Heinz Zoller

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease
    Heinz Zoller
    Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    Hepatology 42:466-72. 2005
  2. ncbi Iron supplementation in athletes--first do no harm
    Heinz Zoller
    Department of Medicine, University of Cambridge, Cambridge, UK
    Nutrition 20:615-9. 2004
  3. doi Identification of mutations in SLC40A1 that affect ferroportin function and phenotype of human ferroportin iron overload
    Roman Mayr
    Department of Medicine II, Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Gastroenterology 140:2056-63, 2063.e1. 2011
  4. doi Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia
    Igor Theurl
    Deparment of Medicine I, Medical University Innsbruck, Innsbruck, Austria
    Br J Haematol 148:449-55. 2010
  5. ncbi Diagnosis of hepatic iron overload: a family study illustrating pitfalls in diagnosing hemochromatosis
    Melanie Schranz
    Department of Medicine, Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Diagn Mol Pathol 18:53-60. 2009
  6. ncbi Patatin-like phospholipase domain-containing protein 3 rs738409-G in recipients of liver transplants is a risk factor for graft steatosis
    Armin Finkenstedt
    Department of Medicine II, Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Clin Gastroenterol Hepatol 11:1667-72. 2013
  7. ncbi Hemochromatosis: genetic testing and clinical practice
    Heinz Zoller
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    Clin Gastroenterol Hepatol 3:945-58. 2005
  8. doi Cystatin C is a strong predictor of survival in patients with cirrhosis: is a cystatin C-based MELD better?
    Armin Finkenstedt
    Department of Medicine II Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Liver Int 32:1211-6. 2012
  9. pmc Ferroportin disease: a systematic meta-analysis of clinical and molecular findings
    Roman Mayr
    Department of Medicine II, Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    J Hepatol 53:941-9. 2010
  10. doi Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency
    Armin Finkenstedt
    Department of Medicine II, Medical University of Innsbruck, Innsbruck, Austria
    Br J Haematol 144:789-93. 2009

Collaborators

Detail Information

Publications35

  1. ncbi Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease
    Heinz Zoller
    Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    Hepatology 42:466-72. 2005
    ..Finally, macrophage iron storage in ferroportin disease is associated with elevated serum pro-hepcidin levels...
  2. ncbi Iron supplementation in athletes--first do no harm
    Heinz Zoller
    Department of Medicine, University of Cambridge, Cambridge, UK
    Nutrition 20:615-9. 2004
    ....
  3. doi Identification of mutations in SLC40A1 that affect ferroportin function and phenotype of human ferroportin iron overload
    Roman Mayr
    Department of Medicine II, Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Gastroenterology 140:2056-63, 2063.e1. 2011
    ....
  4. doi Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia
    Igor Theurl
    Deparment of Medicine I, Medical University Innsbruck, Innsbruck, Austria
    Br J Haematol 148:449-55. 2010
    ..This indicates that other ACD-related factors may overcome the regulatory effects of GDF15 on hepcidin expression during inflammation...
  5. ncbi Diagnosis of hepatic iron overload: a family study illustrating pitfalls in diagnosing hemochromatosis
    Melanie Schranz
    Department of Medicine, Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Diagn Mol Pathol 18:53-60. 2009
    ..Should they be uninformative, further genetic tests should be recommended only if iron overload in liver tissue has been confirmed chemically...
  6. ncbi Patatin-like phospholipase domain-containing protein 3 rs738409-G in recipients of liver transplants is a risk factor for graft steatosis
    Armin Finkenstedt
    Department of Medicine II, Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Clin Gastroenterol Hepatol 11:1667-72. 2013
    ..We investigated the association of donor and recipient risk alleles with the development of graft steatosis after liver transplantation...
  7. ncbi Hemochromatosis: genetic testing and clinical practice
    Heinz Zoller
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    Clin Gastroenterol Hepatol 3:945-58. 2005
    ..As our mechanistic understanding of iron pathophysiology improves, our desire to integrate clinical decision making with the results of laboratory tests and molecular analysis of human genes poses increasing challenges...
  8. doi Cystatin C is a strong predictor of survival in patients with cirrhosis: is a cystatin C-based MELD better?
    Armin Finkenstedt
    Department of Medicine II Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Liver Int 32:1211-6. 2012
    ..Our objective was to assess whether or not the substitution of creatinine by cystatin C improves the prognostic performance of the model...
  9. pmc Ferroportin disease: a systematic meta-analysis of clinical and molecular findings
    Roman Mayr
    Department of Medicine II, Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    J Hepatol 53:941-9. 2010
    ..The aim of the analysis is to determine the penetrance of SLC40A1 mutations and to evaluate in silico tools to predict the functional impairment of ferroportin mutations as an alternative to in vitro studies...
  10. doi Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency
    Armin Finkenstedt
    Department of Medicine II, Medical University of Innsbruck, Innsbruck, Austria
    Br J Haematol 144:789-93. 2009
    ..528 pg/ml). Serum hepcidin concentrations correlated positively with haemoglobin and negatively with serum GDF15. These results suggest that GDF15 contributes to low hepcidin expression and iron loading in PKD...
  11. pmc Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation
    Armin Finkenstedt
    Department of Medicine II Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    J Hepatol 53:1101-7. 2010
    ..Ceruloplasmin is a multi-copper ferroxidase that is secreted into plasma and facilitates cellular iron export and iron binding to transferrin...
  12. ncbi Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis
    Heinz Zoller
    Department of Medicine, University Hospital of Innsbruck, Innsbruck, Austria
    Gastroenterology 125:746-54. 2003
    ..Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transporter-1 and FPN1, respectively, to transfer iron from the duodenal lumen to the circulation...
  13. doi Acute-on-chronic liver failure: excellent outcomes after liver transplantation but high mortality on the wait list
    Armin Finkenstedt
    Departments of Internal Medicine II, Innsbruck Medical University, Innsbruck, Austria
    Liver Transpl 19:879-86. 2013
    ..In conclusion, this study shows that LT remains the only therapeutic option for the vast majority of patients with ACLF. However, LT was feasible in less than one fourth of the patients with a 5-year survival rate greater than 80%...
  14. doi Evaluation of liver fat in the presence of iron with MRI using T2* correction: a clinical approach
    Benjamin Henninger
    Department of Radiology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria
    Eur Radiol 23:1643-9. 2013
    ..To assess magnetic resonance imaging (MRI) with conventional chemical shift-based sequences with and without T2* correction for the evaluation of steatosis hepatitis (SH) in the presence of iron...
  15. ncbi Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1
    Heinz Zoller
    Department of Medicine, University Hospital of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Blood Cells Mol Dis 29:488-97. 2002
    ..This provides evidence for a negative feed-back loop between intracellular iron availability and transmembrane iron transport...
  16. pmc Saccadic latency in hepatic encephalopathy: a pilot study
    Florian Krismer
    Department of Medicine II Gastroenterology and Hepatology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria
    Metab Brain Dis 25:285-95. 2010
    ..Unlike psychometric test performance, these ocular responses were unaffected by renal function and can be obtained clinically within a matter of minutes by non-trained personnel...
  17. pmc MNGIE Syndrome: Liver Cirrhosis Should Be Ruled Out Prior to Bone Marrow Transplantation
    Armin Finkenstedt
    Department of Medicine II Gastroenterology and Hepatology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    JIMD Rep 10:41-4. 2013
    ..Considerable amounts of thymidine phosphorylase are expressed in liver tissue which may prevent accumulation of toxic metabolites...
  18. pmc Specific acquisition of functional CD59 but not CD46 or CD55 by hepatitis C virus
    Asim Ejaz
    Institute of Virology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 7:e45770. 2012
    ..In summary our data indicate that HCV incorporates selectively CD59 in its envelope to gain resistance to CML in serum of infected individuals...
  19. pmc Immunoglobulin subclass 4 for the diagnosis of immunoglobulin subclass 4-associated diseases in an unselected liver and pancreas clinic population
    Livia Dorn
    Department of Medicine II Gastroenterology and Hepatology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria
    HPB (Oxford) 14:122-5. 2012
    ..The aim of the present study was to assess the performance of serum IgG(4) as a diagnostic parameter in an unselected liver and pancreas clinic population...
  20. ncbi Autocrine formation of hepcidin induces iron retention in human monocytes
    Igor Theurl
    Department of General Internal Medicine, Medical University, Innsbruck, Innsbruck, Austria
    Blood 111:2392-9. 2008
    ..Our results suggest that ferroportin expression in inflammatory monocytes is negatively affected by autocrine formation of hepcidin, thus contributing to iron sequestration within monocytes as found in ACD...
  21. ncbi CFTR gene mutations in pancreatitis: Frequency and clinical manifestations in an Austrian patient cohort
    Heinz Zoller
    Department of Medicine, Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Austria
    Wien Klin Wochenschr 119:527-33. 2007
    ..2% in the central European population. The aim of the current study was to investigate the association between clinical manifestations of pancreatitis and CFTR carrier status...
  22. ncbi Cardiac phosphorus-31 two-dimensional chemical shift imaging in patients with hereditary hemochromatosis
    Michael F H Schocke
    Department of Radiology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Tyrol, Austria
    Magn Reson Imaging 22:515-21. 2004
    ..The decreased PCr to beta-ATP ratios in HHC might be caused by mitochondrial impairment due to cardiac iron overload...
  23. doi Interferon-alpha therapy in patients with hepatitis C virus infection increases plasma phenylalanine and the phenylalanine to tyrosine ratio
    Heinz Zoller
    Department of Internal Medicine, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    J Interferon Cytokine Res 32:216-20. 2012
    ..Future studies should show whether side effects of IFN-α treatment such as mood changes and depression will be associated with the alterations of Phe metabolism...
  24. ncbi Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3
    Igor Theurl
    Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    J Infect Dis 190:819-25. 2004
    ..The translation initiation factor 3 (eIF3) is essential for HCV translation, and thus the effects that iron perturbations have on eIF3 expression and HCV translation were studied here...
  25. ncbi Effects of 24h working on-call on psychoneuroendocrine and oculomotor function: A randomized cross-over trial
    Florian Ernst
    Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria Department of Neurology, Paracelsus Medical University Salzburg, Salzburg, Austria
    Psychoneuroendocrinology 47:221-31. 2014
    ..The lack of studies conducted in clinical care environments and the ongoing public dialogue concerning OCD led to a detailed investigation of a working schedule including sleep fragmentation and extended work hours...
  26. ncbi Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    Herbert Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Hepatol 38:419-25. 2003
    ..Severe alcoholic hepatitis (AH) is associated with high mortality. Tumor necrosis factor-alpha (TNFalpha) has been demonstrated to play an important role in its pathophysiology...
  27. ncbi Posttraumatic splenic artery aneurysm presenting as occult gastrointestinal bleeding
    Robert Koch
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    Wien Klin Wochenschr 115:668-71. 2003
    ..SAA is a very rare cause of upper gastrointestinal bleeding, but it must be considered when no other common bleeding source can be detected...
  28. pmc Identification and in silico analysis of 14 novel GJB1, MPZ and PMP22 gene mutations
    Gabriel Miltenberger-Miltenyi
    Division of Clinical Genetics, Innsbruck Medical University, Innsbruck, Austria
    Eur J Hum Genet 17:1154-9. 2009
    ..The CMT1Adup, GJB1, MPZ and PMP22 mutation frequencies were in the range of those described in other CMT patient collectives with different ethnical backgrounds...
  29. ncbi Treatment of intractable pruritus in drug induced cholestasis with albumin dialysis: a report of two cases
    Romuald Bellmann
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse, Innsbruck, Austria
    ASAIO J 50:387-91. 2004
    ..In conclusion, extracorporeal albumin dialysis appears to be a therapeutic option in severe drug induced cholestasis refractory to medical treatment...
  30. ncbi Erythroid 5-aminolevulinate synthase, ferrochelatase and DMT1 expression in erythroid progenitors: differential pathways for erythropoietin and iron-dependent regulation
    Heinz Zoller
    Department of Medicine, University Hospital Innsbruck, Anichstrasse 25, A 6020 Innsbruck, Austria
    Br J Haematol 118:619-26. 2002
    ..These data provide new insights into the complex biochemical interaction between iron metabolism, haem biosynthesis and EPO biology...
  31. pmc Nanomedicines in the treatment of patients with hepatitis C co-infected with HIV--focus on pegylated interferon-alpha
    Heinz Zoller
    Innsbruck Medical University, University Hospital of Innsbruck, Department of Medicine, Clinical Division of Gastroenterology and Hepatology, Anichstrasse 35, Austria
    Int J Nanomedicine 1:399-409. 2006
    ....
  32. pmc Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea
    Peter Heinz-Erian
    Department of Pediatrics II, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Am J Hum Genet 84:188-96. 2009
    ..We delineate syndromic CSD as a distinct disease entity caused by SPINT2 loss-of-function mutations. SPINT2 mutations might lead to an excess of yet unknown serine protease activity in affected tissues...
  33. doi MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity
    Thomas Muller
    Department of Pediatrics II, Innsbruck Medical University, 6020 Innsbruck, Austria
    Nat Genet 40:1163-5. 2008
    ..In addition, mislocalization of transferrin receptor in MVID enterocytes suggests that MYO5B deficiency causes defective trafficking of apical and basolateral proteins in MVID...
  34. ncbi Adaptive changes of duodenal iron transport proteins in celiac disease
    Donatella Barisani
    Department of Experimental and Environmental Medicine and Medical Biotechnology, University of Milano Bicocca, 20052 Monza, Italy
    Physiol Genomics 17:316-25. 2004
    ....
  35. ncbi Occult celiac disease prevents penetrance of hemochromatosis
    Andreas Geier
    Department of Internal Medicine III, Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    World J Gastroenterol 11:3323-6. 2005
    ..To report a patient with C282Y homozygocity, depleted body iron and intestinal atrophy caused by celiac disease (CD) who experienced resolution of the enteropathy with subsequent normalization of iron metabolism upon gluten-free diet...