M Widschwendter

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Circulating methylated DNA: a new generation of tumor markers
    Martin Widschwendter
    Department of Gynaecological Oncology, UCL Elizabeth Garrett Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 12:7205-8. 2006
  2. pmc Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study
    Martin Widschwendter
    Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
    PLoS ONE 3:e2656. 2008
  3. pmc MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status
    H M Muller
    Department of Obstetrics and Gynecology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Br J Cancer 89:1934-9. 2003
  4. ncbi Pre-eclampsia: a disorder of placental mitochondria?
    M Widschwendter
    Dept of Gynecology and Obstetrics, Innsbruck University, Austria
    Mol Med Today 4:286-91. 1998
  5. ncbi Analysis of aberrant DNA methylation and human papillomavirus DNA in cervicovaginal specimens to detect invasive cervical cancer and its precursors
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Innsbruck, Austria
    Clin Cancer Res 10:3396-400. 2004
  6. ncbi DNA hypomethylation and ovarian cancer biology
    Martin Widschwendter
    Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria
    Cancer Res 64:4472-80. 2004
  7. ncbi DNA methylation and breast carcinogenesis
    Martin Widschwendter
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, California, CA 90089 9181, USA
    Oncogene 21:5462-82. 2002
  8. ncbi The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer. Commentary re: J. Kwong et al., Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin. Cancer Res., 8: 131-137, 2002, and H-Z. Zou et al., D
    Martin Widschwendter
    University of Southern California Norris Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9181, USA
    Clin Cancer Res 8:17-21. 2002
  9. ncbi Loss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer
    M Widschwendter
    Department of Gynecology and Obstetrics, University of Innsbruck, Austria
    Cancer Res 57:4158-61. 1997
  10. ncbi Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer
    M Widschwendter
    Department of Obstetrics and Gynecology, University of Innsbruck, Austria
    J Natl Cancer Inst 92:826-32. 2000

Collaborators

Detail Information

Publications50

  1. ncbi Circulating methylated DNA: a new generation of tumor markers
    Martin Widschwendter
    Department of Gynaecological Oncology, UCL Elizabeth Garrett Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 12:7205-8. 2006
  2. pmc Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study
    Martin Widschwendter
    Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
    PLoS ONE 3:e2656. 2008
    ..However, whether DNA methylation in normal unrelated cells is associated with BC risk and whether these imprints can be related to factors which can be modified by the environment, is unclear...
  3. pmc MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status
    H M Muller
    Department of Obstetrics and Gynecology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Br J Cancer 89:1934-9. 2003
    ..Furthermore, we speculate that MeCP2, regulated by OR, plays a key role in the differentiation processes in human breast tissues...
  4. ncbi Pre-eclampsia: a disorder of placental mitochondria?
    M Widschwendter
    Dept of Gynecology and Obstetrics, Innsbruck University, Austria
    Mol Med Today 4:286-91. 1998
    ..This hypothesis is the topic of ongoing studies that, if confirmed, would be highly relevant to preventative strategies for this disease...
  5. ncbi Analysis of aberrant DNA methylation and human papillomavirus DNA in cervicovaginal specimens to detect invasive cervical cancer and its precursors
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Innsbruck, Austria
    Clin Cancer Res 10:3396-400. 2004
    ....
  6. ncbi DNA hypomethylation and ovarian cancer biology
    Martin Widschwendter
    Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria
    Cancer Res 64:4472-80. 2004
    ....
  7. ncbi DNA methylation and breast carcinogenesis
    Martin Widschwendter
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, California, CA 90089 9181, USA
    Oncogene 21:5462-82. 2002
    ....
  8. ncbi The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer. Commentary re: J. Kwong et al., Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin. Cancer Res., 8: 131-137, 2002, and H-Z. Zou et al., D
    Martin Widschwendter
    University of Southern California Norris Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9181, USA
    Clin Cancer Res 8:17-21. 2002
  9. ncbi Loss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer
    M Widschwendter
    Department of Gynecology and Obstetrics, University of Innsbruck, Austria
    Cancer Res 57:4158-61. 1997
    ..Our results clearly indicate a crucial role of RAR-beta in the carcinogenesis of breast cancer...
  10. ncbi Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer
    M Widschwendter
    Department of Obstetrics and Gynecology, University of Innsbruck, Austria
    J Natl Cancer Inst 92:826-32. 2000
    ..RAR-beta2 expression is reduced in many malignant tumors, and we examined whether methylation of RAR-beta2 could be responsible for this silencing...
  11. ncbi Epigenetic downregulation of the retinoic acid receptor-beta2 gene in breast cancer
    M Widschwendter
    Department of Obstetrics and Gynecology, University of Innsbruck, Austria
    J Mammary Gland Biol Neoplasia 6:193-201. 2001
    ..Both the time of commencement of chemoprevention and the choice of substances that are able either to prevent de novo methylation or to reverse methylation-caused gene silencing may be important considerations...
  12. ncbi Paclitaxel- and docetaxel-dependent activation of CA-125 expression in human ovarian carcinoma cells
    C Marth
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria
    Cancer Res 57:3818-22. 1997
    ..This may explain the CA-125 fluctuations observed in vivo under paclitaxel treatment and may indicate that CA-125 is not a reliable tumor marker during taxane chemotherapy...
  13. ncbi New insights into p53 regulation and gene therapy for cancer
    A G Zeimet
    Department of Obstetrics and Gynecology, University Hospital, Innsbruck, Austria
    Biochem Pharmacol 60:1153-63. 2000
    ....
  14. pmc Retinoic acid modulates prolactin receptor expression and prolactin-induced STAT-5 activation in breast cancer cells in vitro
    M Widschwendter
    Department of Gynecology and Obstetrics, University of Innsbruck, Austria
    Br J Cancer 79:204-10. 1999
    ..This action could be responsible for the anti-tumour effects of retinoids...
  15. ncbi Ascitic interleukin-12 is an independent prognostic factor in ovarian cancer
    A G Zeimet
    Department of Obstetrics and Gynecology, University Hospital, University of Innsbruck, Austria
    J Clin Oncol 16:1861-8. 1998
    ..Whereas interleukin (IL)- 12 initiates the differentiation of naive Th0 cells toward Th1 phenotype, IL-4 and IL-10 mediate the development of Th2-type immunity...
  16. pmc Cisplatin resistance is associated with reduced interferon-gamma-sensitivity and increased HER-2 expression in cultured ovarian carcinoma cells
    C Marth
    Department of Obstetrics and Gynaecology, University Hospital, Innsbruck, Austria
    Br J Cancer 76:1328-32. 1997
    ....
  17. ncbi Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma
    B Meister
    Department of Pediatrics, University of Innsbruck, Austria
    Anticancer Res 18:1777-86. 1998
    ....
  18. ncbi Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas
    A G Zeimet
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria
    Gene Ther 9:1093-100. 2002
    ..Either the absence of CAR, alphavbeta3 and alphavbeta5 or the pronounced heterogeneity in their expression might seriously compromise the efficiency of adenovirus-based gene therapy in ovarian cancer...
  19. pmc High serum levels of soluble CD44 variant isoform v5 are associated with favourable clinical outcome in ovarian cancer
    A G Zeimet
    Department of Obstetrics and Gynecology, University Hospital, Innsbruck, Austria
    Br J Cancer 76:1646-51. 1997
    ....
  20. ncbi Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells
    H Weiss
    Department of General Surgery, University Hospital Innsbruck and The Tyrolean Cancer Research Institute, Innsbruck, Austria
    Int J Cancer 92:877-82. 2001
    ..These data indicate a role of SOC entry for cell proliferation in cancer cells and suggest a novel anti-proliferative NSAID mechanism in addition to its known influence on lipid metabolism...
  21. ncbi [Prediction of preeclampsia:new hypotheses, new approaches]
    H M Muller
    Universitätsklinik für Gynäkologie und Geburtshilfe, Innsbruck, Osterreich
    Gynakol Geburtshilfliche Rundsch 38:222-31. 1998
    ..In this paper, we discuss potential ways to find specific and sensitive predictive parameters according to the current knowledge of the pathophysiology of this pregnancy-induced severe disorder...
  22. ncbi Gene methylation data--a new challenge for bioinformaticians?
    G Goebel
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Austria
    Methods Inf Med 44:516-9. 2005
    ..Additionally we outline chances and new research questions in the field of DNA methylation...
  23. ncbi [Tumorectomy in conscious patient with suspected pregnancy associated breast cancer under cervical epidural anesthesia]
    B Rainer
    Univ Klinik für Anästhesie und Allgemeine Intensivmedizin, Universitatsklinik Innsbruck, Austria
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:412-4. 2004
    ..General anesthesia during pregnancy can potentially be harmful for the fetus (hypoxia, acidosis, premature delivery, teratogenicity). We decided to anesthetize the patient with a cervical segmental epidural block...
  24. ncbi Methylated DNA as a possible screening marker for neoplastic disease in several body fluids
    Hannes M Müller
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria
    Expert Rev Mol Diagn 3:443-58. 2003
    ..Due to the ubiquity of DNA methylation changes and the possibility to detect methylated DNA in several body fluids, this specifically altered DNA may serve as a potential new screening marker for neoplastic disease...
  25. ncbi Pregnancy as a tissue expander in the correction of a scar deformity
    Barbara Del Frari
    Department of Plastic and Reconstructive Surgery, Leopold Franzens University, Innsbruck, Austria
    Am J Obstet Gynecol 190:579-80. 2004
    ..We present a case of a woman with posttraumatic scarring of the lower abdomen and thigh where tissue expansion during pregnancy was successfully used for scar correction...
  26. ncbi Circulating tumor-specific DNA: a marker for monitoring efficacy of adjuvant therapy in cancer patients
    Heidi Fiegl
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Cancer Res 65:1141-5. 2005
    ..It remains to be seen whether modifications made in adjuvant therapeutic strategies based on detection of circulating nucleic acids will improve survival as well as quality of life...
  27. ncbi CDH1 and CDH13 methylation in serum is an independent prognostic marker in cervical cancer patients
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Innsbruck, Austria
    Int J Cancer 109:163-6. 2004
    ..Our results suggest that detection of aberrant methylation of CDH1/CDH13 may be of potential use as a marker for selecting cervical cancer patients at high risk for relapse who could benefit from additional systemic therapy...
  28. ncbi CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Nat Genet 38:787-93. 2006
    ..Sporadic cases of mismatch repair deficiency occur almost exclusively as a consequence of CIMP-associated methylation of MLH1 . We propose a robust new marker panel to classify CIMP+ tumors...
  29. ncbi Methylated DNA collected by tampons--a new tool to detect endometrial cancer
    Heidi Fiegl
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Cancer Epidemiol Biomarkers Prev 13:882-8. 2004
    ..The methods developed in this study provide the basis for a prospective clinical trial to screen asymptomatic women who are at high risk for endometrial cancer...
  30. ncbi A subpopulation of mitochondria prevents cytosolic calcium overload in endothelial cells after cold ischemia/reperfusion
    A Amberger
    D. Swarovski Research Laboratory, Department of Transplant and General Surgery, University Hospital Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    Transplantation 71:1821-7. 2001
    ..These mitochondria protect cells against cytosolic calcium overload and probably against subsequent cell injury...
  31. ncbi A DNA methylation pattern similar to normal tissue is associated with better prognosis in human cervical cancer
    Hannes M Müller
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Cancer Lett 209:231-6. 2004
    ..This study shows for the first time that working solely with DNA methylation pattern a subgroup of cervical cancer patients can be defined that demonstrated strong similarity to non-neoplastic probands and had a better prognosis...
  32. ncbi Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, A 6020 Innsbruck, Austria
    Gynecol Oncol 93:407-16. 2004
    ..The aim of this study was to investigate the expression and methylation pattern of hTERT in ovarian and cervical cancer tissue and their correlation with clinicopathological features and outcome of the disease...
  33. pmc Toll-like receptor 9 expression in breast and ovarian cancer is associated with poorly differentiated tumors
    Regina Berger
    Department of Gynecology and Obstetrics, Medical University Innsbruck, Innsbruck, Austria
    Cancer Sci 101:1059-66. 2010
    ....
  34. ncbi DNA methylation in serum of breast cancer patients: an independent prognostic marker
    Hannes M Müller
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Cancer Res 63:7641-5. 2003
    ..7. DNA methylation of particular genes in pretherapeutic sera of breast cancer patients, especially of RASSF1A/APC, is more powerful than standard prognostic parameters...
  35. ncbi Methylation changes in faecal DNA: a marker for colorectal cancer screening?
    Hannes M Müller
    Department of General and Transplant Surgery, Medical University Innsbruck, A 6020 Innsbruck, Austria
    Lancet 363:1283-5. 2004
    ..Whether a combination of genetic and epigenetic markers will identify colorectal cancer at an early stage remains to be shown...
  36. ncbi Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer
    Heidi Fiegl
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Cancer Res 66:29-33. 2006
    ..04). These data support the view that in addition to HER-2/neu-associated signaling, epigenetic changes in cancer as well as in tumor stroma cells might attribute to the specific biological features of HER-2/neu-positive cancers...
  37. ncbi DNA methylation in serum and tumors of cervical cancer patients
    Andreas Widschwendter
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Innsbruck, Austria
    Clin Cancer Res 10:565-71. 2004
    ..The aim of this study was to investigate the methylation status of various genes in cervical cancer patients and their association with clinicopathological characteristics and outcome of the disease...
  38. ncbi Analysis of methylated genes in peritoneal fluids of ovarian cancer patients: a new prognostic tool
    Hannes M Müller
    Departments of Obstetrics and Gynecology and Biostatistics and Documentation, Medical University Innsbruck, Innsbruck, Austria
    Clin Chem 50:2171-3. 2004
  39. ncbi DNA methylation changes in sera of women in early pregnancy are similar to those in advanced breast cancer patients
    Hannes M Müller
    Department of Obstetrics and Gynecology, Central Blood Transfusion and Immunology, Medical University Innsbruck, Innsbruck, Austria
    Clin Chem 50:1065-8. 2004
  40. ncbi Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen
    Martin Widschwendter
    Department of Urology, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, 90089 9176, USA
    Cancer Res 64:3807-13. 2004
    ....
  41. ncbi Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer
    Susanna Ekholm-Reed
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Cancer Res 64:795-800. 2004
    ..These results indicate that hCdc4 function is an absolute prerequisite for cell cycle regulation of cyclin E levels, and loss of hCdc4 function is sufficient to deregulate cyclin E...
  42. doi Methylated NEUROD1 promoter is a marker for chemosensitivity in breast cancer
    Heidi Fiegl
    Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 14:3494-502. 2008
    ..The aim of this proof-of-principle study was to assess whether NEUROD1 DNA methylation is able to predict the response to neoadjuvant and adjuvant chemotherapy...
  43. doi HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer
    Heidi Fiegl
    Department of Gynecological Oncology, UCL EGA Institute for Women s Health, University College London, United Kingdom
    Int J Cancer 123:725-9. 2008
    ..03)]. These findings support the view that the technical inability to optimally cytoreduce ovarian cancer is associated with particular molecular alterations in the tumor which per se define a subgroup of patients with poor outcome...
  44. ncbi FBXW7/hCDC4 is a general tumor suppressor in human cancer
    Shahab Akhoondi
    Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
    Cancer Res 67:9006-12. 2007
    ..Our study is the first comprehensive screen of FBXW7 mutations in various human malignancies and shows that FBXW7 is a general tumor suppressor in human cancer...
  45. ncbi DNA hypomethylation is prevalent even in low-grade breast cancers
    Kesmic Jackson
    Department of Biochemistry, Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA
    Cancer Biol Ther 3:1225-31. 2004
    ....
  46. ncbi Prognostic DNA methylation marker in serum of cancer patients
    Hannes M Müller
    Department of General and Transplant Surgery, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Ann N Y Acad Sci 1022:44-9. 2004
    ..This finding indicates great potential for the use of these epigenetic markers in clinical, routine risk assessment in patients with various malignancies...
  47. ncbi Epigenetic stem cell signature in cancer
    Martin Widschwendter
    Department of Gynecological Oncology, Institute for Women s Health, University College London, London WC1E 6DH, UK
    Nat Genet 39:157-8. 2007
    ....
  48. pmc 5-methylcytosine--the fifth base of DNA: the fifth wheel on a car or a highly promising diagnostic and therapeutic target in cancer?
    Martin Widschwendter
    Dis Markers 23:1-3. 2007
  49. ncbi Detection of low molecular weight derivatives of cyclin E1 is a function of cyclin E1 protein levels in breast cancer
    Charles Spruck
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 66:7355-60. 2006
    ..Therefore, the detection of LMW derivatives of cyclin E1 is likely a function of cyclin E1 protein levels, and the activity of the proteolytic machinery responsible for their generation is not a tumor-specific property...
  50. ncbi Hypomethylation and hypermethylation of DNA in Wilms tumors
    Melanie Ehrlich
    Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana, LA 70112, USA
    Oncogene 21:6694-702. 2002
    ..This suggests that the DNA hypomethylation contributes independently to oncogenesis or tumor progression...