K Zatloukal

Summary

Affiliation: University of Graz
Country: Austria

Publications

  1. pmc Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitro
    Elke Janig
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Am J Pathol 171:1474-82. 2007
  2. pmc Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies
    K Zatloukal
    Department of Pathology, University of Graz, Graz, Austria
    Am J Pathol 156:1263-74. 2000
  3. pmc p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases
    Kurt Zatloukal
    Department of Pathology, Karl Franzens University, Graz, Austria
    Am J Pathol 160:255-63. 2002
  4. ncbi request reprint Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related?
    H Denk
    Department of Pathology, Medical University of Graz, Graz, Austria
    J Pathol 208:653-61. 2006
  5. ncbi request reprint Sequence of events in the assembly of Mallory body components in mouse liver: clues to the pathogenesis and significance of Mallory body formation
    C Stumptner
    Department of Pathology, University of Graz, School of Medicine, Austria
    J Hepatol 34:665-75. 2001
  6. pmc Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent
    C Stumptner
    Departments of Pathology and Surgery, double dagger University of Graz School of Medicine, Graz, Austria
    Am J Pathol 154:1701-10. 1999
  7. ncbi request reprint How a cell deals with abnormal proteins. Pathogenetic mechanisms in protein aggregation diseases
    A Aigelsreiter
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Pathobiology 74:145-58. 2007
  8. doi request reprint SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway
    A Hrzenjak
    Saldow Research Unit for Molecular Pathology of Gynecologic Tumors, Department of Pathology, Medical University of Graz, Graz, Austria
    J Pathol 216:495-504. 2008
  9. pmc Functions of c-Jun in liver and heart development
    R Eferl
    Department of Pathology, University of Graz, A 8036 Graz, Austria
    J Cell Biol 145:1049-61. 1999
  10. ncbi request reprint Nonviral gene transfer into fetal mouse livers (a comparison between the cationic polymer PEI and naked DNA)
    H Gharwan
    Institute of Pathology, University of Graz, Auenbruggerplatz, Graz, Styria, Austria
    Gene Ther 10:810-7. 2003

Collaborators

Detail Information

Publications38

  1. pmc Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitro
    Elke Janig
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Am J Pathol 171:1474-82. 2007
    ..The interaction of both proteins was further analyzed by electron microscopy, size exclusion chromatography, and mass spectrometry, in which clusterin was found in a stable complex with elastin after UV exposure...
  2. pmc Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies
    K Zatloukal
    Department of Pathology, University of Graz, Graz, Austria
    Am J Pathol 156:1263-74. 2000
    ..Our results point to a protective role of CKs in certain types of toxic liver injury and suggest that MBs by themselves are not harmful to hepatocytes but may be considered as a product of a novel defense mechanism in hepatocytes...
  3. pmc p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases
    Kurt Zatloukal
    Department of Pathology, Karl Franzens University, Graz, Austria
    Am J Pathol 160:255-63. 2002
    ..The presence of p62 along with other stress proteins and ubiquitin in cytoplasmic inclusions indicates deposition as aggregates as a third line of defense against misfolded proteins in addition to refolding and degradation...
  4. ncbi request reprint Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related?
    H Denk
    Department of Pathology, Medical University of Graz, Graz, Austria
    J Pathol 208:653-61. 2006
    ..If p62 is induced alone, or at least prevails, IHBs may arise by aggregation. However, if abnormal keratins are present in addition to p62, p62 associates and co-aggregates with keratins, finally leading to classical MBs...
  5. ncbi request reprint Sequence of events in the assembly of Mallory body components in mouse liver: clues to the pathogenesis and significance of Mallory body formation
    C Stumptner
    Department of Pathology, University of Graz, School of Medicine, Austria
    J Hepatol 34:665-75. 2001
    ....
  6. pmc Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent
    C Stumptner
    Departments of Pathology and Surgery, double dagger University of Graz School of Medicine, Graz, Austria
    Am J Pathol 154:1701-10. 1999
    ..These features suggest a role of p62 in signal transduction and possibly also carcinogenesis. IHBs observed in the hepatocellular carcinoma cells presented are the first indications of a role of p62 in disease...
  7. ncbi request reprint How a cell deals with abnormal proteins. Pathogenetic mechanisms in protein aggregation diseases
    A Aigelsreiter
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Pathobiology 74:145-58. 2007
    ..The cellular defense mechanisms involved in protein quality control as well as the pathogenesis of protein aggregation diseases will be discussed...
  8. doi request reprint SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway
    A Hrzenjak
    Saldow Research Unit for Molecular Pathology of Gynecologic Tumors, Department of Pathology, Medical University of Graz, Graz, Austria
    J Pathol 216:495-504. 2008
    ..Taken together, our study indicates that HDACs might be considered as potential drug targets in the therapy of stromal sarcomas and that SAHA might be a promising therapeutic agent for endometrial stromal sarcoma...
  9. pmc Functions of c-Jun in liver and heart development
    R Eferl
    Department of Pathology, University of Graz, A 8036 Graz, Austria
    J Cell Biol 145:1049-61. 1999
    ....
  10. ncbi request reprint Nonviral gene transfer into fetal mouse livers (a comparison between the cationic polymer PEI and naked DNA)
    H Gharwan
    Institute of Pathology, University of Graz, Auenbruggerplatz, Graz, Styria, Austria
    Gene Ther 10:810-7. 2003
    ..8 x 10(3) RLU/mg of tissue protein), indicating that fetal tissue is especially amenable to the uptake and expression of naked DNA...
  11. ncbi request reprint CD44 and variants in melanocytic skin neoplasms
    H Schaider
    Department of Dermatology, University of Graz, Austria
    J Cutan Pathol 25:199-203. 1998
    ..We conclude that CD44s and splice variants can not be regarded as indicators for tumor progression in malignant melanomas. However, v5 may potentially serve as a diagnostic marker for melanocytic skin lesions...
  12. pmc Bile acid-induced Mallory body formation in drug-primed mouse liver
    Peter Fickert
    Department of Medicine, Karl Franzens University, Auenbruggerplatz 25, A 8036 Graz, Austria
    Am J Pathol 161:2019-26. 2002
    ..Furthermore, CBDL and CA feeding resulted in rapid neoformation of MBs in drug-primed mice. It is concluded that MB formation in cholestatic liver diseases may be triggered by the action of potentially toxic bile acids...
  13. ncbi request reprint In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62
    Conny Stumptner
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Hepatology 46:851-60. 2007
    ....
  14. pmc A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis
    Peter Fickert
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Austria
    Am J Pathol 171:525-36. 2007
    ..This model may be valuable to investigate the mechanisms of xenobiotic-induced chronic cholangiopathies and its sequels including biliary fibrosis...
  15. ncbi request reprint From Mallory to Mallory-Denk bodies: what, how and why?
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Exp Cell Res 313:2033-49. 2007
    ..Although it remains unclear whether MDBs serve a bystander, protective or injury promoting function, they do serve an important role as histological and potential progression markers in several liver diseases...
  16. pmc Cytokeratins as targets for bile acid-induced toxicity
    Peter Fickert
    Department of Medicine, University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Am J Pathol 160:491-9. 2002
    ..Thus, increased hepatocellular CK expression and phosphorylation in cholestasis may be caused by retention of toxic bile acids and reflect a hepatocellular stress response with potential beneficial effects...
  17. ncbi request reprint The keratin cytoskeleton in liver diseases
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, A 8036 Graz, Austria
    J Pathol 204:367-76. 2004
    ..The functional relevance of keratins in human diseases has recently been underlined by the identification of mutations in keratin genes in patients with liver cirrhosis...
  18. ncbi request reprint Interaction of stress proteins with misfolded keratins
    Elke Janig
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Eur J Cell Biol 84:329-39. 2005
    ..Furthermore, we found clusterin in association with elastic fibers in the extracellular matrix in several chronic liver diseases, including ASH and alpha1-antitrypsin deficiency, implying a possible role of clusterin in liver fibrosis...
  19. ncbi request reprint Intermediate filament protein inclusions
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, A 8036 Graz, Austria
    Methods Cell Biol 78:205-28. 2004
  20. ncbi request reprint Mallory body--a disease-associated type of sequestosome
    Cornelia Stumptner
    Department of Pathology, School of Medicine, University of Graz, Graz, Austria
    Hepatology 35:1053-62. 2002
    ..In conclusion, the constant presence of p62 in MBs suggests that binding of p62 to abnormal keratins may allow hepatocytes to dispose potentially harmful proteins in a biologically inert manner...
  21. ncbi request reprint Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    Peter Fickert
    Deparment of Medicine, Medical University, Graz, Austria
    Gastroenterology 127:261-74. 2004
    ....
  22. ncbi request reprint Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas
    Andelko Hrzenjak
    Department of Pathology, Medical University, Graz, Austria
    J Pathol 204:19-27. 2004
    ..SFRP4 may therefore be a putative tumour suppressor involved in deregulation of the Wnt pathway and in the pathogenesis of ESS and UES...
  23. ncbi request reprint Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress
    Martin Wagner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Drug Metab Dispos 35:1694-9. 2007
    ..Induction of the adaptive transporter response after CBDL is independent of the degree of the inflammatory response. Rather, retention of biliary constituents may determine transporter expression in CBDL...
  24. ncbi request reprint Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles
    Peter Fickert
    Department of Medicine, Karl Franzens University, Graz, Austria
    Gastroenterology 123:1238-51. 2002
    ..The effects of ursodeoxycholic acid (UDCA) in biliary obstruction are unclear. We aimed to determine the effects of UDCA in bile duct-ligated and in Mdr2 knockout (Mdr2(-/-)) mice with biliary strictures...
  25. ncbi request reprint Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice
    Gernot Zollner
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Karl Franzens University, Graz, A 8036 Austria
    Am J Physiol Gastrointest Liver Physiol 282:G184-91. 2002
    ..These findings support the concept that downregulation of Ntcp in cholestasis limits intracytoplasmatic accumulation of potentially toxic bile acids...
  26. ncbi request reprint Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins
    Peter Fickert
    Department of Medicine, Karl Franzens University Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    J Hepatol 38:387-94. 2003
    ....
  27. ncbi request reprint Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Liver Int 27:920-9. 2007
    ..We therefore investigated expression of genes for bile acid synthesis, detoxification and alternative basolateral export and regulatory nuclear factors in primary biliary cirrhosis (PBC)...
  28. doi request reprint Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis
    Carolin Lackner
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
    J Hepatol 48:821-8. 2008
    ..Ballooning degeneration is considered a hallmark of steatohepatitis, but enlarged hepatocytes may also be observed in a variety of other acute and chronic liver diseases...
  29. ncbi request reprint Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis
    Gernot Zollner
    Division of Gastroenterology and Hepatology, Department of Medicine, Karl Franzens University, Auenbruggerplatz 15, A 8036, Graz, Austria
    J Hepatol 38:717-27. 2003
    ....
  30. ncbi request reprint The differentiation antigen NY-BR-1 is a potential target for antibody-based therapies in breast cancer
    Inka Seil
    Georg Speyer Haus, Institute for Biomedical Research, Frankfurt, Germany
    Int J Cancer 120:2635-42. 2007
    ....
  31. ncbi request reprint Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice
    Martin Wagner
    Department of Medicine, Karl Franzens University, Graz, Austria
    Gastroenterology 125:825-38. 2003
    ..We aimed to investigate the role of the nuclear bile acid receptor (farnesoid X receptor [FXR]) in mediating changes in ABC transporter expression and in determining liver injury...
  32. ncbi request reprint 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    Peter Fickert
    Department of Medicine, Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University Graz, Austria
    Gastroenterology 130:465-81. 2006
    ..Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(23) homologue of ursodeoxycholic acid with 1 fewer methylene group in its side chain...
  33. pmc Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice
    Peter Fickert
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Am J Pathol 168:410-22. 2006
    ..Thus, we demonstrate that LCA feeding in mice leads to segmental bile duct obstruction, destructive cholangitis, periductal fibrosis, and an adaptive transporter and metabolic enzyme response...
  34. ncbi request reprint Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine
    Gernot Zollner
    Division of Gastroenterology and Hepatology, Department of Medicine, Karl Franzens University, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Hepatol 39:480-8. 2003
    ..Whether adaptive changes in ATP-binding cassette (ABC) transporter expression are stimulated by bile acids and their nuclear receptor FXR is unknown...
  35. ncbi request reprint CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice
    Martin Wagner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Hepatology 42:420-30. 2005
    ....
  36. ncbi request reprint Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis
    Thomas Muller
    Department of Pediatrics, University of Innsbruck, Innsbruck, Austria
    Hepatology 39:963-9. 2004
    ..By sequestering potentially harmful misfolded ubiquitinated proteins as inert cytoplasmic inclusion bodies (e.g., as MBs), p62 may be a major player in an important cellular rescue mechanism in oxidative hepatocyte injury...
  37. ncbi request reprint Oncosis represents the main type of cell death in mouse models of cholestasis
    Peter Fickert
    Laboratory of Experimental Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University, Auenbruggerplatz 15, A 8036 Graz, Austria
    J Hepatol 42:378-85. 2005
    ..Since the mechanisms leading to hepatocyte death in cholestasis are not well defined, we aimed to obtain closer insights into the related pathogenetic principles...
  38. ncbi request reprint Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 289:G798-805. 2005
    ....