Rudolf Zechner

Summary

Affiliation: University of Graz
Country: Austria

Publications

  1. ncbi request reprint Lipolysis: pathway under construction
    Rudolf Zechner
    Institute of Molecular Biosciences, Karl Franzens University Graz, Graz, Austria
    Curr Opin Lipidol 16:333-40. 2005
  2. pmc FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    Cell Metab 15:279-91. 2012
  3. doi request reprint Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    J Lipid Res 50:3-21. 2009
  4. pmc Functional cardiac lipolysis in mice critically depends on comparative gene identification-58
    Kathrin A Zierler
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 288:9892-904. 2013
  5. ncbi request reprint Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Cell Metab 3:309-19. 2006
  6. ncbi request reprint Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
  7. ncbi request reprint Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    Robert Zimmermann
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Science 306:1383-6. 2004
  8. pmc Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids
    Gabriele Schoiswohl
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    J Lipid Res 51:490-9. 2010
  9. pmc The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
    Astrid Gruber
    Institute of Molecular Biosciences, University of Graz, Humboldtstrasse, A 8010 Graz, Austria
    J Biol Chem 285:12289-98. 2010
  10. pmc Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)
    Franz P W Radner
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    J Biol Chem 285:7300-11. 2010

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Lipolysis: pathway under construction
    Rudolf Zechner
    Institute of Molecular Biosciences, Karl Franzens University Graz, Graz, Austria
    Curr Opin Lipidol 16:333-40. 2005
    ..This review focuses on the function of recently discovered enzymes in adipose tissue lipolysis and fatty acid mobilization...
  2. pmc FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    Cell Metab 15:279-91. 2012
    ....
  3. doi request reprint Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    J Lipid Res 50:3-21. 2009
    ..This review focuses on the structure, function, and regulation of lipolytic enzymes with a special emphasis on ATGL...
  4. pmc Functional cardiac lipolysis in mice critically depends on comparative gene identification-58
    Kathrin A Zierler
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 288:9892-904. 2013
    ..In summary, this study demonstrates that functional muscle lipolysis depends on both CGI-58 and ATGL...
  5. ncbi request reprint Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Cell Metab 3:309-19. 2006
    ..These data establish an important biochemical function for CGI-58 in the lipolytic degradation of fat, implicating this lipolysis activator in the pathogenesis of CDS...
  6. ncbi request reprint Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
    ..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis...
  7. ncbi request reprint Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    Robert Zimmermann
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Science 306:1383-6. 2004
    ..Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals...
  8. pmc Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids
    Gabriele Schoiswohl
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    J Lipid Res 51:490-9. 2010
    ..Thus, ATGL activity is required for proper energy supply of the skeletal muscle during exercise...
  9. pmc The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
    Astrid Gruber
    Institute of Molecular Biosciences, University of Graz, Humboldtstrasse, A 8010 Graz, Austria
    J Biol Chem 285:12289-98. 2010
    ..In summary, our study shows that the N-terminal, Trp-rich region of CGI-58 is essential for correct localization and ATGL-activating function of CGI-58...
  10. pmc Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)
    Franz P W Radner
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    J Biol Chem 285:7300-11. 2010
    ..This mechanism may also underlie the pathogenesis of ichthyosis in neutral lipid storage disease patients lacking functional CGI-58...
  11. ncbi request reprint Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis
    Elke M Wagner
    Institute of Molecular Biology, Biochemistry, and Microbiology, University of Graz, Graz, Austria
    J Lipid Res 45:356-65. 2004
    ..These results suggest that in the absence of LPL in AT, lipogenesis is activated through increased SREBP-1 expression and processing triggered by decreased availability of nutrition-derived FAs, elevated insulin, and low leptin levels...
  12. doi request reprint The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 283:17211-20. 2008
    ..Together, our results demonstrate that the C-terminal region of ATGL is essential for proper localization of the enzyme and suppresses enzyme activity...
  13. pmc The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively
    Irina Cornaciu
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    PLoS ONE 6:e26349. 2011
    ....
  14. pmc Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance
    Ulrike Taschler
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 286:17467-77. 2011
    ..Defective degradation of 2-AG does not provoke cannabinoid-like effects on feeding behavior, lipid storage, and energy expenditure, which may be explained by desensitization of CBR...
  15. doi request reprint Adipose triglyceride lipase contributes to cancer-associated cachexia
    Suman K Das
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Science 333:233-8. 2011
    ..Hsl-deficient mice with tumors were also protected although to a lesser degree. Thus, functional lipolysis is essential in the pathogenesis of CAC. Pharmacological inhibition of metabolic lipases may help prevent cachexia...
  16. ncbi request reprint Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 281:40236-41. 2006
    ..Together, ATGL and HSL are responsible for more than 95% of the TG hydrolase activity present in murine WAT. Additional known or unknown lipases appear to play only a quantitatively minor role in fat cell lipolysis...
  17. ncbi request reprint Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue
    Robert Zimmermann
    Institute of Molecular Biology, Biochemistry, and Microbiology, University of Graz, Graz, Austria
    J Lipid Res 44:2089-99. 2003
    ..These metabolic adaptations result in decreased fat mass in HSL-ko mice...
  18. ncbi request reprint Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase
    Petra C Kienesberger
    Institute of Molecular Biosciences, University of Graz 8010, Graz, Austria
    J Biol Chem 283:5908-17. 2008
    ..Regulation of enzyme expression by the nutritional status and insulin suggests a role of NRE in the catabolism of lipid precursors and/or mediators that affect energy metabolism in mammals...
  19. pmc Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue
    Dagmar Kratky
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    J Clin Invest 115:161-7. 2005
    ..Our results suggest that EL activity in AT and other peripheral tissues might contribute to the tissue uptake of free fatty acids, which could have important implications for the metabolism of plasma lipoproteins...
  20. doi request reprint Fate of fat: the role of adipose triglyceride lipase in lipolysis
    Robert Zimmermann
    Insitute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Biochim Biophys Acta 1791:494-500. 2009
    ..This review focuses on the importance of ATGL as TG lipase within the "lipolytic machinery" and the current knowledge of molecular mechanisms that regulate ATGL activity...
  21. pmc Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier
    Nina M Pollak
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Lipid Res 54:1092-102. 2013
    ..These findings strongly suggest that Plin5 functions as a lipolytic barrier to protect the cardiac TG pool from uncontrolled TG mobilization and the excessive release of free FAs...
  22. pmc Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases
    Thomas O Eichmann
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 287:41446-57. 2012
    ..Because ATGL preferentially generates sn-1,3 and sn-2,3, it suggests that TAG-derived DAG cannot directly enter phospholipid synthesis or activate protein kinase C without prior isomerization...
  23. pmc Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase
    Manju Kumari
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Cell Metab 15:691-702. 2012
    ..This gain of function provides a plausible biochemical mechanism for the development of liver steatosis in subjects carrying the I148M variant...
  24. pmc Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver
    Renate Schreiber
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Lipid Res 50:2514-23. 2009
    ..Interestingly, however, Gus was capable of hydrolyzing the naturally occurring vitamin A metabolite retinoyl beta-glucuronide. In conclusion, our observations implicate that both Es22 and Gus play a role in liver retinoid metabolism...
  25. pmc Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissues
    Maria Morak
    Institute of Biochemistry, Graz University of Technology, Graz, Austria
    Mol Cell Proteomics 11:1777-89. 2012
    ..Among these enzymes, Es1, Es10, and Es31-like represent lipase candidates as they catalyze the hydrolysis of long-chain acylglycerols...
  26. pmc Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
    Chandramohan Chitraju
    Department of Molecular Biosciences, University of Graz, Lipidomics Research Center, 8010 Graz, Austria
    J Lipid Res 53:2141-52. 2012
    ..We demonstrate that lipidomic analysis of LDs enables phenotyping of nutritional stress. TG species are best suited for such phenotyping, whereas structural analysis of TG, DG, and PL molecular species provides metabolic insights...
  27. ncbi request reprint Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast
    Christoph F Kurat
    Institute of Molecular Biosciences, University of Graz, Schubertstrasse 1, A8010 Graz, Austria
    J Biol Chem 281:491-500. 2006
    ..Our data identify yeast Tgl4 as a functional ortholog of mammalian adipose triglyceride lipase...
  28. pmc Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363
    Marlene Buchebner
    Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    J Lipid Res 51:2896-908. 2010
    ..We conclude that additional enzymes must exist that cooperate with HSL to regulate CE levels in macrophages. KIAA1363 affects AcMAGE hydrolase activity but is of minor importance as a direct CE hydrolase in macrophages...
  29. pmc ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Nat Med 17:1076-85. 2011
    ..These findings reveal a potential treatment for the excessive cardiac lipid accumulation and often-lethal cardiomyopathy in people with neutral lipid storage disease, a disease marked by reduced or absent ATGL activity...
  30. pmc Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling
    Petra C Kienesberger
    From the Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 284:30218-29. 2009
    ....
  31. pmc The impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
    Chandramohan Chitraju
    Department of Molecular Biosciences, University of Graz, Lipidomics Research Center, Graz, Austria
    J Lipid Res 54:2185-94. 2013
    ..Taken together, lipidomes of hepatocyte LDs are sensitive responders to nutritional and genetic stress. ..
  32. ncbi request reprint Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle
    Guenter Haemmerle
    Institute of Molecular Biology, Biochemistry, and Microbiology, University of Graz, Heinrichstrasse 31A, Graz A 8010, Austria
    J Biol Chem 277:12946-52. 2002
    ..These changes result in an "anti-atherogenic" lipoprotein profile...
  33. ncbi request reprint The lipolytic proteome of mouse adipose tissue
    Ruth Birner-Gruenberger
    Institute of Biochemistry, Graz University of Technology, Petersgasse 12 2, Graz, Austria
    Mol Cell Proteomics 4:1710-7. 2005
    ..Thus our results show the first map of the lipolytic proteome of mouse adipose tissue and demonstrate the general applicability of our method for rapid profiling and identification of lipolytic activities in complex biological samples...
  34. doi request reprint Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Am J Physiol Endocrinol Metab 297:E289-96. 2009
    ..These observations indicate an ATGL-independent function of CGI-58. This review summarizes recent findings with the goal of relating structural variants of ATGL and CGI-58 to functional consequences in lipid metabolism...
  35. doi request reprint Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury
    Tarek Moustafa
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Gastroenterology 142:140-151.e12. 2012
    ..The liver controls central processes of lipid and bile acid homeostasis. We aimed to investigate whether alterations in lipid metabolism contribute to the pathogenesis of chronic cholestatic liver disease in mice...
  36. pmc Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
    Petra C Kienesberger
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Lipid Res 50:S63-8. 2009
    ..This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis...
  37. doi request reprint Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine
    Monika Riederer
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31A, A 8010 Graz, Austria
    Atherosclerosis 204:412-7. 2009
    ..These data support the concept that adipose tissue NNMT contributes to the increased plasma homocysteine levels in patients treated with NA...
  38. pmc Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity
    Juliane G Strauss
    Institute of Molecular Biology, Biochemistry and Microbiology, University of Graz, Harrachgasse 21, A 8010 Graz, Austria
    Biochem J 368:69-79. 2002
    ..Thus our results demonstrate that EDL mediates both HDL binding and uptake, and the selective uptake of HDL-CE, independently of lipolysis and CLA-1...
  39. pmc Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    Prog Lipid Res 50:14-27. 2011
    ..Special emphasis will be given to ATGL, its regulation, and physiological function...
  40. doi request reprint Recent insights into the structure and function of comparative gene identification-58
    Monika Oberer
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Curr Opin Lipidol 22:149-58. 2011
    ..This review aims at establishing a structure-function relationship of this still rather enigmatic protein based on recent studies characterizing different functions of CGI-58...
  41. ncbi request reprint Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle
    Christa Nöhammer
    Department of Pathology, Pharmacology and Toxicology, University of Graz, Graz, Austria
    Lab Invest 83:259-69. 2003
    ....
  42. pmc Transmission of Campylobacter hyointestinalis from a pig to a human
    Gregor Gorkiewicz
    Institute of Molecular Biology, Biochemistry and Microbiology, Karl Franzens University, Graz, Austria
    J Clin Microbiol 40:2601-5. 2002
    ..hyointestinalis strain originating from porcine feces. Subsequent typing of the human and the porcine isolates by pulsed-field gel electrophoresis revealed similar macrorestriction profiles, indicating transmission of this pathogen...
  43. pmc Species-specific identification of campylobacters by partial 16S rRNA gene sequencing
    Gregor Gorkiewicz
    Institute of Molecular Biology, Biochemistry and Microbiology, Karl Franzens University, Graz, Austria
    J Clin Microbiol 41:2537-46. 2003
    ..We recommend 16S rDNA sequence analysis as an effective, rapid procedure for the specific identification of campylobacters...
  44. doi request reprint Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers
    Karoline Etschmaier
    Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria
    J Neurochem 119:1016-28. 2011
    ..Our findings imply that ATGL is involved in brain fatty acid metabolism, particularly in regions mediating transport and exchange processes: the brain-CSF interface, the blood-CSF barrier, and the blood-brain barrier...
  45. ncbi request reprint Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis
    Guenter Haemmerle
    Institute of Molecular Biology, Biochemistry, and Microbiology, University of Graz, Graz A 8010, Austria
    J Biol Chem 277:4806-15. 2002
    ..From these in vivo results we conclude that HSL is the rate-limiting enzyme for the cellular catabolism of DG in adipose tissue and muscle...
  46. ncbi request reprint LPL-mediated lipolysis of VLDL induces an upregulation of AU-rich mRNAs and an activation of HuR in endothelial cells
    Marisa M O Tschernatsch
    Institute of Molecular Biosciences, Karl Franzens University, Graz, Heinrichstrasse 31 A, 8010 Graz, Austria
    Atherosclerosis 189:310-7. 2006
    ....
  47. ncbi request reprint Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism
    Karina Preiss-Landl
    Institute of Molecular Bioloogy, Biochemistry and Microbiology, Karl Frasnzens University, Graz, Heinrichstrasse 31A, A 8010 Graz, Austria
    Curr Opin Lipidol 13:471-81. 2002
    ..The aim of this review is to summarize and discuss recent advances in the understanding of the physiological role of lipoprotein lipase in lipid and energy metabolism...
  48. pmc Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase
    Ouliana Ziouzenkova
    Cardiovascular Division, Brigham and Women s Hospital, Harvard University, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:2730-5. 2003
    ....
  49. ncbi request reprint Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake
    Martin Merkel
    Department of Medicine, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 277:7405-11. 2002
    ..In the absence of active LPL in the same tissue, inactive LPL only mediates selective cholesterol ester uptake...
  50. pmc Tissue-specific expression of human lipoprotein lipase in the vascular system affects vascular reactivity in transgenic mice
    Victor E Esenabhalu
    Department of Medical Biochemistry and Medical Molecular Biology, Karl Franzens University of Graz, Harrachgasse 21 III, A 8010 Graz, Austria
    Br J Pharmacol 135:143-54. 2002
    ..Thus, vascular LPL activity might represent a primary risk factor for atherosclerosis independently from cholesterol/LDL levels...
  51. pmc Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis
    Brendan N Reid
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 283:13087-99. 2008
    ....
  52. ncbi request reprint Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model
    Daniel Goti
    Institute of Medical Biochemistry and Molecular Biology, University Graz, Harrachgasse 21, Graz 8010, Austria
    J Biol Chem 277:28537-44. 2002
    ..The relevance of LPL-dependent alphaTocH uptake across the BBB was confirmed in LPL-deficient mice. The absence of LPL resulted in significantly lower cerebral alphaTocH concentrations than observed in control animals...
  53. ncbi request reprint Letting lipids go: hormone-sensitive lipase
    Guenter Haemmerle
    Institute of Molecular Biology, Karl Franzens University, Graz, Autria
    Curr Opin Lipidol 14:289-97. 2003
    ..The aim of this review is to evaluate the role of hormone-sensitive lipase in this process...
  54. ncbi request reprint The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
    Veit Schoenborn
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular Clinical Pharmacology, Innsbruck Medical University, Schopfstrasse 41, A 6020 Innsbruck, Austria
    Diabetes 55:1270-5. 2006
    ..These results complement previous findings of functional studies in mammals and elucidate a potential role of ATGL in pathways involved in components of the metabolic syndrome...
  55. ncbi request reprint Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression
    Ayanna Augustus
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 279:25050-7. 2004
    ..Thus, the loss of LpL in the heart leads to defective plasma metabolism of TG. Moreover, fatty acids derived from lipoprotein TG and not just albumin-associated fatty acids are important for cardiac lipid metabolism and gene regulation...
  56. ncbi request reprint Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation
    Lori L Hensley
    The Central Arkansas Veterans HealthCare System and Department of Medicine, Division of Endocrinology, University of Arkansas for Medicla Sciences, Little Rock, 72205, USA
    J Biol Chem 278:32702-9. 2003
    ..Therefore, these data suggest that the absence of the 3'-UTR results in a translationally unrepressed LPL, resulting in a moderate overexpression of adipose LPL activity...
  57. ncbi request reprint Endothelial and lipoprotein lipases in human and mouse placenta
    Marie L S Lindegaard
    Department of Clinical Biochemistry, Rigshospitalet, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 46:2339-46. 2005
    ..Nevertheless, the two lipases might have overlapping functions in the mouse placenta. Our data also suggest that the major portions of both proteins are stored in an inactive form in human term placenta...
  58. doi request reprint Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice
    Montserrat Pinent
    Institute for Genomics and Bioinformatics, Graz University of Technology, 8010 Graz, Austria
    Genomics 92:26-32. 2008
    ..We hypothesize that the intermediary metabolites of the lipolytic pathways are signaling molecules and activators of a wide range of biochemical and cellular processes in mammals...