Affiliation: University of Graz
Zechner R, Langin D. Hormone-sensitive lipase deficiency in humans. Cell Metab. 2014;20:199-201 pubmed publisher
..Albert et al. (2014) demonstrate that the lack of hormone-sensitive lipase, a member of the enzyme trio that catabolizes fat, has pronounced effects on lipid metabolism, glucose homeostasis, and cell signaling in humans. ..
Schreiber R, Hofer P, Taschler U, Voshol P, Rechberger G, Kotzbeck P, et al
. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015;112:13850-5 pubmed publisher
..These results argue for the existence of an adaptive interdependence between lipolysis and lipid synthesis. Pharmacological inhibition of ATGL may prove useful to prevent HFD-induced obesity and insulin resistance. ..
Schweiger M, Zechner R. Breaking the Barrier--Chaperone-Mediated Autophagy of Perilipins Regulates the Lipolytic Degradation of Fat. Cell Metab. 2015;22:60-1 pubmed publisher
Heier C, Radner F, Moustafa T, Schreiber R, Grond S, Eichmann T, et al
. G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis. J Biol Chem. 2015;290:26141-50 pubmed publisher
..We conclude that G0S2 acts as a potent ATGL inhibitor in the heart modulating cardiac substrate utilization by regulating cardiac lipolysis. ..
Mussbacher M, Stessel H, WÃ¶lkart G, Haemmerle G, Zechner R, Mayer B, et al
. Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice. J Mol Cell Cardiol. 2014;77:11-9 pubmed publisher
..In summary, our data point to a hitherto unrecognized link between proteasomal function, PPARÎ± signaling and cardiovascular disease. ..
Zechner R, Zimmermann R, Eichmann T, Kohlwein S, Haemmerle G, Lass A, et al
. FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012;15:279-91 pubmed publisher
Zechner R, Kienesberger P, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res. 2009;50:3-21 pubmed publisher
..This review focuses on the structure, function, and regulation of lipolytic enzymes with a special emphasis on ATGL. ..
Schrammel A, Mussbacher M, Winkler S, Haemmerle G, Stessel H, Wölkart G, et al
. Cardiac oxidative stress in a mouse model of neutral lipid storage disease. Biochim Biophys Acta. 2013;1831:1600-8 pubmed publisher
..Upregulation of soluble guanylate cyclase and cardiac tetrahydrobiopterin might be regarded as counterregulatory mechanisms in cardiac ATGL deficiency. ..
Das S, Stadelmeyer E, Schauer S, Schwarz A, Strohmaier H, Claudel T, et al
. Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58. Int J Mol Sci. 2015;16:8555-68 pubmed publisher
..Therefore, we suggest that miR-124a may be involved in the regulation of several cellular and organismal metabolic parameters, including lipid storage and plasma FA concentration. ..