational change required for oligomerization, with phosphorylation resulting in ring breakdown...
  12. doi request reprint CENP-T proteins are conserved centromere receptors of the Ndc80 complex
    Alexander Schleiffer
    IMP IMBA Bioinformatics Core Facility, Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nat Cell Biol 14:604-13. 2012
    ..Our results reveal the molecular function of CENP-T proteins and demonstrate how the Ndc80 complex is anchored to centromeres in a manner that couples chromosome movement to spindle dynamics...
  13. pmc A protein interaction map of the mitotic spindle
    Jonathan Wong
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Mol Biol Cell 18:3800-9. 2007
    ..The wealth of protein interactions presented here highlights the extent to which mitotic spindle protein functions and regulation are integrated with each other and with other cellular activities...
  14. doi request reprint A blueprint for kinetochores - new insights into the molecular mechanics of cell division
    Fabienne Lampert
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nat Rev Mol Cell Biol 12:407-12. 2011
    ....
  15. pmc Architecture of the budding yeast kinetochore reveals a conserved molecular core
    Stefan Westermann
    Department of Molecular and Cell Biology, Barker Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 163:215-22. 2003
    ..We propose that a molecular core consisting of CENP-A, -C, -H, and Ndc80/HEC has been conserved from yeast to humans to link centromeres to spindle microtubules...
  16. pmc Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p
    Tomasz Zimniak
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Cell Biol 186:379-91. 2009
    ..Our results define a mechanism for the use and regulation of CH domains in an EB1 protein...
  17. doi request reprint Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation
    Tomasz Zimniak
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 22:787-93. 2012
    ..Our work shows that Ipl1/Aurora is not only the catalytic subunit of the CPC but also an important regulatory target that allows Cdk1 to coordinate chromosome biorientation with spindle morphogenesis...
  18. ncbi request reprint Post-translational modifications regulate microtubule function
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Rev Mol Cell Biol 4:938-47. 2003
  19. pmc Stefan Westermann: a close look at kinetochore function. Interviewed by Caitlan Sedwick
    Stefan Westermann
    J Cell Biol 179:810-1. 2007
    b>Stefan Westermann is probing the structure and function of the yeast kinetochore.
  20. ncbi request reprint Identification of CfNek, a novel member of the NIMA family of cell cycle regulators, as a polypeptide copurifying with tubulin polyglutamylation activity in Crithidia
    Stefan Westermann
    Max Planck Institute for Biophysical Chemistry, Department of Biochemistry, Am Fassberg 11, 37077 Goettingen, Germany
    J Cell Sci 115:5003-12. 2002
    ..After purification on a Ni(2+)-column the recombinant enzyme preparation displays ATP-dependent tubulin polyglutamylation activity as well as casein-phosphorylation activity...